Drosophila melanogaster

200 known processes

E2f (Dmel_CG6376)

E2F transcription factor

(Aliases: E(var)3-93E,drosE2F1,DmE2F-1,E(Sev-CycE)3A,dE2f1,e2f1,l(3)j3C2,DRTF1/E2F,Dmel\CG6376,l(3)07172,e2f,CG6376,E(var)93E,Dp,l(3)rM729,E2f1,E2F-1,dE2F1,dE2F,l(3)j3B1,de2f1,Evar(3)164,E2F1,E2F,E(var)3-95E,dE2f,def21)

E2f biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 223 0.436
Human
regulation of cell cycle phase transition GO:1901987 130 0.273
Human Fly
intrinsic apoptotic signaling pathway GO:0097193 16 0.262
Human Mouse
positive regulation of rna metabolic process GO:0051254 271 0.243
regulation of cell differentiation GO:0045595 302 0.222
dorsal ventral axis specification GO:0009950 66 0.211
Fly
death GO:0016265 284 0.200
nuclear division GO:0000280 332 0.193
regionalization GO:0003002 416 0.190
Fly
regulation of cell cycle GO:0051726 291 0.186
nurse cell apoptotic process GO:0045476 17 0.155
regulation of reproductive process GO:2000241 54 0.154
organelle fission GO:0048285 340 0.136
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.136
regulation of multi organism process GO:0043900 131 0.134
tissue morphogenesis GO:0048729 297 0.127
positive regulation of gene expression GO:0010628 290 0.127
negative regulation of cell cycle phase transition GO:1901988 103 0.126
Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.126
imaginal disc derived wing morphogenesis GO:0007476 337 0.122
imaginal disc derived appendage morphogenesis GO:0035114 395 0.122
regulation of apoptotic process GO:0042981 130 0.117
regulation of nurse cell apoptotic process GO:0045477 9 0.116
positive regulation of macromolecule metabolic process GO:0010604 405 0.116
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.116
axis specification GO:0009798 167 0.113
Fly
regulation of mitotic cell cycle GO:0007346 190 0.108
Human Fly
cell cycle phase transition GO:0044770 140 0.106
Human Mouse Fly
mitotic nuclear division GO:0007067 213 0.106
regulation of mitotic cell cycle phase transition GO:1901990 130 0.104
Human Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.100
imaginal disc derived appendage development GO:0048737 399 0.095
phagocytosis GO:0006909 215 0.095
regulation of cell cycle process GO:0010564 181 0.089
Human Fly
dna metabolic process GO:0006259 227 0.085
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.083
Fly
protein complex assembly GO:0006461 200 0.082
catabolic process GO:0009056 409 0.081
organic substance catabolic process GO:1901575 308 0.081
macromolecular complex assembly GO:0065003 256 0.080
vesicle mediated transport GO:0016192 381 0.079
response to temperature stimulus GO:0009266 106 0.077
dna integrity checkpoint GO:0031570 81 0.074
Human
programmed cell death GO:0012501 257 0.074
apoptotic process involved in development GO:1902742 20 0.073
cell death GO:0008219 279 0.072
organophosphate metabolic process GO:0019637 195 0.070
carbohydrate derivative metabolic process GO:1901135 217 0.070
establishment or maintenance of cell polarity GO:0007163 167 0.070
protein localization GO:0008104 284 0.067
positive regulation of multi organism process GO:0043902 40 0.065
embryonic axis specification GO:0000578 107 0.065
Fly
response to abiotic stimulus GO:0009628 341 0.064
Rat
microtubule organizing center organization GO:0031023 168 0.063
embryonic pattern specification GO:0009880 174 0.063
Fly
establishment of protein localization GO:0045184 163 0.062
organonitrogen compound metabolic process GO:1901564 318 0.060
nucleobase containing compound catabolic process GO:0034655 165 0.060
pole plasm assembly GO:0007315 61 0.059
transcription from rna polymerase ii promoter GO:0006366 368 0.059
dorsal ventral pattern formation GO:0009953 133 0.058
Fly
mitotic dna integrity checkpoint GO:0044774 75 0.058
cellular catabolic process GO:0044248 372 0.057
heterocycle catabolic process GO:0046700 166 0.057
cellular nitrogen compound catabolic process GO:0044270 165 0.056
blastoderm segmentation GO:0007350 159 0.056
Fly
intracellular signal transduction GO:0035556 300 0.056
Human Mouse
oocyte axis specification GO:0007309 108 0.056
Fly
cellular macromolecule localization GO:0070727 220 0.053
