Drosophila melanogaster

40 known processes

pio (Dmel_CG3541)

piopio

(Aliases: CG30167,CG3541,Dmel\CG3541,Pio)

pio biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
open tracheal system development GO:0007424 204 0.855
chitin based embryonic cuticle biosynthetic process GO:0008362 16 0.735
morphogenesis of a branching epithelium GO:0061138 45 0.719
branching involved in open tracheal system development GO:0060446 45 0.672
respiratory system development GO:0060541 213 0.660
cuticle development GO:0042335 86 0.601
apposition of dorsal and ventral imaginal disc derived wing surfaces GO:0007475 15 0.554
morphogenesis of an epithelium GO:0002009 276 0.544
chitin based cuticle development GO:0040003 49 0.521
tube morphogenesis GO:0035239 191 0.387
imaginal disc derived appendage development GO:0048737 399 0.373
imaginal disc derived wing morphogenesis GO:0007476 337 0.360
post embryonic appendage morphogenesis GO:0035120 385 0.349
morphogenesis of a branching structure GO:0001763 45 0.308
tissue morphogenesis GO:0048729 297 0.303
synapse assembly GO:0007416 143 0.263
branching morphogenesis of an epithelial tube GO:0048754 45 0.255
striated muscle cell differentiation GO:0051146 90 0.204
kidney development GO:0001822 3 0.175
wing disc morphogenesis GO:0007472 344 0.174
cell recognition GO:0008037 102 0.171
regulation of tube architecture open tracheal system GO:0035152 68 0.161
negative regulation of extracellular matrix disassembly GO:0010716 1 0.159
cellular component assembly involved in morphogenesis GO:0010927 151 0.156
appendage development GO:0048736 401 0.152
extracellular structure organization GO:0043062 46 0.136
imaginal disc derived appendage morphogenesis GO:0035114 395 0.130
heart development GO:0007507 82 0.128
nephron development GO:0072006 3 0.122
connective tissue development GO:0061448 3 0.122
molting cycle process GO:0022404 29 0.121
muscle attachment GO:0016203 36 0.118
reproductive behavior GO:0019098 122 0.117
epithelial tube morphogenesis GO:0060562 88 0.109
homeostatic process GO:0042592 199 0.093
actin cytoskeleton organization GO:0030036 206 0.090
regulation of cell differentiation GO:0045595 302 0.090
muscle cell differentiation GO:0042692 103 0.087
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.086
regulation of multicellular organismal development GO:2000026 414 0.086
actin filament based process GO:0030029 220 0.084
single organism behavior GO:0044708 391 0.075
terminal branching open tracheal system GO:0007430 17 0.074
embryonic morphogenesis GO:0048598 206 0.071
developmental growth GO:0048589 280 0.071
synapse organization GO:0050808 196 0.070
regulation of tube size open tracheal system GO:0035151 43 0.070
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.068
regulation of anatomical structure morphogenesis GO:0022603 242 0.067
neuron projection guidance GO:0097485 241 0.067
skin development GO:0043588 65 0.067
kidney epithelium development GO:0072073 3 0.067
body morphogenesis GO:0010171 2 0.066
tube development GO:0035295 244 0.065
sensory perception GO:0007600 196 0.065
central nervous system development GO:0007417 201 0.064
circulatory system development GO:0072359 82 0.064
muscle structure development GO:0061061 224 0.064
cell projection assembly GO:0030031 94 0.062
extracellular matrix organization GO:0030198 32 0.061
regulation of nervous system development GO:0051960 248 0.061
molting cycle GO:0042303 56 0.060
macromolecular complex assembly GO:0065003 256 0.060
mating GO:0007618 120 0.058
trachea development GO:0060438 29 0.058
locomotory behavior GO:0007626 176 0.054
regulation of tube diameter open tracheal system GO:0035158 11 0.054
organelle assembly GO:0070925 198 0.051
regulation of molecular function GO:0065009 217 0.050
cell adhesion GO:0007155 136 0.049
regulation of anatomical structure size GO:0090066 163 0.049
heart morphogenesis GO:0003007 32 0.046
regulation of cell proliferation GO:0042127 163 0.046
gliogenesis GO:0042063 80 0.046
positive regulation of cell differentiation GO:0045597 64 0.045
regulation of localization GO:0032879 275 0.044
striated muscle cell development GO:0055002 50 0.044
camera type eye development GO:0043010 4 0.044
regulation of cell morphogenesis GO:0022604 163 0.043
carboxylic acid metabolic process GO:0019752 92 0.043
cellular macromolecule localization GO:0070727 220 0.041
detection of stimulus GO:0051606 156 0.040
positive regulation of multicellular organismal process GO:0051240 143 0.040
morphogenesis of embryonic epithelium GO:0016331 94 0.040
biological adhesion GO:0022610 138 0.040
