Drosophila melanogaster

83 known processes

Irk2 (Dmel_CG4370)

Inwardly rectifying potassium channel 2

(Aliases: Dmel\CG4370,CG4370,irk2,CG10180,dKirII)

Irk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.684
response to light stimulus GO:0009416 124 0.616
Rat
appendage development GO:0048736 401 0.606
heart process GO:0003015 37 0.523
Human Rat
kidney development GO:0001822 3 0.434
Rat
negative regulation of signal transduction GO:0009968 206 0.417
appendage morphogenesis GO:0035107 397 0.404
negative regulation of signaling GO:0023057 219 0.398
sensory perception GO:0007600 196 0.370
Rat
bmp signaling pathway GO:0030509 27 0.363
imaginal disc derived wing vein specification GO:0007474 48 0.356
imaginal disc derived appendage morphogenesis GO:0035114 395 0.344
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.322
wing disc morphogenesis GO:0007472 344 0.284
transcription from rna polymerase ii promoter GO:0006366 368 0.246
circadian behavior GO:0048512 76 0.243
Fly
circadian rhythm GO:0007623 105 0.227
Fly
enzyme linked receptor protein signaling pathway GO:0007167 179 0.210
immune response regulating signaling pathway GO:0002764 2 0.207
defense response GO:0006952 300 0.203
Rat
response to monosaccharide GO:0034284 4 0.201
Rat
imaginal disc derived appendage development GO:0048737 399 0.198
response to abiotic stimulus GO:0009628 341 0.187
Rat
response to glucose GO:0009749 2 0.184
Rat
cellular response to organic substance GO:0071310 132 0.184
Rat
cation transport GO:0006812 110 0.183
negative regulation of insulin secretion GO:0046676 1 0.183
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.171
heart contraction GO:0060047 26 0.169
Human Rat
regulation of mapk cascade GO:0043408 92 0.166
regionalization GO:0003002 416 0.154
imaginal disc derived wing morphogenesis GO:0007476 337 0.153
negative regulation of cell communication GO:0010648 223 0.147
regulation of system process GO:0044057 36 0.138
Human Rat
locomotory behavior GO:0007626 176 0.132
Fly
urogenital system development GO:0001655 72 0.129
Rat
protein modification process GO:0036211 438 0.126
regulation of bmp signaling pathway GO:0030510 23 0.122
regulation of cell death GO:0010941 173 0.118
regulation of transport GO:0051049 181 0.116
detection of stimulus GO:0051606 156 0.114
cation transmembrane transport GO:0098655 88 0.111
ion transport GO:0006811 145 0.110
response to radiation GO:0009314 155 0.109
Rat
rhythmic process GO:0048511 106 0.109
Fly
l amino acid import GO:0043092 2 0.109
Rat
response to hexose GO:0009746 3 0.104
Rat
mapk cascade GO:0000165 107 0.101
negative regulation of response to stimulus GO:0048585 258 0.099
regulation of cellular response to growth factor stimulus GO:0090287 13 0.099
regulation of protein metabolic process GO:0051246 256 0.098
organic anion transport GO:0015711 28 0.097
Rat
phosphorylation GO:0016310 294 0.096
cellular homeostasis GO:0019725 80 0.093
Rat
organic acid transport GO:0015849 18 0.092
Rat
response to organic substance GO:0010033 284 0.092
Human Rat
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.089
organic substance transport GO:0071702 257 0.087
Human Rat
positive regulation of protein metabolic process GO:0051247 128 0.083
circulatory system process GO:0003013 37 0.083
Human Rat
intracellular signal transduction GO:0035556 300 0.082
regulation of multicellular organismal development GO:2000026 414 0.082
post embryonic appendage morphogenesis GO:0035120 385 0.080
regulation of phosphorus metabolic process GO:0051174 210 0.079
circulatory system development GO:0072359 82 0.077
response to endogenous stimulus GO:0009719 119 0.076
Human Rat
cellular response to chemical stimulus GO:0070887 199 0.076
Rat
germ line stem cell division GO:0042078 25 0.074
blood circulation GO:0008015 26 0.070
Human Rat
renal system development GO:0072001 72 0.070
Rat
amino acid transport GO:0006865 12 0.069
Rat
cellular response to radiation GO:0071478 52 0.069
regulation of cellular ketone metabolic process GO:0010565 3 0.069
positive regulation of cell communication GO:0010647 250 0.069
neurological system process GO:0050877 358 0.069
Human Rat
protein complex assembly GO:0006461 200 0.068
Human Rat
response to organophosphorus GO:0046683 2 0.068
Human
protein complex biogenesis GO:0070271 201 0.067
Human Rat
