Drosophila melanogaster

142 known processes

Mkk4 (Dmel_CG9738)

MAP kinase kinase 4

(Aliases: 142758_at,mkk4,DMKK4,CT27508,Dmel\CG9738,MKK4,dMKK4,CG9738,JNKK2,Mpk4,SEK1/MKK4,D-MKK4)

Mkk4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axonogenesis GO:0007409 290 0.621
Fly
axon guidance GO:0007411 233 0.450
synaptic transmission GO:0007268 288 0.442
Worm
negative regulation of rna metabolic process GO:0051253 251 0.425
eye development GO:0001654 323 0.358
meiotic cell cycle GO:0051321 171 0.352
taxis GO:0042330 304 0.324
axon development GO:0061564 297 0.318
Fly
compound eye morphogenesis GO:0001745 249 0.305
negative regulation of transcription dna templated GO:0045892 237 0.296
sensory organ morphogenesis GO:0090596 260 0.264
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.258
dendrite development GO:0016358 204 0.254
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.201
spindle organization GO:0007051 253 0.196
regulation of nervous system development GO:0051960 248 0.191
chemotaxis GO:0006935 249 0.177
multi organism behavior GO:0051705 175 0.169
muscle structure development GO:0061061 224 0.164
Rat
dendrite morphogenesis GO:0048813 199 0.156
negative regulation of rna biosynthetic process GO:1902679 240 0.145
neurological system process GO:0050877 358 0.145
compound eye photoreceptor development GO:0042051 78 0.144
regulation of neurogenesis GO:0050767 158 0.142
neuron projection guidance GO:0097485 241 0.140
regulation of cell development GO:0060284 215 0.137
positive regulation of multicellular organismal process GO:0051240 143 0.135
ras protein signal transduction GO:0007265 88 0.134
response to organic substance GO:0010033 284 0.129
Rat
compound eye development GO:0048749 307 0.129
regionalization GO:0003002 416 0.128
Zebrafish Fly
mitotic spindle organization GO:0007052 220 0.121
positive regulation of biosynthetic process GO:0009891 316 0.118
Rat Fly
regulation of cell differentiation GO:0045595 302 0.117
Fly
stem cell differentiation GO:0048863 117 0.113
organelle assembly GO:0070925 198 0.112
transcription from rna polymerase ii promoter GO:0006366 368 0.109
organelle fission GO:0048285 340 0.105
cellular protein modification process GO:0006464 438 0.103
ribonucleotide metabolic process GO:0009259 145 0.101
photoreceptor cell differentiation GO:0046530 170 0.098
regulation of ras protein signal transduction GO:0046578 93 0.098
organelle localization GO:0051640 148 0.097
regulation of intracellular signal transduction GO:1902531 236 0.094
actin filament organization GO:0007015 126 0.092
Fly
male gamete generation GO:0048232 201 0.091
regulation of cell cycle GO:0051726 291 0.090
fertilization GO:0009566 26 0.089
regulation of neuron differentiation GO:0045664 103 0.088
endomembrane system organization GO:0010256 119 0.088
organonitrogen compound metabolic process GO:1901564 318 0.086
small gtpase mediated signal transduction GO:0007264 88 0.086
meiotic nuclear division GO:0007126 151 0.086
segmentation GO:0035282 207 0.084
stem cell proliferation GO:0072089 88 0.082
ethanolamine containing compound metabolic process GO:0042439 4 0.078
macromolecular complex assembly GO:0065003 256 0.078
positive regulation of cellular biosynthetic process GO:0031328 316 0.076
Rat Fly
nuclear division GO:0000280 332 0.074
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.072
negative regulation of nucleic acid templated transcription GO:1903507 240 0.072
membrane organization GO:0061024 112 0.071
Fly
amine metabolic process GO:0009308 12 0.071
eye morphogenesis GO:0048592 260 0.071
neuron recognition GO:0008038 101 0.071
determination of adult lifespan GO:0008340 137 0.071
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.070
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.069
Rat Fly
negative regulation of cell cycle process GO:0010948 109 0.068
eye photoreceptor cell differentiation GO:0001754 145 0.067
mitotic nuclear division GO:0007067 213 0.065
organophosphate metabolic process GO:0019637 195 0.063
organic substance catabolic process GO:1901575 308 0.062
dorsal ventral pattern formation GO:0009953 133 0.061
Zebrafish
protein complex biogenesis GO:0070271 201 0.060
ribonucleoside triphosphate metabolic process GO:0009199 119 0.060
