Drosophila melanogaster

96 known processes

Tip60 (Dmel_CG6121)

CG6121 gene product from transcript CG6121-RA

(Aliases: CG6121,EG:EG0007.7,dmHAG405,Dmel\TIP60,Dmel\CG6121,dTip60,Dmel/TIP60,6121,EG0007.7,dTIP60,DmEG0007.7)

Tip60 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular metabolic process GO:0031324 382 0.947
negative regulation of cellular biosynthetic process GO:0031327 277 0.895
negative regulation of transcription dna templated GO:0045892 237 0.833
negative regulation of nucleic acid templated transcription GO:1903507 240 0.717
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.713
positive regulation of developmental growth GO:0048639 62 0.663
cytoskeleton dependent cytokinesis GO:0061640 81 0.642
negative regulation of rna biosynthetic process GO:1902679 240 0.519
cytokinesis GO:0000910 90 0.515
negative regulation of rna metabolic process GO:0051253 251 0.444
dna integrity checkpoint GO:0031570 81 0.441
Fly
mitotic cell cycle checkpoint GO:0007093 88 0.439
negative regulation of response to stimulus GO:0048585 258 0.437
regulation of developmental growth GO:0048638 174 0.430
transcription from rna polymerase ii promoter GO:0006366 368 0.382
Mouse Rat
growth GO:0040007 359 0.364
negative regulation of cellular component organization GO:0051129 108 0.360
developmental growth GO:0048589 280 0.351
regulation of cell cycle GO:0051726 291 0.347
protein modification process GO:0036211 438 0.340
protein localization to organelle GO:0033365 82 0.338
Worm
negative regulation of gene expression GO:0010629 387 0.336
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.329
cellular macromolecule catabolic process GO:0044265 136 0.308
regulation of cell cycle process GO:0010564 181 0.306
meiotic cytokinesis GO:0033206 33 0.304
positive regulation of developmental process GO:0051094 143 0.300
cellular protein localization GO:0034613 160 0.296
Worm
mitotic g2 m transition checkpoint GO:0044818 70 0.292
positive regulation of cell communication GO:0010647 250 0.281
regulation of mitotic cell cycle GO:0007346 190 0.279
cell death GO:0008219 279 0.276
regulation of anatomical structure morphogenesis GO:0022603 242 0.276
cellular protein modification process GO:0006464 438 0.275
multi organism behavior GO:0051705 175 0.274
catabolic process GO:0009056 409 0.274
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.269
dendrite development GO:0016358 204 0.264
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.261
positive regulation of multicellular organism growth GO:0040018 21 0.258
modification dependent protein catabolic process GO:0019941 78 0.257
meiotic nuclear division GO:0007126 151 0.251
mitotic cell cycle phase transition GO:0044772 138 0.250
positive regulation of response to stimulus GO:0048584 323 0.234
establishment or maintenance of cell polarity GO:0007163 167 0.230
meiotic cell cycle GO:0051321 171 0.230
organelle fission GO:0048285 340 0.218
organic substance catabolic process GO:1901575 308 0.210
modification dependent macromolecule catabolic process GO:0043632 79 0.208
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.203
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.200
Mouse Rat
g2 dna damage checkpoint GO:0031572 69 0.194
positive regulation of multicellular organismal process GO:0051240 143 0.192
dna damage checkpoint GO:0000077 78 0.188
Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.187
Mouse Rat
mitotic g2 dna damage checkpoint GO:0007095 69 0.183
negative regulation of protein tyrosine kinase activity GO:0061099 5 0.181
protein localization GO:0008104 284 0.180
Worm
regionalization GO:0003002 416 0.177
negative regulation of cell cycle process GO:0010948 109 0.175
positive regulation of transcription dna templated GO:0045893 266 0.170
Mouse Rat
regulation of localization GO:0032879 275 0.166
positive regulation of nucleic acid templated transcription GO:1903508 266 0.164
Mouse Rat
proteolysis GO:0006508 192 0.162
