Drosophila melanogaster

0 known processes

CG4194 (Dmel_CG4194)

CG4194 gene product from transcript CG4194-RA

(Aliases: Dmel\CG4194,EG:22E5.6)

CG4194 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
developmental growth GO:0048589 280 0.151
response to abiotic stimulus GO:0009628 341 0.103
epithelial cell development GO:0002064 274 0.097
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.089
establishment of localization in cell GO:0051649 402 0.089
endosomal transport GO:0016197 44 0.088
ovarian follicle cell development GO:0030707 248 0.087
small molecule metabolic process GO:0044281 305 0.086
notch signaling pathway GO:0007219 120 0.085
homeostatic process GO:0042592 199 0.079
columnar cuboidal epithelial cell development GO:0002066 249 0.075
single organism intracellular transport GO:1902582 207 0.073
intracellular transport GO:0046907 228 0.072
epithelial cell differentiation GO:0030855 322 0.071
growth GO:0040007 359 0.064
salivary gland morphogenesis GO:0007435 145 0.063
exocrine system development GO:0035272 162 0.062
salivary gland development GO:0007431 162 0.061
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.058
post embryonic appendage morphogenesis GO:0035120 385 0.058
imaginal disc derived appendage development GO:0048737 399 0.052
regulation of notch signaling pathway GO:0008593 100 0.050
endomembrane system organization GO:0010256 119 0.050
regulation of multicellular organismal development GO:2000026 414 0.050
carboxylic acid metabolic process GO:0019752 92 0.048
gland morphogenesis GO:0022612 145 0.048
positive regulation of biosynthetic process GO:0009891 316 0.047
organic acid metabolic process GO:0006082 103 0.046
organonitrogen compound metabolic process GO:1901564 318 0.045
regulation of nervous system development GO:0051960 248 0.044
imaginal disc derived appendage morphogenesis GO:0035114 395 0.043
eye photoreceptor cell differentiation GO:0001754 145 0.042
regionalization GO:0003002 416 0.041
single organism biosynthetic process GO:0044711 206 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.041
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.040
cellular homeostasis GO:0019725 80 0.040
mating GO:0007618 120 0.039
response to decreased oxygen levels GO:0036293 58 0.039
embryonic morphogenesis GO:0048598 206 0.038
tube development GO:0035295 244 0.038
organ growth GO:0035265 56 0.037
appendage development GO:0048736 401 0.037
cell cell signaling involved in cell fate commitment GO:0045168 210 0.037
transcription from rna polymerase ii promoter GO:0006366 368 0.037
border follicle cell migration GO:0007298 113 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.036
wing disc morphogenesis GO:0007472 344 0.036
respiratory system development GO:0060541 213 0.035
body morphogenesis GO:0010171 2 0.035
forebrain development GO:0030900 2 0.035
tube morphogenesis GO:0035239 191 0.035
localization of cell GO:0051674 257 0.034
detection of stimulus GO:0051606 156 0.034
positive regulation of gene expression GO:0010628 290 0.034
regulation of neuron differentiation GO:0045664 103 0.034
regulation of cell differentiation GO:0045595 302 0.034
regulation of localization GO:0032879 275 0.033
positive regulation of transcription dna templated GO:0045893 266 0.033
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.033
cell migration GO:0016477 238 0.033
organophosphate metabolic process GO:0019637 195 0.032
dendrite development GO:0016358 204 0.032
positive regulation of cellular biosynthetic process GO:0031328 316 0.032
gland development GO:0048732 191 0.032
cellular chemical homeostasis GO:0055082 40 0.031
photoreceptor cell differentiation GO:0046530 170 0.031
positive regulation of nucleic acid templated transcription GO:1903508 266 0.030
positive regulation of macromolecule metabolic process GO:0010604 405 0.030
ameboidal type cell migration GO:0001667 151 0.030
taxis GO:0042330 304 0.030
chemical homeostasis GO:0048878 92 0.030
regulation of anatomical structure morphogenesis GO:0022603 242 0.029
eggshell formation GO:0030703 105 0.029
mesoderm development GO:0007498 78 0.029
chemotaxis GO:0006935 249 0.029
neurological system process GO:0050877 358 0.028
epithelial cell migration GO:0010631 148 0.028
tissue migration GO:0090130 155 0.028
response to oxygen levels GO:0070482 59 0.028
response to oxygen containing compound GO:1901700 200 0.028
endocytosis GO:0006897 310 0.028
segmentation GO:0035282 207 0.027
organic substance transport GO:0071702 257 0.027
organic substance catabolic process GO:1901575 308 0.027
