Drosophila melanogaster

0 known processes

H2.0 (Dmel_CG11607)

Homeodomain protein 2.0

(Aliases: CG11607,Dmel\CG11607)

H2.0 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tube morphogenesis GO:0035239 191 0.187
Mouse
tube development GO:0035295 244 0.146
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 266 0.145
tissue morphogenesis GO:0048729 297 0.125
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.115
negative regulation of rna biosynthetic process GO:1902679 240 0.110
positive regulation of gene expression GO:0010628 290 0.107
post embryonic appendage morphogenesis GO:0035120 385 0.095
growth GO:0040007 359 0.095
Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.090
morphogenesis of an epithelium GO:0002009 276 0.090
embryonic morphogenesis GO:0048598 206 0.090
Mouse
appendage development GO:0048736 401 0.088
imaginal disc derived appendage morphogenesis GO:0035114 395 0.085
positive regulation of transcription dna templated GO:0045893 266 0.084
positive regulation of rna metabolic process GO:0051254 271 0.083
positive regulation of cellular biosynthetic process GO:0031328 316 0.082
appendage morphogenesis GO:0035107 397 0.080
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.079
wing disc morphogenesis GO:0007472 344 0.079
brain development GO:0007420 120 0.079
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.078
anterior posterior pattern specification GO:0009952 136 0.077
imaginal disc derived appendage development GO:0048737 399 0.074
digestive system development GO:0055123 149 0.071
Mouse
negative regulation of gene expression GO:0010629 387 0.071
compound eye development GO:0048749 307 0.068
locomotory behavior GO:0007626 176 0.066
positive regulation of rna biosynthetic process GO:1902680 266 0.065
photoreceptor cell differentiation GO:0046530 170 0.065
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.065
sensory organ morphogenesis GO:0090596 260 0.063
digestive tract morphogenesis GO:0048546 127 0.063
Mouse
neurological system process GO:0050877 358 0.062
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.060
hindgut morphogenesis GO:0007442 58 0.058
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.058
eye development GO:0001654 323 0.057
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.056
hindbrain development GO:0030902 2 0.055
regulation of cell differentiation GO:0045595 302 0.053
Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.053
head development GO:0060322 135 0.052
Fly
detection of stimulus GO:0051606 156 0.051
negative regulation of rna metabolic process GO:0051253 251 0.051
negative regulation of cellular metabolic process GO:0031324 382 0.050
cell death GO:0008219 279 0.049
open tracheal system development GO:0007424 204 0.049
negative regulation of transcription dna templated GO:0045892 237 0.049
response to abiotic stimulus GO:0009628 341 0.049
response to organic substance GO:0010033 284 0.048
compound eye morphogenesis GO:0001745 249 0.048
negative regulation of nucleic acid templated transcription GO:1903507 240 0.047
eye morphogenesis GO:0048592 260 0.047
epithelial tube morphogenesis GO:0060562 88 0.045
positive regulation of biosynthetic process GO:0009891 316 0.045
negative regulation of signaling GO:0023057 219 0.044
taxis GO:0042330 304 0.043
regulation of multicellular organismal development GO:2000026 414 0.042
Mouse
response to light stimulus GO:0009416 124 0.042
negative regulation of developmental process GO:0051093 201 0.042
Mouse
small molecule metabolic process GO:0044281 305 0.041
single organism behavior GO:0044708 391 0.041
regionalization GO:0003002 416 0.041
establishment or maintenance of cell polarity GO:0007163 167 0.041
negative regulation of biosynthetic process GO:0009890 277 0.040
negative regulation of response to stimulus GO:0048585 258 0.039
Mouse
kidney development GO:0001822 3 0.039
dendrite morphogenesis GO:0048813 199 0.039
regulation of localization GO:0032879 275 0.038
negative regulation of signal transduction GO:0009968 206 0.038
catabolic process GO:0009056 409 0.038
respiratory system development GO:0060541 213 0.038
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.038
embryonic development via the syncytial blastoderm GO:0001700 148 0.037
positive regulation of macromolecule metabolic process GO:0010604 405 0.037
actin cytoskeleton organization GO:0030036 206 0.036
regulation of anatomical structure morphogenesis GO:0022603 242 0.035
digestive tract development GO:0048565 149 0.035
Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.034
negative regulation of cell differentiation GO:0045596 143 0.033
Mouse
embryonic organ development GO:0048568 50 0.033
Mouse
eye photoreceptor cell differentiation GO:0001754 145 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.033
branching morphogenesis of an epithelial tube GO:0048754 45 0.032
male gamete generation GO:0048232 201 0.031
malpighian tubule development GO:0072002 64 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.030
