Drosophila melanogaster

125 known processes

MED6 (Dmel_CG9473)

Mediator complex subunit 6

(Aliases: BcDNA:LD15729,dMed6,Dmel\CG9473,anon-EST:Posey279,dMED6,Trap32,dTRAP32,Med6,p35,CG9473)

MED6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of neuroblast proliferation GO:1902692 34 0.990
negative regulation of neuroblast proliferation GO:0007406 27 0.988
stem cell proliferation GO:0072089 88 0.959
negative regulation of cell cycle phase transition GO:1901988 103 0.955
negative regulation of neural precursor cell proliferation GO:2000178 27 0.954
regulation of nervous system development GO:0051960 248 0.921
transcription from rna polymerase ii promoter GO:0006366 368 0.909
mitotic g2 dna damage checkpoint GO:0007095 69 0.909
regulation of multicellular organismal development GO:2000026 414 0.873
mitotic dna integrity checkpoint GO:0044774 75 0.867
mitotic g2 m transition checkpoint GO:0044818 70 0.867
regulation of neural precursor cell proliferation GO:2000177 35 0.853
mitotic cell cycle checkpoint GO:0007093 88 0.847
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.825
g2 dna damage checkpoint GO:0031572 69 0.815
negative regulation of stem cell proliferation GO:2000647 30 0.813
regulation of stem cell proliferation GO:0072091 40 0.802
regulation of mitotic cell cycle phase transition GO:1901990 130 0.797
regulation of cell cycle phase transition GO:1901987 130 0.786
negative regulation of cell proliferation GO:0008285 69 0.784
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.784
mrna polyadenylation GO:0006378 11 0.775
cell cycle phase transition GO:0044770 140 0.698
mitotic dna damage checkpoint GO:0044773 74 0.688
negative regulation of multicellular organismal process GO:0051241 142 0.680
dna integrity checkpoint GO:0031570 81 0.654
negative regulation of mitotic cell cycle GO:0045930 109 0.622
negative regulation of nucleic acid templated transcription GO:1903507 240 0.602
negative regulation of cell cycle process GO:0010948 109 0.546
negative regulation of cell differentiation GO:0045596 143 0.539
cell cycle checkpoint GO:0000075 95 0.537
negative regulation of biosynthetic process GO:0009890 277 0.524
sex comb development GO:0045498 8 0.518
negative regulation of cell cycle GO:0045786 116 0.517
negative regulation of nervous system development GO:0051961 92 0.513
dna damage checkpoint GO:0000077 78 0.487
cell proliferation GO:0008283 299 0.487
neuroblast proliferation GO:0007405 74 0.485
regulation of neurogenesis GO:0050767 158 0.484
regulation of cell development GO:0060284 215 0.472
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.461
segmentation GO:0035282 207 0.436
negative regulation of neurogenesis GO:0050768 53 0.415
negative regulation of cell development GO:0010721 62 0.413
regulation of cell cycle GO:0051726 291 0.402
mitotic cell cycle phase transition GO:0044772 138 0.377
cullin deneddylation GO:0010388 3 0.368
negative regulation of cellular metabolic process GO:0031324 382 0.363
positive regulation of rna metabolic process GO:0051254 271 0.347
Human
columnar cuboidal epithelial cell development GO:0002066 249 0.347
developmental growth GO:0048589 280 0.320
organic substance transport GO:0071702 257 0.280
protein transport GO:0015031 155 0.275
embryo development ending in birth or egg hatching GO:0009792 152 0.266
Worm
positive regulation of nucleic acid templated transcription GO:1903508 266 0.261
Human
regulation of cell differentiation GO:0045595 302 0.258
regulation of cell proliferation GO:0042127 163 0.257
rna polyadenylation GO:0043631 12 0.255
negative regulation of gene expression GO:0010629 387 0.254
nuclear division GO:0000280 332 0.253
regulation of cellular component biogenesis GO:0044087 201 0.246
growth GO:0040007 359 0.243
establishment of protein localization GO:0045184 163 0.239
histolysis GO:0007559 102 0.232
negative regulation of rna biosynthetic process GO:1902679 240 0.232
response to biotic stimulus GO:0009607 294 0.229
oocyte development GO:0048599 124 0.226
response to bacterium GO:0009617 198 0.222
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.171
regulation of mitotic cell cycle GO:0007346 190 0.162
photoreceptor cell differentiation GO:0046530 170 0.152
gene silencing by rna GO:0031047 57 0.149
gene silencing GO:0016458 138 0.146
mrna metabolic process GO:0016071 124 0.146
organelle fission GO:0048285 340 0.136
cellular protein localization GO:0034613 160 0.132
positive regulation of transcription dna templated GO:0045893 266 0.132
Human
protein modification by small protein conjugation GO:0032446 79 0.130
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.127
oocyte differentiation GO:0009994 145 0.126