compound eye photoreceptor cell differentiation GO:0001751 140 0.059
protein complex assembly GO:0006461 200 0.059
regulation of organelle organization GO:0033043 196 0.059
cellular macromolecule localization GO:0070727 220 0.058
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.058
protein modification process GO:0036211 438 0.058
regulation of neuron projection development GO:0010975 69 0.058
single organism membrane organization GO:0044802 93 0.057
photoreceptor cell development GO:0042461 96 0.056
ribonucleoside metabolic process GO:0009119 127 0.055
meiotic cell cycle process GO:1903046 132 0.054
eye photoreceptor cell development GO:0042462 81 0.054
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.053
glycosyl compound catabolic process GO:1901658 112 0.052
vesicle mediated transport GO:0016192 381 0.051
Fly
positive regulation of phosphorus metabolic process GO:0010562 139 0.051
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.050
positive regulation of nucleic acid templated transcription GO:1903508 266 0.050
Fly
regulation of small gtpase mediated signal transduction GO:0051056 93 0.049
oocyte differentiation GO:0009994 145 0.049
regulation of phosphorus metabolic process GO:0051174 210 0.049
positive regulation of macromolecule metabolic process GO:0010604 405 0.049
cell recognition GO:0008037 102 0.049
regulation of cell cycle process GO:0010564 181 0.049
cellular catabolic process GO:0044248 372 0.049
Fly
growth GO:0040007 359 0.048
Rat Fly
brain development GO:0007420 120 0.048
aromatic compound catabolic process GO:0019439 166 0.048
synapse assembly GO:0007416 143 0.048
guanosine containing compound metabolic process GO:1901068 74 0.048
guanosine containing compound catabolic process GO:1901069 74 0.047
endocytosis GO:0006897 310 0.046
Fly
nucleoside phosphate catabolic process GO:1901292 110 0.045
phosphorylation GO:0016310 294 0.045
hindgut morphogenesis GO:0007442 58 0.044
positive regulation of protein metabolic process GO:0051247 128 0.044
negative regulation of cell development GO:0010721 62 0.044
embryonic pattern specification GO:0009880 174 0.044
regulation of molecular function GO:0065009 217 0.044
cation transport GO:0006812 110 0.043
dna metabolic process GO:0006259 227 0.042
Rat
single organism behavior GO:0044708 391 0.042
intracellular transport GO:0046907 228 0.042
negative regulation of cell cycle phase transition GO:1901988 103 0.042
spermatogenesis GO:0007283 200 0.041
negative regulation of biosynthetic process GO:0009890 277 0.041
regulation of phosphate metabolic process GO:0019220 210 0.041
blastoderm segmentation GO:0007350 159 0.040
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.040
locomotory behavior GO:0007626 176 0.040
meiotic chromosome segregation GO:0045132 59 0.040
cell fate determination GO:0001709 91 0.040
negative regulation of neurogenesis GO:0050768 53 0.040
positive regulation of rna metabolic process GO:0051254 271 0.040
Fly
positive regulation of cellular component organization GO:0051130 156 0.039
negative regulation of cell differentiation GO:0045596 143 0.039
synaptic growth at neuromuscular junction GO:0051124 119 0.039
cell death GO:0008219 279 0.038
Rat
appendage development GO:0048736 401 0.038
protein localization GO:0008104 284 0.038
catabolic process GO:0009056 409 0.038
Fly
cellular amine metabolic process GO:0044106 12 0.038
organic cyclic compound catabolic process GO:1901361 168 0.037
spindle elongation GO:0051231 83 0.037
establishment of localization in cell GO:0051649 402 0.037
purine nucleoside triphosphate catabolic process GO:0009146 108 0.037
regulation of response to stress GO:0080134 200 0.037
positive regulation of phosphate metabolic process GO:0045937 139 0.037
leg disc development GO:0035218 92 0.036
negative regulation of gene expression GO:0010629 387 0.036
Worm
regulation of mitotic cell cycle GO:0007346 190 0.036
gland development GO:0048732 191 0.036
regulation of protein complex assembly GO:0043254 42 0.036
lipid biosynthetic process GO:0008610 46 0.036
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.035
Rat Fly
regulation of cell morphogenesis GO:0022604 163 0.035
mapk cascade GO:0000165 107 0.035