regulation of mitotic cell cycle phase transition GO:1901990 130 0.158
organelle assembly GO:0070925 198 0.158
cellular catabolic process GO:0044248 372 0.156
embryo development ending in birth or egg hatching GO:0009792 152 0.156
Worm
regulation of cell cycle phase transition GO:1901987 130 0.146
negative regulation of cell cycle GO:0045786 116 0.145
proteasomal protein catabolic process GO:0010498 59 0.140
axis specification GO:0009798 167 0.134
chromosome organization GO:0051276 360 0.131
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.131
Mouse Rat
histone modification GO:0016570 106 0.129
nuclear division GO:0000280 332 0.126
regulation of erbb signaling pathway GO:1901184 42 0.122
positive regulation of growth GO:0045927 75 0.122
organic substance transport GO:0071702 257 0.122
regulation of multicellular organismal development GO:2000026 414 0.119
Worm
mitotic cytokinesis GO:0000281 50 0.117
cellular protein catabolic process GO:0044257 83 0.116
phosphorylation GO:0016310 294 0.114
response to organic substance GO:0010033 284 0.114
cell cycle phase transition GO:0044770 140 0.113
multi organism reproductive behavior GO:0044705 121 0.111
negative regulation of nervous system development GO:0051961 92 0.107
peptidyl amino acid modification GO:0018193 105 0.106
negative regulation of signaling GO:0023057 219 0.103
positive regulation of cellular biosynthetic process GO:0031328 316 0.101
Mouse Rat
mitotic dna integrity checkpoint GO:0044774 75 0.097
macromolecular complex assembly GO:0065003 256 0.095
macromolecule catabolic process GO:0009057 161 0.093
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.093
regulation of protein deacetylation GO:0090311 2 0.093
regulation of programmed cell death GO:0043067 152 0.087
single organism behavior GO:0044708 391 0.087
ubiquitin dependent protein catabolic process GO:0006511 78 0.085
multicellular organismal aging GO:0010259 140 0.085
cellular macromolecule localization GO:0070727 220 0.084
Worm
synapse assembly GO:0007416 143 0.083
positive regulation of signaling GO:0023056 243 0.081
protein import GO:0017038 55 0.079
programmed cell death GO:0012501 257 0.079
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.077
regulation of cell differentiation GO:0045595 302 0.076
protein acetylation GO:0006473 39 0.076
developmental maturation GO:0021700 172 0.075
female meiotic division GO:0007143 70 0.075
regulation of cell shape GO:0008360 113 0.073
macromolecule deacylation GO:0098732 11 0.072
notch signaling pathway GO:0007219 120 0.072
negative regulation of cell cycle phase transition GO:1901988 103 0.071
protein phosphorylation GO:0006468 169 0.070
appendage morphogenesis GO:0035107 397 0.067
positive regulation of signal transduction GO:0009967 223 0.066
organic acid metabolic process GO:0006082 103 0.066
cytokinetic process GO:0032506 27 0.064
regulation of cellular component biogenesis GO:0044087 201 0.062
protein catabolic process GO:0030163 101 0.061
male meiosis cytokinesis GO:0007112 26 0.061
cell maturation GO:0048469 144 0.061
positive regulation of cellular component organization GO:0051130 156 0.061
negative regulation of cell communication GO:0010648 223 0.061
positive regulation of nervous system development GO:0051962 69 0.059
protein localization to nucleus GO:0034504 55 0.059
intracellular transport GO:0046907 228 0.059
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.058
regulation of cell development GO:0060284 215 0.056
larval development GO:0002164 104 0.055
Worm
body morphogenesis GO:0010171 2 0.055
Worm
oxoacid metabolic process GO:0043436 103 0.055
carboxylic acid metabolic process GO:0019752 92 0.054
cell division GO:0051301 248 0.053
morphogenesis of a branching epithelium GO:0061138 45 0.051
histone h4 k16 acetylation GO:0043984 4 0.051
Fly
mitotic nuclear division GO:0007067 213 0.051
regulation of cellular protein metabolic process GO:0032268 243 0.050
Fly
segmentation GO:0035282 207 0.049
regulation of growth GO:0040008 233 0.048