locomotory behavior GO:0007626 176 0.027
cellular ion homeostasis GO:0006873 39 0.027
epithelium migration GO:0090132 148 0.027
catabolic process GO:0009056 409 0.027
single organism catabolic process GO:0044712 228 0.026
tissue morphogenesis GO:0048729 297 0.026
compound eye development GO:0048749 307 0.026
organonitrogen compound biosynthetic process GO:1901566 117 0.026
regulation of anatomical structure size GO:0090066 163 0.026
regulation of neurogenesis GO:0050767 158 0.026
lipid metabolic process GO:0006629 121 0.026
imaginal disc derived wing morphogenesis GO:0007476 337 0.026
sensory organ morphogenesis GO:0090596 260 0.025
vesicle mediated transport GO:0016192 381 0.025
anatomical structure homeostasis GO:0060249 97 0.025
digestive tract development GO:0048565 149 0.025
central nervous system development GO:0007417 201 0.025
nuclear division GO:0000280 332 0.025
regulation of cell development GO:0060284 215 0.025
regulation of developmental growth GO:0048638 174 0.025
positive regulation of rna biosynthetic process GO:1902680 266 0.025
positive regulation of rna metabolic process GO:0051254 271 0.024
response to other organism GO:0051707 293 0.024
response to lipopolysaccharide GO:0032496 4 0.024
cell maturation GO:0048469 144 0.024
appendage morphogenesis GO:0035107 397 0.024
camera type eye development GO:0043010 4 0.024
cellular response to dna damage stimulus GO:0006974 223 0.024
cellular response to chemical stimulus GO:0070887 199 0.024
regulation of cell cycle GO:0051726 291 0.024
synaptic transmission GO:0007268 288 0.023
detection of chemical stimulus GO:0009593 93 0.023
androgen metabolic process GO:0008209 1 0.023
phagocytosis GO:0006909 215 0.023
ion homeostasis GO:0050801 55 0.023
lateral inhibition GO:0046331 206 0.023
cellular protein modification process GO:0006464 438 0.023
cellular lipid metabolic process GO:0044255 83 0.023
organelle fission GO:0048285 340 0.023
regulation of molecular function GO:0065009 217 0.022
eye development GO:0001654 323 0.022
cellular catabolic process GO:0044248 372 0.022
connective tissue development GO:0061448 3 0.021
oxoacid metabolic process GO:0043436 103 0.021
positive regulation of molecular function GO:0044093 136 0.021
carbohydrate derivative metabolic process GO:1901135 217 0.021
nucleoside phosphate metabolic process GO:0006753 162 0.021
regulation of cell projection organization GO:0031344 92 0.021
blastoderm segmentation GO:0007350 159 0.021
embryonic pattern specification GO:0009880 174 0.021
ribose phosphate metabolic process GO:0019693 145 0.021
eye morphogenesis GO:0048592 260 0.021
regulation of response to stress GO:0080134 200 0.021
compound eye morphogenesis GO:0001745 249 0.021
positive regulation of cell communication GO:0010647 250 0.021
dendrite morphogenesis GO:0048813 199 0.021
cellular response to decreased oxygen levels GO:0036294 30 0.021
cell motility GO:0048870 251 0.021
immune response GO:0006955 246 0.020
open tracheal system development GO:0007424 204 0.020
eye photoreceptor cell development GO:0042462 81 0.020
positive regulation of transport GO:0051050 92 0.020
reproductive behavior GO:0019098 122 0.020
hindbrain development GO:0030902 2 0.020
myotube cell development GO:0014904 3 0.020
cell division GO:0051301 248 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
response to monosaccharide GO:0034284 4 0.020
secondary metabolic process GO:0019748 75 0.020
cellular amino acid metabolic process GO:0006520 61 0.020
positive regulation of signaling GO:0023056 243 0.020
regulation of cellular amine metabolic process GO:0033238 3 0.019
intracellular signal transduction GO:0035556 300 0.019
head development GO:0060322 135 0.019
cell cycle phase transition GO:0044770 140 0.019
regulation of transport GO:0051049 181 0.019
secretion by cell GO:0032940 101 0.019
regulation of cellular ketone metabolic process GO:0010565 3 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
cellular macromolecule localization GO:0070727 220 0.019
telencephalon development GO:0021537 2 0.019
programmed cell death GO:0012501 257 0.019
embryonic organ development GO:0048568 50 0.019
morphogenesis of an epithelium GO:0002009 276 0.019
digestive tract morphogenesis GO:0048546 127 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
oxidation reduction process GO:0055114 123 0.019
immune system process GO:0002376 347 0.019
response to starvation GO:0042594 97 0.019
ovarian follicle cell migration GO:0007297 121 0.018
purine nucleotide metabolic process GO:0006163 146 0.018
