Drosophila melanogaster

77 known processes

tow (Dmel_CG14821)

target of wingless

(Aliases: CG14821,Dmel\CG14821)

tow biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tissue morphogenesis GO:0048729 297 0.831
appendage development GO:0048736 401 0.394
positive regulation of macromolecule metabolic process GO:0010604 405 0.348
regulation of multicellular organismal development GO:2000026 414 0.341
eggshell chorion assembly GO:0007306 66 0.338
establishment of planar polarity GO:0001736 87 0.315
appendage morphogenesis GO:0035107 397 0.284
wing disc morphogenesis GO:0007472 344 0.214
post embryonic appendage morphogenesis GO:0035120 385 0.143
regulation of organ morphogenesis GO:2000027 78 0.142
imaginal disc derived appendage development GO:0048737 399 0.137
morphogenesis of a polarized epithelium GO:0001738 93 0.129
negative regulation of signal transduction GO:0009968 206 0.125
negative regulation of transcription dna templated GO:0045892 237 0.116
positive regulation of response to stimulus GO:0048584 323 0.114
endocytosis GO:0006897 310 0.108
negative regulation of nucleic acid templated transcription GO:1903507 240 0.106
eggshell formation GO:0030703 105 0.101
smoothened signaling pathway GO:0007224 49 0.100
imaginal disc derived appendage morphogenesis GO:0035114 395 0.094
negative regulation of biosynthetic process GO:0009890 277 0.094
chorion containing eggshell formation GO:0007304 105 0.091
neuron recognition GO:0008038 101 0.085
negative regulation of cellular metabolic process GO:0031324 382 0.084
establishment of tissue polarity GO:0007164 87 0.083
neurological system process GO:0050877 358 0.083
dendrite morphogenesis GO:0048813 199 0.079
locomotory behavior GO:0007626 176 0.071
spinal cord development GO:0021510 1 0.071
negative regulation of rna biosynthetic process GO:1902679 240 0.070
regulation of cell differentiation GO:0045595 302 0.069
regulation of mitotic cell cycle GO:0007346 190 0.068
morphogenesis of an epithelium GO:0002009 276 0.066
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.066
nucleotide catabolic process GO:0009166 109 0.065
vesicle mediated transport GO:0016192 381 0.062
positive regulation of cell migration GO:0030335 2 0.061
dendrite development GO:0016358 204 0.061
epithelial cell differentiation GO:0030855 322 0.060
regulation of cell development GO:0060284 215 0.060
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.060
single organism behavior GO:0044708 391 0.060
small molecule metabolic process GO:0044281 305 0.059
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.058
regulation of anatomical structure morphogenesis GO:0022603 242 0.057
negative regulation of cellular biosynthetic process GO:0031327 277 0.057
negative regulation of signaling GO:0023057 219 0.056
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.056
regulation of notch signaling pathway GO:0008593 100 0.054
regulation of localization GO:0032879 275 0.053
ovarian follicle cell development GO:0030707 248 0.052
sensory organ morphogenesis GO:0090596 260 0.052
negative regulation of rna metabolic process GO:0051253 251 0.052
positive regulation of multicellular organismal process GO:0051240 143 0.050
protein phosphorylation GO:0006468 169 0.049
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.049
organonitrogen compound metabolic process GO:1901564 318 0.047
metal ion transport GO:0030001 74 0.047
chemotaxis GO:0006935 249 0.046
phosphorylation GO:0016310 294 0.046
regulation of anatomical structure size GO:0090066 163 0.046
purine containing compound catabolic process GO:0072523 112 0.046
positive regulation of developmental process GO:0051094 143 0.045
circulatory system process GO:0003013 37 0.045
regulation of molecular function GO:0065009 217 0.044
regulation of cell cycle GO:0051726 291 0.043
positive regulation of gene expression GO:0010628 290 0.043
cation transport GO:0006812 110 0.043
compound eye photoreceptor cell differentiation GO:0001751 140 0.043
regulation of protein metabolic process GO:0051246 256 0.043
