Drosophila melanogaster

121 known processes

SPE (Dmel_CG16705)

Spatzle-Processing Enzyme

(Aliases: proPO-AE,Sp4,SP4,Dmel\CG16705,CG16705,CT37173,c-SP4,spe)

SPE biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
antifungal humoral response GO:0019732 12 0.998
humoral immune response GO:0006959 117 0.996
immune response GO:0006955 246 0.993
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002816 3 0.989
immune system process GO:0002376 347 0.980
peptide metabolic process GO:0006518 80 0.970
response to fungus GO:0009620 50 0.964
regulation of humoral immune response GO:0002920 51 0.953
antimicrobial peptide production GO:0002775 46 0.951
activation of innate immune response GO:0002218 4 0.951
antimicrobial humoral response GO:0019730 99 0.943
antibacterial humoral response GO:0019731 44 0.942
defense response to other organism GO:0098542 225 0.940
pattern recognition receptor signaling pathway GO:0002221 2 0.921
defense response to fungus GO:0050832 48 0.904
defense response to gram positive bacterium GO:0050830 41 0.879
phenol containing compound metabolic process GO:0018958 57 0.862
Fly
defense response to bacterium GO:0042742 178 0.858
innate immune response activating signal transduction GO:0002758 2 0.844
regulation of antimicrobial humoral response GO:0002759 50 0.828
melanization defense response GO:0035006 45 0.808
Fly
immune response activating signal transduction GO:0002757 2 0.799
response to bacterium GO:0009617 198 0.797
response to biotic stimulus GO:0009607 294 0.793
positive regulation of antibacterial peptide production GO:0002803 20 0.785
defense response GO:0006952 300 0.782
positive regulation of antimicrobial humoral response GO:0002760 28 0.780
regulation of immune response GO:0050776 118 0.780
regulation of cellular amide metabolic process GO:0034248 39 0.754
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0006964 12 0.737
regulation of immune effector process GO:0002697 52 0.720
regulation of production of molecular mediator of immune response GO:0002700 44 0.695
positive regulation of melanization defense response GO:0035008 1 0.688
Fly
positive regulation of response to biotic stimulus GO:0002833 31 0.683
biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002815 3 0.669
cellular amide metabolic process GO:0043603 80 0.665
production of molecular mediator of immune response GO:0002440 46 0.663
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.638
regulation of multi organism process GO:0043900 131 0.633
response to other organism GO:0051707 293 0.629
positive regulation of humoral immune response GO:0002922 28 0.624
glycosaminoglycan metabolic process GO:0030203 11 0.618
response to external biotic stimulus GO:0043207 293 0.601
regulation of response to biotic stimulus GO:0002831 63 0.595
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.584
innate immune response GO:0045087 144 0.582
toll signaling pathway GO:0008063 25 0.561
organic hydroxy compound metabolic process GO:1901615 83 0.550
Fly
regulation of defense response GO:0031347 102 0.541
positive regulation of response to external stimulus GO:0032103 44 0.539
melanin metabolic process GO:0006582 47 0.523
Fly
regulation of immune system process GO:0002682 176 0.512
positive regulation of immune response GO:0050778 63 0.505
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0006965 3 0.493
positive regulation of defense response GO:0031349 59 0.490
regulation of response to stress GO:0080134 200 0.480
peptidoglycan metabolic process GO:0000270 3 0.474
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.470
positive regulation of cellular amide metabolic process GO:0034250 26 0.458
regulation of antimicrobial peptide production GO:0002784 44 0.456
regulation of innate immune response GO:0045088 71 0.415
Fly
antibacterial peptide production GO:0002778 22 0.412
positive regulation of antimicrobial peptide production GO:0002225 28 0.408
dorsal ventral axis specification GO:0009950 66 0.382
Fly
immune response regulating signaling pathway GO:0002764 2 0.378
organonitrogen compound metabolic process GO:1901564 318 0.375
regulation of secondary metabolic process GO:0043455 7 0.345
Fly
negative regulation of defense response to bacterium GO:1900425 7 0.319
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.312
positive regulation of multi organism process GO:0043902 40 0.310
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.307
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.306
antibacterial peptide biosynthetic process GO:0002780 22 0.294
antimicrobial peptide biosynthetic process GO:0002777 38 0.285
axis specification GO:0009798 167 0.285
Fly
regulation of response to external stimulus GO:0032101 115 0.277
regulation of melanization defense response GO:0035007 6 0.276
Fly
defense response to gram negative bacterium GO:0050829 94 0.272
peptidoglycan catabolic process GO:0009253 3 0.269