brain development GO:0007420 120 0.018
actin filament based process GO:0030029 220 0.018
spermatogenesis GO:0007283 200 0.018
cellular cation homeostasis GO:0030003 38 0.018
intracellular protein transport GO:0006886 104 0.018
regulation of cellular component biogenesis GO:0044087 201 0.018
secretion GO:0046903 109 0.018
cellular component assembly involved in morphogenesis GO:0010927 151 0.018
regulation of catalytic activity GO:0050790 185 0.018
photoreceptor cell development GO:0042461 96 0.018
digestive system development GO:0055123 149 0.018
carbohydrate derivative biosynthetic process GO:1901137 85 0.018
negative regulation of signaling GO:0023057 219 0.018
axis specification GO:0009798 167 0.018
steroid catabolic process GO:0006706 1 0.018
cellular amine metabolic process GO:0044106 12 0.018
chromosome organization GO:0051276 360 0.018
response to organophosphorus GO:0046683 2 0.018
nucleotide metabolic process GO:0009117 161 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
female meiotic division GO:0007143 70 0.017
cation transmembrane transport GO:0098655 88 0.017
purine ribonucleotide metabolic process GO:0009150 145 0.017
response to nutrient levels GO:0031667 114 0.017
organic cyclic compound catabolic process GO:1901361 168 0.017
developmental maturation GO:0021700 172 0.017
regulation of mitotic cell cycle GO:0007346 190 0.017
negative regulation of developmental process GO:0051093 201 0.017
response to biotic stimulus GO:0009607 294 0.017
negative regulation of cell communication GO:0010648 223 0.017
aromatic compound catabolic process GO:0019439 166 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
tissue death GO:0016271 102 0.017
regulation of cell cycle process GO:0010564 181 0.017
cation homeostasis GO:0055080 51 0.017
amine metabolic process GO:0009308 12 0.016
ethanolamine containing compound metabolic process GO:0042439 4 0.016
macromolecular complex assembly GO:0065003 256 0.016
multi organism behavior GO:0051705 175 0.016
mitotic cell cycle phase transition GO:0044772 138 0.016
cellular response to oxygen levels GO:0071453 30 0.016
vitamin metabolic process GO:0006766 2 0.016
protein localization GO:0008104 284 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
cellular response to hexose stimulus GO:0071331 1 0.016
response to external biotic stimulus GO:0043207 293 0.016
regulation of embryonic development GO:0045995 68 0.016
single organism behavior GO:0044708 391 0.016
heterocycle catabolic process GO:0046700 166 0.016
response to hexose GO:0009746 3 0.016
developmental programmed cell death GO:0010623 138 0.016
cell adhesion GO:0007155 136 0.016
synapse organization GO:0050808 196 0.016
response to extracellular stimulus GO:0009991 116 0.015
cell proliferation GO:0008283 299 0.015
chorion containing eggshell formation GO:0007304 105 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
stem cell proliferation GO:0072089 88 0.015
compound eye photoreceptor cell differentiation GO:0001751 140 0.015
regulation of neuron projection development GO:0010975 69 0.015
protein complex assembly GO:0006461 200 0.015
neuron projection guidance GO:0097485 241 0.015
dorsal ventral pattern formation GO:0009953 133 0.015
positive regulation of exocytosis GO:0045921 4 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.015
biological adhesion GO:0022610 138 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
regulation of growth GO:0040008 233 0.015
embryonic development via the syncytial blastoderm GO:0001700 148 0.015
regulation of synapse structure and activity GO:0050803 128 0.015
nucleobase containing compound catabolic process GO:0034655 165 0.015
defense response GO:0006952 300 0.015
negative regulation of gene expression GO:0010629 387 0.015
salivary gland histolysis GO:0035070 88 0.015
anterior posterior axis specification embryo GO:0008595 103 0.015
regulation of cell morphogenesis GO:0022604 163 0.015
salivary gland cell autophagic cell death GO:0035071 83 0.015
g protein coupled receptor signaling pathway GO:0007186 136 0.015
membrane organization GO:0061024 112 0.015
sensory perception of smell GO:0007608 80 0.015
xenobiotic catabolic process GO:0042178 1 0.014
regulation of synaptic transmission GO:0050804 69 0.014
cell recognition GO:0008037 102 0.014
kidney development GO:0001822 3 0.014
protein modification process GO:0036211 438 0.014
regulation of production of molecular mediator of immune response GO:0002700 44 0.014
axon guidance GO:0007411 233 0.014
proteolysis GO:0006508 192 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