negative regulation of protein metabolic process GO:0051248 85 0.046
negative regulation of signal transduction GO:0009968 206 0.046
gene silencing GO:0016458 138 0.045
establishment of localization in cell GO:0051649 402 0.045
negative regulation of gene expression epigenetic GO:0045814 77 0.045
chromatin silencing GO:0006342 76 0.045
protein localization to peroxisome GO:0072662 2 0.045
negative regulation of phosphorus metabolic process GO:0010563 45 0.044
compound eye development GO:0048749 307 0.043
regulation of phosphorylation GO:0042325 147 0.043
negative regulation of biosynthetic process GO:0009890 277 0.042
negative regulation of multicellular organismal process GO:0051241 142 0.042
Worm
positive regulation of transport GO:0051050 92 0.042
positive regulation of rna metabolic process GO:0051254 271 0.041
Mouse Rat
multicellular organismal reproductive behavior GO:0033057 110 0.041
reproductive structure development GO:0048608 74 0.041
regulation of response to stress GO:0080134 200 0.040
Fly
protein acylation GO:0043543 42 0.040
histone h3 k9 acetylation GO:0043970 3 0.039
maintenance of protein location GO:0045185 28 0.038
regulation of response to external stimulus GO:0032101 115 0.038
maintenance of location in cell GO:0051651 28 0.038
protein targeting GO:0006605 64 0.037
cognition GO:0050890 141 0.037
embryonic axis specification GO:0000578 107 0.036
mitotic dna damage checkpoint GO:0044773 74 0.036
determination of adult lifespan GO:0008340 137 0.036
cellular macromolecular complex assembly GO:0034622 153 0.035
lipid metabolic process GO:0006629 121 0.035
protein complex biogenesis GO:0070271 201 0.035
protein complex assembly GO:0006461 200 0.034
regulation of wnt signaling pathway GO:0030111 68 0.034
cellular response to chemical stimulus GO:0070887 199 0.034
Rat
reproductive system development GO:0061458 74 0.034
synapse organization GO:0050808 196 0.033
appendage development GO:0048736 401 0.033
regulation of synapse organization GO:0050807 110 0.033
microtubule based movement GO:0007018 51 0.033
positive regulation of autophagy GO:0010508 21 0.033
negative regulation of mitotic cell cycle GO:0045930 109 0.032
negative regulation of receptor activity GO:2000272 3 0.031
reproductive behavior GO:0019098 122 0.031
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.030
Mouse Rat
muscle structure development GO:0061061 224 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.030
intracellular signal transduction GO:0035556 300 0.030
Fly
autophagy GO:0006914 108 0.030
larval midgut cell programmed cell death GO:0035096 19 0.029
regulation of phosphate metabolic process GO:0019220 210 0.029
imaginal disc derived wing morphogenesis GO:0007476 337 0.028
nucleotide excision repair GO:0006289 8 0.028
regulation of cell morphogenesis GO:0022604 163 0.028
phagocytosis GO:0006909 215 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.028
cell cycle checkpoint GO:0000075 95 0.028
Fly
death GO:0016265 284 0.027
protein ubiquitination GO:0016567 70 0.027
embryonic pattern specification GO:0009880 174 0.027
peptidyl lysine acetylation GO:0018394 39 0.027
regulation of dendrite development GO:0050773 37 0.027
single organism cellular localization GO:1902580 180 0.027
protein transport GO:0015031 155 0.026
positive regulation of biosynthetic process GO:0009891 316 0.026
Mouse Rat
response to nutrient levels GO:0031667 114 0.026
negative regulation of apoptotic process GO:0043066 63 0.025
meiotic cell cycle process GO:1903046 132 0.025
cellular response to starvation GO:0009267 61 0.025
negative regulation of molecular function GO:0044092 51 0.025
imaginal disc derived appendage development GO:0048737 399 0.024
anatomical structure homeostasis GO:0060249 97 0.024
neuroblast proliferation GO:0007405 74 0.024
cytoplasmic transport GO:0016482 130 0.024
negative regulation of neurogenesis GO:0050768 53 0.023
negative regulation of developmental process GO:0051093 201 0.023
Worm
