Drosophila melanogaster

67 known processes

DNApol-epsilon (Dmel_CG6768)

DNA polymerase epsilon

(Aliases: CG6768,BAB17608,Dmel\CG6768,pol-epsilon,6768)

DNApol-epsilon biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
centrosome cycle GO:0007098 137 0.660
dna metabolic process GO:0006259 227 0.577
dna conformation change GO:0071103 105 0.551
centrosome organization GO:0051297 163 0.386
negative regulation of biosynthetic process GO:0009890 277 0.305
nuclear division GO:0000280 332 0.298
cellular response to dna damage stimulus GO:0006974 223 0.261
microtubule organizing center organization GO:0031023 168 0.259
regulation of gene expression epigenetic GO:0040029 128 0.242
negative regulation of nucleic acid templated transcription GO:1903507 240 0.212
negative regulation of rna metabolic process GO:0051253 251 0.198
chromosome organization GO:0051276 360 0.186
embryo development ending in birth or egg hatching GO:0009792 152 0.183
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.174
chromosome segregation GO:0007059 157 0.174
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.164
organelle fission GO:0048285 340 0.163
regulation of cell cycle process GO:0010564 181 0.153
macromolecular complex assembly GO:0065003 256 0.146
dna packaging GO:0006323 91 0.143
negative regulation of gene expression GO:0010629 387 0.139
negative regulation of gene expression epigenetic GO:0045814 77 0.137
gene silencing GO:0016458 138 0.130
establishment of localization in cell GO:0051649 402 0.129
negative regulation of rna biosynthetic process GO:1902679 240 0.128
chromatin silencing GO:0006342 76 0.124
sister chromatid segregation GO:0000819 92 0.118
negative regulation of transcription dna templated GO:0045892 237 0.114
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.105
chromatin organization GO:0006325 207 0.095
dna replication GO:0006260 48 0.084
regulation of cell cycle GO:0051726 291 0.084
protein complex assembly GO:0006461 200 0.082
spindle organization GO:0007051 253 0.075
mitotic sister chromatid segregation GO:0000070 87 0.074
negative regulation of cellular biosynthetic process GO:0031327 277 0.072
cell cycle checkpoint GO:0000075 95 0.071
mitotic nuclear division GO:0007067 213 0.070
negative regulation of cellular metabolic process GO:0031324 382 0.070
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.070
nuclear dna replication GO:0033260 1 0.069
cell cycle dna replication GO:0044786 23 0.066
protein complex biogenesis GO:0070271 201 0.066
response to external biotic stimulus GO:0043207 293 0.063
negative regulation of cell cycle GO:0045786 116 0.062
catabolic process GO:0009056 409 0.062
cell division GO:0051301 248 0.061
central nervous system development GO:0007417 201 0.059
small molecule metabolic process GO:0044281 305 0.057
response to biotic stimulus GO:0009607 294 0.056
response to other organism GO:0051707 293 0.055
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.054
centrosome duplication GO:0051298 121 0.053
mitotic cell cycle phase transition GO:0044772 138 0.053
protein localization GO:0008104 284 0.052
mrna metabolic process GO:0016071 124 0.050
cellular protein localization GO:0034613 160 0.050
mitotic spindle organization GO:0007052 220 0.050
transcription from rna polymerase ii promoter GO:0006366 368 0.049
regulation of mitotic cell cycle GO:0007346 190 0.049
regulation of cell cycle phase transition GO:1901987 130 0.049
regulation of multicellular organismal development GO:2000026 414 0.048
mitotic cell cycle checkpoint GO:0007093 88 0.046
growth GO:0040007 359 0.046
establishment or maintenance of cell polarity GO:0007163 167 0.044
organelle assembly GO:0070925 198 0.043
cell proliferation GO:0008283 299 0.042
organic substance transport GO:0071702 257 0.042
regulation of cell differentiation GO:0045595 302 0.042
cellular macromolecular complex assembly GO:0034622 153 0.040
negative regulation of cell cycle phase transition GO:1901988 103 0.040
organic substance catabolic process GO:1901575 308 0.040
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.039
regulation of mitotic cell cycle phase transition GO:1901990 130 0.038
response to oxygen containing compound GO:1901700 200 0.038
cellular catabolic process GO:0044248 372 0.037
