Drosophila melanogaster

0 known processes

PRL-1 (Dmel_CG4993)

CG4993 gene product from transcript CG4993-RB

(Aliases: BcDNA:RE40268,CG4993,PRL,PrL-1,BG:DS07473.3,Dmel\CG4993)

PRL-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
developmental growth GO:0048589 280 0.566
regulation of growth GO:0040008 233 0.432
growth GO:0040007 359 0.344
establishment of localization in cell GO:0051649 402 0.316
single organism intracellular transport GO:1902582 207 0.291
hippo signaling GO:0035329 20 0.288
intracellular transport GO:0046907 228 0.284
positive regulation of nucleic acid templated transcription GO:1903508 266 0.256
death GO:0016265 284 0.250
endocytosis GO:0006897 310 0.249
regulation of protein metabolic process GO:0051246 256 0.241
regulation of apoptotic process GO:0042981 130 0.230
regulation of developmental growth GO:0048638 174 0.218
cellular protein modification process GO:0006464 438 0.213
apoptotic process GO:0006915 159 0.208
cytoplasmic transport GO:0016482 130 0.196
cellular response to dna damage stimulus GO:0006974 223 0.187
negative regulation of cellular metabolic process GO:0031324 382 0.174
programmed cell death GO:0012501 257 0.173
positive regulation of macromolecule metabolic process GO:0010604 405 0.168
cell death GO:0008219 279 0.163
g protein coupled receptor signaling pathway GO:0007186 136 0.161
neurological system process GO:0050877 358 0.154
negative regulation of multicellular organismal process GO:0051241 142 0.152
positive regulation of phosphate metabolic process GO:0045937 139 0.142
negative regulation of cell communication GO:0010648 223 0.142
regulation of mitotic cell cycle GO:0007346 190 0.129
proteolysis GO:0006508 192 0.127
negative regulation of biosynthetic process GO:0009890 277 0.124
maintenance of location GO:0051235 73 0.124
regulation of programmed cell death GO:0043067 152 0.123
regulation of phosphorylation GO:0042325 147 0.120
positive regulation of gene expression GO:0010628 290 0.117
regulation of cell cycle GO:0051726 291 0.117
cellular response to abiotic stimulus GO:0071214 58 0.116
protein localization GO:0008104 284 0.113
cellular response to light stimulus GO:0071482 37 0.106
negative regulation of gene expression GO:0010629 387 0.106
response to organic substance GO:0010033 284 0.105
taxis GO:0042330 304 0.104
negative regulation of signaling GO:0023057 219 0.102
vesicle mediated transport GO:0016192 381 0.100
regulation of molecular function GO:0065009 217 0.099
nucleocytoplasmic transport GO:0006913 72 0.096
cell growth GO:0016049 108 0.092
cell proliferation GO:0008283 299 0.092
response to light stimulus GO:0009416 124 0.092
activation of innate immune response GO:0002218 4 0.089
negative regulation of response to stimulus GO:0048585 258 0.089
regulation of cell death GO:0010941 173 0.085
adult behavior GO:0030534 137 0.084
tube development GO:0035295 244 0.082
phosphorylation GO:0016310 294 0.081
negative regulation of signal transduction GO:0009968 206 0.080
positive regulation of secretion GO:0051047 22 0.080
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.079
negative regulation of programmed cell death GO:0043069 72 0.079
positive regulation of cellular protein metabolic process GO:0032270 118 0.078
jnk cascade GO:0007254 50 0.077
multicellular organismal homeostasis GO:0048871 41 0.077
tor signaling GO:0031929 32 0.076
regulation of cellular localization GO:0060341 136 0.072
protein targeting GO:0006605 64 0.070
cell type specific apoptotic process GO:0097285 38 0.069
positive regulation of phosphorylation GO:0042327 87 0.068
multicellular organism growth GO:0035264 46 0.066
mapk cascade GO:0000165 107 0.065
negative regulation of cell death GO:0060548 81 0.065
negative regulation of mitotic cell cycle GO:0045930 109 0.065
dna repair GO:0006281 54 0.064
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.062
cell division GO:0051301 248 0.062
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.061
regulation of cell proliferation GO:0042127 163 0.060
tube morphogenesis GO:0035239 191 0.060
negative regulation of cellular biosynthetic process GO:0031327 277 0.060
axon guidance GO:0007411 233 0.059
regulation of phosphorus metabolic process GO:0051174 210 0.058
single organism carbohydrate metabolic process GO:0044723 72 0.057
protein modification process GO:0036211 438 0.056
neuron projection guidance GO:0097485 241 0.056
regulation of cellular protein metabolic process GO:0032268 243 0.055