regulation of epithelial cell differentiation GO:0030856 4 0.014
establishment of tissue polarity GO:0007164 87 0.014
exocytosis GO:0006887 28 0.014
phosphorylation GO:0016310 294 0.014
cellular amide metabolic process GO:0043603 80 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
positive regulation of signal transduction GO:0009967 223 0.014
protein complex biogenesis GO:0070271 201 0.014
humoral immune response GO:0006959 117 0.014
negative regulation of cell cycle process GO:0010948 109 0.014
anterior posterior pattern specification GO:0009952 136 0.014
retina development in camera type eye GO:0060041 4 0.014
rna localization GO:0006403 115 0.014
organophosphate catabolic process GO:0046434 112 0.014
autophagic cell death GO:0048102 83 0.014
metal ion transport GO:0030001 74 0.014
chromosome segregation GO:0007059 157 0.014
response to temperature stimulus GO:0009266 106 0.014
protein transport GO:0015031 155 0.014
actin cytoskeleton organization GO:0030036 206 0.014
cellular ketone metabolic process GO:0042180 24 0.013
regulation of cellular localization GO:0060341 136 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
regulation of response to external stimulus GO:0032101 115 0.013
histolysis GO:0007559 102 0.013
muscle structure development GO:0061061 224 0.013
positive regulation of multicellular organismal process GO:0051240 143 0.013
purine containing compound metabolic process GO:0072521 155 0.013
positive regulation of developmental process GO:0051094 143 0.013
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.013
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.013
intracellular ph reduction GO:0051452 7 0.013
death GO:0016265 284 0.013
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
cellular response to carbohydrate stimulus GO:0071322 4 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
spindle organization GO:0007051 253 0.013
regulation of organelle organization GO:0033043 196 0.013
cell death GO:0008219 279 0.013
spinal cord development GO:0021510 1 0.013
striated muscle cell development GO:0055002 50 0.013
response to bacterium GO:0009617 198 0.013
tripartite regional subdivision GO:0007351 103 0.013
antimicrobial humoral response GO:0019730 99 0.013
estrogen metabolic process GO:0008210 1 0.013
gene silencing GO:0016458 138 0.013
response to organic substance GO:0010033 284 0.013
chromatin organization GO:0006325 207 0.013
sensory perception GO:0007600 196 0.013
male courtship behavior GO:0008049 63 0.012
peptide metabolic process GO:0006518 80 0.012
anterior posterior axis specification GO:0009948 109 0.012
axon development GO:0061564 297 0.012
compound eye photoreceptor development GO:0042051 78 0.012
positive regulation of cell migration GO:0030335 2 0.012
positive regulation of response to external stimulus GO:0032103 44 0.012
regulation of membrane potential GO:0042391 35 0.012
protein heterooligomerization GO:0051291 4 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
regulation of catabolic process GO:0009894 170 0.012
negative regulation of cellular metabolic process GO:0031324 382 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
cellular response to monosaccharide stimulus GO:0071326 2 0.012
cytoplasmic transport GO:0016482 130 0.012
cholesterol transport GO:0030301 2 0.012
mesodermal cell migration GO:0008078 7 0.012
hindgut development GO:0061525 58 0.012
pigment metabolic process GO:0042440 84 0.012
cellular protein localization GO:0034613 160 0.012
male mating behavior GO:0060179 70 0.012
response to light stimulus GO:0009416 124 0.012
chromatin modification GO:0016568 147 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
positive regulation of secretion GO:0051047 22 0.012
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.012
hormone catabolic process GO:0042447 3 0.012
imaginal disc derived wing hair organization GO:0035317 45 0.012
limb development GO:0060173 1 0.012
embryonic hindgut morphogenesis GO:0048619 48 0.012
defense response to bacterium GO:0042742 178 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.012
hindgut morphogenesis GO:0007442 58 0.012
neuropeptide signaling pathway GO:0007218 45 0.012
peptidyl amino acid modification GO:0018193 105 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
courtship behavior GO:0007619 68 0.012
nephron development GO:0072006 3 0.012
regulation of gene expression epigenetic GO:0040029 128 0.012
nitrogen compound transport GO:0071705 85 0.012
gastrulation GO:0007369 70 0.012