nucleobase containing compound catabolic process GO:0034655 165 0.037
morphogenesis of an epithelium GO:0002009 276 0.037
regulation of cellular protein metabolic process GO:0032268 243 0.035
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.035
cellular macromolecule localization GO:0070727 220 0.035
intracellular transport GO:0046907 228 0.034
carboxylic acid metabolic process GO:0019752 92 0.034
determination of adult lifespan GO:0008340 137 0.033
carbohydrate derivative metabolic process GO:1901135 217 0.033
tube morphogenesis GO:0035239 191 0.033
exocrine system development GO:0035272 162 0.033
protein dna complex assembly GO:0065004 63 0.033
nucleoside triphosphate metabolic process GO:0009141 120 0.032
organophosphate metabolic process GO:0019637 195 0.032
response to organic substance GO:0010033 284 0.032
regulation of localization GO:0032879 275 0.031
covalent chromatin modification GO:0016569 106 0.031
mitotic g2 dna damage checkpoint GO:0007095 69 0.031
single organism catabolic process GO:0044712 228 0.030
regulation of organelle organization GO:0033043 196 0.030
death GO:0016265 284 0.030
protein phosphorylation GO:0006468 169 0.029
meiotic nuclear division GO:0007126 151 0.029
regulation of cell shape GO:0008360 113 0.028
peptidyl amino acid modification GO:0018193 105 0.028
organonitrogen compound metabolic process GO:1901564 318 0.028
single organism biosynthetic process GO:0044711 206 0.028
immune system process GO:0002376 347 0.027
cellular protein modification process GO:0006464 438 0.026
regulation of chromosome organization GO:0033044 64 0.025
proteolysis GO:0006508 192 0.025
mitotic g2 m transition checkpoint GO:0044818 70 0.025
rna processing GO:0006396 147 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.025
mitotic dna integrity checkpoint GO:0044774 75 0.025
protein localization to organelle GO:0033365 82 0.024
protein modification process GO:0036211 438 0.024
humoral immune response GO:0006959 117 0.024
regulation of cellular catabolic process GO:0031329 157 0.024
regulation of cell development GO:0060284 215 0.023
cellular response to organic substance GO:0071310 132 0.023
protein transport GO:0015031 155 0.023
double strand break repair GO:0006302 26 0.023
purine nucleoside triphosphate catabolic process GO:0009146 108 0.023
g2 dna damage checkpoint GO:0031572 69 0.023
establishment of protein localization GO:0045184 163 0.023
positive regulation of transcription dna templated GO:0045893 266 0.023
negative regulation of mitotic cell cycle GO:0045930 109 0.023
gland development GO:0048732 191 0.023
enzyme linked receptor protein signaling pathway GO:0007167 179 0.022
ubiquitin dependent protein catabolic process GO:0006511 78 0.022
anatomical structure homeostasis GO:0060249 97 0.022
negative regulation of cellular component organization GO:0051129 108 0.022
nucleocytoplasmic transport GO:0006913 72 0.021
regulation of cellular ketone metabolic process GO:0010565 3 0.021
cellular nitrogen compound catabolic process GO:0044270 165 0.021
regulation of cellular localization GO:0060341 136 0.020
developmental programmed cell death GO:0010623 138 0.020
body morphogenesis GO:0010171 2 0.020
regulation of dna metabolic process GO:0051052 34 0.020
developmental growth GO:0048589 280 0.020
apoptotic process GO:0006915 159 0.020
aging GO:0007568 143 0.020
protein dna complex subunit organization GO:0071824 86 0.020
cellular macromolecule catabolic process GO:0044265 136 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
modification dependent protein catabolic process GO:0019941 78 0.019
single organism intracellular transport GO:1902582 207 0.019
regulation of protein metabolic process GO:0051246 256 0.018
appendage development GO:0048736 401 0.018
protein maturation GO:0051604 71 0.018
dna repair GO:0006281 54 0.018
regulation of mitosis GO:0007088 56 0.018
negative regulation of cell cycle process GO:0010948 109 0.018
dna damage checkpoint GO:0000077 78 0.018
cellular protein complex assembly GO:0043623 71 0.017
immune effector process GO:0002252 98 0.017
regulation of cell morphogenesis GO:0022604 163 0.017
dna endoreduplication GO:0042023 22 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.017
regulation of nuclear division GO:0051783 58 0.017
dna dependent dna replication GO:0006261 17 0.017
