Drosophila melanogaster

10 known processes

TwdlF (Dmel_CG14639)

TweedleF

(Aliases: CG14639,Dmel\CG14639)

TwdlF biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
vesicle mediated transport GO:0016192 381 0.064
imaginal disc derived appendage development GO:0048737 399 0.053
appendage development GO:0048736 401 0.052
protein hydroxylation GO:0018126 1 0.049
imaginal disc derived wing morphogenesis GO:0007476 337 0.047
negative regulation of cellular metabolic process GO:0031324 382 0.047
imaginal disc derived appendage morphogenesis GO:0035114 395 0.045
small molecule metabolic process GO:0044281 305 0.045
negative regulation of cellular biosynthetic process GO:0031327 277 0.044
wing disc morphogenesis GO:0007472 344 0.041
cell cell signaling involved in cell fate commitment GO:0045168 210 0.041
neurological system process GO:0050877 358 0.039
body morphogenesis GO:0010171 2 0.039
Fly
detection of stimulus GO:0051606 156 0.038
growth GO:0040007 359 0.038
positive regulation of macromolecule metabolic process GO:0010604 405 0.037
appendage morphogenesis GO:0035107 397 0.037
negative regulation of response to stimulus GO:0048585 258 0.036
post embryonic appendage morphogenesis GO:0035120 385 0.036
organic acid metabolic process GO:0006082 103 0.036
negative regulation of rna metabolic process GO:0051253 251 0.034
spermatid differentiation GO:0048515 114 0.033
organonitrogen compound metabolic process GO:1901564 318 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.033
endocytosis GO:0006897 310 0.033
detection of stimulus involved in sensory perception GO:0050906 92 0.033
catabolic process GO:0009056 409 0.032
cilium assembly GO:0042384 38 0.031
regionalization GO:0003002 416 0.031
synaptic transmission GO:0007268 288 0.030
single organism biosynthetic process GO:0044711 206 0.030
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.029
response to abiotic stimulus GO:0009628 341 0.029
carboxylic acid metabolic process GO:0019752 92 0.029
phagocytosis GO:0006909 215 0.029
regulation of cell cycle GO:0051726 291 0.028
cell death GO:0008219 279 0.028
negative regulation of signal transduction GO:0009968 206 0.027
defense response GO:0006952 300 0.027
immune system process GO:0002376 347 0.027
detection of external stimulus GO:0009581 66 0.027
spermatogenesis GO:0007283 200 0.026
negative regulation of rna biosynthetic process GO:1902679 240 0.026
cellular ketone metabolic process GO:0042180 24 0.026
death GO:0016265 284 0.026
sensory perception of chemical stimulus GO:0007606 116 0.026
cellular amino acid metabolic process GO:0006520 61 0.026
response to organophosphorus GO:0046683 2 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.025
phosphorylation GO:0016310 294 0.025
cellularization GO:0007349 90 0.025
negative regulation of transcription dna templated GO:0045892 237 0.025
cell motility GO:0048870 251 0.025
peptidyl proline hydroxylation GO:0019511 1 0.025
response to other organism GO:0051707 293 0.024
regulation of cellular amine metabolic process GO:0033238 3 0.024
response to extracellular stimulus GO:0009991 116 0.024
neuron projection guidance GO:0097485 241 0.024
lateral inhibition GO:0046331 206 0.024
developmental growth GO:0048589 280 0.024
steroid catabolic process GO:0006706 1 0.024
regulation of cellular ketone metabolic process GO:0010565 3 0.024
carbohydrate derivative metabolic process GO:1901135 217 0.023
negative regulation of biosynthetic process GO:0009890 277 0.023
oxoacid metabolic process GO:0043436 103 0.023
transcription from rna polymerase ii promoter GO:0006366 368 0.023
connective tissue development GO:0061448 3 0.023
kidney development GO:0001822 3 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
regulation of synapse structure and activity GO:0050803 128 0.022
protein modification process GO:0036211 438 0.022
defense response to other organism GO:0098542 225 0.022
intracellular signal transduction GO:0035556 300 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.022
negative regulation of cell communication GO:0010648 223 0.022
multicellular organismal aging GO:0010259 140 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
sensory perception GO:0007600 196 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.021
fat soluble vitamin metabolic process GO:0006775 1 0.021
positive regulation of nucleic acid templated transcription GO:1903508 266 0.021
programmed cell death GO:0012501 257 0.021
