Drosophila melanogaster

48 known processes

fh (Dmel_CG8971)

frataxin homolog

(Aliases: Dmel\CG8971,dfh,DFH,X25,CG8971,BcDNA:AT09528,Dfh)

fh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
circadian rhythm GO:0007623 105 0.355
regulation of immune response GO:0050776 118 0.226
response to external biotic stimulus GO:0043207 293 0.219
defense response to bacterium GO:0042742 178 0.179
neurological system process GO:0050877 358 0.177
response to oxidative stress GO:0006979 86 0.160
aging GO:0007568 143 0.142
Worm
response to biotic stimulus GO:0009607 294 0.134
defense response to other organism GO:0098542 225 0.131
regulation of response to stress GO:0080134 200 0.122
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.117
multicellular organismal aging GO:0010259 140 0.113
Worm
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.110
response to radiation GO:0009314 155 0.100
rhythmic process GO:0048511 106 0.094
regulation of defense response GO:0031347 102 0.084
locomotory behavior GO:0007626 176 0.083
mitochondrion organization GO:0007005 65 0.083
negative regulation of neuron death GO:1901215 18 0.080
response to oxygen containing compound GO:1901700 200 0.079
immune response activating signal transduction GO:0002757 2 0.077
regulation of cell death GO:0010941 173 0.075
regulation of circadian rhythm GO:0042752 49 0.074
response to abiotic stimulus GO:0009628 341 0.071
neuron death GO:0070997 27 0.071
response to bacterium GO:0009617 198 0.070
single organism behavior GO:0044708 391 0.068
detection of stimulus GO:0051606 156 0.066
organonitrogen compound metabolic process GO:1901564 318 0.064
regulation of neuron death GO:1901214 26 0.063
negative regulation of defense response GO:0031348 35 0.060
positive regulation of response to stimulus GO:0048584 323 0.059
determination of adult lifespan GO:0008340 137 0.058
Worm
phagocytosis GO:0006909 215 0.058
response to other organism GO:0051707 293 0.057
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.057
sensory organ morphogenesis GO:0090596 260 0.057
cellular response to oxidative stress GO:0034599 28 0.057
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.056
taxis GO:0042330 304 0.056
regulation of programmed cell death GO:0043067 152 0.056
endocytosis GO:0006897 310 0.055
vesicle mediated transport GO:0016192 381 0.055
immune effector process GO:0002252 98 0.053
ion transmembrane transport GO:0034220 122 0.053
localization of cell GO:0051674 257 0.052
immune response GO:0006955 246 0.051
g protein coupled receptor signaling pathway GO:0007186 136 0.051
organic substance catabolic process GO:1901575 308 0.050
immune system process GO:0002376 347 0.050
regulation of innate immune response GO:0045088 71 0.049
negative regulation of cell death GO:0060548 81 0.049
establishment of localization in cell GO:0051649 402 0.049
regulation of photoreceptor cell differentiation GO:0046532 34 0.048
positive regulation of signal transduction GO:0009967 223 0.045
response to hydrogen peroxide GO:0042542 11 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.043
organelle fission GO:0048285 340 0.042
regulation of catabolic process GO:0009894 170 0.041
regulation of intracellular signal transduction GO:1902531 236 0.041
macromolecule catabolic process GO:0009057 161 0.041
catecholamine biosynthetic process GO:0042423 3 0.041
positive regulation of nucleic acid templated transcription GO:1903508 266 0.041
defense response to gram negative bacterium GO:0050829 94 0.040
nucleobase containing small molecule metabolic process GO:0055086 174 0.040
regulation of neurogenesis GO:0050767 158 0.039
ion transport GO:0006811 145 0.039
regulation of cell cycle GO:0051726 291 0.039
negative regulation of immune response GO:0050777 39 0.039
innate immune response activating signal transduction GO:0002758 2 0.039
cellular response to dna damage stimulus GO:0006974 223 0.038
transmembrane transport GO:0055085 139 0.038
small molecule metabolic process GO:0044281 305 0.037
negative regulation of cellular metabolic process GO:0031324 382 0.037
rhythmic behavior GO:0007622 76 0.037
cellular amide metabolic process GO:0043603 80 0.037
positive regulation of cellular biosynthetic process GO:0031328 316 0.037
mapk cascade GO:0000165 107 0.036
negative regulation of programmed cell death GO:0043069 72 0.035
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.035