small molecule metabolic process GO:0044281 305 0.040
epithelial cell migration open tracheal system GO:0007427 32 0.040
sensory perception of mechanical stimulus GO:0050954 72 0.040
organic acid metabolic process GO:0006082 103 0.039
molting cycle chitin based cuticle GO:0007591 56 0.039
neurological system process GO:0050877 358 0.039
compound eye morphogenesis GO:0001745 249 0.039
negative regulation of biosynthetic process GO:0009890 277 0.038
myofibril assembly GO:0030239 36 0.038
cell proliferation GO:0008283 299 0.038
response to abiotic stimulus GO:0009628 341 0.037
mesenchymal cell development GO:0014031 1 0.037
mesenchymal cell differentiation GO:0048762 1 0.037
oxoacid metabolic process GO:0043436 103 0.037
embryonic organ development GO:0048568 50 0.037
sensory organ morphogenesis GO:0090596 260 0.037
male mating behavior GO:0060179 70 0.037
organonitrogen compound metabolic process GO:1901564 318 0.036
negative regulation of gene expression GO:0010629 387 0.035
tracheal outgrowth open tracheal system GO:0007426 18 0.035
protein localization GO:0008104 284 0.035
single organism biosynthetic process GO:0044711 206 0.035
muscle organ development GO:0007517 127 0.034
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.034
cell cell junction assembly GO:0007043 38 0.034
tube fusion GO:0035146 17 0.033
growth GO:0040007 359 0.033
cell death GO:0008219 279 0.033
extracellular matrix disassembly GO:0022617 4 0.033
regulation of catalytic activity GO:0050790 185 0.033
apoptotic process GO:0006915 159 0.033
peptidyl amino acid modification GO:0018193 105 0.033
positive regulation of cellular amine metabolic process GO:0033240 0 0.033
regulation of cellular component biogenesis GO:0044087 201 0.032
intracellular signal transduction GO:0035556 300 0.032
axon development GO:0061564 297 0.031
positive regulation of signal transduction GO:0009967 223 0.031
muscle cell development GO:0055001 50 0.031
skeletal muscle organ development GO:0060538 48 0.031
forebrain development GO:0030900 2 0.031
regulation of wnt signaling pathway GO:0030111 68 0.031
cellular protein modification process GO:0006464 438 0.031
appendage morphogenesis GO:0035107 397 0.031
cellular component disassembly GO:0022411 46 0.030
head development GO:0060322 135 0.030
mesoderm development GO:0007498 78 0.029
taxis GO:0042330 304 0.029
synaptic target recognition GO:0008039 45 0.029
motor neuron axon guidance GO:0008045 58 0.029
defense response to other organism GO:0098542 225 0.029
cell motility GO:0048870 251 0.028
regionalization GO:0003002 416 0.028
single organism catabolic process GO:0044712 228 0.028
embryonic pattern specification GO:0009880 174 0.028
response to organic substance GO:0010033 284 0.028
wnt signaling pathway GO:0016055 98 0.028
regulation of locomotion GO:0040012 42 0.028
response to mechanical stimulus GO:0009612 28 0.026
positive regulation of cellular component organization GO:0051130 156 0.026
myotube cell development GO:0014904 3 0.026
skeletal muscle fiber development GO:0048741 3 0.026
protein complex biogenesis GO:0070271 201 0.026
response to bacterium GO:0009617 198 0.026
multicellular organismal reproductive behavior GO:0033057 110 0.026
axon guidance GO:0007411 233 0.026
localization of cell GO:0051674 257 0.026
epiboly GO:0090504 2 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.025
chromosome organization GO:0051276 360 0.025
cranial nerve development GO:0021545 1 0.025
urogenital system development GO:0001655 72 0.025
regulation of developmental growth GO:0048638 174 0.024
positive regulation of molecular function GO:0044093 136 0.024
response to monosaccharide GO:0034284 4 0.024
actomyosin structure organization GO:0031032 56 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.024
somatic muscle development GO:0007525 66 0.024
water homeostasis GO:0030104 3 0.024
positive regulation of signaling GO:0023056 243 0.024
regulation of intracellular signal transduction GO:1902531 236 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
regulation of cell shape GO:0008360 113 0.024
multi organism behavior GO:0051705 175 0.023
hindbrain development GO:0030902 2 0.023
ameboidal type cell migration GO:0001667 151 0.023
regulation of cell adhesion GO:0030155 27 0.023
nephron epithelium development GO:0072009 3 0.023
cellular protein localization GO:0034613 160 0.023
camera type eye morphogenesis GO:0048593 2 0.023
organelle fission GO:0048285 340 0.023
positive regulation of nervous system development GO:0051962 69 0.023
filopodium assembly GO:0046847 33 0.023
developmental growth involved in morphogenesis GO:0060560 65 0.022