cellular component assembly involved in morphogenesis GO:0010927 151 0.021
organelle fission GO:0048285 340 0.021
response to external biotic stimulus GO:0043207 293 0.021
androgen metabolic process GO:0008209 1 0.020
cellular protein modification process GO:0006464 438 0.020
nuclear division GO:0000280 332 0.020
central nervous system development GO:0007417 201 0.020
estrogen metabolic process GO:0008210 1 0.020
developmental pigmentation GO:0048066 68 0.020
regulation of intracellular signal transduction GO:1902531 236 0.020
microtubule bundle formation GO:0001578 27 0.020
response to lipopolysaccharide GO:0032496 4 0.020
sensory perception of mechanical stimulus GO:0050954 72 0.020
positive regulation of lipid storage GO:0010884 4 0.020
amine metabolic process GO:0009308 12 0.020
organic substance catabolic process GO:1901575 308 0.019
negative regulation of signaling GO:0023057 219 0.019
male gamete generation GO:0048232 201 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.019
cell migration GO:0016477 238 0.019
peptidyl threonine phosphorylation GO:0018107 2 0.019
hormone catabolic process GO:0042447 3 0.019
regulation of cell death GO:0010941 173 0.019
positive regulation of cellular biosynthetic process GO:0031328 316 0.019
regulation of response to stress GO:0080134 200 0.019
cilium organization GO:0044782 41 0.019
immune response GO:0006955 246 0.018
cellular catabolic process GO:0044248 372 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
cholesterol transport GO:0030301 2 0.018
salivary gland development GO:0007431 162 0.018
regulation of multicellular organismal development GO:2000026 414 0.018
spermatid development GO:0007286 98 0.018
regulation of programmed cell death GO:0043067 152 0.018
regulation of localization GO:0032879 275 0.018
cell cycle phase transition GO:0044770 140 0.018
fat soluble vitamin biosynthetic process GO:0042362 1 0.018
regulation of cell cycle process GO:0010564 181 0.018
segmentation GO:0035282 207 0.018
positive regulation of rna biosynthetic process GO:1902680 266 0.018
positive regulation of transcription dna templated GO:0045893 266 0.018
cell projection assembly GO:0030031 94 0.018
organic substance transport GO:0071702 257 0.018
forebrain development GO:0030900 2 0.018
negative regulation of cell cycle GO:0045786 116 0.018
cellular amine metabolic process GO:0044106 12 0.018
camera type eye development GO:0043010 4 0.018
chromosome organization GO:0051276 360 0.018
organic cyclic compound catabolic process GO:1901361 168 0.017
detection of abiotic stimulus GO:0009582 66 0.017
cholesterol homeostasis GO:0042632 3 0.017
response to oxygen containing compound GO:1901700 200 0.017
chromatin silencing GO:0006342 76 0.017
mrna processing GO:0006397 104 0.017
positive regulation of signaling GO:0023056 243 0.017
vitamin biosynthetic process GO:0009110 1 0.017
neuropeptide signaling pathway GO:0007218 45 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.017
pigment metabolic process GO:0042440 84 0.017
regulation of nervous system development GO:0051960 248 0.017
cellular response to chemical stimulus GO:0070887 199 0.017
purine nucleotide metabolic process GO:0006163 146 0.017
pigmentation GO:0043473 75 0.017
single organism catabolic process GO:0044712 228 0.017
regulation of apoptotic process GO:0042981 130 0.017
heterochromatin organization GO:0070828 25 0.017
limb development GO:0060173 1 0.017
peptidyl proline modification GO:0018208 3 0.016
cilium morphogenesis GO:0060271 39 0.016
autophagic cell death GO:0048102 83 0.016
regulation of cellular protein metabolic process GO:0032268 243 0.016
apoptotic process GO:0006915 159 0.016
eye pigmentation GO:0048069 43 0.016
sperm individualization GO:0007291 48 0.016
response to bacterium GO:0009617 198 0.016
regulation of synapse assembly GO:0051963 94 0.016
negative regulation of gene expression GO:0010629 387 0.016
response to nutrient levels GO:0031667 114 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.016
axon guidance GO:0007411 233 0.016
sensory perception of sound GO:0007605 56 0.016
ethanolamine containing compound metabolic process GO:0042439 4 0.016
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.016
protein localization GO:0008104 284 0.016
purine containing compound metabolic process GO:0072521 155 0.016
camera type eye morphogenesis GO:0048593 2 0.016
endomembrane system organization GO:0010256 119 0.016
retina development in camera type eye GO:0060041 4 0.016
