Drosophila melanogaster

44 known processes

dbo (Dmel_CG6224)

diablo

(Aliases: Dm.DBO,Smac,CG6224,DIABLO,Dmel\CG6224)

dbo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
wing disc morphogenesis GO:0007472 344 0.251
cellular catabolic process GO:0044248 372 0.231
Human
protein modification process GO:0036211 438 0.217
Human Fly
embryonic morphogenesis GO:0048598 206 0.181
appendage morphogenesis GO:0035107 397 0.177
protein localization GO:0008104 284 0.170
growth GO:0040007 359 0.154
appendage development GO:0048736 401 0.154
actin filament based process GO:0030029 220 0.145
Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.143
macromolecule catabolic process GO:0009057 161 0.132
Human
mrna metabolic process GO:0016071 124 0.129
actin cytoskeleton organization GO:0030036 206 0.109
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.097
cilium morphogenesis GO:0060271 39 0.092
negative regulation of response to stimulus GO:0048585 258 0.088
endocytosis GO:0006897 310 0.083
Fly
organic substance catabolic process GO:1901575 308 0.081
Human
positive regulation of catabolic process GO:0009896 105 0.080
cellular macromolecule catabolic process GO:0044265 136 0.077
Human
imaginal disc derived appendage development GO:0048737 399 0.077
intracellular signal transduction GO:0035556 300 0.075
positive regulation of rna metabolic process GO:0051254 271 0.074
imaginal disc derived appendage morphogenesis GO:0035114 395 0.069
heterocycle catabolic process GO:0046700 166 0.069
regionalization GO:0003002 416 0.066
regulation of intracellular signal transduction GO:1902531 236 0.065
regulation of cellular response to stress GO:0080135 89 0.065
establishment or maintenance of cell polarity GO:0007163 167 0.064
catabolic process GO:0009056 409 0.063
Human
ameboidal type cell migration GO:0001667 151 0.063
Fly
organelle assembly GO:0070925 198 0.059
respiratory system development GO:0060541 213 0.058
nucleobase containing compound catabolic process GO:0034655 165 0.057
tissue morphogenesis GO:0048729 297 0.056
rna processing GO:0006396 147 0.053
morphogenesis of an epithelium GO:0002009 276 0.053
morphogenesis of a polarized epithelium GO:0001738 93 0.053
eye photoreceptor cell differentiation GO:0001754 145 0.053
non sensory hair organization GO:0035316 47 0.052
jnk cascade GO:0007254 50 0.051
cellular macromolecule localization GO:0070727 220 0.051
positive regulation of signal transduction GO:0009967 223 0.050
positive regulation of response to stimulus GO:0048584 323 0.050
digestive system development GO:0055123 149 0.050
regulation of mrna metabolic process GO:1903311 72 0.048
rubidium ion transport GO:0035826 1 0.048
establishment of localization in cell GO:0051649 402 0.048
Human
organelle localization GO:0051640 148 0.047
phosphorylation GO:0016310 294 0.046
positive regulation of cell communication GO:0010647 250 0.045
body morphogenesis GO:0010171 2 0.044
modification dependent macromolecule catabolic process GO:0043632 79 0.044
Human
posttranscriptional regulation of gene expression GO:0010608 145 0.043
response to organic substance GO:0010033 284 0.042
cell division GO:0051301 248 0.041
rna catabolic process GO:0006401 37 0.041
positive regulation of signaling GO:0023056 243 0.041
cellular macromolecular complex assembly GO:0034622 153 0.041
actin filament organization GO:0007015 126 0.040
embryonic axis specification GO:0000578 107 0.039
chromosome segregation GO:0007059 157 0.039
regulation of mrna processing GO:0050684 71 0.039
cellular protein localization GO:0034613 160 0.038
establishment of planar polarity GO:0001736 87 0.038
establishment of cell polarity GO:0030010 40 0.037
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.037
regulation of response to stress GO:0080134 200 0.036
stress activated protein kinase signaling cascade GO:0031098 55 0.036
compound eye development GO:0048749 307 0.036
macromolecular complex assembly GO:0065003 256 0.035
regulation of protein metabolic process GO:0051246 256 0.034
Fly
mrna processing GO:0006397 104 0.033
open tracheal system development GO:0007424 204 0.033
