Drosophila melanogaster

65 known processes

fab1 (Dmel_CG6355)

CG6355 gene product from transcript CG6355-RA

(Aliases: fab-1,Fab1,PIKfyve,Dmel\CG6355,EG:52C10.5,CG6355)

fab1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal development GO:2000026 414 0.290
negative regulation of organ growth GO:0046621 15 0.247
single organism intracellular transport GO:1902582 207 0.139
regulation of imaginal disc growth GO:0045570 26 0.107
intracellular transport GO:0046907 228 0.103
embryonic morphogenesis GO:0048598 206 0.101
vesicle mediated transport GO:0016192 381 0.097
imaginal disc growth GO:0007446 37 0.095
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.094
tube development GO:0035295 244 0.090
compound eye development GO:0048749 307 0.089
eye morphogenesis GO:0048592 260 0.086
catabolic process GO:0009056 409 0.085
chromosome organization GO:0051276 360 0.081
regulation of growth GO:0040008 233 0.081
organonitrogen compound metabolic process GO:1901564 318 0.078
compound eye morphogenesis GO:0001745 249 0.077
cell cycle phase transition GO:0044770 140 0.075
regulation of developmental growth GO:0048638 174 0.074
axis specification GO:0009798 167 0.074
negative regulation of imaginal disc growth GO:0045571 8 0.065
regulation of proteolysis GO:0030162 87 0.064
endosomal transport GO:0016197 44 0.063
protein complex assembly GO:0006461 200 0.062
cellularization GO:0007349 90 0.061
negative regulation of rna metabolic process GO:0051253 251 0.060
response to bacterium GO:0009617 198 0.060
response to organic substance GO:0010033 284 0.059
negative regulation of cell cycle process GO:0010948 109 0.054
proteolysis GO:0006508 192 0.053
tube morphogenesis GO:0035239 191 0.053
eye development GO:0001654 323 0.053
protein modification process GO:0036211 438 0.053
cellular macromolecule localization GO:0070727 220 0.052
regulation of cell proliferation GO:0042127 163 0.052
regulation of cell cycle GO:0051726 291 0.051
tissue morphogenesis GO:0048729 297 0.051
single organism membrane fusion GO:0044801 42 0.051
cellular macromolecule catabolic process GO:0044265 136 0.049
cellular protein modification process GO:0006464 438 0.049
nucleoside triphosphate metabolic process GO:0009141 120 0.049
small molecule metabolic process GO:0044281 305 0.049
single organism catabolic process GO:0044712 228 0.048
organic substance catabolic process GO:1901575 308 0.048
regulation of apoptotic process GO:0042981 130 0.047
mitotic cell cycle phase transition GO:0044772 138 0.046
negative regulation of signal transduction GO:0009968 206 0.046
negative regulation of developmental growth GO:0048640 64 0.044
regulation of cellular response to stress GO:0080135 89 0.043
organelle fusion GO:0048284 46 0.043
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.043
purine containing compound metabolic process GO:0072521 155 0.042
negative regulation of transcription dna templated GO:0045892 237 0.042
nuclear division GO:0000280 332 0.042
regulation of intracellular signal transduction GO:1902531 236 0.041
intracellular signal transduction GO:0035556 300 0.041
regionalization GO:0003002 416 0.040
cell cell signaling involved in cell fate commitment GO:0045168 210 0.040
positive regulation of peptidase activity GO:0010952 29 0.040
cell growth GO:0016049 108 0.040
segmentation GO:0035282 207 0.039
ribose phosphate metabolic process GO:0019693 145 0.039
purine nucleoside triphosphate catabolic process GO:0009146 108 0.039
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.039
purine nucleotide catabolic process GO:0006195 109 0.039
cytoplasmic transport GO:0016482 130 0.038
protein localization GO:0008104 284 0.038
spermatid development GO:0007286 98 0.038
protein transport GO:0015031 155 0.037
protein modification by small protein conjugation or removal GO:0070647 106 0.037
purine containing compound catabolic process GO:0072523 112 0.036
nucleoside phosphate metabolic process GO:0006753 162 0.036
regulation of endopeptidase activity GO:0052548 36 0.036
organophosphate metabolic process GO:0019637 195 0.036
nucleoside phosphate catabolic process GO:1901292 110 0.035
regulation of neural precursor cell proliferation GO:2000177 35 0.035
endocytosis GO:0006897 310 0.034
negative regulation of growth GO:0045926 84 0.034
pigmentation GO:0043473 75 0.034
nucleoside catabolic process GO:0009164 112 0.034
negative regulation of cell cycle GO:0045786 116 0.034
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.034
nucleotide catabolic process GO:0009166 109 0.033
response to other organism GO:0051707 293 0.033
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.033
purine nucleoside catabolic process GO:0006152 112 0.033
purine nucleotide metabolic process GO:0006163 146 0.033