cellular catabolic process GO:0044248 372 0.035
regulation of immune system process GO:0002682 176 0.035
positive regulation of transcription dna templated GO:0045893 266 0.034
response to virus GO:0009615 28 0.033
innate immune response GO:0045087 144 0.033
cellular response to reactive oxygen species GO:0034614 14 0.033
defense response GO:0006952 300 0.032
immune response regulating signaling pathway GO:0002764 2 0.032
purine ribonucleoside metabolic process GO:0046128 127 0.032
single organism biosynthetic process GO:0044711 206 0.032
adult behavior GO:0030534 137 0.032
single organism cellular localization GO:1902580 180 0.031
positive regulation of rna metabolic process GO:0051254 271 0.031
dna damage checkpoint GO:0000077 78 0.030
regulation of transport GO:0051049 181 0.030
long term memory GO:0007616 62 0.030
circadian behavior GO:0048512 76 0.030
epithelial cell differentiation GO:0030855 322 0.030
camera type eye development GO:0043010 4 0.030
transcription from rna polymerase ii promoter GO:0006366 368 0.030
axon guidance GO:0007411 233 0.029
regulation of response to external stimulus GO:0032101 115 0.029
cellular response to oxygen containing compound GO:1901701 79 0.029
cellular response to chemical stimulus GO:0070887 199 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.028
pattern recognition receptor signaling pathway GO:0002221 2 0.028
chemotaxis GO:0006935 249 0.028
central nervous system development GO:0007417 201 0.028
negative regulation of immune system process GO:0002683 50 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
negative regulation of apoptotic process GO:0043066 63 0.027
locomotor rhythm GO:0045475 56 0.027
activation of innate immune response GO:0002218 4 0.027
photoreceptor cell differentiation GO:0046530 170 0.027
death GO:0016265 284 0.027
sensory perception GO:0007600 196 0.026
female meiotic division GO:0007143 70 0.026
response to oxygen radical GO:0000305 3 0.026
Worm
cellular response to organonitrogen compound GO:0071417 36 0.026
response to starvation GO:0042594 97 0.026
organonitrogen compound biosynthetic process GO:1901566 117 0.025
regulation of cellular amine metabolic process GO:0033238 3 0.025
positive regulation of gene expression GO:0010628 290 0.025
regulation of apoptotic process GO:0042981 130 0.025
organophosphate metabolic process GO:0019637 195 0.025
homeostatic process GO:0042592 199 0.024
regulation of autophagy GO:0010506 62 0.024
positive regulation of cell communication GO:0010647 250 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.024
catabolic process GO:0009056 409 0.023
positive regulation of signaling GO:0023056 243 0.023
mrna catabolic process GO:0006402 33 0.023
positive regulation of rna biosynthetic process GO:1902680 266 0.023
cellular amino acid metabolic process GO:0006520 61 0.023
eye morphogenesis GO:0048592 260 0.023
negative regulation of cellular response to oxidative stress GO:1900408 1 0.023
response to lipopolysaccharide GO:0032496 4 0.023
carbohydrate derivative metabolic process GO:1901135 217 0.023
negative regulation of cell cycle phase transition GO:1901988 103 0.023
appendage morphogenesis GO:0035107 397 0.023
positive regulation of molecular function GO:0044093 136 0.023
columnar cuboidal epithelial cell development GO:0002066 249 0.022
regulation of mitotic cell cycle GO:0007346 190 0.022
phosphorylation GO:0016310 294 0.022
negative regulation of response to oxidative stress GO:1902883 1 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.021
organic substance transport GO:0071702 257 0.021
ribonucleotide metabolic process GO:0009259 145 0.021
response to extracellular stimulus GO:0009991 116 0.020
single organism catabolic process GO:0044712 228 0.020
negative regulation of transcription dna templated GO:0045892 237 0.020
cellular nitrogen compound catabolic process GO:0044270 165 0.020
cell death GO:0008219 279 0.020
eye photoreceptor cell differentiation GO:0001754 145 0.020
negative regulation of mitotic cell cycle GO:0045930 109 0.020
negative regulation of gene expression GO:0010629 387 0.019
negative regulation of cell differentiation GO:0045596 143 0.019
negative regulation of response to stimulus GO:0048585 258 0.019
cellular amine metabolic process GO:0044106 12 0.019
positive regulation of biosynthetic process GO:0009891 316 0.019