regulation of cellular component biogenesis GO:0044087 201 0.032
cell recognition GO:0008037 102 0.032
negative regulation of cellular component organization GO:0051129 108 0.032
establishment of monopolar cell polarity GO:0061162 15 0.032
establishment of organelle localization GO:0051656 122 0.032
regulation of cytoskeleton organization GO:0051493 89 0.032
cell migration GO:0016477 238 0.031
Fly
limb morphogenesis GO:0035108 1 0.031
rrna processing GO:0006364 3 0.031
embryonic development via the syncytial blastoderm GO:0001700 148 0.031
regulation of cell cell adhesion GO:0022407 21 0.031
regulation of anatomical structure size GO:0090066 163 0.031
regulation of organelle organization GO:0033043 196 0.031
synaptic target recognition GO:0008039 45 0.030
phagocytosis GO:0006909 215 0.030
Fly
rna splicing GO:0008380 83 0.029
protein ubiquitination GO:0016567 70 0.029
Human Fly
organic cyclic compound catabolic process GO:1901361 168 0.029
regulation of multicellular organismal development GO:2000026 414 0.029
positive regulation of macromolecule metabolic process GO:0010604 405 0.029
Fly
cellular nitrogen compound catabolic process GO:0044270 165 0.029
single organism intracellular transport GO:1902582 207 0.028
Human
establishment of tissue polarity GO:0007164 87 0.028
segmentation GO:0035282 207 0.028
extracellular matrix constituent secretion GO:0070278 4 0.027
limb development GO:0060173 1 0.027
regulation of establishment of planar polarity GO:0090175 22 0.027
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.027
mrna catabolic process GO:0006402 33 0.026
embryonic pattern specification GO:0009880 174 0.026
regulation of proteolysis GO:0030162 87 0.026
Fly
positive regulation of gene expression GO:0010628 290 0.026
negative regulation of gene expression GO:0010629 387 0.025
regulation of wnt signaling pathway GO:0030111 68 0.024
spermatid development GO:0007286 98 0.024
Fly
regulation of phosphorylation GO:0042325 147 0.024
proteolysis GO:0006508 192 0.024
Human Fly
proteasomal protein catabolic process GO:0010498 59 0.024
Human
male gamete generation GO:0048232 201 0.024
Fly
establishment of protein localization GO:0045184 163 0.023
stress activated mapk cascade GO:0051403 52 0.023
cellular response to peptide GO:1901653 28 0.023
positive regulation of proteolysis GO:0045862 52 0.023
Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.023
protein transport GO:0015031 155 0.023
central nervous system development GO:0007417 201 0.023
ubiquitin dependent protein catabolic process GO:0006511 78 0.023
Human
multi organism behavior GO:0051705 175 0.023
imaginal disc derived wing hair organization GO:0035317 45 0.023
establishment or maintenance of monopolar cell polarity GO:0061339 15 0.023
regulation of cell morphogenesis GO:0022604 163 0.023
modification dependent protein catabolic process GO:0019941 78 0.023
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.022
cellular response to dna damage stimulus GO:0006974 223 0.022
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.022
establishment of epithelial cell apical basal polarity GO:0045198 10 0.022
cellular protein modification process GO:0006464 438 0.022
Human Fly
positive regulation of cellular catabolic process GO:0031331 95 0.021
gene silencing GO:0016458 138 0.021
positive regulation of transcription dna templated GO:0045893 266 0.021
spindle organization GO:0007051 253 0.021
anterior posterior axis specification GO:0009948 109 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.021
o glycan processing GO:0016266 3 0.021
convergent extension GO:0060026 2 0.021
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
Fly
aromatic compound catabolic process GO:0019439 166 0.021
regulation of cellular component size GO:0032535 98 0.021
mapk cascade GO:0000165 107 0.021
biological adhesion GO:0022610 138 0.020
oligosaccharide metabolic process GO:0009311 18 0.020
regulation of jnk cascade GO:0046328 40 0.020
anterior posterior pattern specification GO:0009952 136 0.020
protein modification by small protein conjugation GO:0032446 79 0.020
Human Fly