defense response to bacterium GO:0042742 178 0.022
protein phosphorylation GO:0006468 169 0.021
regulation of membrane potential GO:0042391 35 0.021
establishment of protein localization GO:0045184 163 0.021
regulation of cell cycle GO:0051726 291 0.021
innate immune response GO:0045087 144 0.020
positive regulation of developmental growth GO:0048639 62 0.020
positive regulation of developmental process GO:0051094 143 0.020
terminal region determination GO:0007362 25 0.019
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.019
stem cell differentiation GO:0048863 117 0.019
meiotic cell cycle GO:0051321 171 0.019
negative regulation of response to stimulus GO:0048585 258 0.019
cellular response to chemical stimulus GO:0070887 199 0.019
negative regulation of cellular biosynthetic process GO:0031327 277 0.019
adult locomotory behavior GO:0008344 76 0.019
meiotic nuclear division GO:0007126 151 0.019
regulation of cell migration GO:0030334 22 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.019
positive regulation of cellular component biogenesis GO:0044089 80 0.019
cellular amine metabolic process GO:0044106 12 0.019
establishment of localization in cell GO:0051649 402 0.018
protein modification process GO:0036211 438 0.018
anatomical structure homeostasis GO:0060249 97 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
positive regulation of cell communication GO:0010647 250 0.018
striated muscle myosin thick filament assembly GO:0071688 3 0.018
response to glucose GO:0009749 2 0.018
negative regulation of cellular component organization GO:0051129 108 0.018
organic substance catabolic process GO:1901575 308 0.018
negative regulation of rna metabolic process GO:0051253 251 0.018
epidermis development GO:0008544 65 0.018
cognition GO:0050890 141 0.018
synaptic growth at neuromuscular junction GO:0051124 119 0.018
larval somatic muscle development GO:0007526 19 0.017
purine nucleotide catabolic process GO:0006195 109 0.017
renal system development GO:0072001 72 0.017
axonogenesis GO:0007409 290 0.017
negative regulation of cell proliferation GO:0008285 69 0.017
programmed cell death GO:0012501 257 0.017
adult behavior GO:0030534 137 0.017
defense response to gram negative bacterium GO:0050829 94 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
enzyme linked receptor protein signaling pathway GO:0007167 179 0.017
regulation of neurogenesis GO:0050767 158 0.016
cellular macromolecular complex assembly GO:0034622 153 0.016
synaptic transmission GO:0007268 288 0.016
response to endogenous stimulus GO:0009719 119 0.016
peptidyl tyrosine phosphorylation GO:0018108 24 0.016
blastoderm segmentation GO:0007350 159 0.016
dendrite development GO:0016358 204 0.016
regulation of neuron differentiation GO:0045664 103 0.016
protein complex assembly GO:0006461 200 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
regulation of tube diameter GO:0035296 14 0.016
chemotaxis GO:0006935 249 0.016
positive regulation of response to stimulus GO:0048584 323 0.015
positive regulation of phosphorus metabolic process GO:0010562 139 0.015
organic substance transport GO:0071702 257 0.015
mating behavior GO:0007617 106 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
regulation of apoptotic process GO:0042981 130 0.015
kidney morphogenesis GO:0060993 3 0.015
single organism carbohydrate metabolic process GO:0044723 72 0.015
actin filament organization GO:0007015 126 0.015
cellular catabolic process GO:0044248 372 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
positive regulation of cell migration GO:0030335 2 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.015
regulation of embryonic development GO:0045995 68 0.015
brain development GO:0007420 120 0.015
gland development GO:0048732 191 0.015
reproductive structure development GO:0048608 74 0.014
eye development GO:0001654 323 0.014
immune response GO:0006955 246 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of hydrolase activity GO:0051336 97 0.014
spindle assembly GO:0051225 80 0.014
catabolic process GO:0009056 409 0.014
neuron maturation GO:0042551 31 0.014
pigment metabolic process GO:0042440 84 0.014
regulation of tube length open tracheal system GO:0035159 24 0.014
branch fusion open tracheal system GO:0035147 17 0.014
regulation of cellular amine metabolic process GO:0033238 3 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
nuclear division GO:0000280 332 0.014
cardiovascular system development GO:0072358 82 0.014
cell maturation GO:0048469 144 0.014
cellular homeostasis GO:0019725 80 0.014
cell migration GO:0016477 238 0.014
