Drosophila melanogaster

45 known processes

gukh (Dmel_CG31043)

GUK-holder

(Aliases: Gukh,CG6003,GUKH,GUKh,CG14288,GukH,Dmel\CG31043,CG5456,anon-WO0118547.205,CG14287,CG31043)

gukh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axonogenesis GO:0007409 290 0.256
neuron projection guidance GO:0097485 241 0.222
axon guidance GO:0007411 233 0.202
chemotaxis GO:0006935 249 0.195
axon development GO:0061564 297 0.171
cellular protein modification process GO:0006464 438 0.130
actin filament based process GO:0030029 220 0.106
chromatin organization GO:0006325 207 0.102
synapse organization GO:0050808 196 0.095
taxis GO:0042330 304 0.091
response to abiotic stimulus GO:0009628 341 0.089
imaginal disc derived appendage morphogenesis GO:0035114 395 0.089
positive regulation of transcription dna templated GO:0045893 266 0.088
protein ubiquitination GO:0016567 70 0.079
positive regulation of gene expression GO:0010628 290 0.077
cellular response to dna damage stimulus GO:0006974 223 0.072
regionalization GO:0003002 416 0.070
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.069
protein modification by small protein conjugation GO:0032446 79 0.063
lateral inhibition GO:0046331 206 0.062
positive regulation of cellular biosynthetic process GO:0031328 316 0.061
protein modification process GO:0036211 438 0.061
post embryonic appendage morphogenesis GO:0035120 385 0.060
negative regulation of gene expression GO:0010629 387 0.059
dna conformation change GO:0071103 105 0.058
peptidyl lysine acetylation GO:0018394 39 0.056
phosphorylation GO:0016310 294 0.056
macromolecule catabolic process GO:0009057 161 0.055
positive regulation of rna metabolic process GO:0051254 271 0.055
camera type eye development GO:0043010 4 0.054
regulation of synaptic transmission GO:0050804 69 0.054
protein modification by small protein conjugation or removal GO:0070647 106 0.053
single organism behavior GO:0044708 391 0.051
positive regulation of signal transduction GO:0009967 223 0.049
positive regulation of rna biosynthetic process GO:1902680 266 0.048
response to radiation GO:0009314 155 0.048
positive regulation of macromolecule metabolic process GO:0010604 405 0.048
morphogenesis of an epithelium GO:0002009 276 0.047
modification dependent macromolecule catabolic process GO:0043632 79 0.047
dna metabolic process GO:0006259 227 0.046
ras protein signal transduction GO:0007265 88 0.045
negative regulation of cellular metabolic process GO:0031324 382 0.045
posttranscriptional regulation of gene expression GO:0010608 145 0.044
retina development in camera type eye GO:0060041 4 0.043
wing disc morphogenesis GO:0007472 344 0.043
appendage morphogenesis GO:0035107 397 0.043
eye development GO:0001654 323 0.042
growth GO:0040007 359 0.042
positive regulation of response to stimulus GO:0048584 323 0.042
small molecule metabolic process GO:0044281 305 0.040
regulation of cell cycle phase transition GO:1901987 130 0.040
epithelial cell development GO:0002064 274 0.039
adult behavior GO:0030534 137 0.039
establishment or maintenance of cell polarity GO:0007163 167 0.039
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.039
epithelial cell differentiation GO:0030855 322 0.039
appendage development GO:0048736 401 0.038
regulation of phosphate metabolic process GO:0019220 210 0.037
intracellular signal transduction GO:0035556 300 0.037
tissue morphogenesis GO:0048729 297 0.037
protein phosphorylation GO:0006468 169 0.036
nucleobase containing compound catabolic process GO:0034655 165 0.036
imaginal disc derived appendage development GO:0048737 399 0.036
nuclear division GO:0000280 332 0.036
cellular catabolic process GO:0044248 372 0.036
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.036
regulation of phosphorylation GO:0042325 147 0.035
chromosome organization GO:0051276 360 0.034
negative regulation of developmental process GO:0051093 201 0.034
reproductive behavior GO:0019098 122 0.034
cell proliferation GO:0008283 299 0.034
negative regulation of cellular biosynthetic process GO:0031327 277 0.034
antimicrobial humoral response GO:0019730 99 0.033
aging GO:0007568 143 0.033
imaginal disc derived wing morphogenesis GO:0007476 337 0.033
wnt signaling pathway GO:0016055 98 0.033
photoreceptor cell axon guidance GO:0072499 23 0.033
