Drosophila melanogaster

164 known processes

Trl (Dmel_CG33261)

Trithorax-like

(Aliases: Trl-GAGA,Adf-2-519,trl,Gaf,CG9343,l(3)s2325,Adf-2,E(var)3-trl,gaga,TfGAGA/Adf-2,Adf2,anon-EST:fe2E12,TRL,E(var)62,GAGA,Gaga,Dmel\CG33261,GAF,Nc70F,CG33261,NC70F)

Trl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regionalization GO:0003002 416 0.996
Fly
negative regulation of biosynthetic process GO:0009890 277 0.994
negative regulation of cellular biosynthetic process GO:0031327 277 0.989
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.964
epithelial cell development GO:0002064 274 0.948
Fly
ovarian follicle cell development GO:0030707 248 0.948
Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.938
meiotic cell cycle process GO:1903046 132 0.895
Fly
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.851
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.816
positive regulation of biosynthetic process GO:0009891 316 0.796
negative regulation of gene expression GO:0010629 387 0.756
negative regulation of transcription dna templated GO:0045892 237 0.682
dorsal ventral pattern formation GO:0009953 133 0.681
anterior posterior pattern specification GO:0009952 136 0.650
Fly
cognition GO:0050890 141 0.629
negative regulation of cellular metabolic process GO:0031324 382 0.593
meiosis i GO:0007127 59 0.566
Fly
regulation of cell differentiation GO:0045595 302 0.565
Fly
multi organism behavior GO:0051705 175 0.537
Fly
morphogenesis of follicular epithelium GO:0016333 36 0.533
neuron projection guidance GO:0097485 241 0.518
Fly
negative regulation of cell communication GO:0010648 223 0.511
vesicle mediated transport GO:0016192 381 0.464
embryonic axis specification GO:0000578 107 0.454
Fly
positive regulation of macromolecule metabolic process GO:0010604 405 0.431
epithelial cell differentiation GO:0030855 322 0.430
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.391
positive regulation of rna metabolic process GO:0051254 271 0.382
negative regulation of signal transduction GO:0009968 206 0.373
regulation of cellular component biogenesis GO:0044087 201 0.345
positive regulation of transcription dna templated GO:0045893 266 0.336
columnar cuboidal epithelial cell development GO:0002066 249 0.308
Fly
dendrite morphogenesis GO:0048813 199 0.297
Fly
ovarian follicle cell migration GO:0007297 121 0.284
Fly
anterior posterior axis specification GO:0009948 109 0.283
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.264
dendrite development GO:0016358 204 0.264
Fly
tripartite regional subdivision GO:0007351 103 0.254
Fly
spermatogenesis GO:0007283 200 0.254
negative regulation of response to stimulus GO:0048585 258 0.252
oocyte construction GO:0007308 112 0.246
germarium derived egg chamber formation GO:0007293 101 0.245
negative regulation of nucleic acid templated transcription GO:1903507 240 0.231
chromatin silencing GO:0006342 76 0.228
head development GO:0060322 135 0.219
Fly
muscle cell differentiation GO:0042692 103 0.212
Fly
positive regulation of response to stimulus GO:0048584 323 0.208
axis specification GO:0009798 167 0.208
Fly
appendage development GO:0048736 401 0.185
leg disc morphogenesis GO:0007478 80 0.184
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.183
Fly
positive regulation of gene expression GO:0010628 290 0.178
gene silencing GO:0016458 138 0.175
tissue death GO:0016271 102 0.159
Fly
chemotaxis GO:0006935 249 0.158
Fly
developmental programmed cell death GO:0010623 138 0.147
Fly
regulation of multicellular organismal development GO:2000026 414 0.133
Fly
brain development GO:0007420 120 0.130
Fly
chromatin remodeling GO:0006338 72 0.128
regulation of reproductive process GO:2000241 54 0.124
axonogenesis GO:0007409 290 0.104
Fly
germarium derived female germ line cyst encapsulation GO:0030708 8 0.102
regulation of chromatin silencing GO:0031935 36 0.100
negative regulation of gene expression epigenetic GO:0045814 77 0.100
meiotic cell cycle GO:0051321 171 0.100
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.096
negative regulation of rna metabolic process GO:0051253 251 0.087
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.086
embryonic pattern specification GO:0009880 174 0.079
Fly
