Drosophila melanogaster

141 known processes

MED4 (Dmel_CG8609)

Mediator complex subunit 4

(Aliases: Trap36,dp34,Dmel\CG8609,CG8609,Med4/TRAP36,Med4,dTRAP36,p34)

MED4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of neuroblast proliferation GO:0007406 27 0.997
negative regulation of stem cell proliferation GO:2000647 30 0.988
negative regulation of neural precursor cell proliferation GO:2000178 27 0.891
negative regulation of developmental process GO:0051093 201 0.880
regulation of neuroblast proliferation GO:1902692 34 0.809
negative regulation of cell differentiation GO:0045596 143 0.786
neuroblast proliferation GO:0007405 74 0.769
regulation of nervous system development GO:0051960 248 0.732
transcription from rna polymerase ii promoter GO:0006366 368 0.729
regulation of neural precursor cell proliferation GO:2000177 35 0.720
neural precursor cell proliferation GO:0061351 75 0.651
regulation of stem cell proliferation GO:0072091 40 0.627
negative regulation of nervous system development GO:0051961 92 0.620
regulation of multicellular organismal development GO:2000026 414 0.506
stem cell proliferation GO:0072089 88 0.500
regulation of cell differentiation GO:0045595 302 0.486
regulation of cell development GO:0060284 215 0.464
regulation of neurogenesis GO:0050767 158 0.459
negative regulation of neurogenesis GO:0050768 53 0.340
negative regulation of multicellular organismal process GO:0051241 142 0.243
cellular response to uv GO:0034644 12 0.159
organelle fission GO:0048285 340 0.147
negative regulation of cell development GO:0010721 62 0.147
autophagic cell death GO:0048102 83 0.135
positive regulation of lipid storage GO:0010884 4 0.133
cellular response to radiation GO:0071478 52 0.130
response to temperature stimulus GO:0009266 106 0.120
gland morphogenesis GO:0022612 145 0.108
eye pigmentation GO:0048069 43 0.104
cell proliferation GO:0008283 299 0.104
tissue death GO:0016271 102 0.099
response to ecdysone GO:0035075 34 0.096
regulation of cell proliferation GO:0042127 163 0.093
response to abiotic stimulus GO:0009628 341 0.090
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.086
response to light stimulus GO:0009416 124 0.085
response to radiation GO:0009314 155 0.084
phototransduction GO:0007602 52 0.084
phototransduction visible light GO:0007603 27 0.083
stem cell differentiation GO:0048863 117 0.081
developmental programmed cell death GO:0010623 138 0.081
negative regulation of cell proliferation GO:0008285 69 0.080
eye pigment biosynthetic process GO:0006726 32 0.077
detection of abiotic stimulus GO:0009582 66 0.075
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.070
sister chromatid segregation GO:0000819 92 0.070
chromosome organization GO:0051276 360 0.069
exocrine system development GO:0035272 162 0.069
positive regulation of nucleic acid templated transcription GO:1903508 266 0.065
cholesterol transport GO:0030301 2 0.065
pigment metabolic process GO:0042440 84 0.063
phagocytosis recognition GO:0006910 1 0.063
regionalization GO:0003002 416 0.056
salivary gland development GO:0007431 162 0.056
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.053
dna templated transcription initiation GO:0006352 25 0.052
histolysis GO:0007559 102 0.050
salivary gland cell autophagic cell death GO:0035071 83 0.050
negative regulation of rna biosynthetic process GO:1902679 240 0.048
nuclear division GO:0000280 332 0.047
cellular response to abiotic stimulus GO:0071214 58 0.044
response to uv GO:0009411 24 0.043
positive regulation of cellular biosynthetic process GO:0031328 316 0.042
taxis GO:0042330 304 0.042
mitotic nuclear division GO:0007067 213 0.041
detection of external stimulus GO:0009581 66 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.040
developmental pigmentation GO:0048066 68 0.039
dendrite development GO:0016358 204 0.039
organonitrogen compound metabolic process GO:1901564 318 0.039
membrane organization GO:0061024 112 0.039
cellular catabolic process GO:0044248 372 0.037