purine nucleoside triphosphate catabolic process GO:0009146 108 0.042
regulation of programmed cell death GO:0043067 152 0.041
cellular nitrogen compound catabolic process GO:0044270 165 0.041
cellular component assembly involved in morphogenesis GO:0010927 151 0.041
negative regulation of developmental process GO:0051093 201 0.040
blood circulation GO:0008015 26 0.040
skeletal muscle organ development GO:0060538 48 0.040
protein complex biogenesis GO:0070271 201 0.039
phagocytosis GO:0006909 215 0.039
peptidyl threonine phosphorylation GO:0018107 2 0.039
positive regulation of cell motility GO:2000147 3 0.039
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.039
endomembrane system organization GO:0010256 119 0.038
regulation of transport GO:0051049 181 0.038
regulation of smoothened signaling pathway GO:0008589 28 0.038
rho protein signal transduction GO:0007266 14 0.038
detection of light stimulus GO:0009583 58 0.037
cell division GO:0051301 248 0.037
imaginal disc derived wing vein specification GO:0007474 48 0.036
positive regulation of molecular function GO:0044093 136 0.036
response to abiotic stimulus GO:0009628 341 0.036
imaginal disc derived wing morphogenesis GO:0007476 337 0.035
homeostatic process GO:0042592 199 0.035
epithelial cell migration GO:0010631 148 0.035
positive regulation of cell communication GO:0010647 250 0.035
eye morphogenesis GO:0048592 260 0.035
transcription from rna polymerase ii promoter GO:0006366 368 0.034
enzyme linked receptor protein signaling pathway GO:0007167 179 0.034
purine ribonucleotide catabolic process GO:0009154 109 0.034
wnt signaling pathway GO:0016055 98 0.033
regulation of apoptotic process GO:0042981 130 0.033
spinal cord patterning GO:0021511 1 0.033
cellular response to carbohydrate stimulus GO:0071322 4 0.033
amine metabolic process GO:0009308 12 0.032
positive regulation of transcription dna templated GO:0045893 266 0.032
localization of cell GO:0051674 257 0.032
negative regulation of cell communication GO:0010648 223 0.031
macromolecular complex assembly GO:0065003 256 0.031
axis specification GO:0009798 167 0.031
negative regulation of gene expression GO:0010629 387 0.031
positive regulation of signal transduction GO:0009967 223 0.031
notch signaling pathway GO:0007219 120 0.031
cell cell adhesion GO:0098609 26 0.031
positive regulation of cellular component organization GO:0051130 156 0.031
small gtpase mediated signal transduction GO:0007264 88 0.031
compound eye morphogenesis GO:0001745 249 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.030
camera type eye development GO:0043010 4 0.030
regulation of cellular amine metabolic process GO:0033238 3 0.029
dorsal appendage formation GO:0046843 47 0.029
detection of external stimulus GO:0009581 66 0.029
developmental maturation GO:0021700 172 0.029
purine nucleoside metabolic process GO:0042278 127 0.028
multi organism behavior GO:0051705 175 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
immune response activating signal transduction GO:0002757 2 0.028
regulation of blood circulation GO:1903522 21 0.028
adult behavior GO:0030534 137 0.028
catabolic process GO:0009056 409 0.028
regulation of nervous system development GO:0051960 248 0.028
organic cyclic compound catabolic process GO:1901361 168 0.028
nucleoside triphosphate catabolic process GO:0009143 108 0.027
developmental growth GO:0048589 280 0.027
cellular catabolic process GO:0044248 372 0.027
neuron projection guidance GO:0097485 241 0.027
positive regulation of rna biosynthetic process GO:1902680 266 0.027
cellular response to chemical stimulus GO:0070887 199 0.027
positive regulation of nucleic acid templated transcription GO:1903508 266 0.027
positive regulation of cellular biosynthetic process GO:0031328 316 0.027
regulation of cellular response to growth factor stimulus GO:0090287 13 0.027
response to organophosphorus GO:0046683 2 0.026
tube development GO:0035295 244 0.026
eye photoreceptor cell differentiation GO:0001754 145 0.026
heart contraction GO:0060047 26 0.026
