Drosophila melanogaster

26 known processes

Sym (Dmel_CG2097)

Symplekin

(Aliases: Dmel\CG2097,CG2097,dSymp)

Sym biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of macromolecule metabolic process GO:0010604 405 0.413
transcription from rna polymerase ii promoter GO:0006366 368 0.397
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.384
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.319
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.298
catabolic process GO:0009056 409 0.275
intracellular transport GO:0046907 228 0.226
intracellular signal transduction GO:0035556 300 0.209
cellular response to dna damage stimulus GO:0006974 223 0.207
cellular catabolic process GO:0044248 372 0.199
positive regulation of nucleic acid templated transcription GO:1903508 266 0.189
rna processing GO:0006396 147 0.185
positive regulation of rna biosynthetic process GO:1902680 266 0.177
regulation of phosphorus metabolic process GO:0051174 210 0.168
negative regulation of gene expression GO:0010629 387 0.163
positive regulation of phosphate metabolic process GO:0045937 139 0.159
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.157
positive regulation of gene expression GO:0010628 290 0.157
chromosome organization GO:0051276 360 0.156
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.138
organic substance catabolic process GO:1901575 308 0.134
regulation of cell differentiation GO:0045595 302 0.116
positive regulation of phosphorus metabolic process GO:0010562 139 0.110
positive regulation of cellular biosynthetic process GO:0031328 316 0.110
cellular protein modification process GO:0006464 438 0.104
cellular protein localization GO:0034613 160 0.102
dna metabolic process GO:0006259 227 0.101
cellular macromolecule localization GO:0070727 220 0.098
protein localization GO:0008104 284 0.093
regulation of cellular protein metabolic process GO:0032268 243 0.093
small molecule metabolic process GO:0044281 305 0.089
tissue morphogenesis GO:0048729 297 0.085
negative regulation of nucleic acid templated transcription GO:1903507 240 0.085
epithelial cell differentiation GO:0030855 322 0.085
wing disc morphogenesis GO:0007472 344 0.084
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.084
defense response GO:0006952 300 0.081
response to external biotic stimulus GO:0043207 293 0.081
positive regulation of signal transduction GO:0009967 223 0.080
regulation of phosphate metabolic process GO:0019220 210 0.080
cell migration GO:0016477 238 0.079
Worm
protein catabolic process GO:0030163 101 0.078
positive regulation of cell communication GO:0010647 250 0.076
regulation of catabolic process GO:0009894 170 0.075
establishment of localization in cell GO:0051649 402 0.073
regulation of molecular function GO:0065009 217 0.073
dna repair GO:0006281 54 0.072
phosphorylation GO:0016310 294 0.071
modification dependent macromolecule catabolic process GO:0043632 79 0.071
segmentation GO:0035282 207 0.071
proteolysis GO:0006508 192 0.070
positive regulation of transcription dna templated GO:0045893 266 0.069
carbohydrate derivative metabolic process GO:1901135 217 0.069
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.068
cytoplasmic transport GO:0016482 130 0.067
regulation of cell cycle process GO:0010564 181 0.067
positive regulation of response to stimulus GO:0048584 323 0.067
regulation of intracellular signal transduction GO:1902531 236 0.067
ubiquitin dependent protein catabolic process GO:0006511 78 0.066
defense response to other organism GO:0098542 225 0.064
purine nucleotide catabolic process GO:0006195 109 0.063
single organism cellular localization GO:1902580 180 0.063
embryo development ending in birth or egg hatching GO:0009792 152 0.062
Worm
sister chromatid segregation GO:0000819 92 0.061
macromolecule catabolic process GO:0009057 161 0.061
nucleotide catabolic process GO:0009166 109 0.059
regulation of immune system process GO:0002682 176 0.057
purine containing compound catabolic process GO:0072523 112 0.056
small gtpase mediated signal transduction GO:0007264 88 0.056
cellular nitrogen compound catabolic process GO:0044270 165 0.056
snrna 3 end processing GO:0034472 14 0.055
immune system process GO:0002376 347 0.054
positive regulation of biosynthetic process GO:0009891 316 0.054
