Drosophila melanogaster

44 known processes

pix (Dmel_CG5651)

pixie

(Aliases: E3-c,CG5651,Dmel\CG5651,BEST:GH18088)

pix biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
programmed cell death GO:0012501 257 0.456
cell death GO:0008219 279 0.385
larval development GO:0002164 104 0.205
Worm
translation GO:0006412 69 0.173
spindle elongation GO:0051231 83 0.170
translational initiation GO:0006413 11 0.148
tor signaling GO:0031929 32 0.142
death GO:0016265 284 0.134
telomere organization GO:0032200 21 0.109
negative regulation of response to stimulus GO:0048585 258 0.108
developmental programmed cell death GO:0010623 138 0.072
negative regulation of cell communication GO:0010648 223 0.069
eye photoreceptor cell development GO:0042462 81 0.068
negative regulation of growth GO:0045926 84 0.068
nuclear division GO:0000280 332 0.062
spindle organization GO:0007051 253 0.056
autophagic vacuole assembly GO:0000045 2 0.055
body morphogenesis GO:0010171 2 0.054
Worm
regulation of cell cycle process GO:0010564 181 0.053
mitotic spindle organization GO:0007052 220 0.052
detection of chemical stimulus GO:0009593 93 0.052
cell growth GO:0016049 108 0.051
mitotic cell cycle phase transition GO:0044772 138 0.049
dna metabolic process GO:0006259 227 0.047
eggshell chorion gene amplification GO:0007307 9 0.045
compound eye morphogenesis GO:0001745 249 0.044
growth GO:0040007 359 0.043
regulation of translation GO:0006417 56 0.042
Yeast
epithelial cell development GO:0002064 274 0.041
organelle fission GO:0048285 340 0.041
mitotic nuclear division GO:0007067 213 0.041
regulation of cell morphogenesis GO:0022604 163 0.039
negative regulation of apoptotic process GO:0043066 63 0.039
lipid biosynthetic process GO:0008610 46 0.039
negative regulation of signaling GO:0023057 219 0.038
negative regulation of signal transduction GO:0009968 206 0.037
positive regulation of macromolecule metabolic process GO:0010604 405 0.037
Yeast
negative regulation of cellular metabolic process GO:0031324 382 0.036
cell adhesion GO:0007155 136 0.036
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.036
carboxylic acid metabolic process GO:0019752 92 0.035
homeostatic process GO:0042592 199 0.034
cellular response to dna damage stimulus GO:0006974 223 0.034
cellular component assembly involved in morphogenesis GO:0010927 151 0.034
cell cycle phase transition GO:0044770 140 0.034
apoptotic process GO:0006915 159 0.033
regulation of cell development GO:0060284 215 0.033
regulation of growth GO:0040008 233 0.033
negative regulation of cell differentiation GO:0045596 143 0.032
posttranscriptional regulation of gene expression GO:0010608 145 0.032
Yeast
tube development GO:0035295 244 0.032
histolysis GO:0007559 102 0.031
stem cell differentiation GO:0048863 117 0.030
salivary gland histolysis GO:0035070 88 0.030
regulation of cell division GO:0051302 72 0.030
torc1 signaling GO:0038202 12 0.029
telomere maintenance GO:0000723 21 0.029
autophagic cell death GO:0048102 83 0.028
regulation of protein metabolic process GO:0051246 256 0.028
Yeast
developmental pigmentation GO:0048066 68 0.028
organonitrogen compound metabolic process GO:1901564 318 0.028
appendage morphogenesis GO:0035107 397 0.027
response to light stimulus GO:0009416 124 0.027
asymmetric stem cell division GO:0098722 49 0.027
response to abiotic stimulus GO:0009628 341 0.026
mitochondrion degradation GO:0000422 8 0.026
dna biosynthetic process GO:0071897 24 0.026
cellular response to hexose stimulus GO:0071331 1 0.026
fat soluble vitamin biosynthetic process GO:0042362 1 0.025
tissue death GO:0016271 102 0.024
apoptotic signaling pathway GO:0097190 27 0.024
chemotaxis GO:0006935 249 0.024
response to radiation GO:0009314 155 0.024
organic acid metabolic process GO:0006082 103 0.024
regulation of cellular component biogenesis GO:0044087 201 0.023
sensory organ morphogenesis GO:0090596 260 0.023
regulation of nucleotide metabolic process GO:0006140 62 0.023
regulation of cell proliferation GO:0042127 163 0.023