regionalization GO:0003002 416 0.238
Fly
peptide biosynthetic process GO:0043043 42 0.234
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.229
positive regulation of immune effector process GO:0002699 28 0.224
positive regulation of immune system process GO:0002684 68 0.224
glycosaminoglycan catabolic process GO:0006027 3 0.221
secondary metabolic process GO:0019748 75 0.215
Fly
regulation of toll signaling pathway GO:0008592 17 0.212
defense response to virus GO:0051607 23 0.191
response to peptidoglycan GO:0032494 2 0.189
positive regulation of response to stimulus GO:0048584 323 0.187
immune effector process GO:0002252 98 0.185
regulation of antibacterial peptide production GO:0002786 22 0.179
positive regulation of defense response to bacterium GO:1900426 23 0.174
protein maturation GO:0051604 71 0.174
dorsal ventral pattern formation GO:0009953 133 0.170
Fly
biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002812 14 0.169
hemolymph coagulation GO:0042381 10 0.165
Fly
positive regulation of antifungal peptide biosynthetic process GO:0006967 5 0.162
endocytosis GO:0006897 310 0.159
Fly
positive regulation of innate immune response GO:0045089 38 0.152
Fly
positive regulation of biosynthetic process GO:0009891 316 0.148
positive regulation of cellular biosynthetic process GO:0031328 316 0.146
vesicle mediated transport GO:0016192 381 0.146
Fly
negative regulation of peptide hormone processing GO:0060570 1 0.137
organonitrogen compound biosynthetic process GO:1901566 117 0.136
activation of immune response GO:0002253 5 0.134
negative regulation of response to external stimulus GO:0032102 22 0.118
phagocytosis GO:0006909 215 0.110
Fly
amide biosynthetic process GO:0043604 42 0.104
positive regulation of signaling GO:0023056 243 0.102
response to nitrogen compound GO:1901698 90 0.100
wound healing GO:0042060 75 0.099
Fly
negative regulation of cell communication GO:0010648 223 0.090
detection of stimulus GO:0051606 156 0.088
organic substance catabolic process GO:1901575 308 0.085
carbohydrate derivative metabolic process GO:1901135 217 0.084
positive regulation of cell communication GO:0010647 250 0.084
negative regulation of defense response GO:0031348 35 0.083
mucosal immune response GO:0002385 10 0.073
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.071
regulation of defense response to bacterium GO:1900424 30 0.070
melanotic encapsulation of foreign target GO:0035011 30 0.069
positive regulation of antifungal peptide production GO:0002804 6 0.061
positive regulation of signal transduction GO:0009967 223 0.060
pigment metabolic process involved in pigmentation GO:0043474 33 0.055
response to virus GO:0009615 28 0.053
negative regulation of gene expression GO:0010629 387 0.051
negative regulation of cellular metabolic process GO:0031324 382 0.050
regulation of defense response to fungus GO:1900150 6 0.049
response to molecule of bacterial origin GO:0002237 7 0.049
aging GO:0007568 143 0.049
cell adhesion GO:0007155 136 0.047
imaginal disc derived appendage morphogenesis GO:0035114 395 0.047
jnk cascade GO:0007254 50 0.045
negative regulation of signal transduction GO:0009968 206 0.044
response to organophosphorus GO:0046683 2 0.044
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.044
regulation of antifungal peptide production GO:0002788 6 0.043
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.042
cellular response to lipid GO:0071396 20 0.041
response to nutrient levels GO:0031667 114 0.040
hormone metabolic process GO:0042445 33 0.040
appendage development GO:0048736 401 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.040
response to organic substance GO:0010033 284 0.039
carboxylic acid metabolic process GO:0019752 92 0.039
regulation of antifungal peptide biosynthetic process GO:0002810 5 0.039
protein processing GO:0016485 68 0.037
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.036
organ or tissue specific immune response GO:0002251 10 0.036
apical junction assembly GO:0043297 32 0.035
positive regulation of hemocyte proliferation GO:0035208 4 0.035
organic acid metabolic process GO:0006082 103 0.034
cellular response to molecule of bacterial origin GO:0071219 3 0.034
homeostatic process GO:0042592 199 0.034
cellular response to organic substance GO:0071310 132 0.033
blastoderm segmentation GO:0007350 159 0.033
regulation of molecular function GO:0065009 217 0.033
response to endogenous stimulus GO:0009719 119 0.033
retina development in camera type eye GO:0060041 4 0.032
regulation of response to wounding GO:1903034 19 0.032
negative regulation of multi organism process GO:0043901 29 0.032
antifungal peptide biosynthetic process GO:0002783 5 0.032
negative regulation of signaling GO:0023057 219 0.031
antifungal peptide production GO:0002781 7 0.031
single organism behavior GO:0044708 391 0.030
biological adhesion GO:0022610 138 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.030