response to light stimulus GO:0009416 124 0.052
enzyme linked receptor protein signaling pathway GO:0007167 179 0.052
mitotic nuclear division GO:0007067 213 0.052
protein transport GO:0015031 155 0.052
epithelial cell development GO:0002064 274 0.051
chromatin modification GO:0016568 147 0.051
regulation of multicellular organismal development GO:2000026 414 0.051
cellular response to lipopolysaccharide GO:0071222 3 0.050
regulation of cellular amino acid metabolic process GO:0006521 0 0.050
response to abiotic stimulus GO:0009628 341 0.049
purine ribonucleoside catabolic process GO:0046130 112 0.049
microtubule organizing center organization GO:0031023 168 0.048
purine nucleoside metabolic process GO:0042278 127 0.048
protein modification process GO:0036211 438 0.047
dna damage checkpoint GO:0000077 78 0.047
regionalization GO:0003002 416 0.047
nucleoside catabolic process GO:0009164 112 0.046
ribonucleoside catabolic process GO:0042454 112 0.046
regulation of protein metabolic process GO:0051246 256 0.046
organic substance transport GO:0071702 257 0.045
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.045
regulation of localization GO:0032879 275 0.044
morphogenesis of an epithelium GO:0002009 276 0.044
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.044
positive regulation of cellular protein metabolic process GO:0032270 118 0.044
nucleoside triphosphate catabolic process GO:0009143 108 0.043
regulation of catalytic activity GO:0050790 185 0.042
glycosyl compound catabolic process GO:1901658 112 0.042
negative regulation of response to stimulus GO:0048585 258 0.042
negative regulation of rna biosynthetic process GO:1902679 240 0.041
organelle fission GO:0048285 340 0.041
nucleoside triphosphate metabolic process GO:0009141 120 0.040
ribonucleotide catabolic process GO:0009261 109 0.040
protein localization to organelle GO:0033365 82 0.040
single organism catabolic process GO:0044712 228 0.040
purine ribonucleoside metabolic process GO:0046128 127 0.040
regulation of phosphorylation GO:0042325 147 0.039
eye morphogenesis GO:0048592 260 0.039
positive regulation of signaling GO:0023056 243 0.039
regulation of cellular component size GO:0032535 98 0.039
regulation of small gtpase mediated signal transduction GO:0051056 93 0.039
purine nucleoside catabolic process GO:0006152 112 0.038
regulation of cell cycle GO:0051726 291 0.038
ras protein signal transduction GO:0007265 88 0.038
cellular macromolecule catabolic process GO:0044265 136 0.038
glycosyl compound metabolic process GO:1901657 127 0.038
ncrna 3 end processing GO:0043628 17 0.038
protein import into nucleus GO:0006606 51 0.037
intracellular protein transport GO:0006886 104 0.037
purine containing compound metabolic process GO:0072521 155 0.037
single organism nuclear import GO:1902593 51 0.035
positive regulation of catabolic process GO:0009896 105 0.035
purine nucleoside triphosphate catabolic process GO:0009146 108 0.034
centrosome organization GO:0051297 163 0.033
organophosphate metabolic process GO:0019637 195 0.032
regulation of cellular ketone metabolic process GO:0010565 3 0.032
positive regulation of catalytic activity GO:0043085 118 0.032
response to biotic stimulus GO:0009607 294 0.032
nuclear division GO:0000280 332 0.032
negative regulation of transcription dna templated GO:0045892 237 0.032
response to lipopolysaccharide GO:0032496 4 0.032
protein phosphorylation GO:0006468 169 0.031
carbohydrate derivative catabolic process GO:1901136 118 0.031
response to bacterium GO:0009617 198 0.031
positive regulation of intracellular signal transduction GO:1902533 116 0.030
body morphogenesis GO:0010171 2 0.030
nucleobase containing compound catabolic process GO:0034655 165 0.030
purine nucleoside triphosphate metabolic process GO:0009144 119 0.029
positive regulation of protein metabolic process GO:0051247 128 0.029
purine ribonucleotide catabolic process GO:0009154 109 0.029
g protein coupled receptor signaling pathway GO:0007186 136 0.029
gtp catabolic process GO:0006184 72 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.028
regulation of protein localization GO:0032880 76 0.028
negative regulation of cell cycle phase transition GO:1901988 103 0.028