regulation of wound healing GO:0061041 13 0.025
negative regulation of phosphorus metabolic process GO:0010563 45 0.025
epithelial cell development GO:0002064 274 0.024
ion transport GO:0006811 145 0.024
cellular macromolecule localization GO:0070727 220 0.024
regulation of phosphorylation GO:0042325 147 0.024
ribonucleotide metabolic process GO:0009259 145 0.024
spinal cord dorsal ventral patterning GO:0021513 1 0.024
phototransduction GO:0007602 52 0.024
tissue migration GO:0090130 155 0.023
regulation of organelle organization GO:0033043 196 0.023
aromatic compound catabolic process GO:0019439 166 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.023
positive regulation of rna metabolic process GO:0051254 271 0.023
muscle cell differentiation GO:0042692 103 0.023
g protein coupled receptor signaling pathway GO:0007186 136 0.023
golgi organization GO:0007030 66 0.023
regulation of epithelial cell proliferation GO:0050678 4 0.023
protein modification process GO:0036211 438 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.022
regulation of growth GO:0040008 233 0.022
nuclear division GO:0000280 332 0.022
epidermal growth factor receptor signaling pathway GO:0007173 58 0.022
photoreceptor cell differentiation GO:0046530 170 0.022
positive regulation of proteolysis GO:0045862 52 0.022
cell cycle phase transition GO:0044770 140 0.022
cell motility GO:0048870 251 0.022
striated muscle cell differentiation GO:0051146 90 0.022
establishment or maintenance of cell polarity GO:0007163 167 0.022
nucleoside triphosphate metabolic process GO:0009141 120 0.022
chemical homeostasis GO:0048878 92 0.021
cellular homeostasis GO:0019725 80 0.021
nucleoside phosphate catabolic process GO:1901292 110 0.021
ras protein signal transduction GO:0007265 88 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
nucleobase containing compound catabolic process GO:0034655 165 0.021
wound healing GO:0042060 75 0.020
cell death GO:0008219 279 0.020
ribonucleotide catabolic process GO:0009261 109 0.020
chitin based cuticle development GO:0040003 49 0.020
posttranscriptional regulation of gene expression GO:0010608 145 0.020
regionalization GO:0003002 416 0.020
regulation of cellular component size GO:0032535 98 0.020
cell junction assembly GO:0034329 42 0.020
single organism catabolic process GO:0044712 228 0.020
positive regulation of biosynthetic process GO:0009891 316 0.020
cellular response to oxygen containing compound GO:1901701 79 0.020
gtp metabolic process GO:0046039 72 0.020
ion homeostasis GO:0050801 55 0.020
organelle assembly GO:0070925 198 0.020
immune response regulating signaling pathway GO:0002764 2 0.020
negative regulation of response to stimulus GO:0048585 258 0.020
regulation of cell migration GO:0030334 22 0.020
positive regulation of gtpase activity GO:0043547 43 0.019
molting cycle process GO:0022404 29 0.019
regulation of catalytic activity GO:0050790 185 0.019
organonitrogen compound catabolic process GO:1901565 128 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
positive regulation of cellular component biogenesis GO:0044089 80 0.019
cell migration GO:0016477 238 0.019
positive regulation of hydrolase activity GO:0051345 78 0.019
carbohydrate derivative metabolic process GO:1901135 217 0.019
molting cycle GO:0042303 56 0.019
proteolysis GO:0006508 192 0.019
negative regulation of nervous system development GO:0051961 92 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
oocyte development GO:0048599 124 0.018
cell cell junction organization GO:0045216 55 0.018
negative regulation of intracellular signal transduction GO:1902532 57 0.018
peptidyl threonine modification GO:0018210 3 0.018
cellular amine metabolic process GO:0044106 12 0.018
regulation of cellular protein metabolic process GO:0032268 243 0.018
regulation of cell proliferation GO:0042127 163 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
purine nucleoside catabolic process GO:0006152 112 0.018
organic substance transport GO:0071702 257 0.018
skeletal muscle fiber development GO:0048741 3 0.018