embryonic axis specification GO:0000578 107 0.012
cation transport GO:0006812 110 0.012
malpighian tubule development GO:0072002 64 0.012
mitotic nuclear division GO:0007067 213 0.012
signal release GO:0023061 49 0.012
regulation of protein metabolic process GO:0051246 256 0.012
organonitrogen compound catabolic process GO:1901565 128 0.012
positive regulation of cellular component organization GO:0051130 156 0.011
response to radiation GO:0009314 155 0.011
response to alcohol GO:0097305 95 0.011
ion transport GO:0006811 145 0.011
negative regulation of cellular biosynthetic process GO:0031327 277 0.011
cellular response to organic substance GO:0071310 132 0.011
muscle fiber development GO:0048747 12 0.011
innate immune response GO:0045087 144 0.011
tissue homeostasis GO:0001894 36 0.011
chaeta development GO:0022416 97 0.011
regulation of immune system process GO:0002682 176 0.011
negative regulation of response to stimulus GO:0048585 258 0.011
monovalent inorganic cation homeostasis GO:0055067 7 0.011
mesenchymal cell development GO:0014031 1 0.011
wnt signaling pathway GO:0016055 98 0.011
cell cell junction organization GO:0045216 55 0.011
cholesterol homeostasis GO:0042632 3 0.011
establishment of protein localization GO:0045184 163 0.011
regulation of organ morphogenesis GO:2000027 78 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
negative regulation of biosynthetic process GO:0009890 277 0.011
morphogenesis of a polarized epithelium GO:0001738 93 0.011
hair cell differentiation GO:0035315 47 0.011
cellular response to hypoxia GO:0071456 28 0.011
macromolecule catabolic process GO:0009057 161 0.011
somatic muscle development GO:0007525 66 0.011
maintenance of location GO:0051235 73 0.011
protein phosphorylation GO:0006468 169 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
antimicrobial peptide production GO:0002775 46 0.011
axonogenesis GO:0007409 290 0.011
detection of stimulus involved in sensory perception GO:0050906 92 0.011
benzene containing compound metabolic process GO:0042537 3 0.011
regulation of cellular response to stress GO:0080135 89 0.011
single organism cellular localization GO:1902580 180 0.011
synapse assembly GO:0007416 143 0.011
striated muscle cell differentiation GO:0051146 90 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
regulation of cell substrate adhesion GO:0010810 2 0.011
fat soluble vitamin metabolic process GO:0006775 1 0.011
establishment or maintenance of cell polarity GO:0007163 167 0.011
multicellular organismal homeostasis GO:0048871 41 0.011
locomotor rhythm GO:0045475 56 0.011
segment specification GO:0007379 33 0.011
olfactory behavior GO:0042048 97 0.011
neural precursor cell proliferation GO:0061351 75 0.011
regulation of behavior GO:0050795 75 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
establishment of planar polarity GO:0001736 87 0.010
purine ribonucleotide catabolic process GO:0009154 109 0.010
dna metabolic process GO:0006259 227 0.010
defense response to other organism GO:0098542 225 0.010
negative regulation of nucleic acid templated transcription GO:1903507 240 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.010
response to copper ion GO:0046688 4 0.010
heart development GO:0007507 82 0.010
limb morphogenesis GO:0035108 1 0.010
positive regulation of developmental growth GO:0048639 62 0.010
cellular response to extracellular stimulus GO:0031668 64 0.010
skeletal muscle fiber development GO:0048741 3 0.010
eggshell chorion assembly GO:0007306 66 0.010
pattern recognition receptor signaling pathway GO:0002221 2 0.010
positive regulation of cell motility GO:2000147 3 0.010
sensory perception of chemical stimulus GO:0007606 116 0.010
regulation of vesicle mediated transport GO:0060627 59 0.010
posttranscriptional regulation of gene expression GO:0010608 145 0.010
immune response activating signal transduction GO:0002757 2 0.010
hematopoietic progenitor cell differentiation GO:0002244 1 0.010
negative regulation of cell cycle phase transition GO:1901988 103 0.010

CG4194 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.077
nervous system disease DOID:863 0 0.042
disease of metabolism DOID:0014667 0 0.030
sensory system disease DOID:0050155 0 0.029
eye and adnexa disease DOID:1492 0 0.029
eye disease DOID:5614 0 0.027
inherited metabolic disorder DOID:655 0 0.019
acquired metabolic disease DOID:0060158 0 0.017
carbohydrate metabolism disease DOID:0050013 0 0.016
diabetes mellitus DOID:9351 0 0.014
type 2 diabetes mellitus DOID:9352 0 0.014
glucose metabolism disease DOID:4194 0 0.014