cell fate determination GO:0001709 91 0.017
regulation of molecular function GO:0065009 217 0.017
regulation of apoptotic process GO:0042981 130 0.017
single organism cellular localization GO:1902580 180 0.016
nuclear transport GO:0051169 72 0.016
phosphorylation GO:0016310 294 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
vesicle mediated transport GO:0016192 381 0.016
cytoplasmic transport GO:0016482 130 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
cellular amino acid metabolic process GO:0006520 61 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
regulation of cell division GO:0051302 72 0.015
modification dependent macromolecule catabolic process GO:0043632 79 0.015
cellular response to oxygen containing compound GO:1901701 79 0.015
negative regulation of cell communication GO:0010648 223 0.015
phagocytosis GO:0006909 215 0.015
meiotic cell cycle process GO:1903046 132 0.015
chemotaxis GO:0006935 249 0.015
nuclear pore organization GO:0006999 1 0.015
multicellular organismal aging GO:0010259 140 0.015
eye development GO:0001654 323 0.015
programmed cell death GO:0012501 257 0.015
camera type eye development GO:0043010 4 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
purine nucleoside monophosphate metabolic process GO:0009126 50 0.014
protein catabolic process GO:0030163 101 0.014
nucleotide metabolic process GO:0009117 161 0.014
cellular response to chemical stimulus GO:0070887 199 0.014
regulation of catabolic process GO:0009894 170 0.014
ribonucleoside monophosphate catabolic process GO:0009158 39 0.014
regulation of gene silencing GO:0060968 63 0.014
meiotic chromosome segregation GO:0045132 59 0.014
regulation of microtubule based process GO:0032886 49 0.014
regulation of protein transport GO:0051223 57 0.014
chromosome separation GO:0051304 42 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.014
regulation of cell proliferation GO:0042127 163 0.014
ncrna metabolic process GO:0034660 43 0.014
antimicrobial humoral response GO:0019730 99 0.013
macromolecule catabolic process GO:0009057 161 0.013
amine metabolic process GO:0009308 12 0.013
nucleobase containing compound transport GO:0015931 56 0.013
dna recombination GO:0006310 32 0.013
negative regulation of response to stimulus GO:0048585 258 0.013
regulation of protein catabolic process GO:0042176 55 0.013
negative regulation of signal transduction GO:0009968 206 0.013
regulation of immune effector process GO:0002697 52 0.013
cellular response to external stimulus GO:0071496 66 0.012
negative regulation of organelle organization GO:0010639 56 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
immune response GO:0006955 246 0.012
compound eye development GO:0048749 307 0.012
mitotic dna damage checkpoint GO:0044773 74 0.012
carbohydrate metabolic process GO:0005975 82 0.012
regulation of proteolysis GO:0030162 87 0.012
establishment of protein localization to organelle GO:0072594 62 0.012
positive regulation of cellular biosynthetic process GO:0031328 316 0.012
regulation of cell death GO:0010941 173 0.012
intracellular protein transport GO:0006886 104 0.012
purine containing compound metabolic process GO:0072521 155 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
histone methylation GO:0016571 40 0.011
tissue morphogenesis GO:0048729 297 0.011
notch signaling pathway GO:0007219 120 0.011
regulation of protein localization GO:0032880 76 0.011
cellular amine metabolic process GO:0044106 12 0.011
cellular ketone metabolic process GO:0042180 24 0.011
striated muscle cell differentiation GO:0051146 90 0.011
ribonucleotide metabolic process GO:0009259 145 0.011
heterocycle catabolic process GO:0046700 166 0.011
taxis GO:0042330 304 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
dna biosynthetic process GO:0071897 24 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.010
dna duplex unwinding GO:0032508 16 0.010
macromolecule methylation GO:0043414 45 0.010
nuclear transcribed mrna catabolic process GO:0000956 24 0.010
ribonucleoside triphosphate metabolic process GO:0009199 119 0.010
negative regulation of developmental process GO:0051093 201 0.010
aromatic compound catabolic process GO:0019439 166 0.010

DNApol-epsilon disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018
nervous system disease DOID:863 0 0.018