axon development GO:0061564 297 0.125
neural precursor cell proliferation GO:0061351 75 0.123
cellular macromolecule catabolic process GO:0044265 136 0.120
oocyte construction GO:0007308 112 0.118
positive regulation of biosynthetic process GO:0009891 316 0.116
Human
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.115
histone methylation GO:0016571 40 0.110
heterochromatin organization GO:0070828 25 0.105
sex differentiation GO:0007548 81 0.104
Worm
macromolecule methylation GO:0043414 45 0.102
rna processing GO:0006396 147 0.101
macromolecule catabolic process GO:0009057 161 0.097
negative regulation of transcription dna templated GO:0045892 237 0.096
imaginal disc derived leg segmentation GO:0036011 26 0.095
appendage segmentation GO:0035285 26 0.095
histone lysine methylation GO:0034968 32 0.094
regulation of cellular localization GO:0060341 136 0.091
response to ecdysone GO:0035075 34 0.090
cellular response to ketone GO:1901655 17 0.086
eye photoreceptor cell differentiation GO:0001754 145 0.086
endomembrane system organization GO:0010256 119 0.084
developmental programmed cell death GO:0010623 138 0.082
cellular response to chemical stimulus GO:0070887 199 0.082
regulation of notch signaling pathway GO:0008593 100 0.081
enzyme linked receptor protein signaling pathway GO:0007167 179 0.080
regulation of growth GO:0040008 233 0.080
eye morphogenesis GO:0048592 260 0.078
protein deneddylation GO:0000338 8 0.078
ovarian follicle cell development GO:0030707 248 0.077
cell maturation GO:0048469 144 0.077
secretion by cell GO:0032940 101 0.076
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.075
Human
taxis GO:0042330 304 0.072
salivary gland histolysis GO:0035070 88 0.071
response to organic cyclic compound GO:0014070 89 0.068
regulation of transport GO:0051049 181 0.068
cell motility GO:0048870 251 0.068
dna templated transcription initiation GO:0006352 25 0.067
negative regulation of cellular biosynthetic process GO:0031327 277 0.066
negative regulation of developmental process GO:0051093 201 0.066
establishment or maintenance of cell polarity GO:0007163 167 0.065
stem cell differentiation GO:0048863 117 0.063
g1 s transition of mitotic cell cycle GO:0000082 31 0.062
positive regulation of gene expression GO:0010628 290 0.062
Human
cellular response to uv GO:0034644 12 0.061
negative regulation of cell communication GO:0010648 223 0.061
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.061
Human
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.059
epithelium migration GO:0090132 148 0.057
response to abiotic stimulus GO:0009628 341 0.057
protein modification by small protein conjugation or removal GO:0070647 106 0.057
gland development GO:0048732 191 0.056
protein modification process GO:0036211 438 0.056
compound eye morphogenesis GO:0001745 249 0.056
organic substance catabolic process GO:1901575 308 0.055
regulation of immune response GO:0050776 118 0.055
response to endogenous stimulus GO:0009719 119 0.055
cellular macromolecule localization GO:0070727 220 0.054
salivary gland cell autophagic cell death GO:0035071 83 0.053
cell migration GO:0016477 238 0.052
mrna processing GO:0006397 104 0.051
regulation of developmental growth GO:0048638 174 0.051
intracellular transport GO:0046907 228 0.050
oocyte axis specification GO:0007309 108 0.050
regulation of immune system process GO:0002682 176 0.049
muscle organ development GO:0007517 127 0.048
protein localization GO:0008104 284 0.047
regulation of gene expression epigenetic GO:0040029 128 0.045
regulation of intracellular transport GO:0032386 64 0.044
sensory organ morphogenesis GO:0090596 260 0.044
cell division GO:0051301 248 0.043
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.043
phosphorylation of rna polymerase ii c terminal domain GO:0070816 1 0.042
autophagic cell death GO:0048102 83 0.042
cellular response to organonitrogen compound GO:0071417 36 0.041
cytoplasmic transport GO:0016482 130 0.041
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.040
appendage development GO:0048736 401 0.040
compound eye photoreceptor cell differentiation GO:0001751 140 0.040
protein alkylation GO:0008213 43 0.040
protein modification by small protein removal GO:0070646 28 0.039
cell cycle g1 s phase transition GO:0044843 31 0.039
positive regulation of rna biosynthetic process GO:1902680 266 0.038
Human
developmental maturation GO:0021700 172 0.038
epithelial cell development GO:0002064 274 0.038
response to sterol GO:0036314 34 0.038
positive regulation of macromolecule metabolic process GO:0010604 405 0.037
Human
response to organonitrogen compound GO:0010243 75 0.037
positive regulation of developmental process GO:0051094 143 0.037