cellular response to radiation GO:0071478 52 0.055
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.055
regulation of multi organism process GO:0043900 131 0.054
innate immune response activating signal transduction GO:0002758 2 0.053
mitotic cell cycle phase transition GO:0044772 138 0.053
response to ethanol GO:0045471 59 0.052
response to abiotic stimulus GO:0009628 341 0.052
axon development GO:0061564 297 0.052
organelle localization GO:0051640 148 0.052
negative regulation of apoptotic process GO:0043066 63 0.050
chemotaxis GO:0006935 249 0.050
positive regulation of cellular biosynthetic process GO:0031328 316 0.049
intracellular signal transduction GO:0035556 300 0.049
regionalization GO:0003002 416 0.048
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.047
regulation of secretion GO:0051046 44 0.047
cellular catabolic process GO:0044248 372 0.047
positive regulation of transcription dna templated GO:0045893 266 0.046
transcription from rna polymerase ii promoter GO:0006366 368 0.045
cell cycle phase transition GO:0044770 140 0.045
regulation of organelle organization GO:0033043 196 0.044
positive regulation of multicellular organismal process GO:0051240 143 0.044
regulation of intracellular signal transduction GO:1902531 236 0.044
organic substance transport GO:0071702 257 0.044
embryonic morphogenesis GO:0048598 206 0.044
negative regulation of growth GO:0045926 84 0.043
positive regulation of phosphorus metabolic process GO:0010562 139 0.043
cellular chemical homeostasis GO:0055082 40 0.042
negative regulation of cell cycle GO:0045786 116 0.042
regulation of transport GO:0051049 181 0.042
cellular macromolecule localization GO:0070727 220 0.041
single organism catabolic process GO:0044712 228 0.041
positive regulation of molecular function GO:0044093 136 0.040
cellular response to organic substance GO:0071310 132 0.040
regulation of cell size GO:0008361 63 0.040
negative regulation of transcription dna templated GO:0045892 237 0.040
response to starvation GO:0042594 97 0.040
response to radiation GO:0009314 155 0.040
carbohydrate metabolic process GO:0005975 82 0.039
heart process GO:0003015 37 0.039
single organism cellular localization GO:1902580 180 0.039
regulation of anatomical structure size GO:0090066 163 0.038
signal transduction by phosphorylation GO:0023014 107 0.038
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.038
maintenance of protein location GO:0045185 28 0.038
organonitrogen compound metabolic process GO:1901564 318 0.037
organic substance catabolic process GO:1901575 308 0.037
positive regulation of mapk cascade GO:0043410 63 0.036
catabolic process GO:0009056 409 0.036
regulation of catabolic process GO:0009894 170 0.036
ras protein signal transduction GO:0007265 88 0.036
positive regulation of protein metabolic process GO:0051247 128 0.036
homeostatic process GO:0042592 199 0.036
response to nitrogen compound GO:1901698 90 0.036
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.036
regulation of cell cycle process GO:0010564 181 0.035
cellular protein localization GO:0034613 160 0.035
regulation of cellular component size GO:0032535 98 0.035
regulation of locomotion GO:0040012 42 0.035
regulation of mapk cascade GO:0043408 92 0.035
regulation of protein kinase activity GO:0045859 51 0.035
cellular response to mechanical stimulus GO:0071260 2 0.034
mrna metabolic process GO:0016071 124 0.034
cell migration GO:0016477 238 0.033
protein transport GO:0015031 155 0.033
regulation of cellular catabolic process GO:0031329 157 0.032
pigmentation GO:0043473 75 0.032
response to oxygen containing compound GO:1901700 200 0.032
defense response GO:0006952 300 0.032
tissue morphogenesis GO:0048729 297 0.031
immune response regulating signaling pathway GO:0002764 2 0.031
cellular response to endogenous stimulus GO:0071495 80 0.031
positive regulation of signal transduction GO:0009967 223 0.031
positive regulation of developmental process GO:0051094 143 0.031
cardiovascular system development GO:0072358 82 0.031
regulation of response to stress GO:0080134 200 0.031
regulation of secretion by cell GO:1903530 39 0.030
notch signaling pathway GO:0007219 120 0.030
pattern recognition receptor signaling pathway GO:0002221 2 0.030
phagocytosis GO:0006909 215 0.030
small gtpase mediated signal transduction GO:0007264 88 0.030
positive regulation of signaling GO:0023056 243 0.029
cell adhesion GO:0007155 136 0.029
protein localization to organelle GO:0033365 82 0.029