negative regulation of developmental process GO:0051093 201 0.077
organonitrogen compound metabolic process GO:1901564 318 0.072
chitin based cuticle development GO:0040003 49 0.070
Fly
learning GO:0007612 75 0.070
small molecule metabolic process GO:0044281 305 0.068
imaginal disc derived appendage morphogenesis GO:0035114 395 0.067
wing disc morphogenesis GO:0007472 344 0.067
tissue morphogenesis GO:0048729 297 0.059
Fly
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.059
developmental growth GO:0048589 280 0.055
Fly
learning or memory GO:0007611 141 0.053
cytoplasmic transport GO:0016482 130 0.052
cell maturation GO:0048469 144 0.052
cellular response to chemical stimulus GO:0070887 199 0.052
Fly
segmentation GO:0035282 207 0.052
Fly
cellular response to oxygen containing compound GO:1901701 79 0.051
Fly
dna metabolic process GO:0006259 227 0.051
dna alkylation GO:0006305 4 0.050
salivary gland histolysis GO:0035070 88 0.049
Fly
positive regulation of cellular protein metabolic process GO:0032270 118 0.048
appendage morphogenesis GO:0035107 397 0.048
membrane organization GO:0061024 112 0.047
spermatid differentiation GO:0048515 114 0.046
positive regulation of cellular component organization GO:0051130 156 0.045
female germ line cyst encapsulation GO:0048139 8 0.045
positive regulation of signal transduction GO:0009967 223 0.045
morphogenesis of an epithelium GO:0002009 276 0.045
Fly
blastoderm segmentation GO:0007350 159 0.044
Fly
gland development GO:0048732 191 0.044
Fly
regulation of protein metabolic process GO:0051246 256 0.043
negative regulation of cellular component organization GO:0051129 108 0.042
cuticle development GO:0042335 86 0.041
Fly
intracellular transport GO:0046907 228 0.041
imaginal disc derived wing vein specification GO:0007474 48 0.041
protein localization GO:0008104 284 0.041
Fly
male meiosis GO:0007140 52 0.040
Fly
dna methylation GO:0006306 4 0.040
organelle inheritance GO:0048308 2 0.040
eggshell chorion assembly GO:0007306 66 0.040
Fly
oocyte differentiation GO:0009994 145 0.039
anterior posterior axis specification embryo GO:0008595 103 0.038
Fly
regulation of localization GO:0032879 275 0.038
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.038
Fly
response to nutrient levels GO:0031667 114 0.038
regulation of anatomical structure size GO:0090066 163 0.038
Fly
oocyte development GO:0048599 124 0.037
positive regulation of multicellular organismal process GO:0051240 143 0.036
imaginal disc pattern formation GO:0007447 91 0.036
endomembrane system organization GO:0010256 119 0.035
endocytosis GO:0006897 310 0.035
developmental maturation GO:0021700 172 0.035
positive regulation of nucleic acid templated transcription GO:1903508 266 0.034
histone acetylation GO:0016573 38 0.033
transcription from rna polymerase ii promoter GO:0006366 368 0.033
single organism cellular localization GO:1902580 180 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.032
negative regulation of rna biosynthetic process GO:1902679 240 0.031
negative regulation of signaling GO:0023057 219 0.031
salivary gland morphogenesis GO:0007435 145 0.030
Fly
regulation of multi organism process GO:0043900 131 0.030
catabolic process GO:0009056 409 0.030
Fly
apoptotic process GO:0006915 159 0.030
Fly
eye development GO:0001654 323 0.029
Fly
dna methylation or demethylation GO:0044728 4 0.029
neurological system process GO:0050877 358 0.028
Fly
positive regulation of protein metabolic process GO:0051247 128 0.028
hematopoietic or lymphoid organ development GO:0048534 57 0.028
growth GO:0040007 359 0.027
Fly
single organism intracellular transport GO:1902582 207 0.026
imaginal disc derived appendage development GO:0048737 399 0.025
response to organic cyclic compound GO:0014070 89 0.025
Fly
eggshell formation GO:0030703 105 0.024
Fly
single organism behavior GO:0044708 391 0.024
Fly
memory GO:0007613 94 0.024
oocyte axis specification GO:0007309 108 0.023
sex determination GO:0007530 18 0.022
peptidyl lysine acetylation GO:0018394 39 0.022
humoral immune response GO:0006959 117 0.022
Fly
regulation of cellular component size GO:0032535 98 0.021
amine metabolic process GO:0009308 12 0.020
oocyte anterior posterior axis specification GO:0007314 72 0.020