regulation of localization GO:0032879 275 0.020
carbohydrate biosynthetic process GO:0016051 17 0.019
cell cell adhesion GO:0098609 26 0.019
posttranscriptional gene silencing by rna GO:0035194 45 0.019
signal transduction by phosphorylation GO:0023014 107 0.019
negative regulation of cell communication GO:0010648 223 0.019
nuclear transcribed mrna catabolic process GO:0000956 24 0.019
sensory perception of chemical stimulus GO:0007606 116 0.019
regulation of notch signaling pathway GO:0008593 100 0.019
ribonucleoprotein complex subunit organization GO:0071826 28 0.019
notch signaling pathway GO:0007219 120 0.018
negative regulation of signal transduction GO:0009968 206 0.018
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 24 0.018
response to abiotic stimulus GO:0009628 341 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
wnt signaling pathway GO:0016055 98 0.017
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.017
neuron recognition GO:0008038 101 0.017
tube morphogenesis GO:0035239 191 0.017
cilium organization GO:0044782 41 0.017
blastoderm segmentation GO:0007350 159 0.017
developmental growth GO:0048589 280 0.017
rhythmic process GO:0048511 106 0.017
circadian sleep wake cycle sleep GO:0050802 23 0.017
chemosensory behavior GO:0007635 106 0.016
compound eye photoreceptor development GO:0042051 78 0.016
negative regulation of signaling GO:0023057 219 0.016
response to radiation GO:0009314 155 0.016
hair cell differentiation GO:0035315 47 0.016
cell adhesion GO:0007155 136 0.016
segment polarity determination GO:0007367 25 0.016
rna localization GO:0006403 115 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
nuclear division GO:0000280 332 0.016
epithelial cell development GO:0002064 274 0.016
Fly
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.016
positive regulation of nucleic acid templated transcription GO:1903508 266 0.016
endosomal transport GO:0016197 44 0.016
Human
negative regulation of wnt signaling pathway GO:0030178 28 0.015
epithelial cell migration GO:0010631 148 0.015
Fly
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
ribonucleoprotein complex biogenesis GO:0022613 31 0.015
cellular protein catabolic process GO:0044257 83 0.015
Human
protein depolymerization GO:0051261 31 0.015
cellular protein complex disassembly GO:0043624 35 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
cytoplasmic transport GO:0016482 130 0.015
Human
protein catabolic process GO:0030163 101 0.015
Human
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.015
death GO:0016265 284 0.015
Human Fly
regulation of stress activated mapk cascade GO:0032872 41 0.015
digestive tract development GO:0048565 149 0.015
regulation of rna splicing GO:0043484 69 0.015
eye development GO:0001654 323 0.015
ribonucleoprotein complex assembly GO:0022618 23 0.015
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.014
response to biotic stimulus GO:0009607 294 0.014
mrna splicing via spliceosome GO:0000398 73 0.014
regulation of tube size open tracheal system GO:0035151 43 0.014
inter male aggressive behavior GO:0002121 60 0.014
response to external biotic stimulus GO:0043207 293 0.014
neurological system process GO:0050877 358 0.014
regulation of actin cytoskeleton organization GO:0032956 42 0.014
vesicle mediated transport GO:0016192 381 0.014
Human Fly
nuclear transport GO:0051169 72 0.014
endomembrane system organization GO:0010256 119 0.014
intracellular transport GO:0046907 228 0.014
Human
regulation of phosphate metabolic process GO:0019220 210 0.014
olfactory behavior GO:0042048 97 0.014
intracellular protein transport GO:0006886 104 0.014
epidermal cell differentiation GO:0009913 51 0.013
tripartite regional subdivision GO:0007351 103 0.013
cellular response to organonitrogen compound GO:0071417 36 0.013
erbb signaling pathway GO:0038127 58 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.013
digestive tract morphogenesis GO:0048546 127 0.013
germarium derived egg chamber formation GO:0007293 101 0.013
Fly
positive regulation of catalytic activity GO:0043085 118 0.013
Fly
negative regulation of organelle organization GO:0010639 56 0.013