cellular amino acid metabolic process GO:0006520 61 0.032
spermatid differentiation GO:0048515 114 0.032
establishment of protein localization to organelle GO:0072594 62 0.032
organophosphate biosynthetic process GO:0090407 46 0.032
organ growth GO:0035265 56 0.031
nucleoside triphosphate catabolic process GO:0009143 108 0.031
oxoacid metabolic process GO:0043436 103 0.031
regulation of cysteine type endopeptidase activity GO:2000116 27 0.030
defense response to bacterium GO:0042742 178 0.030
mitotic sister chromatid segregation GO:0000070 87 0.030
lysosomal transport GO:0007041 13 0.030
negative regulation of gene expression epigenetic GO:0045814 77 0.030
regulation of mitotic cell cycle GO:0007346 190 0.029
nucleotide metabolic process GO:0009117 161 0.029
neurological system process GO:0050877 358 0.029
forebrain development GO:0030900 2 0.029
cell proliferation GO:0008283 299 0.029
ribonucleoside triphosphate catabolic process GO:0009203 108 0.028
membrane fusion GO:0061025 42 0.028
membrane organization GO:0061024 112 0.028
ribonucleoside catabolic process GO:0042454 112 0.028
sister chromatid segregation GO:0000819 92 0.028
digestive tract development GO:0048565 149 0.027
eye photoreceptor cell differentiation GO:0001754 145 0.027
body morphogenesis GO:0010171 2 0.027
establishment or maintenance of cell polarity GO:0007163 167 0.026
carbohydrate derivative catabolic process GO:1901136 118 0.026
positive regulation of response to stimulus GO:0048584 323 0.026
regulation of gene expression epigenetic GO:0040029 128 0.026
sensory organ morphogenesis GO:0090596 260 0.026
chromatin silencing GO:0006342 76 0.025
multicellular organismal aging GO:0010259 140 0.025
protein processing GO:0016485 68 0.025
purine nucleoside metabolic process GO:0042278 127 0.025
response to oxygen containing compound GO:1901700 200 0.025
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.025
mitotic cell cycle embryonic GO:0045448 38 0.025
regulation of organ growth GO:0046620 42 0.024
nucleoside metabolic process GO:0009116 127 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.024
organic acid metabolic process GO:0006082 103 0.024
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.024
developmental growth GO:0048589 280 0.024
response to lipopolysaccharide GO:0032496 4 0.024
programmed cell death GO:0012501 257 0.023
establishment of localization in cell GO:0051649 402 0.023
growth GO:0040007 359 0.023
defense response to other organism GO:0098542 225 0.023
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.023
purine ribonucleotide metabolic process GO:0009150 145 0.023
immune system process GO:0002376 347 0.023
ribonucleotide catabolic process GO:0009261 109 0.023
regulation of cell development GO:0060284 215 0.023
regulation of hydrolase activity GO:0051336 97 0.023
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.023
cell death GO:0008219 279 0.023
epithelial cell development GO:0002064 274 0.022
olfactory behavior GO:0042048 97 0.022
protein maturation GO:0051604 71 0.022
g protein coupled receptor signaling pathway GO:0007186 136 0.022
posttranscriptional regulation of gene expression GO:0010608 145 0.022
muscle structure development GO:0061061 224 0.022
regulation of catabolic process GO:0009894 170 0.022
determination of adult lifespan GO:0008340 137 0.022
nucleobase containing small molecule metabolic process GO:0055086 174 0.022
ribonucleotide metabolic process GO:0009259 145 0.022
apoptotic process GO:0006915 159 0.022
negative regulation of rna biosynthetic process GO:1902679 240 0.022
establishment of protein localization GO:0045184 163 0.022
negative regulation of cellular biosynthetic process GO:0031327 277 0.021
cellular catabolic process GO:0044248 372 0.021
activation of cysteine type endopeptidase activity GO:0097202 17 0.021
cellular response to biotic stimulus GO:0071216 4 0.021
regulation of mitotic sister chromatid segregation GO:0033047 28 0.021
gastrulation GO:0007369 70 0.021
regulation of response to external stimulus GO:0032101 115 0.021
regulation of cell growth GO:0001558 43 0.020
cellular protein localization GO:0034613 160 0.020
anterior posterior pattern specification GO:0009952 136 0.020
organophosphate catabolic process GO:0046434 112 0.020
mitotic nuclear division GO:0007067 213 0.020
response to biotic stimulus GO:0009607 294 0.020
cellular response to lipopolysaccharide GO:0071222 3 0.020
larval development GO:0002164 104 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
negative regulation of cellular metabolic process GO:0031324 382 0.020
heterocycle catabolic process GO:0046700 166 0.020
locomotory behavior GO:0007626 176 0.020
glycosyl compound metabolic process GO:1901657 127 0.019
telencephalon development GO:0021537 2 0.019
