Drosophila melanogaster

87 known processes

l(2)NC136 (Dmel_CG8426)

lethal (2) NC136

(Aliases: not3,NOT3/5,CG8426,not3/5,Dmel\CG8426,CNOT3)

l(2)NC136 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic g2 m transition checkpoint GO:0044818 70 0.738
mitotic dna integrity checkpoint GO:0044774 75 0.490
mitotic g2 dna damage checkpoint GO:0007095 69 0.336
regulation of mitotic cell cycle GO:0007346 190 0.259
mitotic dna damage checkpoint GO:0044773 74 0.233
mitotic cell cycle checkpoint GO:0007093 88 0.225
g2 dna damage checkpoint GO:0031572 69 0.221
cell cycle phase transition GO:0044770 140 0.199
centrosome organization GO:0051297 163 0.182
mitotic cell cycle phase transition GO:0044772 138 0.169
regulation of mitotic cell cycle phase transition GO:1901990 130 0.144
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.139
embryo development ending in birth or egg hatching GO:0009792 152 0.130
Worm
body morphogenesis GO:0010171 2 0.126
heterocycle catabolic process GO:0046700 166 0.126
cellular response to dna damage stimulus GO:0006974 223 0.110
cellular macromolecule catabolic process GO:0044265 136 0.102
regulation of cell cycle process GO:0010564 181 0.095
regulation of cell cycle phase transition GO:1901987 130 0.093
immune system development GO:0002520 57 0.085
regulation of organelle organization GO:0033043 196 0.085
cell cycle checkpoint GO:0000075 95 0.084
dendrite development GO:0016358 204 0.084
negative regulation of cell cycle GO:0045786 116 0.074
ribonucleoprotein complex disassembly GO:0032988 1 0.073
catabolic process GO:0009056 409 0.072
negative regulation of cell cycle process GO:0010948 109 0.072
rna processing GO:0006396 147 0.069
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.068
posttranscriptional regulation of gene expression GO:0010608 145 0.065
regulation of cell cycle GO:0051726 291 0.064
organic substance catabolic process GO:1901575 308 0.063
dna damage checkpoint GO:0000077 78 0.060
dna integrity checkpoint GO:0031570 81 0.059
photoreceptor cell differentiation GO:0046530 170 0.058
regulation of mrna splicing via spliceosome GO:0048024 64 0.058
cellular catabolic process GO:0044248 372 0.056
macromolecule catabolic process GO:0009057 161 0.055
regulation of intracellular transport GO:0032386 64 0.053
multi multicellular organism process GO:0044706 123 0.051
regulation of intracellular protein transport GO:0033157 46 0.050
multicellular organismal reproductive behavior GO:0033057 110 0.047
organophosphate metabolic process GO:0019637 195 0.045
positive regulation of response to stimulus GO:0048584 323 0.045
proteolysis GO:0006508 192 0.045
regulation of growth GO:0040008 233 0.045
actin cytoskeleton organization GO:0030036 206 0.044
regulation of localization GO:0032879 275 0.042
chromatin modification GO:0016568 147 0.041
nucleobase containing compound catabolic process GO:0034655 165 0.040
alternative mrna splicing via spliceosome GO:0000380 60 0.040
response to light stimulus GO:0009416 124 0.040
single organism biosynthetic process GO:0044711 206 0.040
regulation of nucleocytoplasmic transport GO:0046822 35 0.039
hematopoietic or lymphoid organ development GO:0048534 57 0.039
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.039
nuclear transport GO:0051169 72 0.039
regulation of molecular function GO:0065009 217 0.038
single organism nuclear import GO:1902593 51 0.038
hemopoiesis GO:0030097 46 0.037
regulation of mrna processing GO:0050684 71 0.037
developmental growth GO:0048589 280 0.035
aging GO:0007568 143 0.034
Worm
adult behavior GO:0030534 137 0.034
compound eye photoreceptor cell differentiation GO:0001751 140 0.034
positive regulation of molecular function GO:0044093 136 0.033
endocytosis GO:0006897 310 0.033
cellular nitrogen compound catabolic process GO:0044270 165 0.033
larval development GO:0002164 104 0.032
Worm
cellular macromolecular complex assembly GO:0034622 153 0.032
vesicle mediated transport GO:0016192 381 0.032
enzyme linked receptor protein signaling pathway GO:0007167 179 0.032
positive regulation of cellular biosynthetic process GO:0031328 316 0.031
positive regulation of ras protein signal transduction GO:0046579 43 0.031
modification dependent macromolecule catabolic process GO:0043632 79 0.030
reproductive behavior GO:0019098 122 0.030
small molecule metabolic process GO:0044281 305 0.030
stem cell maintenance GO:0019827 67 0.029
dendrite morphogenesis GO:0048813 199 0.029
positive regulation of signaling GO:0023056 243 0.029
regulation of protein metabolic process GO:0051246 256 0.028
regulation of protein transport GO:0051223 57 0.027
aromatic compound catabolic process GO:0019439 166 0.027
phagocytosis GO:0006909 215 0.026
adult locomotory behavior GO:0008344 76 0.026
regulation of cellular protein metabolic process GO:0032268 243 0.025
regulation of catabolic process GO:0009894 170 0.024
negative regulation of biosynthetic process GO:0009890 277 0.023
multi organism behavior GO:0051705 175 0.023
positive regulation of macromolecule metabolic process GO:0010604 405 0.022
microtubule organizing center organization GO:0031023 168 0.022
regulation of mrna metabolic process GO:1903311 72 0.021
multi organism reproductive behavior GO:0044705 121 0.021
regulation of establishment of protein localization GO:0070201 61 0.021
rna splicing GO:0008380 83 0.021
organic substance transport GO:0071702 257 0.021
regulation of translation GO:0006417 56 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.021
regulation of catalytic activity GO:0050790 185 0.021
negative regulation of gene expression GO:0010629 387 0.021