camera type eye development GO:0043010 4 0.030
body morphogenesis GO:0010171 2 0.029
protein modification process GO:0036211 438 0.028
negative regulation of multicellular organismal process GO:0051241 142 0.028
Mouse
embryonic pattern specification GO:0009880 174 0.028
renal tubule development GO:0061326 64 0.028
regulation of response to external stimulus GO:0032101 115 0.028
connective tissue development GO:0061448 3 0.028
cellular protein modification process GO:0006464 438 0.028
morphogenesis of embryonic epithelium GO:0016331 94 0.028
positive regulation of signaling GO:0023056 243 0.028
regulation of cellular ketone metabolic process GO:0010565 3 0.028
regulation of phosphorus metabolic process GO:0051174 210 0.028
pigmentation GO:0043473 75 0.028
stem cell differentiation GO:0048863 117 0.027
intracellular signal transduction GO:0035556 300 0.027
wnt signaling pathway GO:0016055 98 0.027
establishment of localization in cell GO:0051649 402 0.027
gland morphogenesis GO:0022612 145 0.027
regulation of embryonic development GO:0045995 68 0.027
forebrain development GO:0030900 2 0.026
regulation of cell morphogenesis GO:0022604 163 0.026
regulation of cell cycle process GO:0010564 181 0.026
regulation of intracellular signal transduction GO:1902531 236 0.026
morphogenesis of a branching epithelium GO:0061138 45 0.025
central nervous system development GO:0007417 201 0.025
Fly
cell cell junction organization GO:0045216 55 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
negative regulation of cell communication GO:0010648 223 0.025
imaginal disc pattern formation GO:0007447 91 0.024
response to radiation GO:0009314 155 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
nephron development GO:0072006 3 0.024
salivary gland development GO:0007431 162 0.023
transcription from rna polymerase ii promoter GO:0006366 368 0.023
anterior posterior axis specification GO:0009948 109 0.023
embryo development ending in birth or egg hatching GO:0009792 152 0.023
positive regulation of cell communication GO:0010647 250 0.023
nuclear division GO:0000280 332 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.023
ameboidal type cell migration GO:0001667 151 0.023
salivary gland morphogenesis GO:0007435 145 0.023
positive regulation of response to stimulus GO:0048584 323 0.022
Mouse
chromatin organization GO:0006325 207 0.022
developmental programmed cell death GO:0010623 138 0.022
regulation of phosphorylation GO:0042325 147 0.022
regulation of organ morphogenesis GO:2000027 78 0.022
regulation of phosphate metabolic process GO:0019220 210 0.022
regulation of nervous system development GO:0051960 248 0.022
lateral inhibition GO:0046331 206 0.022
carbohydrate derivative biosynthetic process GO:1901137 85 0.022
adult behavior GO:0030534 137 0.022
regulation of immune system process GO:0002682 176 0.022
Mouse
dendrite development GO:0016358 204 0.022
dorsal closure GO:0007391 79 0.022
vesicle mediated transport GO:0016192 381 0.021
spermatogenesis GO:0007283 200 0.021
organonitrogen compound metabolic process GO:1901564 318 0.021
renal tubule morphogenesis GO:0061333 44 0.021
segmentation GO:0035282 207 0.021
embryonic hindgut morphogenesis GO:0048619 48 0.021
epithelial cell differentiation GO:0030855 322 0.021
mesenchymal cell differentiation GO:0048762 1 0.021
imaginal disc derived wing vein specification GO:0007474 48 0.021
gastrulation GO:0007369 70 0.021
nucleobase containing small molecule metabolic process GO:0055086 174 0.020
cellular catabolic process GO:0044248 372 0.020
death GO:0016265 284 0.020
regulation of molecular function GO:0065009 217 0.020
cell fate specification GO:0001708 71 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
leg disc development GO:0035218 92 0.020
eye photoreceptor cell development GO:0042462 81 0.020
organonitrogen compound biosynthetic process GO:1901566 117 0.020
single organism biosynthetic process GO:0044711 206 0.020
negative regulation of cellular component organization GO:0051129 108 0.019
axis specification GO:0009798 167 0.019
regulation of gene expression epigenetic GO:0040029 128 0.018
renal system development GO:0072001 72 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
morphogenesis of a branching structure GO:0001763 45 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
enzyme linked receptor protein signaling pathway GO:0007167 179 0.018
photoreceptor cell development GO:0042461 96 0.018
cellular ketone metabolic process GO:0042180 24 0.018
regulation of immune response GO:0050776 118 0.018
Mouse
anterior posterior axis specification embryo GO:0008595 103 0.018
heterocycle catabolic process GO:0046700 166 0.018
positive regulation of cellular component organization GO:0051130 156 0.018
blastoderm segmentation GO:0007350 159 0.018
malpighian tubule morphogenesis GO:0007443 44 0.018
regulation of cell cycle GO:0051726 291 0.018
regulation of notch signaling pathway GO:0008593 100 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