establishment of ommatidial planar polarity GO:0042067 49 0.018
programmed cell death GO:0012501 257 0.018
nucleoside catabolic process GO:0009164 112 0.018
regulation of hydrolase activity GO:0051336 97 0.017
regulation of purine nucleotide metabolic process GO:1900542 62 0.017
oocyte differentiation GO:0009994 145 0.017
cellular response to organic substance GO:0071310 132 0.017
organophosphate catabolic process GO:0046434 112 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.017
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.017
neural retina development GO:0003407 4 0.016
axon guidance GO:0007411 233 0.016
ribonucleoside metabolic process GO:0009119 127 0.016
head development GO:0060322 135 0.016
eye photoreceptor cell fate commitment GO:0042706 37 0.016
cell cell junction assembly GO:0007043 38 0.016
myotube cell development GO:0014904 3 0.016
mitotic cell cycle phase transition GO:0044772 138 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
somatic muscle development GO:0007525 66 0.016
regulation of neuron projection development GO:0010975 69 0.016
purine ribonucleoside catabolic process GO:0046130 112 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
regulation of heart contraction GO:0008016 21 0.016
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
protein complex assembly GO:0006461 200 0.016
hindbrain development GO:0030902 2 0.016
cellular protein catabolic process GO:0044257 83 0.016
response to endogenous stimulus GO:0009719 119 0.016
glycosyl compound metabolic process GO:1901657 127 0.015
erbb signaling pathway GO:0038127 58 0.015
eye development GO:0001654 323 0.015
purine nucleotide catabolic process GO:0006195 109 0.015
regulation of cellular component movement GO:0051270 42 0.015
striated muscle cell development GO:0055002 50 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
glycosyl compound catabolic process GO:1901658 112 0.015
response to organic substance GO:0010033 284 0.015
regulation of dendrite morphogenesis GO:0048814 28 0.015
positive regulation of nucleotide metabolic process GO:0045981 55 0.015
retina morphogenesis in camera type eye GO:0060042 2 0.015
carboxylic acid metabolic process GO:0019752 92 0.015
tube morphogenesis GO:0035239 191 0.015
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.015
mushroom body development GO:0016319 70 0.015
cell proliferation GO:0008283 299 0.015
regulation of locomotion GO:0040012 42 0.015
ribonucleoside triphosphate catabolic process GO:0009203 108 0.015
axonal defasciculation GO:0007414 12 0.015
ribonucleoside catabolic process GO:0042454 112 0.015
cellular response to lipopolysaccharide GO:0071222 3 0.014
apoptotic process GO:0006915 159 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
positive regulation of phosphate metabolic process GO:0045937 139 0.014
cellular amino acid metabolic process GO:0006520 61 0.014
molting cycle chitin based cuticle GO:0007591 56 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
regulation of response to wounding GO:1903034 19 0.014
cytoskeleton dependent cytokinesis GO:0061640 81 0.014
negative regulation of epithelial cell proliferation GO:0050680 4 0.014
nucleotide metabolic process GO:0009117 161 0.014
single organism biosynthetic process GO:0044711 206 0.014
negative regulation of apoptotic process GO:0043066 63 0.014
positive regulation of phosphorylation GO:0042327 87 0.014
organic substance catabolic process GO:1901575 308 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.014
embryonic development via the syncytial blastoderm GO:0001700 148 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
taxis GO:0042330 304 0.014
signal transduction by phosphorylation GO:0023014 107 0.014
heart process GO:0003015 37 0.014
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
actin cytoskeleton organization GO:0030036 206 0.013
regulation of cell size GO:0008361 63 0.013
memory GO:0007613 94 0.013
purine containing compound metabolic process GO:0072521 155 0.013
positive regulation of cellular protein metabolic process GO:0032270 118 0.013