regulation of cell development GO:0060284 215 0.029
regulation of hippo signaling GO:0035330 14 0.029
open tracheal system development GO:0007424 204 0.029
regulation of phosphate metabolic process GO:0019220 210 0.028
regulation of jnk cascade GO:0046328 40 0.028
intracellular protein transport GO:0006886 104 0.028
biological adhesion GO:0022610 138 0.028
post embryonic appendage morphogenesis GO:0035120 385 0.028
positive regulation of apoptotic process GO:0043065 47 0.027
organophosphate metabolic process GO:0019637 195 0.027
erk1 and erk2 cascade GO:0070371 39 0.027
regulation of localization GO:0032879 275 0.027
positive regulation of rna biosynthetic process GO:1902680 266 0.027
oxoacid metabolic process GO:0043436 103 0.027
larval development GO:0002164 104 0.026
positive regulation of intracellular signal transduction GO:1902533 116 0.026
neuron death GO:0070997 27 0.026
nuclear transport GO:0051169 72 0.026
neuronal action potential GO:0019228 10 0.026
detection of stimulus involved in sensory perception GO:0050906 92 0.026
gliogenesis GO:0042063 80 0.025
cellular ion homeostasis GO:0006873 39 0.025
positive regulation of programmed cell death GO:0043068 62 0.025
response to glucose GO:0009749 2 0.025
synaptic transmission GO:0007268 288 0.025
cation homeostasis GO:0055080 51 0.025
response to extracellular stimulus GO:0009991 116 0.025
establishment of protein localization to organelle GO:0072594 62 0.024
mitotic spindle organization GO:0007052 220 0.024
cellular homeostasis GO:0019725 80 0.024
body morphogenesis GO:0010171 2 0.024
mitotic nuclear division GO:0007067 213 0.024
stress activated mapk cascade GO:0051403 52 0.024
extrinsic apoptotic signaling pathway GO:0097191 1 0.023
regulation of proteolysis GO:0030162 87 0.023
dna metabolic process GO:0006259 227 0.023
dorsal ventral pattern formation GO:0009953 133 0.023
response to nutrient levels GO:0031667 114 0.023
positive regulation of defense response GO:0031349 59 0.023
nucleobase containing compound catabolic process GO:0034655 165 0.023
gland development GO:0048732 191 0.023
negative regulation of heart rate GO:0010459 3 0.023
response to alcohol GO:0097305 95 0.023
cell fate specification GO:0001708 71 0.023
regulation of multicellular organism growth GO:0040014 40 0.022
negative regulation of intracellular signal transduction GO:1902532 57 0.022
ensheathment of neurons GO:0007272 10 0.022
skeletal muscle fiber development GO:0048741 3 0.022
lipid localization GO:0010876 54 0.022
positive regulation of rna metabolic process GO:0051254 271 0.022
regulation of nucleocytoplasmic transport GO:0046822 35 0.022
cation transport GO:0006812 110 0.022
morphogenesis of a branching structure GO:0001763 45 0.022
imaginal disc derived appendage morphogenesis GO:0035114 395 0.022
regulation of cellular ketone metabolic process GO:0010565 3 0.021
ribosomal large subunit biogenesis GO:0042273 1 0.021
wing disc morphogenesis GO:0007472 344 0.021
stress activated protein kinase signaling cascade GO:0031098 55 0.021
circulatory system development GO:0072359 82 0.021
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.021
digestive tract development GO:0048565 149 0.021
positive regulation of growth GO:0045927 75 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
regulation of kinase activity GO:0043549 53 0.021
axonogenesis GO:0007409 290 0.020
embryo development ending in birth or egg hatching GO:0009792 152 0.020
positive regulation of cell size GO:0045793 21 0.020
negative regulation of rna biosynthetic process GO:1902679 240 0.020
appendage development GO:0048736 401 0.020
negative regulation of cell cycle process GO:0010948 109 0.020
regulation of catalytic activity GO:0050790 185 0.020
organic acid metabolic process GO:0006082 103 0.020
regulation of protein modification process GO:0031399 112 0.020
positive regulation of cell communication GO:0010647 250 0.020
cellular ketone metabolic process GO:0042180 24 0.020
regulation of stress activated mapk cascade GO:0032872 41 0.019
protein processing GO:0016485 68 0.019
regulation of response to external stimulus GO:0032101 115 0.019
appendage morphogenesis GO:0035107 397 0.019
action potential GO:0001508 13 0.019
muscle structure development GO:0061061 224 0.019
immune system process GO:0002376 347 0.019
reproductive structure development GO:0048608 74 0.019
connective tissue development GO:0061448 3 0.019
positive regulation of cell death GO:0010942 69 0.019