purine containing compound catabolic process GO:0072523 112 0.035
sensory perception GO:0007600 196 0.035
regulation of synapse structure and activity GO:0050803 128 0.034
Worm
purine nucleotide metabolic process GO:0006163 146 0.034
response to external biotic stimulus GO:0043207 293 0.034
negative regulation of nervous system development GO:0051961 92 0.033
regulation of cell death GO:0010941 173 0.033
Rat
stem cell development GO:0048864 79 0.033
single organism catabolic process GO:0044712 228 0.033
negative regulation of developmental process GO:0051093 201 0.032
telencephalon development GO:0021537 2 0.032
mitochondrion organization GO:0007005 65 0.032
cellular protein localization GO:0034613 160 0.032
intracellular protein transport GO:0006886 104 0.032
embryonic development via the syncytial blastoderm GO:0001700 148 0.032
Fly
regulation of localization GO:0032879 275 0.032
embryo development ending in birth or egg hatching GO:0009792 152 0.032
Fly
stem cell maintenance GO:0019827 67 0.032
positive regulation of response to stimulus GO:0048584 323 0.032
meiosis i GO:0007127 59 0.031
carbohydrate derivative catabolic process GO:1901136 118 0.031
dendrite guidance GO:0070983 21 0.031
nucleoside triphosphate metabolic process GO:0009141 120 0.031
cellular protein complex assembly GO:0043623 71 0.031
regulation of synaptic transmission GO:0050804 69 0.031
chromatin silencing GO:0006342 76 0.031
gtp metabolic process GO:0046039 72 0.031
anterior posterior pattern specification GO:0009952 136 0.031
single organism biosynthetic process GO:0044711 206 0.031
regulation of actin filament length GO:0030832 27 0.031
regulation of cell cycle phase transition GO:1901987 130 0.030
immune system process GO:0002376 347 0.030
Fly
response to bacterium GO:0009617 198 0.030
protein modification by small protein conjugation GO:0032446 79 0.030
cell growth GO:0016049 108 0.029
Rat Fly
spermatid development GO:0007286 98 0.029
cellular macromolecular complex assembly GO:0034622 153 0.029
cellular response to dna damage stimulus GO:0006974 223 0.029
nucleobase containing small molecule metabolic process GO:0055086 174 0.029
defense response to other organism GO:0098542 225 0.029
protein ubiquitination GO:0016567 70 0.029
regulation of dendrite morphogenesis GO:0048814 28 0.029
nucleotide catabolic process GO:0009166 109 0.028
positive regulation of cellular component biogenesis GO:0044089 80 0.028
ribonucleoside catabolic process GO:0042454 112 0.028
single organism intracellular transport GO:1902582 207 0.028
imaginal disc derived appendage development GO:0048737 399 0.028
female meiotic division GO:0007143 70 0.028
organophosphate catabolic process GO:0046434 112 0.028
cytoplasmic transport GO:0016482 130 0.028
negative regulation of cell cycle GO:0045786 116 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.028
nucleoside catabolic process GO:0009164 112 0.027
positive regulation of developmental process GO:0051094 143 0.027
purine ribonucleotide catabolic process GO:0009154 109 0.027
retrograde axon cargo transport GO:0008090 9 0.027
regulation of cellular component biogenesis GO:0044087 201 0.027
actin cytoskeleton reorganization GO:0031532 22 0.027
head development GO:0060322 135 0.027
digestive system development GO:0055123 149 0.027
regulation of catalytic activity GO:0050790 185 0.027
single organism cellular localization GO:1902580 180 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.026
purine nucleoside catabolic process GO:0006152 112 0.026
negative regulation of intracellular signal transduction GO:1902532 57 0.026
regulation of protein modification process GO:0031399 112 0.026
purine nucleoside triphosphate metabolic process GO:0009144 119 0.026
homeostatic process GO:0042592 199 0.026
Fly
ribose phosphate metabolic process GO:0019693 145 0.026
positive regulation of cell communication GO:0010647 250 0.026
cell projection assembly GO:0030031 94 0.026
Fly
regulation of multi organism process GO:0043900 131 0.026
developmental growth GO:0048589 280 0.026
Rat Fly
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.026
defense response to bacterium GO:0042742 178 0.025
pronuclear migration GO:0035046 4 0.025
camera type eye development GO:0043010 4 0.025