body morphogenesis GO:0010171 2 0.053
small molecule metabolic process GO:0044281 305 0.052
regulation of molecular function GO:0065009 217 0.051
phosphorylation GO:0016310 294 0.051
mitotic cell cycle checkpoint GO:0007093 88 0.051
aromatic compound catabolic process GO:0019439 166 0.050
compound eye morphogenesis GO:0001745 249 0.049
nucleoside phosphate metabolic process GO:0006753 162 0.048
regulation of anatomical structure morphogenesis GO:0022603 242 0.048
organic cyclic compound catabolic process GO:1901361 168 0.048
post embryonic appendage morphogenesis GO:0035120 385 0.048
cellular protein modification process GO:0006464 438 0.047
morphogenesis of an epithelium GO:0002009 276 0.047
purine ribonucleotide metabolic process GO:0009150 145 0.047
regulation of catabolic process GO:0009894 170 0.046
regulation of cell shape GO:0008360 113 0.045
positive regulation of nucleic acid templated transcription GO:1903508 266 0.044
single organism biosynthetic process GO:0044711 206 0.044
regulation of catalytic activity GO:0050790 185 0.044
epidermis development GO:0008544 65 0.043
endocytosis GO:0006897 310 0.042
segmentation GO:0035282 207 0.042
Fly
nucleoside triphosphate metabolic process GO:0009141 120 0.041
cell proliferation GO:0008283 299 0.041
positive regulation of biosynthetic process GO:0009891 316 0.041
cell cycle checkpoint GO:0000075 95 0.040
Human
positive regulation of rna biosynthetic process GO:1902680 266 0.040
mitotic cell cycle phase transition GO:0044772 138 0.040
Human Mouse Fly
anterior posterior pattern specification GO:0009952 136 0.040
Fly
positive regulation of apoptotic process GO:0043065 47 0.039
appendage morphogenesis GO:0035107 397 0.039
columnar cuboidal epithelial cell development GO:0002066 249 0.039
ovarian follicle cell development GO:0030707 248 0.038
mrna metabolic process GO:0016071 124 0.038
mitotic dna damage checkpoint GO:0044773 74 0.038
protein modification process GO:0036211 438 0.038
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.038
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.038
developmental maturation GO:0021700 172 0.038
Fly
rna localization GO:0006403 115 0.037
cell division GO:0051301 248 0.037
establishment of localization in cell GO:0051649 402 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.035
regulation of programmed cell death GO:0043067 152 0.035
regulation of organelle organization GO:0033043 196 0.035
ribonucleotide metabolic process GO:0009259 145 0.035
tube development GO:0035295 244 0.035
regulation of cellular catabolic process GO:0031329 157 0.035
positive regulation of response to stimulus GO:0048584 323 0.035
purine nucleotide metabolic process GO:0006163 146 0.034
skin development GO:0043588 65 0.034
apoptotic process GO:0006915 159 0.034
response to external biotic stimulus GO:0043207 293 0.032
nucleobase containing small molecule metabolic process GO:0055086 174 0.032
mitotic g2 dna damage checkpoint GO:0007095 69 0.032
intracellular protein transport GO:0006886 104 0.031
regulation of cellular localization GO:0060341 136 0.031
regulation of protein metabolic process GO:0051246 256 0.030
intracellular transport GO:0046907 228 0.030
pole plasm oskar mrna localization GO:0045451 46 0.030
purine nucleoside triphosphate metabolic process GO:0009144 119 0.030
single organism catabolic process GO:0044712 228 0.030
mitotic g2 m transition checkpoint GO:0044818 70 0.030
positive regulation of molecular function GO:0044093 136 0.029
epithelial cell differentiation GO:0030855 322 0.029
chromosome organization GO:0051276 360 0.029
regulation of localization GO:0032879 275 0.029
response to organic cyclic compound GO:0014070 89 0.029
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.028
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.028
Fly
cytoplasm organization GO:0007028 64 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.027
negative regulation of cell cycle process GO:0010948 109 0.027
Fly
nucleotide metabolic process GO:0009117 161 0.027
cell cycle g1 s phase transition GO:0044843 31 0.027
Human Mouse Fly
epithelial cell development GO:0002064 274 0.027