muscle system process GO:0003012 21 0.014
organ growth GO:0035265 56 0.014
exocrine system development GO:0035272 162 0.014
regulation of neuron projection development GO:0010975 69 0.014
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
reproductive system development GO:0061458 74 0.013
nephron tubule development GO:0072080 3 0.013
epithelial cell migration GO:0010631 148 0.013
negative regulation of cell death GO:0060548 81 0.013
cellular response to organonitrogen compound GO:0071417 36 0.013
glial cell differentiation GO:0010001 35 0.013
intracellular protein transport GO:0006886 104 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
neuronal action potential GO:0019228 10 0.013
imaginal disc derived wing hair organization GO:0035317 45 0.013
death GO:0016265 284 0.013
developmental maturation GO:0021700 172 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.013
substrate adhesion dependent cell spreading GO:0034446 2 0.013
vesicle mediated transport GO:0016192 381 0.013
response to nitrogen compound GO:1901698 90 0.013
myotube differentiation GO:0014902 46 0.013
positive regulation of cellular biosynthetic process GO:0031328 316 0.013
lipid localization GO:0010876 54 0.013
negative regulation of developmental process GO:0051093 201 0.013
response to decreased oxygen levels GO:0036293 58 0.013
compound eye development GO:0048749 307 0.012
nuclear transport GO:0051169 72 0.012
endomembrane system organization GO:0010256 119 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
regulation of cell motility GO:2000145 23 0.012
multicellular organismal signaling GO:0035637 12 0.012
epiboly involved in wound healing GO:0090505 2 0.012
response to other organism GO:0051707 293 0.012
specification of organ identity GO:0010092 3 0.012
indole containing compound biosynthetic process GO:0042435 4 0.012
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.012
circadian behavior GO:0048512 76 0.012
regulation of behavior GO:0050795 75 0.012
regulation of protein modification process GO:0031399 112 0.012
peptidyl tyrosine modification GO:0018212 24 0.012
muscle fiber development GO:0048747 12 0.012
response to oxygen containing compound GO:1901700 200 0.012
endodermal cell differentiation GO:0035987 3 0.012
positive regulation of cell motility GO:2000147 3 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
response to biotic stimulus GO:0009607 294 0.012
larval development GO:0002164 104 0.012
amine metabolic process GO:0009308 12 0.012
regulation of cellular protein metabolic process GO:0032268 243 0.012
basement membrane organization GO:0071711 10 0.011
regulation of protein metabolic process GO:0051246 256 0.011
regulation of epithelial cell proliferation GO:0050678 4 0.011
multi multicellular organism process GO:0044706 123 0.011
regulation of extracellular matrix organization GO:1903053 4 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
positive regulation of neuron differentiation GO:0045666 26 0.011
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
positive regulation of cell development GO:0010720 61 0.011
regulation of phosphorus metabolic process GO:0051174 210 0.011
regulation of cell development GO:0060284 215 0.011
neuromuscular synaptic transmission GO:0007274 67 0.011
regulation of tube size GO:0035150 46 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
regulation of cytoskeleton organization GO:0051493 89 0.011
positive regulation of cell projection organization GO:0031346 29 0.011
detection of external stimulus GO:0009581 66 0.011
salivary gland development GO:0007431 162 0.010
transmission of nerve impulse GO:0019226 12 0.010
glial cell migration GO:0008347 31 0.010
mesodermal cell fate specification GO:0007501 2 0.010
response to hydrogen peroxide GO:0042542 11 0.010
carbohydrate derivative metabolic process GO:1901135 217 0.010
maintenance of location GO:0051235 73 0.010
regulation of organ formation GO:0003156 3 0.010
morphogenesis of a polarized epithelium GO:0001738 93 0.010
regulation of multicellular organism growth GO:0040014 40 0.010
response to wounding GO:0009611 94 0.010
axis specification GO:0009798 167 0.010
regulation of programmed cell death GO:0043067 152 0.010
regulation of synapse assembly GO:0051963 94 0.010
regulation of circadian rhythm GO:0042752 49 0.010
eggshell formation GO:0030703 105 0.010

pio disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.115
bone disease DOID:0080001 0 0.025
musculoskeletal system disease DOID:17 0 0.025
connective tissue disease DOID:65 0 0.025
heart conduction disease DOID:10273 0 0.021
cardiovascular system disease DOID:1287 0 0.021