imaginal disc derived wing morphogenesis GO:0007476 337 0.019
protein hydroxylation GO:0018126 1 0.018
striated muscle tissue development GO:0014706 27 0.018
signal release GO:0023061 49 0.018
protein targeting to nucleus GO:0044744 51 0.018
regulation of neuron apoptotic process GO:0043523 16 0.018
regulation of cell division GO:0051302 72 0.018
negative regulation of notch signaling pathway GO:0045746 41 0.018
aromatic compound catabolic process GO:0019439 166 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.018
cellular carbohydrate metabolic process GO:0044262 22 0.018
regulation of mitosis GO:0007088 56 0.018
cell cell signaling involved in cell fate commitment GO:0045168 210 0.018
positive regulation of cell migration GO:0030335 2 0.018
renal system development GO:0072001 72 0.018
organ growth GO:0035265 56 0.017
regulation of sequestering of calcium ion GO:0051282 3 0.017
compound eye photoreceptor development GO:0042051 78 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.017
single organismal cell cell adhesion GO:0016337 45 0.017
establishment of protein localization GO:0045184 163 0.017
regulation of g protein coupled receptor protein signaling pathway GO:0008277 23 0.017
protein phosphorylation GO:0006468 169 0.017
response to endogenous stimulus GO:0009719 119 0.017
chemical homeostasis GO:0048878 92 0.017
positive regulation of cell motility GO:2000147 3 0.017
morphogenesis of an epithelium GO:0002009 276 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
autophagic vacuole assembly GO:0000045 2 0.017
carboxylic acid metabolic process GO:0019752 92 0.016
rna processing GO:0006396 147 0.016
deactivation of rhodopsin mediated signaling GO:0016059 17 0.016
multicellular organismal signaling GO:0035637 12 0.016
circadian rhythm GO:0007623 105 0.016
epithelial cell differentiation GO:0030855 322 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
regulation of embryonic development GO:0045995 68 0.016
regulation of tor signaling GO:0032006 21 0.016
positive regulation of autophagy GO:0010508 21 0.016
organelle fission GO:0048285 340 0.016
negative regulation of developmental growth GO:0048640 64 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
synapse assembly GO:0007416 143 0.015
negative regulation of cell differentiation GO:0045596 143 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
regulation of multicellular organismal development GO:2000026 414 0.015
cellular macromolecule catabolic process GO:0044265 136 0.015
imaginal disc derived appendage development GO:0048737 399 0.015
regulation of innate immune response GO:0045088 71 0.015
cellular response to carbohydrate stimulus GO:0071322 4 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
positive regulation of response to stimulus GO:0048584 323 0.015
establishment or maintenance of cell polarity GO:0007163 167 0.015
negative regulation of catabolic process GO:0009895 36 0.015
regulation of cytoplasmic transport GO:1903649 47 0.015
cell junction organization GO:0034330 57 0.015
nucleoside catabolic process GO:0009164 112 0.015
maintenance of location in cell GO:0051651 28 0.015
protein maturation GO:0051604 71 0.014
secretion by cell GO:0032940 101 0.014
compound eye development GO:0048749 307 0.014
protein localization to nucleus GO:0034504 55 0.014
cell cell junction organization GO:0045216 55 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
nitrogen compound transport GO:0071705 85 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of neurogenesis GO:0050767 158 0.014
regulation of protein phosphorylation GO:0001932 64 0.014
positive regulation of lipid catabolic process GO:0050996 1 0.014
positive regulation of kinase activity GO:0033674 25 0.014
cellular response to monosaccharide stimulus GO:0071326 2 0.014
reproductive behavior GO:0019098 122 0.014
learning or memory GO:0007611 141 0.014
chromosome segregation GO:0007059 157 0.014
anatomical structure homeostasis GO:0060249 97 0.014
regulation of anatomical structure morphogenesis GO:0022603 242 0.014
regulation of system process GO:0044057 36 0.014
axis specification GO:0009798 167 0.014
sensory organ morphogenesis GO:0090596 260 0.014
cellular response to biotic stimulus GO:0071216 4 0.014
protein import into nucleus GO:0006606 51 0.014
response to hexose GO:0009746 3 0.014
single organism cell adhesion GO:0098602 47 0.014
endomembrane system organization GO:0010256 119 0.013
heart contraction GO:0060047 26 0.013