pole plasm mrna localization GO:0019094 49 0.027
negative regulation of multicellular organismal process GO:0051241 142 0.027
Worm
carbohydrate derivative biosynthetic process GO:1901137 85 0.027
rna processing GO:0006396 147 0.027
negative regulation of developmental process GO:0051093 201 0.026
Worm
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.026
cellular response to biotic stimulus GO:0071216 4 0.026
oocyte development GO:0048599 124 0.026
Fly
ribonucleoside metabolic process GO:0009119 127 0.026
regulation of phosphorus metabolic process GO:0051174 210 0.026
nucleoside metabolic process GO:0009116 127 0.026
anterior posterior axis specification embryo GO:0008595 103 0.026
Fly
response to oxygen containing compound GO:1901700 200 0.026
Rat
wing disc morphogenesis GO:0007472 344 0.025
pole plasm rna localization GO:0007316 52 0.025
mitotic spindle organization GO:0007052 220 0.025
ras protein signal transduction GO:0007265 88 0.025
lipid metabolic process GO:0006629 121 0.025
protein localization to chromatin GO:0071168 3 0.025
positive regulation of phosphorus metabolic process GO:0010562 139 0.025
cellular response to lipopolysaccharide GO:0071222 3 0.025
anterior posterior axis specification GO:0009948 109 0.024
Fly
organic substance transport GO:0071702 257 0.024
ribonucleoside triphosphate metabolic process GO:0009199 119 0.024
small gtpase mediated signal transduction GO:0007264 88 0.024
proteolysis GO:0006508 192 0.024
protein transport GO:0015031 155 0.024
regulation of cell death GO:0010941 173 0.024
appendage development GO:0048736 401 0.024
response to bacterium GO:0009617 198 0.024
positive regulation of cell death GO:0010942 69 0.023
protein complex biogenesis GO:0070271 201 0.023
embryonic morphogenesis GO:0048598 206 0.023
positive regulation of developmental process GO:0051094 143 0.023
innate immune response GO:0045087 144 0.023
chromatin modification GO:0016568 147 0.023
apoptotic signaling pathway GO:0097190 27 0.023
Human Mouse
purine nucleoside catabolic process GO:0006152 112 0.023
positive regulation of phosphate metabolic process GO:0045937 139 0.022
dna damage checkpoint GO:0000077 78 0.022
Human
ribose phosphate metabolic process GO:0019693 145 0.022
spindle organization GO:0007051 253 0.022
positive regulation of signaling GO:0023056 243 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.022
cellular response to oxygen containing compound GO:1901701 79 0.022
Rat
cell maturation GO:0048469 144 0.022
Fly
cellular response to chemical stimulus GO:0070887 199 0.022
Rat
purine containing compound catabolic process GO:0072523 112 0.022
nucleotide catabolic process GO:0009166 109 0.022
regulation of growth GO:0040008 233 0.021
morphogenesis of follicular epithelium GO:0016333 36 0.021
nucleoside phosphate catabolic process GO:1901292 110 0.021
regulation of mrna metabolic process GO:1903311 72 0.021
positive regulation of nurse cell apoptotic process GO:0045850 5 0.021
cytoplasmic transport GO:0016482 130 0.021
cellular response to molecule of bacterial origin GO:0071219 3 0.021
ribonucleoside triphosphate catabolic process GO:0009203 108 0.021
positive regulation of catabolic process GO:0009896 105 0.021
macromolecule catabolic process GO:0009057 161 0.021
purine nucleotide catabolic process GO:0006195 109 0.021
gene silencing by rna GO:0031047 57 0.021
positive regulation of protein metabolic process GO:0051247 128 0.021
single organism cellular localization GO:1902580 180 0.021
purine ribonucleoside catabolic process GO:0046130 112 0.020
response to lipopolysaccharide GO:0032496 4 0.020
glycosyl compound metabolic process GO:1901657 127 0.020
regulation of mrna processing GO:0050684 71 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.020
purine nucleoside metabolic process GO:0042278 127 0.020
ribonucleotide catabolic process GO:0009261 109 0.020
posttranscriptional regulation of gene expression GO:0010608 145 0.020
Human
purine nucleoside triphosphate catabolic process GO:0009146 108 0.020
regulation of response to stress GO:0080134 200 0.020
mitotic sister chromatid segregation GO:0000070 87 0.020
response to organic substance GO:0010033 284 0.020
Rat