regulation of cellular protein catabolic process GO:1903362 44 0.023
regulation of synapse structure and activity GO:0050803 128 0.023
negative regulation of organelle organization GO:0010639 56 0.023
gliogenesis GO:0042063 80 0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.023
negative regulation of erbb signaling pathway GO:1901185 29 0.022
single organism intracellular transport GO:1902582 207 0.022
macroautophagy GO:0016236 42 0.022
response to organic cyclic compound GO:0014070 89 0.022
regulation of proteolysis GO:0030162 87 0.022
compound eye morphogenesis GO:0001745 249 0.022
skeletal muscle fiber development GO:0048741 3 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.022
Mouse Rat
regulation of neuron projection development GO:0010975 69 0.021
oviposition GO:0018991 19 0.021
protein processing GO:0016485 68 0.021
apoptotic signaling pathway GO:0097190 27 0.021
positive regulation of protein deacetylation GO:0090312 2 0.021
response to external biotic stimulus GO:0043207 293 0.020
cell proliferation GO:0008283 299 0.020
blastoderm segmentation GO:0007350 159 0.020
multicellular organism growth GO:0035264 46 0.020
regulation of chromosome organization GO:0033044 64 0.020
Fly
male gamete generation GO:0048232 201 0.020
development of primary sexual characteristics GO:0045137 50 0.020
regulation of cellular response to stress GO:0080135 89 0.019
Fly
covalent chromatin modification GO:0016569 106 0.019
dendrite morphogenesis GO:0048813 199 0.019
negative regulation of cellular protein metabolic process GO:0032269 85 0.019
regulation of neurogenesis GO:0050767 158 0.019
negative regulation of phosphate metabolic process GO:0045936 45 0.019
regulation of molecular function GO:0065009 217 0.019
Fly
response to extracellular stimulus GO:0009991 116 0.019
spindle organization GO:0007051 253 0.019
photoreceptor cell development GO:0042461 96 0.018
oocyte construction GO:0007308 112 0.018
establishment of protein localization GO:0045184 163 0.018
regulation of catalytic activity GO:0050790 185 0.018
cellular response to dna damage stimulus GO:0006974 223 0.018
protein maturation GO:0051604 71 0.017
protein modification by small protein conjugation GO:0032446 79 0.017
chromatin organization GO:0006325 207 0.017
regulation of phosphatase activity GO:0010921 3 0.017
autophagic vacuole assembly GO:0000045 2 0.017
nuclear import GO:0051170 51 0.017
single organism catabolic process GO:0044712 228 0.017
regulation of protein metabolic process GO:0051246 256 0.017
Fly
regulation of chromosome segregation GO:0051983 32 0.017
positive regulation of phosphate metabolic process GO:0045937 139 0.017
endocytosis GO:0006897 310 0.017
Worm
regulation of nervous system development GO:0051960 248 0.017
regulation of cellular catabolic process GO:0031329 157 0.017
establishment of protein localization to organelle GO:0072594 62 0.017
somatic stem cell division GO:0048103 37 0.017
response to other organism GO:0051707 293 0.016
regulation of notch signaling pathway GO:0008593 100 0.016
regulation of protein localization to nucleus GO:1900180 29 0.016
anterior posterior axis specification embryo GO:0008595 103 0.016
histone h4 acetylation GO:0043967 13 0.016
development of primary male sexual characteristics GO:0046546 9 0.016
multi multicellular organism process GO:0044706 123 0.016
epithelial tube morphogenesis GO:0060562 88 0.016
imaginal disc derived appendage morphogenesis GO:0035114 395 0.016
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.015
amine metabolic process GO:0009308 12 0.015
regulation of gene expression epigenetic GO:0040029 128 0.015
Fly
oocyte axis specification GO:0007309 108 0.015
positive regulation of response to extracellular stimulus GO:0032106 8 0.015
regulation of protein catabolic process GO:0042176 55 0.015
regulation of cell death GO:0010941 173 0.015
positive regulation of gene expression GO:0010628 290 0.015
Mouse Rat
neuron projection guidance GO:0097485 241 0.015