purine nucleotide catabolic process GO:0006195 109 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
regulation of cell projection organization GO:0031344 92 0.025
generation of precursor metabolites and energy GO:0006091 42 0.025
regulation of purine nucleotide catabolic process GO:0033121 48 0.024
maternal determination of anterior posterior axis embryo GO:0008358 74 0.024
post embryonic appendage morphogenesis GO:0035120 385 0.024
regulation of cellular amine metabolic process GO:0033238 3 0.024
chaeta development GO:0022416 97 0.024
defense response GO:0006952 300 0.024
Worm Fly
muscle organ development GO:0007517 127 0.024
enzyme linked receptor protein signaling pathway GO:0007167 179 0.024
cellular ketone metabolic process GO:0042180 24 0.024
regulation of actin cytoskeleton organization GO:0032956 42 0.023
response to nutrient levels GO:0031667 114 0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.023
positive regulation of rna biosynthetic process GO:1902680 266 0.023
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.023
actin cytoskeleton organization GO:0030036 206 0.023
Fly
r7 cell differentiation GO:0045466 43 0.022
translation GO:0006412 69 0.022
establishment or maintenance of cell polarity GO:0007163 167 0.022
regulation of wnt signaling pathway GO:0030111 68 0.022
intracellular signal transduction GO:0035556 300 0.022
positive regulation of nervous system development GO:0051962 69 0.022
regulation of dendrite development GO:0050773 37 0.022
positive regulation of gene expression GO:0010628 290 0.022
Fly
positive regulation of cellular catabolic process GO:0031331 95 0.022
Fly
organic hydroxy compound metabolic process GO:1901615 83 0.022
Fly
forebrain development GO:0030900 2 0.022
ribonucleotide catabolic process GO:0009261 109 0.022
regulation of anatomical structure size GO:0090066 163 0.022
asymmetric protein localization GO:0008105 33 0.022
nitrogen compound transport GO:0071705 85 0.022
regulation of phosphorylation GO:0042325 147 0.022
negative regulation of cellular component organization GO:0051129 108 0.022
establishment of organelle localization GO:0051656 122 0.021
cellular response to endogenous stimulus GO:0071495 80 0.021
adult locomotory behavior GO:0008344 76 0.021
regulation of transport GO:0051049 181 0.021
regulation of protein metabolic process GO:0051246 256 0.021
central nervous system development GO:0007417 201 0.021
wing disc pattern formation GO:0035222 66 0.021
regulation of response to biotic stimulus GO:0002831 63 0.021
gtp catabolic process GO:0006184 72 0.021
imaginal disc pattern formation GO:0007447 91 0.021
positive regulation of signaling GO:0023056 243 0.020
cellular amino acid metabolic process GO:0006520 61 0.020
regulation of nucleotide metabolic process GO:0006140 62 0.020
regulation of cytoskeleton organization GO:0051493 89 0.020
ribonucleoside triphosphate catabolic process GO:0009203 108 0.020
regulation of cell shape GO:0008360 113 0.020
cellular response to chemical stimulus GO:0070887 199 0.020
Rat Fly
protein phosphorylation GO:0006468 169 0.020
cytokinesis GO:0000910 90 0.020
cellular lipid metabolic process GO:0044255 83 0.020
regulation of cellular component size GO:0032535 98 0.020
hindgut development GO:0061525 58 0.020
synapse organization GO:0050808 196 0.020
Worm
regulation of ras gtpase activity GO:0032318 38 0.020
spermatid differentiation GO:0048515 114 0.020
multi organism reproductive behavior GO:0044705 121 0.020
nucleotide metabolic process GO:0009117 161 0.020
positive regulation of intracellular signal transduction GO:1902533 116 0.020
chromatin organization GO:0006325 207 0.019
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.019
bmp signaling pathway GO:0030509 27 0.019
nucleoside triphosphate catabolic process GO:0009143 108 0.019
regulation of catabolic process GO:0009894 170 0.019
Fly
cellular response to organic substance GO:0071310 132 0.019
Rat
nucleoside metabolic process GO:0009116 127 0.019
chromosome segregation GO:0007059 157 0.019
positive regulation of cell development GO:0010720 61 0.019
small molecule metabolic process GO:0044281 305 0.019
regulation of meiosis GO:0040020 3 0.019
digestive tract morphogenesis GO:0048546 127 0.018