dendrite morphogenesis GO:0048813 199 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.033
immune system process GO:0002376 347 0.032
regulation of molecular function GO:0065009 217 0.032
intracellular transport GO:0046907 228 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.032
positive regulation of cell communication GO:0010647 250 0.032
olfactory behavior GO:0042048 97 0.032
regulation of mitotic cell cycle GO:0007346 190 0.031
positive regulation of biosynthetic process GO:0009891 316 0.031
blastoderm segmentation GO:0007350 159 0.031
regulation of developmental growth GO:0048638 174 0.031
sensory organ morphogenesis GO:0090596 260 0.031
positive regulation of nucleic acid templated transcription GO:1903508 266 0.031
male gamete generation GO:0048232 201 0.031
developmental growth involved in morphogenesis GO:0060560 65 0.030
catabolic process GO:0009056 409 0.030
regulation of protein metabolic process GO:0051246 256 0.030
carbohydrate derivative metabolic process GO:1901135 217 0.030
programmed cell death GO:0012501 257 0.029
ovarian follicle cell development GO:0030707 248 0.029
cell motility GO:0048870 251 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.029
single organism cellular localization GO:1902580 180 0.029
embryonic pattern specification GO:0009880 174 0.028
regulation of cellular protein metabolic process GO:0032268 243 0.028
cell cell signaling involved in cell fate commitment GO:0045168 210 0.028
body morphogenesis GO:0010171 2 0.028
modification dependent protein catabolic process GO:0019941 78 0.028
synaptic growth at neuromuscular junction GO:0051124 119 0.028
mitotic cell cycle phase transition GO:0044772 138 0.028
spermatid differentiation GO:0048515 114 0.028
cellular protein catabolic process GO:0044257 83 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.028
positive regulation of phosphorus metabolic process GO:0010562 139 0.027
courtship behavior GO:0007619 68 0.027
regulation of nervous system development GO:0051960 248 0.027
developmental maturation GO:0021700 172 0.027
rhythmic behavior GO:0007622 76 0.027
organonitrogen compound metabolic process GO:1901564 318 0.026
segmentation GO:0035282 207 0.026
histone acetylation GO:0016573 38 0.026
rna localization GO:0006403 115 0.026
photoreceptor cell differentiation GO:0046530 170 0.026
eye photoreceptor cell differentiation GO:0001754 145 0.026
developmental growth GO:0048589 280 0.025
regulation of localization GO:0032879 275 0.025
establishment of organelle localization GO:0051656 122 0.025
positive regulation of signaling GO:0023056 243 0.025
phagocytosis GO:0006909 215 0.024
chemosensory behavior GO:0007635 106 0.024
ameboidal type cell migration GO:0001667 151 0.024
microtubule organizing center organization GO:0031023 168 0.024
negative regulation of nucleic acid templated transcription GO:1903507 240 0.024
regulation of synapse structure and activity GO:0050803 128 0.024
regulation of cellular component size GO:0032535 98 0.023
extrinsic apoptotic signaling pathway GO:0097191 1 0.023
camera type eye morphogenesis GO:0048593 2 0.023
cellular nitrogen compound catabolic process GO:0044270 165 0.023
regulation of cell cycle GO:0051726 291 0.023
establishment of localization in cell GO:0051649 402 0.023
synapse assembly GO:0007416 143 0.023
regulation of transport GO:0051049 181 0.023
localization of cell GO:0051674 257 0.022
response to wounding GO:0009611 94 0.022
negative regulation of rna biosynthetic process GO:1902679 240 0.022
forebrain development GO:0030900 2 0.022
photoreceptor cell development GO:0042461 96 0.022
regulation of cell differentiation GO:0045595 302 0.022
regulation of vesicle mediated transport GO:0060627 59 0.022
anatomical structure homeostasis GO:0060249 97 0.021
chromatin modification GO:0016568 147 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.021
response to nutrient levels GO:0031667 114 0.021
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
sensory perception of chemical stimulus GO:0007606 116 0.020
regulation of response to stress GO:0080134 200 0.020
regulation of cellular component biogenesis GO:0044087 201 0.020
regulation of protein ubiquitination GO:0031396 22 0.020
regulation of phosphorus metabolic process GO:0051174 210 0.020