regulation of mitotic cell cycle GO:0007346 190 0.016
neutral lipid biosynthetic process GO:0046460 2 0.016
negative regulation of gene expression epigenetic GO:0045814 77 0.015
polyol biosynthetic process GO:0046173 3 0.015
positive regulation of gene expression GO:0010628 290 0.015
mrna metabolic process GO:0016071 124 0.015
macromolecular complex assembly GO:0065003 256 0.015
anion homeostasis GO:0055081 3 0.015
developmental maturation GO:0021700 172 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
l amino acid import GO:0043092 2 0.015
vitamin metabolic process GO:0006766 2 0.015
cellular response to extracellular stimulus GO:0031668 64 0.015
protein complex assembly GO:0006461 200 0.015
leg disc development GO:0035218 92 0.015
humoral immune response GO:0006959 117 0.015
response to hexose GO:0009746 3 0.015
nucleotide metabolic process GO:0009117 161 0.015
defense response to gram negative bacterium GO:0050829 94 0.015
hindbrain development GO:0030902 2 0.015
response to organic substance GO:0010033 284 0.015
response to temperature stimulus GO:0009266 106 0.015
cellular response to lipopolysaccharide GO:0071222 3 0.015
rna processing GO:0006396 147 0.015
cell proliferation GO:0008283 299 0.015
organelle assembly GO:0070925 198 0.015
xenobiotic catabolic process GO:0042178 1 0.015
spinal cord development GO:0021510 1 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
organonitrogen compound catabolic process GO:1901565 128 0.015
localization of cell GO:0051674 257 0.015
negative regulation of cell cycle process GO:0010948 109 0.015
cellular response to molecule of bacterial origin GO:0071219 3 0.015
sterol homeostasis GO:0055092 4 0.014
triglyceride biosynthetic process GO:0019432 2 0.014
regulation of transport GO:0051049 181 0.014
eye pigment metabolic process GO:0042441 33 0.014
benzene containing compound metabolic process GO:0042537 3 0.014
intracellular protein transmembrane transport GO:0065002 4 0.014
nephron development GO:0072006 3 0.014
defense response to bacterium GO:0042742 178 0.014
regulation of catabolic process GO:0009894 170 0.014
response to biotic stimulus GO:0009607 294 0.014
notch signaling pathway GO:0007219 120 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
innate immune response GO:0045087 144 0.014
dna metabolic process GO:0006259 227 0.014
regulation of gene expression epigenetic GO:0040029 128 0.014
medium chain fatty acid metabolic process GO:0051791 1 0.014
regulation of epithelial cell proliferation GO:0050678 4 0.014
regulation of cell cycle phase transition GO:1901987 130 0.014
gene silencing GO:0016458 138 0.014
organophosphate metabolic process GO:0019637 195 0.014
anatomical structure homeostasis GO:0060249 97 0.014
mitotic cell cycle phase transition GO:0044772 138 0.014
cellular response to external stimulus GO:0071496 66 0.014
homeostatic process GO:0042592 199 0.014
acylglycerol catabolic process GO:0046464 3 0.014
exocrine system development GO:0035272 162 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
chromosome segregation GO:0007059 157 0.014
positive regulation of rna metabolic process GO:0051254 271 0.014
chitin based cuticle development GO:0040003 49 0.014
mitotic g2 dna damage checkpoint GO:0007095 69 0.014
regulation of protein metabolic process GO:0051246 256 0.014
wnt signaling pathway GO:0016055 98 0.014
axon development GO:0061564 297 0.014
regulation of molecular function GO:0065009 217 0.014
salivary gland cell autophagic cell death GO:0035071 83 0.013
aging GO:0007568 143 0.013
cuticle development GO:0042335 86 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
regulation of mitotic cell cycle phase transition GO:1901990 130 0.013
taxis GO:0042330 304 0.013
morphogenesis of an epithelium GO:0002009 276 0.013
pigment metabolic process involved in pigmentation GO:0043474 33 0.013
mitotic g2 m transition checkpoint GO:0044818 70 0.013
response to monosaccharide GO:0034284 4 0.013
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.013
gland development GO:0048732 191 0.013
protein complex biogenesis GO:0070271 201 0.013
transmembrane transport GO:0055085 139 0.013
positive regulation of biosynthetic process GO:0009891 316 0.013
mitotic cell cycle checkpoint GO:0007093 88 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
regulation of catalytic activity GO:0050790 185 0.013
single organism behavior GO:0044708 391 0.013
actin cytoskeleton organization GO:0030036 206 0.013
acetylcholine catabolic process GO:0006581 1 0.013