protein phosphorylation GO:0006468 169 0.064
cellular response to abiotic stimulus GO:0071214 58 0.063
Rat
establishment of localization in cell GO:0051649 402 0.062
Human
regulation of immune system process GO:0002682 176 0.062
regulation of cellular amino acid metabolic process GO:0006521 0 0.060
biological adhesion GO:0022610 138 0.060
immune response activating signal transduction GO:0002757 2 0.060
response to nitrogen compound GO:1901698 90 0.058
Human Rat
negative regulation of cellular metabolic process GO:0031324 382 0.058
regulation of phosphorylation GO:0042325 147 0.057
cellular potassium ion transport GO:0071804 18 0.056
cellular protein modification process GO:0006464 438 0.056
cellular response to mechanical stimulus GO:0071260 2 0.056
Rat
endocytosis GO:0006897 310 0.055
proteolysis GO:0006508 192 0.055
axis specification GO:0009798 167 0.054
muscle contraction GO:0006936 13 0.054
Human Rat
signal transduction by phosphorylation GO:0023014 107 0.053
homeostatic process GO:0042592 199 0.053
Rat
cranial nerve development GO:0021545 1 0.053
Rat
response to alcohol GO:0097305 95 0.053
Rat
cellular ion homeostasis GO:0006873 39 0.053
regulation of apoptotic process GO:0042981 130 0.052
regulation of heart contraction GO:0008016 21 0.051
Human Rat
positive regulation of response to stimulus GO:0048584 323 0.051
tissue migration GO:0090130 155 0.050
actin mediated cell contraction GO:0070252 21 0.049
Rat
muscle system process GO:0003012 21 0.049
Human Rat
organonitrogen compound metabolic process GO:1901564 318 0.049
immune response GO:0006955 246 0.048
muscle structure development GO:0061061 224 0.048
rhythmic behavior GO:0007622 76 0.048
Fly
small molecule metabolic process GO:0044281 305 0.047
regulation of transmembrane transport GO:0034762 27 0.046
epithelial cell development GO:0002064 274 0.046
developmental growth GO:0048589 280 0.046
positive regulation of macromolecule metabolic process GO:0010604 405 0.045
positive regulation of molecular function GO:0044093 136 0.044
Rat
cell proliferation GO:0008283 299 0.043
oxoacid metabolic process GO:0043436 103 0.043
response to lipopolysaccharide GO:0032496 4 0.043
cytokinesis GO:0000910 90 0.042
detection of external stimulus GO:0009581 66 0.041
detection of light stimulus GO:0009583 58 0.041
cellular response to nitrogen compound GO:1901699 51 0.041
Rat
positive regulation of transport GO:0051050 92 0.041
Rat
cell death GO:0008219 279 0.041
cellular ketone metabolic process GO:0042180 24 0.041
positive regulation of cell migration GO:0030335 2 0.040
cellular response to lipopolysaccharide GO:0071222 3 0.040
ion transmembrane transport GO:0034220 122 0.040
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.040
regulation of phosphate metabolic process GO:0019220 210 0.040
negative regulation of peptide secretion GO:0002792 1 0.040
Human
endodermal cell fate commitment GO:0001711 3 0.039
locomotor rhythm GO:0045475 56 0.039
Fly
regulation of cell proliferation GO:0042127 163 0.039
growth GO:0040007 359 0.039
cellular response to molecule of bacterial origin GO:0071219 3 0.039
chemical homeostasis GO:0048878 92 0.039
Rat
ovarian follicle cell development GO:0030707 248 0.038
negative regulation of smoothened signaling pathway GO:0045879 16 0.038
regulation of response to stress GO:0080134 200 0.038
positive regulation of cellular protein metabolic process GO:0032270 118 0.038
carboxylic acid transport GO:0046942 18 0.038
Rat
detection of stimulus involved in sensory perception GO:0050906 92 0.037
positive regulation of cell motility GO:2000147 3 0.036
nephron development GO:0072006 3 0.036
cellular chemical homeostasis GO:0055082 40 0.036
Rat
organic acid metabolic process GO:0006082 103 0.036
connective tissue development GO:0061448 3 0.035
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 0.034
negative regulation of phosphate metabolic process GO:0045936 45 0.034
regulation of muscle contraction GO:0006937 5 0.034
Human Rat
regulation of protein modification process GO:0031399 112 0.034
epithelial cell migration GO:0010631 148 0.034
positive regulation of ion transmembrane transporter activity GO:0032414 4 0.033
Rat
endoderm formation GO:0001706 3 0.033
cellular response to monosaccharide stimulus GO:0071326 2 0.033
Rat
positive regulation of cellular biosynthetic process GO:0031328 316 0.033