positive regulation of immune response GO:0050778 63 0.019
cell type specific apoptotic process GO:0097285 38 0.019
negative regulation of nervous system development GO:0051961 92 0.019
ameboidal type cell migration GO:0001667 151 0.019
chromatin organization GO:0006325 207 0.019
cellular response to nitrogen compound GO:1901699 51 0.019
regulation of response to oxidative stress GO:1902882 4 0.019
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
ribonucleoside metabolic process GO:0009119 127 0.018
regulation of cellular response to oxidative stress GO:1900407 4 0.018
covalent chromatin modification GO:0016569 106 0.018
positive regulation of macromolecule metabolic process GO:0010604 405 0.018
regulation of catalytic activity GO:0050790 185 0.018
cellular lipid metabolic process GO:0044255 83 0.018
synaptic transmission GO:0007268 288 0.018
protein modification by small protein conjugation GO:0032446 79 0.018
regulation of cell size GO:0008361 63 0.018
rna processing GO:0006396 147 0.018
protein transport GO:0015031 155 0.018
regulation of nervous system development GO:0051960 248 0.017
response to nitrogen compound GO:1901698 90 0.017
metal ion transport GO:0030001 74 0.017
cardiovascular system development GO:0072358 82 0.017
regulation of molecular function GO:0065009 217 0.017
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
cellular response to organic substance GO:0071310 132 0.017
nuclear division GO:0000280 332 0.017
negative regulation of intracellular signal transduction GO:1902532 57 0.017
intracellular signal transduction GO:0035556 300 0.017
cellular response to extracellular stimulus GO:0031668 64 0.017
cellular response to starvation GO:0009267 61 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
nucleoside metabolic process GO:0009116 127 0.017
response to organonitrogen compound GO:0010243 75 0.016
response to gravity GO:0009629 26 0.016
cell cycle checkpoint GO:0000075 95 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
negative regulation of cell cycle GO:0045786 116 0.016
pigment metabolic process GO:0042440 84 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
carboxylic acid metabolic process GO:0019752 92 0.016
single organism carbohydrate metabolic process GO:0044723 72 0.016
cellular response to ionizing radiation GO:0071479 15 0.016
negative regulation of biosynthetic process GO:0009890 277 0.016
compound eye morphogenesis GO:0001745 249 0.016
learning or memory GO:0007611 141 0.016
mitotic dna integrity checkpoint GO:0044774 75 0.016
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
response to heat GO:0009408 63 0.016
protein modification process GO:0036211 438 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.016
negative regulation of developmental process GO:0051093 201 0.016
response to ionizing radiation GO:0010212 32 0.016
regulation of cellular component size GO:0032535 98 0.016
forebrain development GO:0030900 2 0.015
response to alcohol GO:0097305 95 0.015
response to organic substance GO:0010033 284 0.015
peptidyl amino acid modification GO:0018193 105 0.015
secretion GO:0046903 109 0.015
nucleoside phosphate metabolic process GO:0006753 162 0.015
response to reactive oxygen species GO:0000302 24 0.015
positive regulation of defense response GO:0031349 59 0.015
stem cell differentiation GO:0048863 117 0.015
regulation of notch signaling pathway GO:0008593 100 0.015
ribose phosphate metabolic process GO:0019693 145 0.015
eye development GO:0001654 323 0.015
epithelial cell migration GO:0010631 148 0.014
epithelial cell development GO:0002064 274 0.014
organic acid metabolic process GO:0006082 103 0.014
response to endogenous stimulus GO:0009719 119 0.014
catechol containing compound biosynthetic process GO:0009713 3 0.014
negative regulation of cell cycle process GO:0010948 109 0.014
peptide metabolic process GO:0006518 80 0.014
dna integrity checkpoint GO:0031570 81 0.014
amine metabolic process GO:0009308 12 0.014
positive regulation of immune system process GO:0002684 68 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
gliogenesis GO:0042063 80 0.014
single organism intracellular transport GO:1902582 207 0.014
negative regulation of innate immune response GO:0045824 30 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
growth GO:0040007 359 0.014
Worm
secretion by cell GO:0032940 101 0.013
modification dependent macromolecule catabolic process GO:0043632 79 0.013