regulation of cell division GO:0051302 72 0.013
growth GO:0040007 359 0.013
regulation of system process GO:0044057 36 0.013
gastrulation GO:0007369 70 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
epithelial tube morphogenesis GO:0060562 88 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
blastoderm segmentation GO:0007350 159 0.013
positive regulation of cell cycle GO:0045787 43 0.013
regulation of developmental growth GO:0048638 174 0.013
regulation of translation GO:0006417 56 0.013
actin filament based process GO:0030029 220 0.012
cuticle development GO:0042335 86 0.012
instar larval development GO:0002168 55 0.012
regulation of cell death GO:0010941 173 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.012
intracellular signal transduction GO:0035556 300 0.012
regulation of neurogenesis GO:0050767 158 0.012
regulation of protein phosphorylation GO:0001932 64 0.012
regulation of cell projection organization GO:0031344 92 0.012
compound eye development GO:0048749 307 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
regulation of embryonic development GO:0045995 68 0.012
photoreceptor cell fate commitment GO:0046552 41 0.012
regulation of gtp catabolic process GO:0033124 44 0.012
spermatogenesis GO:0007283 200 0.012
response to light stimulus GO:0009416 124 0.012
regulation of phosphorus metabolic process GO:0051174 210 0.012
cellular response to abiotic stimulus GO:0071214 58 0.012
transmembrane transport GO:0055085 139 0.012
positive regulation of rho gtpase activity GO:0032321 19 0.012
axon development GO:0061564 297 0.012
regulation of nucleoside metabolic process GO:0009118 50 0.012
heterocycle catabolic process GO:0046700 166 0.011
positive regulation of gtp catabolic process GO:0033126 43 0.011
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.011
larval development GO:0002164 104 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
regulation of gtpase activity GO:0043087 44 0.011
cell adhesion GO:0007155 136 0.011
positive regulation of catabolic process GO:0009896 105 0.011
regulation of wnt signaling pathway GO:0030111 68 0.011
inter male aggressive behavior GO:0002121 60 0.011
cellular response to growth factor stimulus GO:0071363 30 0.011
cellular ketone metabolic process GO:0042180 24 0.011
regulation of erbb signaling pathway GO:1901184 42 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
regulation of catabolic process GO:0009894 170 0.011
regulation of cytoskeleton organization GO:0051493 89 0.011
regulation of establishment of planar polarity GO:0090175 22 0.011
positive regulation of signaling GO:0023056 243 0.011
cellular response to hexose stimulus GO:0071331 1 0.011
biological adhesion GO:0022610 138 0.011
potassium ion transport GO:0006813 20 0.011
synaptic growth at neuromuscular junction GO:0051124 119 0.011
body morphogenesis GO:0010171 2 0.011
morphogenesis of embryonic epithelium GO:0016331 94 0.011
compound eye photoreceptor fate commitment GO:0001752 36 0.011
muscle fiber development GO:0048747 12 0.010
hindgut development GO:0061525 58 0.010
chromosome organization GO:0051276 360 0.010
purine nucleoside triphosphate metabolic process GO:0009144 119 0.010
negative regulation of notch signaling pathway GO:0045746 41 0.010
digestive system development GO:0055123 149 0.010
mitotic cytokinesis GO:0000281 50 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
exocrine system development GO:0035272 162 0.010
single organismal cell cell adhesion GO:0016337 45 0.010
mapk cascade GO:0000165 107 0.010
kidney development GO:0001822 3 0.010
death GO:0016265 284 0.010
guanosine containing compound catabolic process GO:1901069 74 0.010
mrna metabolic process GO:0016071 124 0.010
regulation of mitosis GO:0007088 56 0.010

tow disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
disease of metabolism DOID:0014667 0 0.029
inherited metabolic disorder DOID:655 0 0.029
nervous system disease DOID:863 0 0.024
cardiovascular system disease DOID:1287 0 0.022
acquired metabolic disease DOID:0060158 0 0.011