hematopoietic progenitor cell differentiation GO:0002244 1 0.013
negative regulation of notch signaling pathway GO:0045746 41 0.013
acetate ester metabolic process GO:1900619 2 0.013
immune response regulating signaling pathway GO:0002764 2 0.013
leg disc morphogenesis GO:0007478 80 0.013
response to radiation GO:0009314 155 0.013
negative regulation of cell cycle phase transition GO:1901988 103 0.013
regulation of mrna splicing via spliceosome GO:0048024 64 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
regulation of anatomical structure size GO:0090066 163 0.013
cell division GO:0051301 248 0.013
determination of adult lifespan GO:0008340 137 0.013
eye morphogenesis GO:0048592 260 0.013
regulation of sequestering of triglyceride GO:0010889 3 0.013
synaptic growth at neuromuscular junction GO:0051124 119 0.012
cellular protein localization GO:0034613 160 0.012
axis specification GO:0009798 167 0.012
positive regulation of cell communication GO:0010647 250 0.012
telencephalon development GO:0021537 2 0.012
heterocycle catabolic process GO:0046700 166 0.012
small gtpase mediated signal transduction GO:0007264 88 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
epithelial cell differentiation GO:0030855 322 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
response to glucose GO:0009749 2 0.012
mitotic nuclear division GO:0007067 213 0.012
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.012
mitotic dna integrity checkpoint GO:0044774 75 0.012
acetylcholine metabolic process GO:0008291 2 0.012
positive regulation of cell migration GO:0030335 2 0.012
dendrite development GO:0016358 204 0.012
positive regulation of cell motility GO:2000147 3 0.012
response to pain GO:0048265 3 0.012
open tracheal system development GO:0007424 204 0.012
detection of chemical stimulus GO:0009593 93 0.012
establishment of localization in cell GO:0051649 402 0.012
spindle organization GO:0007051 253 0.012
regulation of synapse organization GO:0050807 110 0.012
response to wounding GO:0009611 94 0.012
rna localization GO:0006403 115 0.012
triglyceride catabolic process GO:0019433 3 0.012
imaginal disc derived wing vein specification GO:0007474 48 0.012
regulation of immune system process GO:0002682 176 0.012
meiotic nuclear division GO:0007126 151 0.012
tissue death GO:0016271 102 0.012
blastoderm segmentation GO:0007350 159 0.012
embryonic pattern specification GO:0009880 174 0.012
drinking behavior GO:0042756 2 0.012
intracellular transport GO:0046907 228 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
sensory perception of smell GO:0007608 80 0.012
regulation of cell differentiation GO:0045595 302 0.012
protein transmembrane transport GO:0071806 4 0.012
secretion GO:0046903 109 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
regulation of notch signaling pathway GO:0008593 100 0.011
cellular response to nutrient levels GO:0031669 62 0.011
cellular homeostasis GO:0019725 80 0.011
ras protein signal transduction GO:0007265 88 0.011
lipid metabolic process GO:0006629 121 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
tissue migration GO:0090130 155 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
regulation of mrna metabolic process GO:1903311 72 0.011
regulation of lipid transport GO:0032368 3 0.011
l glutamate import GO:0051938 1 0.011
mating GO:0007618 120 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
secondary metabolic process GO:0019748 75 0.011
salivary gland morphogenesis GO:0007435 145 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
courtship behavior GO:0007619 68 0.011
wound healing spreading of epidermal cells GO:0035313 1 0.011
neurotransmitter catabolic process GO:0042135 1 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
dna damage checkpoint GO:0000077 78 0.011
positive regulation of catabolic process GO:0009896 105 0.011
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
positive regulation of signal transduction GO:0009967 223 0.011
single organism intracellular transport GO:1902582 207 0.011
neurotransmitter metabolic process GO:0042133 2 0.011
insecticide metabolic process GO:0017143 2 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
synapse organization GO:0050808 196 0.011
regulation of cellular response to stress GO:0080135 89 0.011
dna integrity checkpoint GO:0031570 81 0.011
respiratory system development GO:0060541 213 0.011
g2 dna damage checkpoint GO:0031572 69 0.011