reproductive behavior GO:0019098 122 0.018
ion transmembrane transport GO:0034220 122 0.018
positive regulation of molecular function GO:0044093 136 0.018
imaginal disc derived leg morphogenesis GO:0007480 80 0.018
regulation of immune system process GO:0002682 176 0.018
Fly
signal transduction by phosphorylation GO:0023014 107 0.018
purine ribonucleotide metabolic process GO:0009150 145 0.018
axon midline choice point recognition GO:0016199 26 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
ovarian fusome organization GO:0030723 11 0.017
posttranscriptional regulation of gene expression GO:0010608 145 0.017
Worm
protein modification by small protein conjugation or removal GO:0070647 106 0.017
regulation of bmp signaling pathway GO:0030510 23 0.017
regulation of protein kinase activity GO:0045859 51 0.017
purine ribonucleoside metabolic process GO:0046128 127 0.017
positive regulation of cellular protein metabolic process GO:0032270 118 0.017
ion transport GO:0006811 145 0.017
positive regulation of response to external stimulus GO:0032103 44 0.017
regulation of membrane potential GO:0042391 35 0.017
positive regulation of growth GO:0045927 75 0.017
axis specification GO:0009798 167 0.017
signal transduction in response to dna damage GO:0042770 3 0.016
response to transforming growth factor beta GO:0071559 18 0.016
lateral inhibition GO:0046331 206 0.016
response to growth factor GO:0070848 31 0.016
positive regulation of phosphorylation GO:0042327 87 0.016
regulation of protein polymerization GO:0032271 28 0.016
regulation of nucleotide catabolic process GO:0030811 48 0.016
purine ribonucleoside catabolic process GO:0046130 112 0.016
regulation of cellular ketone metabolic process GO:0010565 3 0.016
glycosyl compound metabolic process GO:1901657 127 0.016
proteolysis GO:0006508 192 0.016
detection of stimulus GO:0051606 156 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
protein targeting GO:0006605 64 0.016
retinal ganglion cell axon guidance GO:0031290 12 0.016
regulation of cellular catabolic process GO:0031329 157 0.015
Fly
localization of cell GO:0051674 257 0.015
Fly
positive regulation of cell motility GO:2000147 3 0.015
salivary gland development GO:0007431 162 0.015
somatic muscle development GO:0007525 66 0.015
exocrine system development GO:0035272 162 0.015
negative regulation of organelle organization GO:0010639 56 0.015
brain morphogenesis GO:0048854 16 0.015
regulation of microtubule cytoskeleton organization GO:0070507 41 0.015
positive regulation of immune response GO:0050778 63 0.015
aging GO:0007568 143 0.015
Fly
protein polymerization GO:0051258 42 0.015
glycerophospholipid metabolic process GO:0006650 23 0.015
developmental programmed cell death GO:0010623 138 0.015
immune response GO:0006955 246 0.015
Fly
regulation of photoreceptor cell differentiation GO:0046532 34 0.015
response to abiotic stimulus GO:0009628 341 0.015
Human Fly
axon choice point recognition GO:0016198 26 0.015
positive regulation of transcription dna templated GO:0045893 266 0.015
Fly
pigmentation GO:0043473 75 0.014
phagocytosis GO:0006909 215 0.014
Fly
response to alcohol GO:0097305 95 0.014
regulation of cellular response to stress GO:0080135 89 0.014
dorsal ventral axon guidance GO:0033563 2 0.014
body morphogenesis GO:0010171 2 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.014
apoptotic process GO:0006915 159 0.014
Rat
nucleobase containing compound catabolic process GO:0034655 165 0.014
positive regulation of protein complex assembly GO:0031334 22 0.014
small molecule biosynthetic process GO:0044283 37 0.014
cell migration GO:0016477 238 0.014
Fly
heterocycle catabolic process GO:0046700 166 0.014
innate immune response GO:0045087 144 0.014
Fly
cell cell signaling involved in cell fate commitment GO:0045168 210 0.014
regulation of anatomical structure morphogenesis GO:0022603 242 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.014
regulation of stem cell proliferation GO:0072091 40 0.014
organonitrogen compound biosynthetic process GO:1901566 117 0.014
organic acid metabolic process GO:0006082 103 0.013
mitotic cell cycle embryonic GO:0045448 38 0.013
phosphatidylcholine metabolic process GO:0046470 3 0.013