imaginal disc growth GO:0007446 37 0.036
cellular response to organic substance GO:0071310 132 0.036
proteolysis GO:0006508 192 0.036
macromolecular complex assembly GO:0065003 256 0.036
regionalization GO:0003002 416 0.036
single organism intracellular transport GO:1902582 207 0.036
ameboidal type cell migration GO:0001667 151 0.035
negative regulation of signal transduction GO:0009968 206 0.035
tissue death GO:0016271 102 0.034
negative regulation of signaling GO:0023057 219 0.033
positive regulation of cellular biosynthetic process GO:0031328 316 0.033
Human
cellular protein modification process GO:0006464 438 0.033
negative regulation of response to stimulus GO:0048585 258 0.033
regulation of localization GO:0032879 275 0.033
dendrite development GO:0016358 204 0.033
central nervous system development GO:0007417 201 0.033
detection of external stimulus GO:0009581 66 0.032
mitotic nuclear division GO:0007067 213 0.032
establishment of localization in cell GO:0051649 402 0.032
meiosis i GO:0007127 59 0.032
methylation GO:0032259 47 0.032
tissue morphogenesis GO:0048729 297 0.031
axon guidance GO:0007411 233 0.031
positive regulation of developmental growth GO:0048639 62 0.029
jak stat cascade GO:0007259 49 0.029
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.029
chaeta development GO:0022416 97 0.029
axis specification GO:0009798 167 0.028
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.028
compound eye development GO:0048749 307 0.028
lateral inhibition GO:0046331 206 0.028
localization of cell GO:0051674 257 0.028
rna 3 end processing GO:0031123 45 0.027
nuclear import GO:0051170 51 0.027
ncrna metabolic process GO:0034660 43 0.027
protein ubiquitination GO:0016567 70 0.026
phosphorylation GO:0016310 294 0.026
oviposition GO:0018991 19 0.026
neuromuscular junction development GO:0007528 149 0.025
wnt signaling pathway GO:0016055 98 0.025
histone h2a ubiquitination GO:0033522 2 0.025
regulation of cellular protein metabolic process GO:0032268 243 0.025
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.025
posttranscriptional regulation of gene expression GO:0010608 145 0.025
regulation of multi organism process GO:0043900 131 0.025
eggshell chorion gene amplification GO:0007307 9 0.025
positive regulation of cell communication GO:0010647 250 0.025
muscle structure development GO:0061061 224 0.025
regulation of wnt signaling pathway GO:0030111 68 0.024
epithelial cell differentiation GO:0030855 322 0.024
imaginal disc derived appendage morphogenesis GO:0035114 395 0.024
sister chromatid segregation GO:0000819 92 0.024
morphogenesis of follicular epithelium GO:0016333 36 0.024
epidermis development GO:0008544 65 0.024
immune response GO:0006955 246 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
Human
cellular response to light stimulus GO:0071482 37 0.023
appendage morphogenesis GO:0035107 397 0.023
regulation of protein modification process GO:0031399 112 0.023
salivary gland development GO:0007431 162 0.023
centrosome cycle GO:0007098 137 0.022
peptidyl amino acid modification GO:0018193 105 0.022
single organism cellular localization GO:1902580 180 0.022
embryonic pattern specification GO:0009880 174 0.021
cellular response to radiation GO:0071478 52 0.021
tissue migration GO:0090130 155 0.021
salivary gland morphogenesis GO:0007435 145 0.021
ovarian follicle cell migration GO:0007297 121 0.021
response to organic substance GO:0010033 284 0.021
mitotic sister chromatid cohesion GO:0007064 6 0.020
response to ketone GO:1901654 34 0.020
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.020
stem cell maintenance GO:0019827 67 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.020
membrane organization GO:0061024 112 0.020
response to other organism GO:0051707 293 0.020
leg disc morphogenesis GO:0007478 80 0.020
protein catabolic process GO:0030163 101 0.020
morphogenesis of an epithelium GO:0002009 276 0.020
secretion GO:0046903 109 0.020
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.019
pole plasm assembly GO:0007315 61 0.019
regulation of circadian rhythm GO:0042752 49 0.019
ubiquitin dependent protein catabolic process GO:0006511 78 0.019
regulation of epithelial cell differentiation GO:0030856 4 0.019
defense response to bacterium GO:0042742 178 0.019
cellular response to abiotic stimulus GO:0071214 58 0.019
cardiovascular system development GO:0072358 82 0.019
nucleosome mobilization GO:0042766 9 0.019
nucleosome positioning GO:0016584 3 0.019
regulation of cytoplasmic transport GO:1903649 47 0.019
cellular response to endogenous stimulus GO:0071495 80 0.018
dorsal ventral axis specification GO:0009950 66 0.018
regulation of protein catabolic process GO:0042176 55 0.018