negative regulation of growth GO:0045926 84 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
monocarboxylic acid transport GO:0015718 3 0.011
chemotaxis GO:0006935 249 0.011
acylglycerol biosynthetic process GO:0046463 2 0.011
glycerolipid catabolic process GO:0046503 3 0.011
cellular response to ethanol GO:0071361 4 0.011
amine catabolic process GO:0009310 1 0.011
anterior posterior axis specification GO:0009948 109 0.011
regulation of developmental growth GO:0048638 174 0.011
chaeta development GO:0022416 97 0.011
response to mercury ion GO:0046689 3 0.011
protein phosphorylation GO:0006468 169 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
toxin metabolic process GO:0009404 2 0.011
skeletal muscle fiber development GO:0048741 3 0.011
kidney epithelium development GO:0072073 3 0.011
ovarian follicle cell development GO:0030707 248 0.011
alternative mrna splicing via spliceosome GO:0000380 60 0.011
neutral lipid catabolic process GO:0046461 3 0.011
rna splicing via transesterification reactions GO:0000375 73 0.011
sperm axoneme assembly GO:0007288 13 0.011
cell cycle checkpoint GO:0000075 95 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.011
peptidyl amino acid modification GO:0018193 105 0.011
neural retina development GO:0003407 4 0.011
mitotic sister chromatid segregation GO:0000070 87 0.010
immune response activating signal transduction GO:0002757 2 0.010
digestive tract development GO:0048565 149 0.010
axonogenesis GO:0007409 290 0.010
ion transport GO:0006811 145 0.010
regulation of cell substrate adhesion GO:0010810 2 0.010
regulation of mrna processing GO:0050684 71 0.010
golgi organization GO:0007030 66 0.010
neuromuscular junction development GO:0007528 149 0.010
synapse assembly GO:0007416 143 0.010
mesenchymal cell development GO:0014031 1 0.010
limb morphogenesis GO:0035108 1 0.010
nephron epithelium development GO:0072009 3 0.010
endodermal cell differentiation GO:0035987 3 0.010
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.010
behavioral response to pain GO:0048266 3 0.010
imaginal disc pattern formation GO:0007447 91 0.010
ion transmembrane transport GO:0034220 122 0.010
signal transduction in response to dna damage GO:0042770 3 0.010
aromatic compound catabolic process GO:0019439 166 0.010
salivary gland histolysis GO:0035070 88 0.010
actin filament based process GO:0030029 220 0.010
dendrite morphogenesis GO:0048813 199 0.010
regulation of immune response GO:0050776 118 0.010
cellular macromolecule localization GO:0070727 220 0.010
extrinsic apoptotic signaling pathway GO:0097191 1 0.010
salt aversion GO:0035199 3 0.010
myotube cell development GO:0014904 3 0.010
cell fate determination GO:0001709 91 0.010
mushroom body development GO:0016319 70 0.010
gland morphogenesis GO:0022612 145 0.010
sister chromatid segregation GO:0000819 92 0.010
positive regulation of apoptotic signaling pathway GO:2001235 4 0.010
regulation of multi organism process GO:0043900 131 0.010
proteolysis GO:0006508 192 0.010
regulation of wnt signaling pathway GO:0030111 68 0.010
cellular biogenic amine catabolic process GO:0042402 1 0.010
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.010
ameboidal type cell migration GO:0001667 151 0.010
cation homeostasis GO:0055080 51 0.010
dorsal ventral pattern formation GO:0009953 133 0.010
regulation of growth GO:0040008 233 0.010
developmental programmed cell death GO:0010623 138 0.010
chromatin organization GO:0006325 207 0.010
embryo development ending in birth or egg hatching GO:0009792 152 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
imaginal disc derived leg morphogenesis GO:0007480 80 0.010
regulation of innate immune response GO:0045088 71 0.010

TwdlF disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
disease of metabolism DOID:0014667 0 0.021
nervous system disease DOID:863 0 0.019
hypertension DOID:10763 0 0.016
artery disease DOID:0050828 0 0.016
vascular disease DOID:178 0 0.016
cardiovascular system disease DOID:1287 0 0.016
inherited metabolic disorder DOID:655 0 0.016
acquired metabolic disease DOID:0060158 0 0.016
musculoskeletal system disease DOID:17 0 0.015
essential hypertension DOID:10825 0 0.013
carbohydrate metabolism disease DOID:0050013 0 0.012
diabetes mellitus DOID:9351 0 0.012
type 2 diabetes mellitus DOID:9352 0 0.012
glucose metabolism disease DOID:4194 0 0.012
central nervous system disease DOID:331 0 0.011
sensory system disease DOID:0050155 0 0.010
urinary system disease DOID:18 0 0.010