response to biotic stimulus GO:0009607 294 0.020
regulation of anatomical structure size GO:0090066 163 0.019
single organism intracellular transport GO:1902582 207 0.019
cellular response to organic substance GO:0071310 132 0.019
Rat
protein alkylation GO:0008213 43 0.019
purine containing compound metabolic process GO:0072521 155 0.019
cell type specific apoptotic process GO:0097285 38 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
oxoacid metabolic process GO:0043436 103 0.019
regulation of chromosome organization GO:0033044 64 0.019
digestive tract development GO:0048565 149 0.019
chromatin remodeling GO:0006338 72 0.019
carbohydrate derivative catabolic process GO:1901136 118 0.019
negative regulation of transcription dna templated GO:0045892 237 0.019
nucleosome organization GO:0034728 59 0.019
connective tissue development GO:0061448 3 0.019
spindle assembly GO:0051225 80 0.019
eye development GO:0001654 323 0.019
cellular macromolecule catabolic process GO:0044265 136 0.019
g2 dna damage checkpoint GO:0031572 69 0.019
single organism carbohydrate metabolic process GO:0044723 72 0.019
mrna processing GO:0006397 104 0.019
oocyte differentiation GO:0009994 145 0.019
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.019
epidermal growth factor receptor signaling pathway GO:0007173 58 0.019
actin filament based process GO:0030029 220 0.018
purine ribonucleoside metabolic process GO:0046128 127 0.018
oocyte construction GO:0007308 112 0.018
Fly
positive regulation of reproductive process GO:2000243 7 0.018
dendrite morphogenesis GO:0048813 199 0.018
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.018
Fly
nucleoside triphosphate catabolic process GO:0009143 108 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
digestive system development GO:0055123 149 0.018
regulation of cell cycle g1 s phase transition GO:1902806 23 0.018
Human Fly
regulation of cell morphogenesis GO:0022604 163 0.018
negative regulation of cell cycle GO:0045786 116 0.018
Fly
ribonucleoside catabolic process GO:0042454 112 0.018
covalent chromatin modification GO:0016569 106 0.017
positive regulation of cell differentiation GO:0045597 64 0.017
cellular carbohydrate metabolic process GO:0044262 22 0.017
regulation of multicellular organismal development GO:2000026 414 0.017
Worm
maternal determination of anterior posterior axis embryo GO:0008358 74 0.017
Fly
posttranscriptional gene silencing by rna GO:0035194 45 0.017
peptidyl amino acid modification GO:0018193 105 0.017
regulation of protein localization GO:0032880 76 0.017
chromosome segregation GO:0007059 157 0.017
reactive oxygen species metabolic process GO:0072593 22 0.017
organophosphate catabolic process GO:0046434 112 0.017
response to other organism GO:0051707 293 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
regulation of phosphorylation GO:0042325 147 0.017
organic acid metabolic process GO:0006082 103 0.016
regulation of gene expression epigenetic GO:0040029 128 0.016
actin cytoskeleton organization GO:0030036 206 0.016
regulation of intracellular transport GO:0032386 64 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.016
muscle organ development GO:0007517 127 0.015
learning or memory GO:0007611 141 0.015
organonitrogen compound biosynthetic process GO:1901566 117 0.015
response to nitrogen compound GO:1901698 90 0.015
histone modification GO:0016570 106 0.015
centrosome organization GO:0051297 163 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
growth GO:0040007 359 0.015
negative regulation of growth GO:0045926 84 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
positive regulation of transcription dna templated GO:0045893 266 0.015
cell migration GO:0016477 238 0.015
positive regulation of signal transduction GO:0009967 223 0.015
cell motility GO:0048870 251 0.015
positive regulation of cellular protein metabolic process GO:0032270 118 0.015
nucleocytoplasmic transport GO:0006913 72 0.015
negative regulation of cellular metabolic process GO:0031324 382 0.015
developmental programmed cell death GO:0010623 138 0.014
modification dependent macromolecule catabolic process GO:0043632 79 0.014