epidermal growth factor receptor signaling pathway GO:0007173 58 0.015
synaptic growth at neuromuscular junction GO:0051124 119 0.015
cell motility GO:0048870 251 0.015
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.015
erbb signaling pathway GO:0038127 58 0.015
signal transduction in response to dna damage GO:0042770 3 0.015
Fly
mapk cascade GO:0000165 107 0.015
homeostatic process GO:0042592 199 0.014
protein targeting to nucleus GO:0044744 51 0.014
regulation of mitosis GO:0007088 56 0.014
vesicle mediated transport GO:0016192 381 0.014
Worm
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 6 0.014
mrna splice site selection GO:0006376 1 0.014
regulation of phosphorus metabolic process GO:0051174 210 0.014
cell aging GO:0007569 2 0.014
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.014
golgi organization GO:0007030 66 0.014
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.014
negative regulation of protein processing GO:0010955 31 0.013
regulation of transport GO:0051049 181 0.013
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.013
chromatin modification GO:0016568 147 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
negative regulation of ras protein signal transduction GO:0046580 13 0.013
regulation of mapk cascade GO:0043408 92 0.013
morphogenesis of a branching structure GO:0001763 45 0.013
muscle organ development GO:0007517 127 0.013
negative regulation of phosphorylation GO:0042326 35 0.012
regulation of autophagy GO:0010506 62 0.012
protein polyubiquitination GO:0000209 11 0.012
response to light stimulus GO:0009416 124 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
protein import into nucleus GO:0006606 51 0.012
regulation of protein processing GO:0070613 32 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
regulation of hydrolase activity GO:0051336 97 0.012
regulation of catabolic process GO:0009894 170 0.012
imaginal disc derived leg morphogenesis GO:0007480 80 0.012
actin cytoskeleton organization GO:0030036 206 0.012
neurological system process GO:0050877 358 0.012
cellular component assembly involved in morphogenesis GO:0010927 151 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.012
pigment cell differentiation GO:0050931 3 0.012
cellularization GO:0007349 90 0.012
establishment of organelle localization GO:0051656 122 0.011
tube morphogenesis GO:0035239 191 0.011
regulation of epidermal growth factor activated receptor activity GO:0007176 4 0.011
regulation of immune response GO:0050776 118 0.011
developmental pigmentation GO:0048066 68 0.011
oocyte differentiation GO:0009994 145 0.011
regulation of dna metabolic process GO:0051052 34 0.011
regulation of protein tyrosine kinase activity GO:0061097 9 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.011
regulation of locomotion GO:0040012 42 0.011
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 1 0.011
g2 m transition of mitotic cell cycle GO:0000086 19 0.011
nuclear transport GO:0051169 72 0.011
cellular response to external stimulus GO:0071496 66 0.011
myotube cell development GO:0014904 3 0.011
dna templated transcription initiation GO:0006352 25 0.011
tripartite regional subdivision GO:0007351 103 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
molting cycle GO:0042303 56 0.011
response to wounding GO:0009611 94 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
stem cell proliferation GO:0072089 88 0.011
histone h4 k12 acetylation GO:0043983 2 0.010
regulation of cytokinesis GO:0032465 3 0.010
positive regulation of catabolic process GO:0009896 105 0.010
positive regulation of cell cycle process GO:0090068 28 0.010
negative regulation of cell death GO:0060548 81 0.010
sex differentiation GO:0007548 81 0.010
regulation of cell projection organization GO:0031344 92 0.010

Tip60 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.028
disease of cellular proliferation DOID:14566 0 0.023
cancer DOID:162 0 0.022
organ system cancer DOID:0050686 0 0.022