muscle structure development GO:0061061 224 0.017
Mouse
adult locomotory behavior GO:0008344 76 0.017
single organism cellular localization GO:1902580 180 0.017
kidney epithelium development GO:0072073 3 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.017
dna metabolic process GO:0006259 227 0.017
actin filament organization GO:0007015 126 0.017
protein localization to nucleus GO:0034504 55 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
columnar cuboidal epithelial cell development GO:0002066 249 0.016
cardiovascular system development GO:0072358 82 0.016
Zebrafish
establishment of planar polarity GO:0001736 87 0.016
oxoacid metabolic process GO:0043436 103 0.016
regulation of establishment of protein localization GO:0070201 61 0.016
cell adhesion GO:0007155 136 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.016
tripartite regional subdivision GO:0007351 103 0.016
positive regulation of cell death GO:0010942 69 0.016
regulation of catabolic process GO:0009894 170 0.016
regulation of cell fate specification GO:0042659 27 0.016
regulation of response to biotic stimulus GO:0002831 63 0.016
urogenital system development GO:0001655 72 0.016
positive regulation of molecular function GO:0044093 136 0.016
actin filament based process GO:0030029 220 0.016
regulation of gene silencing GO:0060968 63 0.016
response to biotic stimulus GO:0009607 294 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
establishment of tissue polarity GO:0007164 87 0.015
programmed cell death GO:0012501 257 0.015
apoptotic process GO:0006915 159 0.015
guanosine containing compound catabolic process GO:1901069 74 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
retina development in camera type eye GO:0060041 4 0.015
nephron tubule morphogenesis GO:0072078 3 0.015
mesenchymal cell development GO:0014031 1 0.015
endocytosis GO:0006897 310 0.015
homeostatic process GO:0042592 199 0.015
protein secretion GO:0009306 45 0.015
regulation of protein modification process GO:0031399 112 0.014
dorsal ventral pattern formation GO:0009953 133 0.014
neuron projection guidance GO:0097485 241 0.014
response to external biotic stimulus GO:0043207 293 0.014
neuron fate commitment GO:0048663 50 0.014
Fly
positive regulation of phosphate metabolic process GO:0045937 139 0.014
regulation of transport GO:0051049 181 0.014
nucleoside metabolic process GO:0009116 127 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
Mouse
response to organophosphorus GO:0046683 2 0.014
aromatic compound catabolic process GO:0019439 166 0.014
head involution GO:0008258 35 0.014
oocyte development GO:0048599 124 0.014
stem cell development GO:0048864 79 0.014
proteolysis GO:0006508 192 0.014
response to lipopolysaccharide GO:0032496 4 0.014
nephron tubule development GO:0072080 3 0.014
cell junction organization GO:0034330 57 0.014
cellular protein catabolic process GO:0044257 83 0.014
amine metabolic process GO:0009308 12 0.014
nephron epithelium development GO:0072009 3 0.014
axon guidance GO:0007411 233 0.014
purine ribonucleotide metabolic process GO:0009150 145 0.014
branching involved in open tracheal system development GO:0060446 45 0.014
regulation of response to stress GO:0080134 200 0.014
kidney morphogenesis GO:0060993 3 0.014
cell fate determination GO:0001709 91 0.013
sensory perception GO:0007600 196 0.013
regulation of protein localization GO:0032880 76 0.013
rna processing GO:0006396 147 0.013
hematopoietic or lymphoid organ development GO:0048534 57 0.013
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.013
mapk cascade GO:0000165 107 0.013
autophagy GO:0006914 108 0.013
cellular macromolecule catabolic process GO:0044265 136 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
sensory perception of mechanical stimulus GO:0050954 72 0.013
protein localization GO:0008104 284 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
regulation of growth GO:0040008 233 0.013
Mouse
axonogenesis GO:0007409 290 0.013
peptidyl amino acid modification GO:0018193 105 0.013
single organism membrane organization GO:0044802 93 0.013
eye antennal disc development GO:0035214 60 0.013
phototaxis GO:0042331 21 0.013
synaptic growth at neuromuscular junction GO:0051124 119 0.013
regulation of cell development GO:0060284 215 0.013
regulation of mapk cascade GO:0043408 92 0.013
detection of external stimulus GO:0009581 66 0.013
regulation of translation GO:0006417 56 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
hindgut development GO:0061525 58 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
axon development GO:0061564 297 0.012
regulation of protein metabolic process GO:0051246 256 0.012
erbb signaling pathway GO:0038127 58 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
cellular response to chemical stimulus GO:0070887 199 0.012
developmental pigmentation GO:0048066 68 0.012
regulation of catalytic activity GO:0050790 185 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