anterior posterior axis specification embryo GO:0008595 103 0.033
cellular response to organic cyclic compound GO:0071407 32 0.032
Rat
dorsal ventral pattern formation GO:0009953 133 0.032
positive regulation of signal transduction GO:0009967 223 0.032
single organism biosynthetic process GO:0044711 206 0.032
body morphogenesis GO:0010171 2 0.032
response to oxygen containing compound GO:1901700 200 0.031
Human Rat
embryonic axis specification GO:0000578 107 0.031
vesicle mediated transport GO:0016192 381 0.031
localization of cell GO:0051674 257 0.031
embryonic morphogenesis GO:0048598 206 0.031
peptidyl threonine phosphorylation GO:0018107 2 0.031
anterior posterior axis specification GO:0009948 109 0.030
regulation of programmed cell death GO:0043067 152 0.030
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.030
sensory perception of chemical stimulus GO:0007606 116 0.029
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.029
potassium ion transport GO:0006813 20 0.029
positive regulation of cellular amine metabolic process GO:0033240 0 0.029
regulation of cellular component movement GO:0051270 42 0.029
Human Rat
macromolecular complex assembly GO:0065003 256 0.029
Human Rat
regulation of membrane potential GO:0042391 35 0.028
determination of ventral identity GO:0048264 1 0.028
regulation of blood circulation GO:1903522 21 0.028
Human Rat
regulation of map kinase activity GO:0043405 17 0.028
inorganic ion transmembrane transport GO:0098660 73 0.028
negative regulation of multicellular organismal process GO:0051241 142 0.028
response to external biotic stimulus GO:0043207 293 0.028
smoothened signaling pathway GO:0007224 49 0.028
regulation of mitotic cell cycle GO:0007346 190 0.028
embryonic pattern specification GO:0009880 174 0.027
pigmentation GO:0043473 75 0.027
regulation of localization GO:0032879 275 0.027
eggshell formation GO:0030703 105 0.027
eye development GO:0001654 323 0.027
cellular metal ion homeostasis GO:0006875 31 0.026
single organism carbohydrate metabolic process GO:0044723 72 0.026
Human
positive regulation of immune response GO:0050778 63 0.026
aging GO:0007568 143 0.026
positive regulation of developmental process GO:0051094 143 0.026
negative regulation of peptide hormone secretion GO:0090278 1 0.026
Human
death GO:0016265 284 0.025
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.025
positive regulation of immune system process GO:0002684 68 0.025
negative regulation of gene expression GO:0010629 387 0.025
regulation of epithelial cell proliferation GO:0050678 4 0.025
anatomical structure homeostasis GO:0060249 97 0.025
establishment of protein localization GO:0045184 163 0.025
cellular amino acid metabolic process GO:0006520 61 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
nephron tubule development GO:0072080 3 0.025
negative regulation of bmp signaling pathway GO:0030514 12 0.025
cellular response to organonitrogen compound GO:0071417 36 0.024
Rat
response to bacterium GO:0009617 198 0.024
phototransduction GO:0007602 52 0.024
regulation of immune response GO:0050776 118 0.024
jnk cascade GO:0007254 50 0.024
negative regulation of phosphorus metabolic process GO:0010563 45 0.024
catabolic process GO:0009056 409 0.024
skeletal muscle fiber development GO:0048741 3 0.024
kidney epithelium development GO:0072073 3 0.024
positive regulation of phosphorus metabolic process GO:0010562 139 0.024
kidney morphogenesis GO:0060993 3 0.024
positive regulation of multicellular organismal process GO:0051240 143 0.024
epithelial cell differentiation GO:0030855 322 0.024
response to purine containing compound GO:0014074 12 0.023
Human
negative regulation of kinase activity GO:0033673 16 0.023
cellular response to endogenous stimulus GO:0071495 80 0.023
Rat
negative regulation of mapk cascade GO:0043409 23 0.023
peptidyl amino acid modification GO:0018193 105 0.023
cell adhesion GO:0007155 136 0.023
regulation of cellular amine metabolic process GO:0033238 3 0.023
cellular response to ionizing radiation GO:0071479 15 0.022
regulation of transmembrane transporter activity GO:0022898 6 0.022
Rat
chromatin organization GO:0006325 207 0.022
positive regulation of phosphate metabolic process GO:0045937 139 0.022
striated muscle contraction GO:0006941 5 0.022
Human Rat
amine metabolic process GO:0009308 12 0.022