cellular lipid metabolic process GO:0044255 83 0.019
intracellular protein transport GO:0006886 104 0.019
negative regulation of developmental process GO:0051093 201 0.019
aromatic compound catabolic process GO:0019439 166 0.019
cellular macromolecular complex assembly GO:0034622 153 0.019
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
organonitrogen compound catabolic process GO:1901565 128 0.019
regulation of multi organism process GO:0043900 131 0.019
organonitrogen compound biosynthetic process GO:1901566 117 0.019
regulation of cell cycle phase transition GO:1901987 130 0.019
stem cell development GO:0048864 79 0.019
cellular response to dna damage stimulus GO:0006974 223 0.019
single organism cellular localization GO:1902580 180 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.019
regulation of protein metabolic process GO:0051246 256 0.019
purine ribonucleoside catabolic process GO:0046130 112 0.018
positive regulation of signal transduction GO:0009967 223 0.018
positive regulation of nucleic acid templated transcription GO:1903508 266 0.018
embryonic pattern specification GO:0009880 174 0.018
spermatogenesis GO:0007283 200 0.018
response to external biotic stimulus GO:0043207 293 0.018
chromosome separation GO:0051304 42 0.018
negative regulation of notch signaling pathway GO:0045746 41 0.018
chromosome segregation GO:0007059 157 0.018
protein targeting GO:0006605 64 0.018
positive regulation of gene expression GO:0010628 290 0.018
protein localization to organelle GO:0033365 82 0.018
blastoderm segmentation GO:0007350 159 0.018
epithelial cell differentiation GO:0030855 322 0.018
photoreceptor cell differentiation GO:0046530 170 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
macromolecular complex assembly GO:0065003 256 0.017
actin filament organization GO:0007015 126 0.017
embryonic axis specification GO:0000578 107 0.017
negative regulation of cell cycle phase transition GO:1901988 103 0.017
negative regulation of signaling GO:0023057 219 0.017
morphogenesis of follicular epithelium GO:0016333 36 0.017
morphogenesis of a polarized epithelium GO:0001738 93 0.017
endosome transport via multivesicular body sorting pathway GO:0032509 12 0.017
defense response to gram negative bacterium GO:0050829 94 0.017
negative regulation of gene expression GO:0010629 387 0.017
purine ribonucleoside metabolic process GO:0046128 127 0.016
branching morphogenesis of an epithelial tube GO:0048754 45 0.016
phosphorylation GO:0016310 294 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
negative regulation of cell death GO:0060548 81 0.016
negative regulation of response to stimulus GO:0048585 258 0.016
positive regulation of biosynthetic process GO:0009891 316 0.016
multi organism behavior GO:0051705 175 0.016
regulation of programmed cell death GO:0043067 152 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
organelle assembly GO:0070925 198 0.016
digestive system development GO:0055123 149 0.016
developmental pigmentation GO:0048066 68 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.016
regulation of phosphorus metabolic process GO:0051174 210 0.016
negative regulation of cell communication GO:0010648 223 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
nuclear body organization GO:0030575 6 0.015
pigment metabolic process GO:0042440 84 0.015
negative regulation of molecular function GO:0044092 51 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
phagocytosis GO:0006909 215 0.015
retina development in camera type eye GO:0060041 4 0.015
response to organic cyclic compound GO:0014070 89 0.015
negative regulation of biosynthetic process GO:0009890 277 0.015
response to abiotic stimulus GO:0009628 341 0.015
regulation of catalytic activity GO:0050790 185 0.015
peptidyl proline modification GO:0018208 3 0.015
retina morphogenesis in camera type eye GO:0060042 2 0.015
lateral inhibition GO:0046331 206 0.015
regulation of molecular function GO:0065009 217 0.015
mitotic spindle organization GO:0007052 220 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.014
regulation of response to stress GO:0080134 200 0.014
multi organism reproductive behavior GO:0044705 121 0.014
covalent chromatin modification GO:0016569 106 0.014
regulation of cell death GO:0010941 173 0.014
regulation of mitosis GO:0007088 56 0.014
protein complex biogenesis GO:0070271 201 0.014
establishment of vesicle localization GO:0051650 51 0.014
detection of stimulus GO:0051606 156 0.014
gtp metabolic process GO:0046039 72 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
protein import GO:0017038 55 0.014
spindle organization GO:0007051 253 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
positive regulation of cell communication GO:0010647 250 0.014