cellular response to lipid GO:0071396 20 0.013
negative regulation of organ growth GO:0046621 15 0.013
regulation of mitotic sister chromatid segregation GO:0033047 28 0.013
positive regulation of protein phosphorylation GO:0001934 34 0.013
establishment of protein localization to peroxisome GO:0072663 2 0.013
centrosome organization GO:0051297 163 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
cellular response to external stimulus GO:0071496 66 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
nuclear import GO:0051170 51 0.013
peptidyl amino acid modification GO:0018193 105 0.013
chromatin modification GO:0016568 147 0.013
insulin like growth factor receptor signaling pathway GO:0048009 5 0.012
digestive tract morphogenesis GO:0048546 127 0.012
single organism carbohydrate catabolic process GO:0044724 7 0.012
single organism membrane organization GO:0044802 93 0.012
positive regulation of biosynthetic process GO:0009891 316 0.012
response to lipopolysaccharide GO:0032496 4 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
positive regulation of behavior GO:0048520 19 0.012
nucleotide metabolic process GO:0009117 161 0.012
metal ion homeostasis GO:0055065 44 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
positive regulation of transferase activity GO:0051347 26 0.012
imaginal disc growth GO:0007446 37 0.012
negative regulation of cell cycle phase transition GO:1901988 103 0.012
peptidyl threonine phosphorylation GO:0018107 2 0.012
small molecule metabolic process GO:0044281 305 0.012
necrotic cell death GO:0070265 1 0.012
meiosis i GO:0007127 59 0.012
positive regulation of secretion by cell GO:1903532 20 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
organonitrogen compound catabolic process GO:1901565 128 0.012
positive regulation of immune system process GO:0002684 68 0.012
regulation of neuron death GO:1901214 26 0.012
purine containing compound metabolic process GO:0072521 155 0.012
immune response activating signal transduction GO:0002757 2 0.012
regulation of ras protein signal transduction GO:0046578 93 0.012
spindle organization GO:0007051 253 0.012
cellular protein catabolic process GO:0044257 83 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
lateral inhibition GO:0046331 206 0.011
urogenital system development GO:0001655 72 0.011
nuclear export GO:0051168 24 0.011
regulation of cellular response to stress GO:0080135 89 0.011
instar larval development GO:0002168 55 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
regulation of cell cycle phase transition GO:1901987 130 0.011
hindbrain development GO:0030902 2 0.011
sex differentiation GO:0007548 81 0.011
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.011
blood circulation GO:0008015 26 0.011
secretion GO:0046903 109 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
chromatin silencing GO:0006342 76 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.011
positive regulation of jun kinase activity GO:0043507 4 0.011
rna 3 end processing GO:0031123 45 0.011
rho protein signal transduction GO:0007266 14 0.011
immune response GO:0006955 246 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.011
positive regulation of transport GO:0051050 92 0.011
imaginal disc derived wing vein specification GO:0007474 48 0.011
cytokinesis GO:0000910 90 0.011
compound eye morphogenesis GO:0001745 249 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
positive regulation of protein modification process GO:0031401 58 0.010
maintenance of gastrointestinal epithelium GO:0030277 3 0.010
regulation of carbohydrate metabolic process GO:0006109 10 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
regulation of cellular component movement GO:0051270 42 0.010
regulation of protein transport GO:0051223 57 0.010
regulation of hormone levels GO:0010817 40 0.010
synapse organization GO:0050808 196 0.010
response to wounding GO:0009611 94 0.010
protein kinase b signaling GO:0043491 1 0.010
regulation of intracellular transport GO:0032386 64 0.010
chromatin remodeling GO:0006338 72 0.010
positive regulation of macroautophagy GO:0016239 8 0.010

PRL-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.041
disease of metabolism DOID:0014667 0 0.027
carbohydrate metabolism disease DOID:0050013 0 0.027
glucose metabolism disease DOID:4194 0 0.027
acquired metabolic disease DOID:0060158 0 0.027
cancer DOID:162 0 0.021
organ system cancer DOID:0050686 0 0.021
diabetes mellitus DOID:9351 0 0.011