intraspecies interaction between organisms GO:0051703 4 0.012
negative regulation of cell cycle process GO:0010948 109 0.012
neuromuscular junction development GO:0007528 149 0.012
immune response activating signal transduction GO:0002757 2 0.012
organic substance catabolic process GO:1901575 308 0.012
nephron morphogenesis GO:0072028 3 0.012
regulation of epithelial cell differentiation GO:0030856 4 0.012
regulation of mrna processing GO:0050684 71 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.012
negative regulation of wnt signaling pathway GO:0030178 28 0.012
mrna metabolic process GO:0016071 124 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
nephron epithelium morphogenesis GO:0072088 3 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
anatomical structure homeostasis GO:0060249 97 0.012
positive regulation of developmental process GO:0051094 143 0.012
Mouse
regulation of intracellular protein transport GO:0033157 46 0.012
eye pigmentation GO:0048069 43 0.012
localization of cell GO:0051674 257 0.012
cell growth GO:0016049 108 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
developmental growth GO:0048589 280 0.012
Mouse
cellular response to biotic stimulus GO:0071216 4 0.012
positive regulation of cell migration GO:0030335 2 0.012
hippo signaling GO:0035329 20 0.012
regulation of programmed cell death GO:0043067 152 0.012
detection of abiotic stimulus GO:0009582 66 0.012
notch signaling pathway GO:0007219 120 0.012
single organism cell adhesion GO:0098602 47 0.012
positive regulation of protein modification process GO:0031401 58 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
telencephalon development GO:0021537 2 0.011
regulation of organelle organization GO:0033043 196 0.011
regulation of cytoskeleton organization GO:0051493 89 0.011
peptidyl lysine modification GO:0018205 57 0.011
nucleotide metabolic process GO:0009117 161 0.011
mrna processing GO:0006397 104 0.011
wing disc pattern formation GO:0035222 66 0.011
camera type eye morphogenesis GO:0048593 2 0.011
dna endoreduplication GO:0042023 22 0.011
cell migration GO:0016477 238 0.011
developmental growth involved in morphogenesis GO:0060560 65 0.011
regulation of mrna splicing via spliceosome GO:0048024 64 0.011
single organism catabolic process GO:0044712 228 0.011
developmental maturation GO:0021700 172 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
response to hexose GO:0009746 3 0.011
activation of innate immune response GO:0002218 4 0.011
cuticle development GO:0042335 86 0.011
photoreceptor cell fate commitment GO:0046552 41 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.011
organic substance transport GO:0071702 257 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
compound eye photoreceptor development GO:0042051 78 0.011
organelle fission GO:0048285 340 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
response to oxygen containing compound GO:1901700 200 0.011
response to endogenous stimulus GO:0009719 119 0.011
developmental induction GO:0031128 3 0.011
regulation of heart morphogenesis GO:2000826 3 0.011
protein transport GO:0015031 155 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
organophosphate metabolic process GO:0019637 195 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
substrate adhesion dependent cell spreading GO:0034446 2 0.011
multicellular organismal homeostasis GO:0048871 41 0.011
protein kinase b signaling GO:0043491 1 0.011
organic acid metabolic process GO:0006082 103 0.010
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.010
response to organic cyclic compound GO:0014070 89 0.010
adherens junction organization GO:0034332 27 0.010
leg disc morphogenesis GO:0007478 80 0.010
regulation of gtpase activity GO:0043087 44 0.010
regulation of cellular localization GO:0060341 136 0.010
cellular macromolecule localization GO:0070727 220 0.010
purine nucleotide metabolic process GO:0006163 146 0.010
regulation of ras protein signal transduction GO:0046578 93 0.010
hematopoietic progenitor cell differentiation GO:0002244 1 0.010
instar larval development GO:0002168 55 0.010
positive regulation of signal transduction GO:0009967 223 0.010
imaginal disc derived leg morphogenesis GO:0007480 80 0.010
phagocytosis GO:0006909 215 0.010
single organismal cell cell adhesion GO:0016337 45 0.010
regulation of epithelial cell proliferation GO:0050678 4 0.010
muscle organ development GO:0007517 127 0.010
Mouse
response to nutrient levels GO:0031667 114 0.010
g protein coupled receptor signaling pathway GO:0007186 136 0.010
regulation of cell shape GO:0008360 113 0.010
organ growth GO:0035265 56 0.010
Mouse
convergent extension GO:0060026 2 0.010

H2.0 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
musculoskeletal system disease DOID:17 0 0.018
bone disease DOID:0080001 0 0.014
connective tissue disease DOID:65 0 0.014
nervous system disease DOID:863 0 0.011
sensory system disease DOID:0050155 0 0.010