eye morphogenesis GO:0048592 260 0.013
protein targeting GO:0006605 64 0.013
regulation of catalytic activity GO:0050790 185 0.013
Fly
reproductive structure development GO:0048608 74 0.013
cell migration involved in gastrulation GO:0042074 9 0.013
ncrna processing GO:0034470 30 0.013
alternative mrna splicing via spliceosome GO:0000380 60 0.012
cell death GO:0008219 279 0.012
Human Fly
photoreceptor cell development GO:0042461 96 0.012
asymmetric protein localization GO:0008105 33 0.012
vesicle organization GO:0016050 44 0.012
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 18 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.012
Human
oligosaccharide biosynthetic process GO:0009312 10 0.012
imaginal disc derived wing vein specification GO:0007474 48 0.012
regulation of tube length open tracheal system GO:0035159 24 0.012
motor neuron axon guidance GO:0008045 58 0.012
smoothened signaling pathway GO:0007224 49 0.012
regulation of epithelial cell proliferation GO:0050678 4 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
Fly
humoral immune response GO:0006959 117 0.012
positive regulation of phosphorylation GO:0042327 87 0.012
regulation of cell shape GO:0008360 113 0.012
epithelium migration GO:0090132 148 0.012
Fly
cellular component assembly involved in morphogenesis GO:0010927 151 0.012
protein complex biogenesis GO:0070271 201 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
single organism cell adhesion GO:0098602 47 0.012
defense response GO:0006952 300 0.012
antimicrobial humoral response GO:0019730 99 0.012
pigmentation GO:0043473 75 0.012
regulation of growth GO:0040008 233 0.012
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.012
protein complex assembly GO:0006461 200 0.012
embryo development ending in birth or egg hatching GO:0009792 152 0.012
chromosome organization GO:0051276 360 0.012
Fly
positive regulation of phosphate metabolic process GO:0045937 139 0.012
spermatid differentiation GO:0048515 114 0.011
Fly
regulation of mrna splicing via spliceosome GO:0048024 64 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
single organism behavior GO:0044708 391 0.011
negative regulation of epithelial cell proliferation GO:0050680 4 0.011
single organism cellular localization GO:1902580 180 0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.011
anterior posterior axis specification embryo GO:0008595 103 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
carboxylic acid metabolic process GO:0019752 92 0.011
rna splicing via transesterification reactions GO:0000375 73 0.011
single organism catabolic process GO:0044712 228 0.011
negative regulation of notch signaling pathway GO:0045746 41 0.011
actin filament bundle organization GO:0061572 28 0.011
aggressive behavior GO:0002118 63 0.011
notch receptor processing GO:0007220 13 0.011
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.010
tube development GO:0035295 244 0.010
regulation of cellular response to growth factor stimulus GO:0090287 13 0.010
regulation of gene expression epigenetic GO:0040029 128 0.010
response to organonitrogen compound GO:0010243 75 0.010
oxoacid metabolic process GO:0043436 103 0.010
imaginal disc derived wing hair site selection GO:0035320 4 0.010
small molecule metabolic process GO:0044281 305 0.010
ommatidial rotation GO:0016318 20 0.010
regulation of protein catabolic process GO:0042176 55 0.010
positive regulation of rna biosynthetic process GO:1902680 266 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.010
regulation of protein modification process GO:0031399 112 0.010
lateral inhibition GO:0046331 206 0.010
epidermal growth factor receptor signaling pathway GO:0007173 58 0.010
imaginal disc derived leg morphogenesis GO:0007480 80 0.010
organelle fission GO:0048285 340 0.010
carbohydrate derivative metabolic process GO:1901135 217 0.010
retina development in camera type eye GO:0060041 4 0.010
regulation of organ morphogenesis GO:2000027 78 0.010

dbo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.014
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010