negative regulation of cell cycle g2 m phase transition GO:1902750 8 0.023
meiotic nuclear division GO:0007126 151 0.023
purine nucleotide catabolic process GO:0006195 109 0.023
negative regulation of developmental process GO:0051093 201 0.022
ribonucleoside triphosphate catabolic process GO:0009203 108 0.022
negative regulation of photoreceptor cell differentiation GO:0046533 8 0.022
cell division GO:0051301 248 0.022
sex differentiation GO:0007548 81 0.021
Worm
embryonic morphogenesis GO:0048598 206 0.021
gland development GO:0048732 191 0.021
mitotic spindle elongation GO:0000022 81 0.020
digestive tract development GO:0048565 149 0.020
regulation of cell size GO:0008361 63 0.020
notch signaling pathway GO:0007219 120 0.020
actin cytoskeleton organization GO:0030036 206 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
organelle assembly GO:0070925 198 0.019
regulation of multicellular organismal development GO:2000026 414 0.019
compound eye development GO:0048749 307 0.019
negative regulation of cellular component organization GO:0051129 108 0.019
salivary gland cell autophagic cell death GO:0035071 83 0.019
cellular response to chemical stimulus GO:0070887 199 0.019
Yeast
purine ribonucleoside metabolic process GO:0046128 127 0.019
negative regulation of gene expression GO:0010629 387 0.018
small molecule metabolic process GO:0044281 305 0.018
regulation of anatomical structure morphogenesis GO:0022603 242 0.018
cell proliferation GO:0008283 299 0.018
regulation of mitochondrion organization GO:0010821 12 0.018
cellular response to monosaccharide stimulus GO:0071326 2 0.018
morphogenesis of an epithelium GO:0002009 276 0.018
regulation of phosphatidylinositol 3 kinase activity GO:0043551 2 0.018
chaeta development GO:0022416 97 0.018
cellular catabolic process GO:0044248 372 0.018
anatomical structure homeostasis GO:0060249 97 0.018
eye photoreceptor cell differentiation GO:0001754 145 0.017
posttranscriptional gene silencing by rna GO:0035194 45 0.017
regulation of meiosis GO:0040020 3 0.017
aging GO:0007568 143 0.017
imaginal disc derived wing morphogenesis GO:0007476 337 0.017
organic substance catabolic process GO:1901575 308 0.017
localization of cell GO:0051674 257 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
hormone catabolic process GO:0042447 3 0.017
regulation of catalytic activity GO:0050790 185 0.016
positive regulation of hydrolase activity GO:0051345 78 0.016
execution phase of apoptosis GO:0097194 7 0.016
oxoacid metabolic process GO:0043436 103 0.016
meiotic cell cycle GO:0051321 171 0.016
lipid metabolic process GO:0006629 121 0.016
regulation of hydrolase activity GO:0051336 97 0.016
endomembrane system organization GO:0010256 119 0.016
regulation of programmed cell death GO:0043067 152 0.016
gonad development GO:0008406 50 0.016
Worm
actin filament based process GO:0030029 220 0.015
negative regulation of cell cycle GO:0045786 116 0.015
purine nucleoside triphosphate catabolic process GO:0009146 108 0.015
protein modification process GO:0036211 438 0.015
macroautophagy GO:0016236 42 0.015
nucleobase containing compound catabolic process GO:0034655 165 0.015
negative regulation of epithelial cell proliferation GO:0050680 4 0.015
double strand break repair GO:0006302 26 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.015
heterocycle catabolic process GO:0046700 166 0.015
regulation of nucleoside metabolic process GO:0009118 50 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.014
regulation of catabolic process GO:0009894 170 0.014
phosphorylation GO:0016310 294 0.014
negative regulation of cell death GO:0060548 81 0.014
regulation of small gtpase mediated signal transduction GO:0051056 93 0.014
positive regulation of execution phase of apoptosis GO:1900119 4 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
catabolic process GO:0009056 409 0.013
multicellular organismal aging GO:0010259 140 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
regulation of cell growth GO:0001558 43 0.013