dephosphorylation GO:0016311 51 0.020
regulation of intracellular signal transduction GO:1902531 236 0.020
detection of stimulus GO:0051606 156 0.020
dendrite development GO:0016358 204 0.019
organic cyclic compound catabolic process GO:1901361 168 0.019
regulation of notch signaling pathway GO:0008593 100 0.019
stem cell development GO:0048864 79 0.019
larval development GO:0002164 104 0.019
carbohydrate derivative biosynthetic process GO:1901137 85 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
single organism intracellular transport GO:1902582 207 0.019
homeostatic process GO:0042592 199 0.019
regulation of small gtpase mediated signal transduction GO:0051056 93 0.019
organic substance transport GO:0071702 257 0.019
columnar cuboidal epithelial cell development GO:0002066 249 0.019
cell division GO:0051301 248 0.019
single organism biosynthetic process GO:0044711 206 0.019
regulation of anatomical structure size GO:0090066 163 0.019
response to mechanical stimulus GO:0009612 28 0.018
multicellular organismal reproductive behavior GO:0033057 110 0.018
intracellular mrna localization GO:0008298 66 0.018
regulation of cell death GO:0010941 173 0.018
establishment of spindle localization GO:0051293 22 0.018
centrosome organization GO:0051297 163 0.018
regulation of ras protein signal transduction GO:0046578 93 0.018
nucleoside phosphate metabolic process GO:0006753 162 0.018
jnk cascade GO:0007254 50 0.018
male courtship behavior GO:0008049 63 0.018
regulation of anatomical structure morphogenesis GO:0022603 242 0.018
purine nucleoside triphosphate catabolic process GO:0009146 108 0.018
actin mediated cell contraction GO:0070252 21 0.018
regulation of catalytic activity GO:0050790 185 0.018
regulation of protein localization GO:0032880 76 0.018
eye morphogenesis GO:0048592 260 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
vesicle mediated transport GO:0016192 381 0.018
negative regulation of signaling GO:0023057 219 0.018
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.018
respiratory system development GO:0060541 213 0.018
receptor clustering GO:0043113 3 0.018
meiotic cell cycle GO:0051321 171 0.018
establishment of vesicle localization GO:0051650 51 0.018
internal peptidyl lysine acetylation GO:0018393 38 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.017
regulation of cell cycle process GO:0010564 181 0.017
negative regulation of cell differentiation GO:0045596 143 0.017
mitotic nuclear division GO:0007067 213 0.017
negative regulation of signal transduction GO:0009968 206 0.017
regulation of wnt signaling pathway GO:0030111 68 0.017
chaeta development GO:0022416 97 0.017
cellular macromolecule localization GO:0070727 220 0.017
protein k48 linked ubiquitination GO:0070936 3 0.017
transcription from rna polymerase ii promoter GO:0006366 368 0.017
positive regulation of gtpase activity GO:0043547 43 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
germ line stem cell maintenance GO:0030718 50 0.017
spermatogenesis GO:0007283 200 0.017
cell aging GO:0007569 2 0.017
establishment of protein localization GO:0045184 163 0.017
protein acetylation GO:0006473 39 0.017
stem cell maintenance GO:0019827 67 0.017
asymmetric stem cell division GO:0098722 49 0.017
protein acylation GO:0043543 42 0.017
oocyte differentiation GO:0009994 145 0.017
embryonic morphogenesis GO:0048598 206 0.016
regulation of endocytosis GO:0030100 37 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.016
peptidyl lysine modification GO:0018205 57 0.016
establishment of spindle orientation GO:0051294 18 0.016
secondary metabolic process GO:0019748 75 0.016
cellular component assembly involved in morphogenesis GO:0010927 151 0.016
aromatic compound catabolic process GO:0019439 166 0.016
response to extracellular stimulus GO:0009991 116 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
cell death GO:0008219 279 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
stem cell proliferation GO:0072089 88 0.016
cranial nerve development GO:0021545 1 0.016
ubiquitin dependent protein catabolic process GO:0006511 78 0.016
dorsal ventral axon guidance GO:0033563 2 0.015
response to biotic stimulus GO:0009607 294 0.015
response to other organism GO:0051707 293 0.015
cellular response to chemical stimulus GO:0070887 199 0.015