negative regulation of response to stimulus GO:0048585 258 0.029
pigment metabolic process GO:0042440 84 0.029
Fly
proteolysis GO:0006508 192 0.029
Fly
neurological system process GO:0050877 358 0.028
cell junction organization GO:0034330 57 0.028
rhythmic process GO:0048511 106 0.027
wing disc morphogenesis GO:0007472 344 0.026
mapk cascade GO:0000165 107 0.026
regulation of phosphorus metabolic process GO:0051174 210 0.026
response to molecule of fungal origin GO:0002238 1 0.026
negative regulation of molecular function GO:0044092 51 0.026
negative regulation of innate immune response GO:0045824 30 0.025
embryonic pattern specification GO:0009880 174 0.025
peptide hormone processing GO:0016486 2 0.025
oxoacid metabolic process GO:0043436 103 0.024
regulation of body fluid levels GO:0050878 14 0.024
Fly
appendage morphogenesis GO:0035107 397 0.024
synaptic transmission GO:0007268 288 0.023
eye development GO:0001654 323 0.023
spermatogenesis GO:0007283 200 0.023
regulation of intracellular signal transduction GO:1902531 236 0.023
wnt signaling pathway GO:0016055 98 0.023
regulation of endopeptidase activity GO:0052548 36 0.023
segmentation GO:0035282 207 0.023
single organism catabolic process GO:0044712 228 0.022
neuron projection guidance GO:0097485 241 0.022
regulation of peptidase activity GO:0052547 39 0.022
signal transduction by phosphorylation GO:0023014 107 0.022
response to lipopolysaccharide GO:0032496 4 0.022
camera type eye development GO:0043010 4 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.022
small molecule metabolic process GO:0044281 305 0.022
cellular response to lipopolysaccharide GO:0071222 3 0.022
response to abiotic stimulus GO:0009628 341 0.021
gene silencing GO:0016458 138 0.021
macromolecular complex assembly GO:0065003 256 0.021
positive regulation of gene expression GO:0010628 290 0.021
spermatid differentiation GO:0048515 114 0.021
stress activated mapk cascade GO:0051403 52 0.021
intracellular signal transduction GO:0035556 300 0.021
regulation of hydrolase activity GO:0051336 97 0.020
cell death GO:0008219 279 0.020
regulation of defense response to virus by host GO:0050691 10 0.020
cellular catabolic process GO:0044248 372 0.020
neurotransmitter catabolic process GO:0042135 1 0.020
open tracheal system development GO:0007424 204 0.020
imaginal disc derived appendage development GO:0048737 399 0.019
negative regulation of immune response GO:0050777 39 0.019
developmental pigmentation GO:0048066 68 0.019
response to extracellular stimulus GO:0009991 116 0.019
aminoglycan metabolic process GO:0006022 18 0.019
determination of adult lifespan GO:0008340 137 0.019
epithelial cell differentiation GO:0030855 322 0.018
regulation of proteolysis GO:0030162 87 0.018
chemotaxis GO:0006935 249 0.018
cellular response to biotic stimulus GO:0071216 4 0.018
sleep GO:0030431 49 0.018
post embryonic appendage morphogenesis GO:0035120 385 0.018
regulation of mapk cascade GO:0043408 92 0.018
cellular biogenic amine catabolic process GO:0042402 1 0.018
oocyte construction GO:0007308 112 0.018
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.018
body morphogenesis GO:0010171 2 0.018
male mating behavior GO:0060179 70 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.018
cellular modified amino acid metabolic process GO:0006575 45 0.018
dendrite morphogenesis GO:0048813 199 0.018
detection of chemical stimulus GO:0009593 93 0.017
meiotic nuclear division GO:0007126 151 0.017
organelle fission GO:0048285 340 0.017
positive regulation of macromolecule metabolic process GO:0010604 405 0.017
organonitrogen compound catabolic process GO:1901565 128 0.017
regulation of phosphate metabolic process GO:0019220 210 0.017
actin filament bundle assembly GO:0051017 26 0.017
endomembrane system organization GO:0010256 119 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
response to organic cyclic compound GO:0014070 89 0.016
positive regulation of phosphate metabolic process GO:0045937 139 0.016
spindle organization GO:0007051 253 0.016
compound eye development GO:0048749 307 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
negative regulation of catalytic activity GO:0043086 42 0.016
transcription from rna polymerase ii promoter GO:0006366 368 0.016
multi multicellular organism process GO:0044706 123 0.016
phosphorylation GO:0016310 294 0.016
catabolic process GO:0009056 409 0.016
macromolecule catabolic process GO:0009057 161 0.016
actin filament organization GO:0007015 126 0.016
actin filament based process GO:0030029 220 0.015
regulation of circadian rhythm GO:0042752 49 0.015
gene silencing by rna GO:0031047 57 0.015
chemical homeostasis GO:0048878 92 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
eye pigmentation GO:0048069 43 0.015
extracellular structure organization GO:0043062 46 0.015
amine catabolic process GO:0009310 1 0.015
negative regulation of phosphorylation GO:0042326 35 0.015