carbohydrate metabolic process GO:0005975 82 0.013
cellular response to peptide GO:1901653 28 0.013
regulation of cellular response to stress GO:0080135 89 0.013
response to light stimulus GO:0009416 124 0.013
cell cycle phase transition GO:0044770 140 0.013
oxoacid metabolic process GO:0043436 103 0.013
cellular response to hydrogen peroxide GO:0070301 7 0.013
jnk cascade GO:0007254 50 0.013
organelle assembly GO:0070925 198 0.013
molting cycle process GO:0022404 29 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
neuron projection guidance GO:0097485 241 0.012
purine nucleoside metabolic process GO:0042278 127 0.012
inorganic ion transmembrane transport GO:0098660 73 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
aromatic compound catabolic process GO:0019439 166 0.012
response to superoxide GO:0000303 3 0.012
Worm
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
cellular response to external stimulus GO:0071496 66 0.012
defense response to virus GO:0051607 23 0.012
neuropeptide signaling pathway GO:0007218 45 0.012
cellular response to hormone stimulus GO:0032870 44 0.012
regulation of cell differentiation GO:0045595 302 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.012
tissue migration GO:0090130 155 0.012
cell migration GO:0016477 238 0.012
chromosome segregation GO:0007059 157 0.012
reactive oxygen species metabolic process GO:0072593 22 0.012
purine containing compound metabolic process GO:0072521 155 0.012
carbohydrate biosynthetic process GO:0016051 17 0.012
dendrite development GO:0016358 204 0.012
regulation of immune effector process GO:0002697 52 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.012
lipid metabolic process GO:0006629 121 0.011
positive regulation of cell motility GO:2000147 3 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
biological adhesion GO:0022610 138 0.011
response to nutrient levels GO:0031667 114 0.011
proteasomal protein catabolic process GO:0010498 59 0.011
segmentation GO:0035282 207 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
generation of precursor metabolites and energy GO:0006091 42 0.011
cellular response to insulin stimulus GO:0032869 28 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
circulatory system development GO:0072359 82 0.011
negative regulation of signal transduction GO:0009968 206 0.011
negative regulation of rna metabolic process GO:0051253 251 0.011
positive regulation of cell death GO:0010942 69 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
cellular response to biotic stimulus GO:0071216 4 0.011
oxidation reduction process GO:0055114 123 0.011
membrane organization GO:0061024 112 0.011
microtubule polymerization or depolymerization GO:0031109 39 0.011
positive regulation of cellular component biogenesis GO:0044089 80 0.011
stress activated mapk cascade GO:0051403 52 0.011
regulation of multicellular organismal development GO:2000026 414 0.011
oxidative phosphorylation GO:0006119 9 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
regulation of phosphorylation GO:0042325 147 0.011
negative regulation of cell communication GO:0010648 223 0.011
positive regulation of developmental process GO:0051094 143 0.010
Worm
cell aging GO:0007569 2 0.010
regulation of cellular localization GO:0060341 136 0.010
positive regulation of apoptotic signaling pathway GO:2001235 4 0.010
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.010
ncrna metabolic process GO:0034660 43 0.010
carbohydrate derivative catabolic process GO:1901136 118 0.010
response to insulin GO:0032868 29 0.010
regulation of cellular ketone metabolic process GO:0010565 3 0.010
regulation of cellular protein metabolic process GO:0032268 243 0.010
intraspecies interaction between organisms GO:0051703 4 0.010
camera type eye morphogenesis GO:0048593 2 0.010
cellular macromolecule localization GO:0070727 220 0.010
regulation of insulin receptor signaling pathway GO:0046626 17 0.010

fh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.022
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
eye disease DOID:5614 0 0.014
cardiovascular system disease DOID:1287 0 0.014
central nervous system disease DOID:331 0 0.013
musculoskeletal system disease DOID:17 0 0.013
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
neurodegenerative disease DOID:1289 0 0.012
motor neuron disease DOID:231 0 0.011