actin cytoskeleton organization GO:0030036 206 0.015
cell cycle checkpoint GO:0000075 95 0.015
rna processing GO:0006396 147 0.015
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.015
negative regulation of phosphorylation GO:0042326 35 0.015
dorsal ventral axis specification GO:0009950 66 0.015
regulation of synapse assembly GO:0051963 94 0.015
regulation of programmed cell death GO:0043067 152 0.015
erbb signaling pathway GO:0038127 58 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.015
centrosome cycle GO:0007098 137 0.015
regulation of stress activated mapk cascade GO:0032872 41 0.015
compound eye morphogenesis GO:0001745 249 0.015
monocarboxylic acid transport GO:0015718 3 0.015
fluid transport GO:0042044 19 0.015
response to organic substance GO:0010033 284 0.015
regulation of protein stability GO:0031647 43 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
organophosphate metabolic process GO:0019637 195 0.015
endocytosis GO:0006897 310 0.014
death GO:0016265 284 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
negative regulation of cell cycle phase transition GO:1901988 103 0.014
compound eye photoreceptor development GO:0042051 78 0.014
mitotic cell cycle checkpoint GO:0007093 88 0.014
response to heat GO:0009408 63 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.014
regulation of neuromuscular synaptic transmission GO:1900073 15 0.014
larval behavior GO:0030537 42 0.014
proteolysis GO:0006508 192 0.014
regulation of apoptotic process GO:0042981 130 0.014
rho protein signal transduction GO:0007266 14 0.014
establishment of tissue polarity GO:0007164 87 0.014
neuron projection extension GO:1990138 32 0.014
organelle assembly GO:0070925 198 0.014
purine nucleoside catabolic process GO:0006152 112 0.014
spermatid development GO:0007286 98 0.014
organophosphate biosynthetic process GO:0090407 46 0.014
single organism carbohydrate metabolic process GO:0044723 72 0.014
regulation of cellular amine metabolic process GO:0033238 3 0.014
determination of adult lifespan GO:0008340 137 0.014
positive regulation of wnt signaling pathway GO:0030177 25 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
signal transduction by phosphorylation GO:0023014 107 0.014
phosphatidylinositol mediated signaling GO:0048015 4 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
stress activated protein kinase signaling cascade GO:0031098 55 0.014
notch signaling pathway GO:0007219 120 0.014
actin filament based movement GO:0030048 26 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
organic acid metabolic process GO:0006082 103 0.013
peripheral nervous system development GO:0007422 52 0.013
positive regulation of nervous system development GO:0051962 69 0.013
protein transport GO:0015031 155 0.013
organic substance catabolic process GO:1901575 308 0.013
regulation of synapse organization GO:0050807 110 0.013
eye photoreceptor cell development GO:0042462 81 0.013
positive regulation of cell motility GO:2000147 3 0.013
positive regulation of transport GO:0051050 92 0.013
regulation of establishment of protein localization GO:0070201 61 0.013
mitotic sister chromatid segregation GO:0000070 87 0.013
leg disc development GO:0035218 92 0.013
response to organophosphorus GO:0046683 2 0.013
neurological system process GO:0050877 358 0.013
humoral immune response GO:0006959 117 0.013
response to oxygen containing compound GO:1901700 200 0.013
cellular protein localization GO:0034613 160 0.013
oxoacid metabolic process GO:0043436 103 0.013
male mating behavior GO:0060179 70 0.013
protein complex biogenesis GO:0070271 201 0.013
nucleotide metabolic process GO:0009117 161 0.013
neural retina development GO:0003407 4 0.013
ribonucleoside metabolic process GO:0009119 127 0.012
regulation of mapk cascade GO:0043408 92 0.012
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.012
regulation of cellular localization GO:0060341 136 0.012
organelle localization GO:0051640 148 0.012
axis specification GO:0009798 167 0.012
regulation of nucleocytoplasmic transport GO:0046822 35 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
defense response GO:0006952 300 0.012
cell junction organization GO:0034330 57 0.012
tripartite regional subdivision GO:0007351 103 0.012