positive regulation of mapk cascade GO:0043410 63 0.020
positive regulation of intracellular signal transduction GO:1902533 116 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.020
spermatid development GO:0007286 98 0.020
eye photoreceptor cell differentiation GO:0001754 145 0.020
regulation of cytoplasmic transport GO:1903649 47 0.020
posttranscriptional gene silencing by rna GO:0035194 45 0.020
terminal cell fate specification open tracheal system GO:0035154 4 0.020
establishment of localization in cell GO:0051649 402 0.020
positive regulation of phosphate metabolic process GO:0045937 139 0.019
positive regulation of proteolysis GO:0045862 52 0.019
positive regulation of cell communication GO:0010647 250 0.019
single organism catabolic process GO:0044712 228 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
organic cyclic compound catabolic process GO:1901361 168 0.019
regulation of protein localization GO:0032880 76 0.019
regulation of cytoskeleton organization GO:0051493 89 0.019
compound eye development GO:0048749 307 0.018
protein localization GO:0008104 284 0.018
negative regulation of cellular metabolic process GO:0031324 382 0.018
negative regulation of phosphatase activity GO:0010923 3 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.018
positive regulation of epidermal growth factor activated receptor activity GO:0045741 1 0.018
mitotic sister chromatid segregation GO:0000070 87 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.018
brain development GO:0007420 120 0.018
mrna metabolic process GO:0016071 124 0.017
regulation of protein catabolic process GO:0042176 55 0.017
negative regulation of nucleic acid templated transcription GO:1903507 240 0.017
eye development GO:0001654 323 0.016
positive regulation of cellular component biogenesis GO:0044089 80 0.016
mrna polyadenylation GO:0006378 11 0.016
regulation of neuron differentiation GO:0045664 103 0.016
negative regulation of protein binding GO:0032091 1 0.016
negative regulation of developmental process GO:0051093 201 0.016
mitotic nuclear division GO:0007067 213 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
positive regulation of rna metabolic process GO:0051254 271 0.015
positive regulation of signal transduction GO:0009967 223 0.015
cellular response to chemical stimulus GO:0070887 199 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
negative regulation of necrotic cell death GO:0060547 1 0.014
positive regulation of protein complex assembly GO:0031334 22 0.014
cell recognition GO:0008037 102 0.014
regulation of transport GO:0051049 181 0.014
nucleoside catabolic process GO:0009164 112 0.014
cellular macromolecule localization GO:0070727 220 0.014
renal tubule development GO:0061326 64 0.014
regulation of proteolysis GO:0030162 87 0.014
nucleoside metabolic process GO:0009116 127 0.014
sister chromatid segregation GO:0000819 92 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.013
transcription from rna polymerase ii promoter GO:0006366 368 0.013
cellular protein localization GO:0034613 160 0.013
rna splicing via transesterification reactions GO:0000375 73 0.013
cell fate specification GO:0001708 71 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
dephosphorylation GO:0016311 51 0.013
appendage morphogenesis GO:0035107 397 0.013
regulation of meiosis GO:0040020 3 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.013
positive regulation of catabolic process GO:0009896 105 0.013
protein catabolic process GO:0030163 101 0.013
cellular protein complex assembly GO:0043623 71 0.013
oviposition GO:0018991 19 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
regulation of intracellular signal transduction GO:1902531 236 0.012
regulation of hydrolase activity GO:0051336 97 0.012
phosphorylation of rna polymerase ii c terminal domain GO:0070816 1 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
organelle inheritance GO:0048308 2 0.012
ubiquitin dependent protein catabolic process GO:0006511 78 0.012
mitochondrial membrane organization GO:0007006 3 0.012
photoreceptor cell development GO:0042461 96 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
regulation of rna splicing GO:0043484 69 0.012
positive regulation of gene expression GO:0010628 290 0.012
response to organic substance GO:0010033 284 0.012
posttranscriptional gene silencing GO:0016441 46 0.012
spermatid differentiation GO:0048515 114 0.011
response to radiation GO:0009314 155 0.011
ras protein signal transduction GO:0007265 88 0.011
axon development GO:0061564 297 0.011
smoothened signaling pathway GO:0007224 49 0.011
rhythmic process GO:0048511 106 0.011
regulation of hemocyte proliferation GO:0035206 37 0.011
gonad development GO:0008406 50 0.011
Worm
protein targeting GO:0006605 64 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.010
positive regulation of hydrolase activity GO:0051345 78 0.010
gland development GO:0048732 191 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
gene silencing by rna GO:0031047 57 0.010
spindle organization GO:0007051 253 0.010
regulation of developmental growth GO:0048638 174 0.010
regulation of phosphate metabolic process GO:0019220 210 0.010
regulation of cell shape GO:0008360 113 0.010
axis specification GO:0009798 167 0.010
regulation of phosphorus metabolic process GO:0051174 210 0.010
single organism intracellular transport GO:1902582 207 0.010
regulation of protein export from nucleus GO:0046825 3 0.010
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.010

l(2)NC136 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
benign neoplasm DOID:0060072 0 0.011
disease of cellular proliferation DOID:14566 0 0.011