proteolysis GO:0006508 192 0.037
chromatin remodeling GO:0006338 72 0.036
cellular response to light stimulus GO:0071482 37 0.036
dendrite morphogenesis GO:0048813 199 0.035
camera type eye development GO:0043010 4 0.034
negative regulation of growth GO:0045926 84 0.033
salivary gland morphogenesis GO:0007435 145 0.033
dna metabolic process GO:0006259 227 0.033
detection of light stimulus GO:0009583 58 0.033
imaginal disc derived leg morphogenesis GO:0007480 80 0.032
cell migration GO:0016477 238 0.032
vesicle mediated transport GO:0016192 381 0.030
regulation of developmental growth GO:0048638 174 0.030
positive regulation of macromolecule metabolic process GO:0010604 405 0.029
response to lipopolysaccharide GO:0032496 4 0.029
carboxylic acid metabolic process GO:0019752 92 0.028
small molecule metabolic process GO:0044281 305 0.028
body morphogenesis GO:0010171 2 0.028
regulation of mitotic cell cycle GO:0007346 190 0.028
phagocytosis GO:0006909 215 0.028
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.028
regulation of localization GO:0032879 275 0.028
appendage segmentation GO:0035285 26 0.027
steroid biosynthetic process GO:0006694 16 0.027
positive regulation of transcription dna templated GO:0045893 266 0.027
heterochromatin organization GO:0070828 25 0.027
segmentation GO:0035282 207 0.026
positive regulation of gene expression GO:0010628 290 0.026
multi organism reproductive behavior GO:0044705 121 0.026
dna repair GO:0006281 54 0.026
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.026
endocytosis GO:0006897 310 0.026
regulation of cellular amine metabolic process GO:0033238 3 0.025
mitotic g2 dna damage checkpoint GO:0007095 69 0.024
regulation of transport GO:0051049 181 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.024
stem cell division GO:0017145 69 0.023
cellular amino acid metabolic process GO:0006520 61 0.023
regulation of intracellular transport GO:0032386 64 0.023
axonogenesis GO:0007409 290 0.023
negative regulation of nucleic acid templated transcription GO:1903507 240 0.023
modification dependent protein catabolic process GO:0019941 78 0.022
lateral inhibition GO:0046331 206 0.022
retina development in camera type eye GO:0060041 4 0.022
negative regulation of rna metabolic process GO:0051253 251 0.022
localization of cell GO:0051674 257 0.022
single organism biosynthetic process GO:0044711 206 0.022
regulation of catalytic activity GO:0050790 185 0.022
leg disc development GO:0035218 92 0.022
apoptotic cell clearance GO:0043277 14 0.021
response to bacterium GO:0009617 198 0.021
cell cell signaling involved in cell fate commitment GO:0045168 210 0.021
cell recognition GO:0008037 102 0.021
oxidation reduction process GO:0055114 123 0.021
amine metabolic process GO:0009308 12 0.020
multi multicellular organism process GO:0044706 123 0.020
muscle organ development GO:0007517 127 0.020
peptidyl lysine methylation GO:0018022 16 0.020
ubiquitin dependent protein catabolic process GO:0006511 78 0.020
negative regulation of cell communication GO:0010648 223 0.020
detection of visible light GO:0009584 38 0.020
positive regulation of cell communication GO:0010647 250 0.020
leg disc morphogenesis GO:0007478 80 0.019
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.019
axon development GO:0061564 297 0.018
regulation of cell cycle process GO:0010564 181 0.018
imaginal disc derived appendage morphogenesis GO:0035114 395 0.018
response to biotic stimulus GO:0009607 294 0.018
negative regulation of signal transduction GO:0009968 206 0.018
protein localization GO:0008104 284 0.018
endomembrane system organization GO:0010256 119 0.018
negative regulation of cellular metabolic process GO:0031324 382 0.018
organic substance transport GO:0071702 257 0.017
multicellular organismal reproductive behavior GO:0033057 110 0.017
organelle fusion GO:0048284 46 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.017
wnt signaling pathway GO:0016055 98 0.017
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