heterocycle catabolic process GO:0046700 166 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
kidney development GO:0001822 3 0.012
cortical cytoskeleton organization GO:0030865 29 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
negative regulation of cell cycle process GO:0010948 109 0.012
regulation of cell cycle g1 s phase transition GO:1902806 23 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
jak stat cascade GO:0007259 49 0.012
limb development GO:0060173 1 0.012
neuromuscular junction development GO:0007528 149 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
glycoprotein metabolic process GO:0009100 41 0.012
regulation of intracellular protein transport GO:0033157 46 0.012
chromosome segregation GO:0007059 157 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
cellular response to decreased oxygen levels GO:0036294 30 0.012
circadian behavior GO:0048512 76 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
regulation of cytoplasmic transport GO:1903649 47 0.012
negative regulation of cell death GO:0060548 81 0.012
cytoplasm organization GO:0007028 64 0.012
signal transduction in response to dna damage GO:0042770 3 0.012
imaginal disc derived leg segmentation GO:0036011 26 0.012
organelle fission GO:0048285 340 0.011
carboxylic acid metabolic process GO:0019752 92 0.011
regulation of jnk cascade GO:0046328 40 0.011
positive regulation of molecular function GO:0044093 136 0.011
asymmetric cell division GO:0008356 37 0.011
neuromuscular synaptic transmission GO:0007274 67 0.011
regulation of immune system process GO:0002682 176 0.011
neuroblast proliferation GO:0007405 74 0.011
positive regulation of cell migration GO:0030335 2 0.011
translation GO:0006412 69 0.011
negative regulation of biosynthetic process GO:0009890 277 0.011
protein depolymerization GO:0051261 31 0.011
negative regulation of synaptic transmission GO:0050805 12 0.011
cell cycle arrest GO:0007050 4 0.011
wing disc pattern formation GO:0035222 66 0.011
sensory perception GO:0007600 196 0.011
nitrogen compound transport GO:0071705 85 0.011
regulation of translation GO:0006417 56 0.011
developmental programmed cell death GO:0010623 138 0.011
meiosis i GO:0007127 59 0.011
regulation of meiosis GO:0040020 3 0.011
cellular response to endogenous stimulus GO:0071495 80 0.011
compound eye development GO:0048749 307 0.011
regulation of antimicrobial humoral response GO:0002759 50 0.011
stress activated mapk cascade GO:0051403 52 0.011
renal system development GO:0072001 72 0.011
negative regulation of response to stimulus GO:0048585 258 0.011
immune response GO:0006955 246 0.011
regulation of catabolic process GO:0009894 170 0.011
endodermal cell fate commitment GO:0001711 3 0.011
response to lipopolysaccharide GO:0032496 4 0.011
epithelial cell migration GO:0010631 148 0.011
positive regulation of gtp catabolic process GO:0033126 43 0.011
inositol lipid mediated signaling GO:0048017 4 0.011
necrotic cell death GO:0070265 1 0.011
brain development GO:0007420 120 0.011
embryo development ending in birth or egg hatching GO:0009792 152 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.011
periodic partitioning GO:0007365 29 0.011
cellular response to oxygen levels GO:0071453 30 0.010
morphogenesis of a branching structure GO:0001763 45 0.010
protein localization GO:0008104 284 0.010
ribose phosphate metabolic process GO:0019693 145 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
stem cell differentiation GO:0048863 117 0.010
negative regulation of transcription dna templated GO:0045892 237 0.010
nephron development GO:0072006 3 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010
synaptic transmission GO:0007268 288 0.010
synaptic vesicle localization GO:0097479 53 0.010
cell junction assembly GO:0034329 42 0.010
positive regulation of neurogenesis GO:0050769 41 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.010
regulation of cellular amide metabolic process GO:0034248 39 0.010
multicellular organismal aging GO:0010259 140 0.010
negative regulation of mitotic cell cycle GO:0045930 109 0.010

gukh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.066
nervous system disease DOID:863 0 0.066
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
disease of metabolism DOID:0014667 0 0.013
organ system cancer DOID:0050686 0 0.013