regulation of cellular catabolic process GO:0031329 157 0.028
modification dependent protein catabolic process GO:0019941 78 0.027
innate immune response GO:0045087 144 0.027
protein targeting to nucleus GO:0044744 51 0.027
cellular macromolecular complex assembly GO:0034622 153 0.027
guanosine containing compound metabolic process GO:1901068 74 0.026
establishment of protein localization GO:0045184 163 0.026
homeostatic process GO:0042592 199 0.026
negative regulation of biosynthetic process GO:0009890 277 0.026
axon development GO:0061564 297 0.025
ncrna metabolic process GO:0034660 43 0.025
organonitrogen compound metabolic process GO:1901564 318 0.025
response to radiation GO:0009314 155 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.025
positive regulation of phosphorylation GO:0042327 87 0.025
nuclear import GO:0051170 51 0.024
heterocycle catabolic process GO:0046700 166 0.024
purine nucleotide metabolic process GO:0006163 146 0.024
axonogenesis GO:0007409 290 0.024
double strand break repair GO:0006302 26 0.024
ribonucleoside triphosphate metabolic process GO:0009199 119 0.024
appendage morphogenesis GO:0035107 397 0.023
anterior posterior axis specification GO:0009948 109 0.023
establishment of protein localization to organelle GO:0072594 62 0.023
positive regulation of molecular function GO:0044093 136 0.023
appendage development GO:0048736 401 0.023
regulation of cellular amine metabolic process GO:0033238 3 0.023
mitotic sister chromatid segregation GO:0000070 87 0.023
single organism intracellular transport GO:1902582 207 0.023
nucleoside phosphate catabolic process GO:1901292 110 0.023
nuclear transport GO:0051169 72 0.023
organonitrogen compound catabolic process GO:1901565 128 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.022
proteasomal protein catabolic process GO:0010498 59 0.022
cellular amino acid metabolic process GO:0006520 61 0.022
positive regulation of multicellular organismal process GO:0051240 143 0.022
protein import GO:0017038 55 0.022
regulation of gene expression epigenetic GO:0040029 128 0.022
apoptotic process GO:0006915 159 0.022
positive regulation of hydrolase activity GO:0051345 78 0.021
mitotic cell cycle phase transition GO:0044772 138 0.021
gtp metabolic process GO:0046039 72 0.021
histone h3 k4 methylation GO:0051568 16 0.021
ribonucleotide metabolic process GO:0009259 145 0.021
dna integrity checkpoint GO:0031570 81 0.021
oxoacid metabolic process GO:0043436 103 0.021
cellular response to chemical stimulus GO:0070887 199 0.021
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.021
cellular protein complex assembly GO:0043623 71 0.020
imaginal disc derived wing morphogenesis GO:0007476 337 0.020
regulation of hydrolase activity GO:0051336 97 0.020
mitotic g2 dna damage checkpoint GO:0007095 69 0.020
protein localization to nucleus GO:0034504 55 0.020
ribose phosphate metabolic process GO:0019693 145 0.020
nucleoside metabolic process GO:0009116 127 0.020
chromatin organization GO:0006325 207 0.020
positive regulation of protein modification process GO:0031401 58 0.020
regulation of cellular component biogenesis GO:0044087 201 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.019
posttranscriptional gene silencing GO:0016441 46 0.019
stem cell differentiation GO:0048863 117 0.019
nucleotide metabolic process GO:0009117 161 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.019
regulation of nucleotide metabolic process GO:0006140 62 0.019
pole cell formation GO:0007279 19 0.019
cellular protein catabolic process GO:0044257 83 0.019
ovarian follicle cell development GO:0030707 248 0.019
negative regulation of rna metabolic process GO:0051253 251 0.019
organic cyclic compound catabolic process GO:1901361 168 0.018
negative regulation of cell communication GO:0010648 223 0.018
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
positive regulation of organelle organization GO:0010638 65 0.018
regulation of cellular localization GO:0060341 136 0.018
negative regulation of cell cycle GO:0045786 116 0.018
purine ribonucleotide metabolic process GO:0009150 145 0.018
ribonucleoside triphosphate catabolic process GO:0009203 108 0.017
protein ubiquitination GO:0016567 70 0.017
regulation of programmed cell death GO:0043067 152 0.017