regulation of developmental growth GO:0048638 174 0.022
hematopoietic or lymphoid organ development GO:0048534 57 0.022
eye antennal disc development GO:0035214 60 0.022
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.022
regulation of cell cycle GO:0051726 291 0.021
regulation of smoothened signaling pathway GO:0008589 28 0.021
secretion by cell GO:0032940 101 0.021
Human
hemopoiesis GO:0030097 46 0.021
cellular response to biotic stimulus GO:0071216 4 0.021
cellular response to oxygen containing compound GO:1901701 79 0.021
Rat
regulation of anatomical structure morphogenesis GO:0022603 242 0.021
regulation of synaptic transmission GO:0050804 69 0.021
purine nucleotide metabolic process GO:0006163 146 0.021
actin filament based movement GO:0030048 26 0.021
Rat
terminal region determination GO:0007362 25 0.021
regulation of organ morphogenesis GO:2000027 78 0.021
regulation of intracellular signal transduction GO:1902531 236 0.021
positive regulation of protein transport GO:0051222 37 0.020
taxis GO:0042330 304 0.020
regulation of reproductive process GO:2000241 54 0.020
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.020
myotube cell development GO:0014904 3 0.020
compound eye development GO:0048749 307 0.020
programmed cell death GO:0012501 257 0.020
carbohydrate homeostasis GO:0033500 12 0.020
Rat
positive regulation of cell proliferation GO:0008284 47 0.020
nerve development GO:0021675 6 0.020
Rat
regulation of molecular function GO:0065009 217 0.020
Rat
regulation of catalytic activity GO:0050790 185 0.020
detection of visible light GO:0009584 38 0.020
regulation of protein phosphorylation GO:0001932 64 0.020
determination of dorsal ventral asymmetry GO:0048262 3 0.019
apoptotic process GO:0006915 159 0.019
regulation of defense response GO:0031347 102 0.019
cellular response to growth factor stimulus GO:0071363 30 0.019
forebrain development GO:0030900 2 0.019
retina development in camera type eye GO:0060041 4 0.019
response to organic cyclic compound GO:0014070 89 0.019
Human Rat
oocyte development GO:0048599 124 0.019
gland morphogenesis GO:0022612 145 0.019
monocarboxylic acid transport GO:0015718 3 0.019
erbb signaling pathway GO:0038127 58 0.019
negative regulation of cell proliferation GO:0008285 69 0.019
cellular amide metabolic process GO:0043603 80 0.019
proteoglycan metabolic process GO:0006029 10 0.018
response to lipid GO:0033993 38 0.018
Rat
cell type specific apoptotic process GO:0097285 38 0.018
compound eye morphogenesis GO:0001745 249 0.018
nephron morphogenesis GO:0072028 3 0.018
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.018
immune system development GO:0002520 57 0.018
regulation of notch signaling pathway GO:0008593 100 0.018
learning or memory GO:0007611 141 0.017
regulation of decapentaplegic signaling pathway GO:0090097 8 0.017
single organism behavior GO:0044708 391 0.017
Fly
carboxylic acid metabolic process GO:0019752 92 0.017
signal release GO:0023061 49 0.017
Human
cellular cation homeostasis GO:0030003 38 0.017
cellular response to hexose stimulus GO:0071331 1 0.017
Rat
carbohydrate derivative biosynthetic process GO:1901137 85 0.017
regulation of protein serine threonine kinase activity GO:0071900 25 0.017
cytokinetic process GO:0032506 27 0.017
sensory organ morphogenesis GO:0090596 260 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
developmental pigmentation GO:0048066 68 0.017
carbohydrate metabolic process GO:0005975 82 0.017
Human
regulation of transferase activity GO:0051338 58 0.017
endomembrane system organization GO:0010256 119 0.017
organic substance catabolic process GO:1901575 308 0.016
epidermal growth factor receptor signaling pathway GO:0007173 58 0.016
negative regulation of developmental process GO:0051093 201 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.016
response to growth factor GO:0070848 31 0.016
nephron epithelium development GO:0072009 3 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
regulation of innate immune response GO:0045088 71 0.016
eye photoreceptor cell differentiation GO:0001754 145 0.016
brain development GO:0007420 120 0.016
eye pigmentation GO:0048069 43 0.016
purine containing compound metabolic process GO:0072521 155 0.016
nitrogen compound transport GO:0071705 85 0.016
Human Rat
lateral inhibition GO:0046331 206 0.016