single organism intracellular transport GO:1902582 207 0.017
cell division GO:0051301 248 0.017
macromolecular complex assembly GO:0065003 256 0.017
regulation of immune system process GO:0002682 176 0.017
compound eye development GO:0048749 307 0.016
open tracheal system development GO:0007424 204 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
single organism membrane organization GO:0044802 93 0.016
negative regulation of biosynthetic process GO:0009890 277 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
cellular response to dna damage stimulus GO:0006974 223 0.015
regulation of growth GO:0040008 233 0.015
mitotic cell cycle phase transition GO:0044772 138 0.015
anterior posterior pattern specification GO:0009952 136 0.015
eye development GO:0001654 323 0.015
detection of stimulus GO:0051606 156 0.015
anterior posterior axis specification embryo GO:0008595 103 0.014
organic substance catabolic process GO:1901575 308 0.014
mrna processing GO:0006397 104 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
ovarian follicle cell development GO:0030707 248 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
androgen metabolic process GO:0008209 1 0.014
tissue migration GO:0090130 155 0.014
cell motility GO:0048870 251 0.014
carotenoid transport GO:0046867 1 0.014
meiotic nuclear division GO:0007126 151 0.014
imaginal disc derived appendage development GO:0048737 399 0.014
establishment of protein localization GO:0045184 163 0.014
mitotic g2 m transition checkpoint GO:0044818 70 0.013
acylglycerol biosynthetic process GO:0046463 2 0.013
cellular ketone metabolic process GO:0042180 24 0.013
positive regulation of rna metabolic process GO:0051254 271 0.013
nucleotide metabolic process GO:0009117 161 0.013
regulation of endocytosis GO:0030100 37 0.013
spermatogenesis GO:0007283 200 0.013
jak stat cascade GO:0007259 49 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
histone methylation GO:0016571 40 0.013
single organism cellular localization GO:1902580 180 0.012
gene silencing GO:0016458 138 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
negative regulation of gene expression GO:0010629 387 0.012
negative regulation of signaling GO:0023057 219 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
cellular response to organic substance GO:0071310 132 0.012
modification dependent macromolecule catabolic process GO:0043632 79 0.012
tripartite regional subdivision GO:0007351 103 0.012
isoprenoid transport GO:0046864 2 0.012
response to other organism GO:0051707 293 0.012
cellular protein catabolic process GO:0044257 83 0.012
cellular lipid catabolic process GO:0044242 16 0.012
regulation of cell projection organization GO:0031344 92 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
synapse assembly GO:0007416 143 0.011
lipid metabolic process GO:0006629 121 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
muscle structure development GO:0061061 224 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
regulation of vesicle mediated transport GO:0060627 59 0.011
macromolecule catabolic process GO:0009057 161 0.011
organelle assembly GO:0070925 198 0.011
regulation of notch signaling pathway GO:0008593 100 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
intracellular transport GO:0046907 228 0.011
negative regulation of response to stimulus GO:0048585 258 0.011
cellular macromolecule localization GO:0070727 220 0.010
oxoacid metabolic process GO:0043436 103 0.010
regulation of phagocytosis GO:0050764 3 0.010
secretion by cell GO:0032940 101 0.010
cellular response to ketone GO:1901655 17 0.010
pigment metabolic process involved in pigmentation GO:0043474 33 0.010
regulation of immune response GO:0050776 118 0.010
tetraterpenoid transport GO:0046866 1 0.010
regulation of cell cycle GO:0051726 291 0.010
cellular lipid metabolic process GO:0044255 83 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010

MED4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.011