death GO:0016265 284 0.020
Fly
cellular protein modification process GO:0006464 438 0.019
programmed cell death GO:0012501 257 0.019
Fly
leg disc development GO:0035218 92 0.019
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.019
positive regulation of rna biosynthetic process GO:1902680 266 0.019
cell cycle phase transition GO:0044770 140 0.018
positive regulation of cell differentiation GO:0045597 64 0.018
multi multicellular organism process GO:0044706 123 0.018
border follicle cell migration GO:0007298 113 0.018
Fly
regulation of developmental growth GO:0048638 174 0.018
homeostatic process GO:0042592 199 0.018
cellular response to organic cyclic compound GO:0071407 32 0.018
Fly
establishment of localization in cell GO:0051649 402 0.018
forebrain development GO:0030900 2 0.018
male meiosis i GO:0007141 9 0.017
Fly
protein modification process GO:0036211 438 0.017
positive regulation of cellular biosynthetic process GO:0031328 316 0.017
cellular protein localization GO:0034613 160 0.017
regulation of viral genome replication GO:0045069 4 0.016
positive regulation of phosphorylation GO:0042327 87 0.016
oocyte microtubule cytoskeleton organization GO:0016325 35 0.016
cell proliferation GO:0008283 299 0.016
positive regulation of organelle organization GO:0010638 65 0.015
positive regulation of transferase activity GO:0051347 26 0.015
antimicrobial humoral response GO:0019730 99 0.015
Fly
meiotic chromosome segregation GO:0045132 59 0.015
Fly
response to oxygen containing compound GO:1901700 200 0.015
Fly
wing disc pattern formation GO:0035222 66 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.014
regulation of oocyte development GO:0060281 27 0.014
axon guidance GO:0007411 233 0.014
Fly
central nervous system development GO:0007417 201 0.014
Fly
regulation of phosphatase activity GO:0010921 3 0.014
nucleoside phosphate metabolic process GO:0006753 162 0.014
regulation of wnt signaling pathway GO:0030111 68 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
organelle fission GO:0048285 340 0.013
germ line cyst encapsulation GO:0048138 8 0.013
histolysis GO:0007559 102 0.013
Fly
chorion containing eggshell formation GO:0007304 105 0.013
Fly
regulation of pole plasm oskar mrna localization GO:0007317 27 0.013
oocyte dorsal ventral axis specification GO:0007310 34 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
positive regulation of cell communication GO:0010647 250 0.013
actin filament organization GO:0007015 126 0.012
regulation of membrane potential GO:0042391 35 0.012
positive regulation of developmental process GO:0051094 143 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
immune system development GO:0002520 57 0.012
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
synaptic transmission GO:0007268 288 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.012
organic substance transport GO:0071702 257 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
Fly
embryo development ending in birth or egg hatching GO:0009792 152 0.011
Fly
negative regulation of protein metabolic process GO:0051248 85 0.011
purine containing compound metabolic process GO:0072521 155 0.011
protein localization to organelle GO:0033365 82 0.011
regulation of hemocyte proliferation GO:0035206 37 0.011
protein transport GO:0015031 155 0.011
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
Fly
response to wounding GO:0009611 94 0.011
negative regulation of transcription factor import into nucleus GO:0042992 4 0.010
cellular amino acid metabolic process GO:0006520 61 0.010
regulation of cell development GO:0060284 215 0.010
actin filament bundle organization GO:0061572 28 0.010
hormone metabolic process GO:0042445 33 0.010

Trl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.018
osteogenesis imperfecta DOID:12347 0 0.018
bone development disease DOID:0080006 0 0.018
bone disease DOID:0080001 0 0.018
disease of anatomical entity DOID:7 0 0.018
musculoskeletal system disease DOID:17 0 0.018
connective tissue disease DOID:65 0 0.018
familial meningioma DOID:4586 0 0.016
nervous system cancer DOID:3093 0 0.016
central nervous system cancer DOID:3620 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
meningioma DOID:3565 0 0.016