amine metabolic process GO:0009308 12 0.014
mrna splicing via spliceosome GO:0000398 73 0.014
pigment metabolic process GO:0042440 84 0.014
cellular protein localization GO:0034613 160 0.014
regulation of transport GO:0051049 181 0.014
negative regulation of cell proliferation GO:0008285 69 0.014
protein phosphorylation GO:0006468 169 0.014
sister chromatid segregation GO:0000819 92 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
positive regulation of phosphorylation GO:0042327 87 0.014
response to radiation GO:0009314 155 0.014
rna transport GO:0050658 46 0.014
sensory organ morphogenesis GO:0090596 260 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
dna packaging GO:0006323 91 0.013
oocyte anterior posterior axis specification GO:0007314 72 0.013
Fly
cell cell signaling involved in cell fate commitment GO:0045168 210 0.013
defense response to other organism GO:0098542 225 0.013
negative regulation of mitotic cell cycle GO:0045930 109 0.013
Fly
muscle cell differentiation GO:0042692 103 0.013
organelle assembly GO:0070925 198 0.013
negative regulation of response to stimulus GO:0048585 258 0.013
intracellular mrna localization GO:0008298 66 0.013
establishment of rna localization GO:0051236 47 0.013
organophosphate biosynthetic process GO:0090407 46 0.013
positive regulation of mapk cascade GO:0043410 63 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
transmembrane transport GO:0055085 139 0.013
purine ribonucleotide catabolic process GO:0009154 109 0.013
eye morphogenesis GO:0048592 260 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
dna biosynthetic process GO:0071897 24 0.012
regulation of transferase activity GO:0051338 58 0.012
regulation of proteolysis GO:0030162 87 0.012
nucleoside catabolic process GO:0009164 112 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
spindle elongation GO:0051231 83 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
macromolecule methylation GO:0043414 45 0.012
defense response to bacterium GO:0042742 178 0.012
cellular lipid metabolic process GO:0044255 83 0.012
tripartite regional subdivision GO:0007351 103 0.012
Fly
negative regulation of translation GO:0017148 28 0.012
forebrain development GO:0030900 2 0.012
Mouse
negative regulation of cell death GO:0060548 81 0.011
Fly
carbohydrate metabolic process GO:0005975 82 0.011
regulation of cellular component size GO:0032535 98 0.011
regulation of protein catabolic process GO:0042176 55 0.011
response to alcohol GO:0097305 95 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.011
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
regulation of cell division GO:0051302 72 0.011
neurological system process GO:0050877 358 0.011
regulation of embryonic development GO:0045995 68 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
compound eye development GO:0048749 307 0.011
peptidyl lysine modification GO:0018205 57 0.011
regulation of hydrolase activity GO:0051336 97 0.011
protein processing GO:0016485 68 0.011
g protein coupled receptor signaling pathway GO:0007186 136 0.011
posttranscriptional gene silencing GO:0016441 46 0.011
regulation of protein modification process GO:0031399 112 0.011
positive regulation of cellular component organization GO:0051130 156 0.010
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.010
regulation of developmental growth GO:0048638 174 0.010
regulation of immune system process GO:0002682 176 0.010
protein maturation GO:0051604 71 0.010
positive regulation of immune system process GO:0002684 68 0.010
chromatin organization GO:0006325 207 0.010
atp metabolic process GO:0046034 49 0.010
response to heat GO:0009408 63 0.010
camera type eye development GO:0043010 4 0.010
larval development GO:0002164 104 0.010
Worm
lateral inhibition GO:0046331 206 0.010
regulation of synapse structure and activity GO:0050803 128 0.010
circadian behavior GO:0048512 76 0.010
response to wounding GO:0009611 94 0.010
negative regulation of biosynthetic process GO:0009890 277 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
protein dna complex subunit organization GO:0071824 86 0.010

E2f disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org