response to biotic stimulus GO:0009607 294 0.016
inorganic cation transmembrane transport GO:0098662 61 0.016
regulation of organ formation GO:0003156 3 0.016
negative regulation of erbb signaling pathway GO:1901185 29 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.016
stem cell development GO:0048864 79 0.016
positive regulation of signaling GO:0023056 243 0.016
positive regulation of protein modification process GO:0031401 58 0.016
columnar cuboidal epithelial cell development GO:0002066 249 0.016
covalent chromatin modification GO:0016569 106 0.016
wnt signaling pathway GO:0016055 98 0.016
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 1 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
positive regulation of defense response GO:0031349 59 0.015
eye morphogenesis GO:0048592 260 0.015
metal ion homeostasis GO:0055065 44 0.015
limb development GO:0060173 1 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
cell migration GO:0016477 238 0.015
regulation of multi organism process GO:0043900 131 0.015
regulation of cell differentiation GO:0045595 302 0.015
jak stat cascade GO:0007259 49 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
positive regulation of phosphorylation GO:0042327 87 0.015
malpighian tubule development GO:0072002 64 0.015
multicellular organismal aging GO:0010259 140 0.015
cardiovascular system development GO:0072358 82 0.015
cellular response to external stimulus GO:0071496 66 0.015
Rat
cellular response to light stimulus GO:0071482 37 0.015
response to organonitrogen compound GO:0010243 75 0.015
Human Rat
wing disc pattern formation GO:0035222 66 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
gland development GO:0048732 191 0.015
positive regulation of cell projection organization GO:0031346 29 0.015
response to oxygen levels GO:0070482 59 0.015
activation of innate immune response GO:0002218 4 0.015
cellular response to lipid GO:0071396 20 0.014
protein processing GO:0016485 68 0.014
negative regulation of phosphorylation GO:0042326 35 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.014
neuromuscular junction development GO:0007528 149 0.014
developmental maturation GO:0021700 172 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
cellular amine metabolic process GO:0044106 12 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
adult behavior GO:0030534 137 0.014
anterior posterior pattern specification GO:0009952 136 0.014
negative regulation of cell death GO:0060548 81 0.014
ion homeostasis GO:0050801 55 0.013
amino acid import GO:0043090 5 0.013
Rat
response to hormone GO:0009725 45 0.013
Rat
proteasomal protein catabolic process GO:0010498 59 0.013
cognition GO:0050890 141 0.013
peptide metabolic process GO:0006518 80 0.013
response to ketone GO:1901654 34 0.013
Rat
ribonucleoside metabolic process GO:0009119 127 0.013
protein catabolic process GO:0030163 101 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
peptidyl threonine modification GO:0018210 3 0.013
mitotic nuclear division GO:0007067 213 0.013
segmentation GO:0035282 207 0.013
negative regulation of catalytic activity GO:0043086 42 0.013
nephron tubule morphogenesis GO:0072078 3 0.013
nephron epithelium morphogenesis GO:0072088 3 0.013
muscle organ development GO:0007517 127 0.013
regulation of ion transmembrane transporter activity GO:0032412 6 0.013
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.013
single organism intracellular transport GO:1902582 207 0.013
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
neuropeptide signaling pathway GO:0007218 45 0.013
endodermal cell differentiation GO:0035987 3 0.013
organic hydroxy compound metabolic process GO:1901615 83 0.012
notch signaling pathway GO:0007219 120 0.012
neuroblast proliferation GO:0007405 74 0.012
chemotaxis GO:0006935 249 0.012
negative regulation of epithelial cell proliferation GO:0050680 4 0.012
chromosome separation GO:0051304 42 0.012
regulation of cellular localization GO:0060341 136 0.012
Human
organophosphate catabolic process GO:0046434 112 0.012
molting cycle chitin based cuticle GO:0007591 56 0.012
chorion containing eggshell formation GO:0007304 105 0.012
regulation of ion transport GO:0043269 39 0.012
negative regulation of catabolic process GO:0009895 36 0.012
pigment metabolic process GO:0042440 84 0.012