peptide metabolic process GO:0006518 80 0.014
localization of cell GO:0051674 257 0.014
regulation of intracellular protein transport GO:0033157 46 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
response to endoplasmic reticulum stress GO:0034976 28 0.014
male gamete generation GO:0048232 201 0.014
regulation of peptidase activity GO:0052547 39 0.013
positive regulation of cellular protein metabolic process GO:0032270 118 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
notch signaling pathway GO:0007219 120 0.013
camera type eye development GO:0043010 4 0.013
positive regulation of cellular biosynthetic process GO:0031328 316 0.013
stem cell proliferation GO:0072089 88 0.013
nucleoside monophosphate metabolic process GO:0009123 52 0.013
jak stat cascade GO:0007259 49 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
chaeta development GO:0022416 97 0.013
cellular response to organic cyclic compound GO:0071407 32 0.013
metaphase anaphase transition of cell cycle GO:0044784 28 0.013
regulation of reproductive process GO:2000241 54 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
single organism behavior GO:0044708 391 0.013
cellular response to organic substance GO:0071310 132 0.013
single organism biosynthetic process GO:0044711 206 0.013
negative regulation of epithelial cell proliferation GO:0050680 4 0.013
organic substance transport GO:0071702 257 0.013
endosome to lysosome transport GO:0008333 7 0.013
atp metabolic process GO:0046034 49 0.013
glycosyl compound catabolic process GO:1901658 112 0.013
wing disc morphogenesis GO:0007472 344 0.012
homeostatic process GO:0042592 199 0.012
maintenance of location GO:0051235 73 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
secretion GO:0046903 109 0.012
response to sterol GO:0036314 34 0.012
cellular amide metabolic process GO:0043603 80 0.012
mesenchymal cell differentiation GO:0048762 1 0.012
regulation of epithelial cell differentiation GO:0030856 4 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
regulation of synapse organization GO:0050807 110 0.012
dna metabolic process GO:0006259 227 0.012
stem cell maintenance GO:0019827 67 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.012
single organism membrane organization GO:0044802 93 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
protein catabolic process GO:0030163 101 0.011
mesoderm development GO:0007498 78 0.011
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.011
regulation of localization GO:0032879 275 0.011
compound eye photoreceptor development GO:0042051 78 0.011
sex differentiation GO:0007548 81 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
negative regulation of catalytic activity GO:0043086 42 0.011
regulation of protein complex assembly GO:0043254 42 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
regulation of organelle organization GO:0033043 196 0.011
dephosphorylation GO:0016311 51 0.011
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.011
synaptic vesicle localization GO:0097479 53 0.011
death GO:0016265 284 0.011
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.011
cellular response to external stimulus GO:0071496 66 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
response to starvation GO:0042594 97 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
mesenchymal cell development GO:0014031 1 0.011
regulation of embryonic development GO:0045995 68 0.011
rhythmic behavior GO:0007622 76 0.010
regulation of sister chromatid segregation GO:0033045 28 0.010
nephron tubule development GO:0072080 3 0.010
mitotic cell cycle checkpoint GO:0007093 88 0.010
nephron epithelium development GO:0072009 3 0.010
mitotic sister chromatid separation GO:0051306 30 0.010
regulation of cell cycle process GO:0010564 181 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
protein modification by small protein conjugation GO:0032446 79 0.010
eye pigmentation GO:0048069 43 0.010
molting cycle chitin based cuticle GO:0007591 56 0.010
negative regulation of apoptotic process GO:0043066 63 0.010
rna processing GO:0006396 147 0.010
positive regulation of protein metabolic process GO:0051247 128 0.010
organelle fission GO:0048285 340 0.010
kidney epithelium development GO:0072073 3 0.010
regulation of cellular protein metabolic process GO:0032268 243 0.010
negative regulation of intracellular signal transduction GO:1902532 57 0.010
response to extracellular stimulus GO:0009991 116 0.010
ameboidal type cell migration GO:0001667 151 0.010

fab1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
disease of cellular proliferation DOID:14566 0 0.021
disease of metabolism DOID:0014667 0 0.019
cancer DOID:162 0 0.018
organ system cancer DOID:0050686 0 0.018