chromosome segregation GO:0007059 157 0.015
sperm individualization GO:0007291 48 0.015
anterior posterior axis specification embryo GO:0008595 103 0.015
protein complex assembly GO:0006461 200 0.015
multicellular organismal aging GO:0010259 140 0.015
regulation of gene expression epigenetic GO:0040029 128 0.015
extrinsic apoptotic signaling pathway GO:0097191 1 0.014
growth GO:0040007 359 0.014
neural retina development GO:0003407 4 0.014
axon development GO:0061564 297 0.014
regulation of protein metabolic process GO:0051246 256 0.014
neurotransmitter metabolic process GO:0042133 2 0.014
response to wounding GO:0009611 94 0.014
Fly
response to organonitrogen compound GO:0010243 75 0.014
cellular amino acid metabolic process GO:0006520 61 0.014
ameboidal type cell migration GO:0001667 151 0.014
salivary gland development GO:0007431 162 0.014
protein modification process GO:0036211 438 0.014
cellularization GO:0007349 90 0.014
neuron death GO:0070997 27 0.014
developmental maturation GO:0021700 172 0.014
neuron recognition GO:0008038 101 0.014
negative regulation of protein metabolic process GO:0051248 85 0.013
negative regulation of developmental process GO:0051093 201 0.013
anterior posterior pattern specification GO:0009952 136 0.013
regulation of cell adhesion GO:0030155 27 0.013
segment polarity determination GO:0007367 25 0.013
mitotic sister chromatid segregation GO:0000070 87 0.013
regulation of catalytic activity GO:0050790 185 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.013
developmental programmed cell death GO:0010623 138 0.013
stress activated protein kinase signaling cascade GO:0031098 55 0.013
negative regulation of intracellular signal transduction GO:1902532 57 0.013
regulation of anatomical structure morphogenesis GO:0022603 242 0.013
posttranscriptional gene silencing GO:0016441 46 0.013
axon guidance GO:0007411 233 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.013
rhythmic behavior GO:0007622 76 0.013
gland morphogenesis GO:0022612 145 0.013
zymogen activation GO:0031638 20 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
septate junction assembly GO:0019991 26 0.012
hormone catabolic process GO:0042447 3 0.012
organophosphate metabolic process GO:0019637 195 0.012
cell proliferation GO:0008283 299 0.012
protein localization GO:0008104 284 0.012
negative regulation of mapk cascade GO:0043409 23 0.012
sensory organ morphogenesis GO:0090596 260 0.012
positive regulation of defense response to virus by host GO:0002230 10 0.012
developmental growth GO:0048589 280 0.012
regulation of cellular response to stress GO:0080135 89 0.012
multi organism behavior GO:0051705 175 0.012
cell cell junction organization GO:0045216 55 0.012
negative regulation of proteolysis GO:0045861 31 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
heterocycle catabolic process GO:0046700 166 0.012
membrane depolarization GO:0051899 4 0.012
retinal cell programmed cell death GO:0046666 25 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
pyridine containing compound metabolic process GO:0072524 3 0.012
ovarian follicle cell development GO:0030707 248 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
regulation of organ morphogenesis GO:2000027 78 0.011
positive regulation of cell motility GO:2000147 3 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 15 0.011
nuclear division GO:0000280 332 0.011
digestive tract development GO:0048565 149 0.011
autophagic cell death GO:0048102 83 0.011
central nervous system development GO:0007417 201 0.011
positive regulation of molecular function GO:0044093 136 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
response to alcohol GO:0097305 95 0.011
response to oxygen containing compound GO:1901700 200 0.011
cellular ketone metabolic process GO:0042180 24 0.011
renal tubule development GO:0061326 64 0.011
anterior posterior axis specification GO:0009948 109 0.011
germarium derived egg chamber formation GO:0007293 101 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
regulation of gene silencing GO:0060968 63 0.011
detection of abiotic stimulus GO:0009582 66 0.011
chromatin silencing GO:0006342 76 0.010
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.010
mitotic nuclear division GO:0007067 213 0.010
negative regulation of cell death GO:0060548 81 0.010
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.010
dendrite development GO:0016358 204 0.010
peripheral nervous system development GO:0007422 52 0.010
negative regulation of cellular amide metabolic process GO:0034249 3 0.010
oxidation reduction process GO:0055114 123 0.010
courtship behavior GO:0007619 68 0.010
establishment of localization in cell GO:0051649 402 0.010

SPE disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
disease of metabolism DOID:0014667 0 0.016
nervous system disease DOID:863 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.011