oocyte differentiation GO:0009994 145 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
regulation of cellular response to oxidative stress GO:1900407 4 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
positive regulation of programmed cell death GO:0043068 62 0.012
negative regulation of hormone biosynthetic process GO:0032353 1 0.012
smoothened signaling pathway involved in ventral spinal cord patterning GO:0021910 0 0.012
sex differentiation GO:0007548 81 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of cell adhesion GO:0030155 27 0.012
oocyte axis specification GO:0007309 108 0.012
chromosome organization GO:0051276 360 0.012
response to alkaloid GO:0043279 26 0.012
Rat
leg disc development GO:0035218 92 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
negative regulation of transferase activity GO:0051348 18 0.012
potassium ion transmembrane transport GO:0071805 18 0.012
mitotic cytokinesis GO:0000281 50 0.012
regulation of protein transport GO:0051223 57 0.012
reproductive system development GO:0061458 74 0.011
pigment biosynthetic process GO:0046148 36 0.011
limb morphogenesis GO:0035108 1 0.011
regulation of protein kinase activity GO:0045859 51 0.011
oocyte dorsal ventral axis specification GO:0007310 34 0.011
retina morphogenesis in camera type eye GO:0060042 2 0.011
nucleotide metabolic process GO:0009117 161 0.011
detection of chemical stimulus GO:0009593 93 0.011
extracellular structure organization GO:0043062 46 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
positive regulation of response to external stimulus GO:0032103 44 0.011
negative regulation of protein phosphorylation GO:0001933 17 0.011
stem cell maintenance GO:0019827 67 0.011
cellular response to carbohydrate stimulus GO:0071322 4 0.011
Rat
negative regulation of cellular biosynthetic process GO:0031327 277 0.011
spinal cord dorsal ventral patterning GO:0021513 1 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
morphogenesis of a branching epithelium GO:0061138 45 0.011
eye photoreceptor cell development GO:0042462 81 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.011
positive regulation of transcription dna templated GO:0045893 266 0.011
negative regulation of rna biosynthetic process GO:1902679 240 0.011
cell cycle arrest GO:0007050 4 0.011
anion transport GO:0006820 41 0.011
Rat
tissue homeostasis GO:0001894 36 0.011
germ line stem cell maintenance GO:0030718 50 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
regulation of intracellular transport GO:0032386 64 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
glycosyl compound biosynthetic process GO:1901659 3 0.011
stem cell division GO:0017145 69 0.011
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.011
activation of protein kinase activity GO:0032147 12 0.011
regulation of jnk cascade GO:0046328 40 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
response to carbohydrate GO:0009743 15 0.011
Rat
stress activated mapk cascade GO:0051403 52 0.011
regulation of secretion by cell GO:1903530 39 0.011
Human
regulation of cellular catabolic process GO:0031329 157 0.011

Irk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
renal tubular transport disease DOID:447 0 0.208
Human
bartter disease DOID:445 0 0.208
Human
kidney disease DOID:557 0 0.208
Human
disease of anatomical entity DOID:7 0 0.208
Human
urinary system disease DOID:18 0 0.208
Human
heart conduction disease DOID:10273 0 0.201
Human
cardiovascular system disease DOID:1287 0 0.201
Human
nervous system disease DOID:863 0 0.109
Human
disease of metabolism DOID:0014667 0 0.095
Human
carbohydrate metabolism disease DOID:0050013 0 0.095
Human
glucose metabolism disease DOID:4194 0 0.095
Human
acquired metabolic disease DOID:0060158 0 0.095
Human
diabetes mellitus DOID:9351 0 0.075
Human
type 2 diabetes mellitus DOID:9352 0 0.075
Human
inherited metabolic disorder DOID:655 0 0.054
Human
sensory system disease DOID:0050155 0 0.047
Human
eye and adnexa disease DOID:1492 0 0.047
Human
eye disease DOID:5614 0 0.047
Human
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
musculoskeletal system disease DOID:17 0 0.014
hypertension DOID:10763 0 0.013
artery disease DOID:0050828 0 0.013
vascular disease DOID:178 0 0.013
central nervous system disease DOID:331 0 0.013
organ system cancer DOID:0050686 0 0.012
auditory system disease DOID:2742 0 0.011
Human