protein complex biogenesis GO:0070271 201 0.017
aromatic compound catabolic process GO:0019439 166 0.017
nitrogen compound transport GO:0071705 85 0.017
mitotic g2 m transition checkpoint GO:0044818 70 0.017
mitotic dna integrity checkpoint GO:0044774 75 0.016
organophosphate catabolic process GO:0046434 112 0.016
nucleocytoplasmic transport GO:0006913 72 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.016
regulation of apoptotic process GO:0042981 130 0.016
regulation of ras protein signal transduction GO:0046578 93 0.016
guanosine containing compound catabolic process GO:1901069 74 0.016
nuclear pore organization GO:0006999 1 0.016
protein modification by small protein conjugation or removal GO:0070647 106 0.016
chemotaxis GO:0006935 249 0.016
ribonucleoside metabolic process GO:0009119 127 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.015
regulation of protein phosphorylation GO:0001932 64 0.015
regulation of cytoplasmic transport GO:1903649 47 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
regulation of transferase activity GO:0051338 58 0.015
cell fate determination GO:0001709 91 0.014
single organism biosynthetic process GO:0044711 206 0.014
photoreceptor cell differentiation GO:0046530 170 0.014
response to other organism GO:0051707 293 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
cell maturation GO:0048469 144 0.014
nucleus organization GO:0006997 45 0.014
regulation of chromosome organization GO:0033044 64 0.014
cellular response to organic substance GO:0071310 132 0.014
regulation of protein modification process GO:0031399 112 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
gene silencing GO:0016458 138 0.014
axis specification GO:0009798 167 0.014
taxis GO:0042330 304 0.014
regulation of protein catabolic process GO:0042176 55 0.014
negative regulation of developmental process GO:0051093 201 0.014
gland morphogenesis GO:0022612 145 0.013
mitotic cell cycle checkpoint GO:0007093 88 0.013
regulation of immune effector process GO:0002697 52 0.013
protein modification by small protein conjugation GO:0032446 79 0.013
response to nitrogen compound GO:1901698 90 0.013
multicellular organismal aging GO:0010259 140 0.013
Worm
regulation of establishment of protein localization GO:0070201 61 0.012
macromolecule methylation GO:0043414 45 0.012
cell motility GO:0048870 251 0.012
Worm
cellular amine metabolic process GO:0044106 12 0.012
mapk cascade GO:0000165 107 0.012
response to organic substance GO:0010033 284 0.012
jak stat cascade GO:0007259 49 0.012
stem cell maintenance GO:0019827 67 0.012
salivary gland development GO:0007431 162 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
regulation of kinase activity GO:0043549 53 0.012
cellular ketone metabolic process GO:0042180 24 0.012
regulation of cell size GO:0008361 63 0.012
negative regulation of signal transduction GO:0009968 206 0.012
exocrine system development GO:0035272 162 0.012
circulatory system process GO:0003013 37 0.012
protein targeting GO:0006605 64 0.012
regulation of defense response GO:0031347 102 0.012
gland development GO:0048732 191 0.012
macromolecular complex assembly GO:0065003 256 0.012
negative regulation of cell differentiation GO:0045596 143 0.011
amine metabolic process GO:0009308 12 0.011
regulation of purine nucleotide catabolic process GO:0033121 48 0.011
nucleobase containing compound transport GO:0015931 56 0.011
imaginal disc derived appendage development GO:0048737 399 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.011
regulation of organelle organization GO:0033043 196 0.011
cellular response to nitrogen compound GO:1901699 51 0.011
aging GO:0007568 143 0.011
Worm
dna packaging GO:0006323 91 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
establishment of tissue polarity GO:0007164 87 0.011
autophagic cell death GO:0048102 83 0.011
regulation of protein kinase activity GO:0045859 51 0.011
regulation of developmental growth GO:0048638 174 0.011
salivary gland morphogenesis GO:0007435 145 0.010
regulation of multi organism process GO:0043900 131 0.010
regulation of protein localization to nucleus GO:1900180 29 0.010
regulation of nucleoside metabolic process GO:0009118 50 0.010

Sym disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.011