regulation of nucleotide catabolic process GO:0030811 48 0.013
dna amplification GO:0006277 11 0.013
aromatic compound catabolic process GO:0019439 166 0.013
guanosine containing compound metabolic process GO:1901068 74 0.013
nucleoside catabolic process GO:0009164 112 0.013
posttranscriptional gene silencing GO:0016441 46 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
regulation of anatomical structure size GO:0090066 163 0.013
gastrulation involving germ band extension GO:0010004 36 0.013
cellular lipid metabolic process GO:0044255 83 0.013
cellular ketone metabolic process GO:0042180 24 0.013
negative regulation of cell cycle phase transition GO:1901988 103 0.012
proteolysis GO:0006508 192 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
vesicle mediated transport GO:0016192 381 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
compound eye photoreceptor development GO:0042051 78 0.012
salivary gland morphogenesis GO:0007435 145 0.012
regulation of gtpase activity GO:0043087 44 0.012
detection of external stimulus GO:0009581 66 0.012
wound healing GO:0042060 75 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
regulation of cell matrix adhesion GO:0001952 1 0.012
genitalia development GO:0048806 26 0.012
Worm
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
Yeast
cellular homeostasis GO:0019725 80 0.012
regulation of neurogenesis GO:0050767 158 0.012
regulation of cell differentiation GO:0045595 302 0.012
single organism carbohydrate metabolic process GO:0044723 72 0.012
regulation of cellular response to stress GO:0080135 89 0.012
salivary gland development GO:0007431 162 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
intracellular signal transduction GO:0035556 300 0.012
inositol lipid mediated signaling GO:0048017 4 0.011
response to glucose GO:0009749 2 0.011
paracrine signaling GO:0038001 7 0.011
negative regulation of cell development GO:0010721 62 0.011
respiratory system development GO:0060541 213 0.011
positive regulation of signaling GO:0023056 243 0.011
eye development GO:0001654 323 0.011
cellular response to organic substance GO:0071310 132 0.011
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.011
negative regulation of biosynthetic process GO:0009890 277 0.011
protein maturation GO:0051604 71 0.011
protein complex disassembly GO:0043241 36 0.011
Yeast
positive regulation of multicellular organismal process GO:0051240 143 0.011
response to extracellular stimulus GO:0009991 116 0.011
extrinsic apoptotic signaling pathway GO:0097191 1 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
negative regulation of nervous system development GO:0051961 92 0.011
regulation of response to stress GO:0080134 200 0.011
regulation of phosphatase activity GO:0010921 3 0.011
regulation of cell shape GO:0008360 113 0.011
organophosphate metabolic process GO:0019637 195 0.011
response to hexose GO:0009746 3 0.011
regulation of developmental growth GO:0048638 174 0.011
positive regulation of cell size GO:0045793 21 0.011
negative regulation of intracellular signal transduction GO:1902532 57 0.010
negative regulation of cell proliferation GO:0008285 69 0.010
protein kinase b signaling GO:0043491 1 0.010
digestive tract morphogenesis GO:0048546 127 0.010
developmental growth GO:0048589 280 0.010
regulation of phosphate metabolic process GO:0019220 210 0.010
chorion containing eggshell formation GO:0007304 105 0.010
cellular protein modification process GO:0006464 438 0.010
regulation of mitochondrial fusion GO:0010635 5 0.010
negative regulation of multicellular organismal process GO:0051241 142 0.010
negative regulation of nucleic acid templated transcription GO:1903507 240 0.010

pix disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.132
aplastic anemia DOID:12449 0 0.132
disease of anatomical entity DOID:7 0 0.132
bone marrow disease DOID:4961 0 0.132
anemia DOID:2355 0 0.132
hematopoietic system disease DOID:74 0 0.132
congenital hypoplastic anemia DOID:1342 0 0.026