limb development GO:0060173 1 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.013
positive regulation of neurogenesis GO:0050769 41 0.013
positive regulation of catabolic process GO:0009896 105 0.013
Fly
protein transport GO:0015031 155 0.013
cell fate specification GO:0001708 71 0.013
adult behavior GO:0030534 137 0.013
actin polymerization or depolymerization GO:0008154 31 0.013
female meiosis chromosome segregation GO:0016321 33 0.013
centrosome separation GO:0051299 20 0.013
cytoskeleton dependent cytokinesis GO:0061640 81 0.013
cellular response to growth factor stimulus GO:0071363 30 0.013
regulation of multicellular organismal development GO:2000026 414 0.013
somatic stem cell maintenance GO:0035019 14 0.013
oocyte axis specification GO:0007309 108 0.013
cell cycle phase transition GO:0044770 140 0.013
single fertilization GO:0007338 24 0.013
instar larval development GO:0002168 55 0.013
regulation of gliogenesis GO:0014013 11 0.013
organonitrogen compound catabolic process GO:1901565 128 0.013
anterior posterior axis specification embryo GO:0008595 103 0.013
regulation of epithelial cell proliferation GO:0050678 4 0.013
regulation of purine nucleotide metabolic process GO:1900542 62 0.013
germarium derived egg chamber formation GO:0007293 101 0.013
embryonic morphogenesis GO:0048598 206 0.012
Fly
macromolecule catabolic process GO:0009057 161 0.012
negative regulation of cellular metabolic process GO:0031324 382 0.012
camera type eye morphogenesis GO:0048593 2 0.012
positive regulation of dendrite morphogenesis GO:0050775 9 0.012
death GO:0016265 284 0.012
Rat
peptidyl amino acid modification GO:0018193 105 0.012
wing disc morphogenesis GO:0007472 344 0.012
cell division GO:0051301 248 0.012
protein catabolic process GO:0030163 101 0.012
regulation of response to external stimulus GO:0032101 115 0.012
kidney development GO:0001822 3 0.012
positive regulation of cell projection organization GO:0031346 29 0.012
reciprocal dna recombination GO:0035825 19 0.012
purine containing compound metabolic process GO:0072521 155 0.012
negative regulation of cell proliferation GO:0008285 69 0.011
negative regulation of cell communication GO:0010648 223 0.011
regulation of gtp catabolic process GO:0033124 44 0.011
regulation of microtubule based process GO:0032886 49 0.011
histone modification GO:0016570 106 0.011
glycerolipid metabolic process GO:0046486 34 0.011
cognition GO:0050890 141 0.011
startle response GO:0001964 16 0.011
positive regulation of cell differentiation GO:0045597 64 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
epithelial cell development GO:0002064 274 0.011
Fly
chromosome organization GO:0051276 360 0.011
lipid metabolic process GO:0006629 121 0.011
regulation of cellular localization GO:0060341 136 0.011
spinal cord development GO:0021510 1 0.011
learning or memory GO:0007611 141 0.011
morphogenesis of embryonic epithelium GO:0016331 94 0.011
Fly
positive regulation of organelle organization GO:0010638 65 0.011
erk1 and erk2 cascade GO:0070371 39 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
larval behavior GO:0030537 42 0.011
cytoskeleton dependent intracellular transport GO:0030705 44 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.011
mesenchymal cell development GO:0014031 1 0.011
positive regulation of ras protein signal transduction GO:0046579 43 0.010
nucleocytoplasmic transport GO:0006913 72 0.010
microtubule based movement GO:0007018 51 0.010
regulation of developmental pigmentation GO:0048070 24 0.010
response to other organism GO:0051707 293 0.010
membrane budding GO:0006900 4 0.010
positive regulation of nucleotide metabolic process GO:0045981 55 0.010
retina development in camera type eye GO:0060041 4 0.010
nuclear export GO:0051168 24 0.010
hematopoietic progenitor cell differentiation GO:0002244 1 0.010
leg disc morphogenesis GO:0007478 80 0.010
positive regulation of cell migration GO:0030335 2 0.010
positive regulation of programmed cell death GO:0043068 62 0.010
Rat

Mkk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
central nervous system disease DOID:331 0 0.033
nervous system disease DOID:863 0 0.033
motor neuron disease DOID:231 0 0.012
neurodegenerative disease DOID:1289 0 0.012