chromosome organization involved in meiosis GO:0070192 10 0.018
nuclear transport GO:0051169 72 0.018
regulation of innate immune response GO:0045088 71 0.018
endocytosis GO:0006897 310 0.018
striated muscle myosin thick filament assembly GO:0071688 3 0.017
reproductive system development GO:0061458 74 0.017
Worm
chromosome segregation GO:0007059 157 0.017
dna alkylation GO:0006305 4 0.017
negative regulation of rna metabolic process GO:0051253 251 0.017
neuron remodeling GO:0016322 29 0.017
organelle assembly GO:0070925 198 0.017
epithelial cell migration GO:0010631 148 0.017
regulation of embryonic development GO:0045995 68 0.016
cellular response to oxygen containing compound GO:1901701 79 0.016
regulation of cellular component size GO:0032535 98 0.016
lipid storage GO:0019915 38 0.016
regulation of protein stability GO:0031647 43 0.016
protein methylation GO:0006479 43 0.016
mrna 3 end processing GO:0031124 28 0.016
axonogenesis GO:0007409 290 0.016
stem cell development GO:0048864 79 0.016
blastoderm segmentation GO:0007350 159 0.016
eye photoreceptor cell development GO:0042462 81 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
Human
defense response to gram negative bacterium GO:0050829 94 0.015
dna methylation or demethylation GO:0044728 4 0.015
protein phosphorylation GO:0006468 169 0.015
tripartite regional subdivision GO:0007351 103 0.015
nephron development GO:0072006 3 0.015
anatomical structure homeostasis GO:0060249 97 0.015
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.015
modification dependent protein catabolic process GO:0019941 78 0.015
posttranscriptional gene silencing by rna GO:0035194 45 0.015
mitotic cell cycle embryonic GO:0045448 38 0.015
multicellular organismal reproductive behavior GO:0033057 110 0.015
response to oxygen containing compound GO:1901700 200 0.014
positive regulation of notch signaling pathway GO:0045747 34 0.014
regulation of cellular amine metabolic process GO:0033238 3 0.014
death GO:0016265 284 0.014
reproductive structure development GO:0048608 74 0.014
Worm
eggshell formation GO:0030703 105 0.014
chromatin modification GO:0016568 147 0.013
development of primary sexual characteristics GO:0045137 50 0.013
Worm
generation of precursor metabolites and energy GO:0006091 42 0.013
posttranscriptional gene silencing GO:0016441 46 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
ecdysone receptor mediated signaling pathway GO:0035076 11 0.013
intracellular receptor signaling pathway GO:0030522 19 0.013
positive regulation of neurogenesis GO:0050769 41 0.012
regulation of protein transport GO:0051223 57 0.012
response to alcohol GO:0097305 95 0.012
asymmetric cell division GO:0008356 37 0.012
cellular catabolic process GO:0044248 372 0.012
pigmentation GO:0043473 75 0.012
neuron projection guidance GO:0097485 241 0.012
positive regulation of signaling GO:0023056 243 0.012
programmed cell death GO:0012501 257 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
organonitrogen compound metabolic process GO:1901564 318 0.012
regulation of epidermal cell differentiation GO:0045604 3 0.012
chemotaxis GO:0006935 249 0.012
small molecule metabolic process GO:0044281 305 0.012
response to peptide GO:1901652 29 0.012
regulation of neuron differentiation GO:0045664 103 0.012
response to external biotic stimulus GO:0043207 293 0.012
protein targeting to nucleus GO:0044744 51 0.011
phagocytosis GO:0006909 215 0.011
chromatin organization GO:0006325 207 0.011
protein localization to nucleus GO:0034504 55 0.011
anterior posterior axis specification embryo GO:0008595 103 0.011
mrna splicing via spliceosome GO:0000398 73 0.011
eye development GO:0001654 323 0.011
anterior posterior pattern specification GO:0009952 136 0.011
morphogenesis of a polarized epithelium GO:0001738 93 0.011
peptidyl tyrosine modification GO:0018212 24 0.011
negative regulation of epithelial cell proliferation GO:0050680 4 0.011
cellular response to organic cyclic compound GO:0071407 32 0.011
cellular response to ecdysone GO:0071390 17 0.011
organ growth GO:0035265 56 0.011
cellular response to nitrogen compound GO:1901699 51 0.011
protein secretion GO:0009306 45 0.011
eggshell chorion assembly GO:0007306 66 0.011
sister chromatid cohesion GO:0007062 18 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.010
dorsal ventral pattern formation GO:0009953 133 0.010
regulation of cell size GO:0008361 63 0.010
nucleocytoplasmic transport GO:0006913 72 0.010
homeostatic process GO:0042592 199 0.010

MED6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.086
disease of cellular proliferation DOID:14566 0 0.086
disease of anatomical entity DOID:7 0 0.069
organ system cancer DOID:0050686 0 0.027