Drosophila melanogaster

108 known processes

flr (Dmel_CG10724)

flare

(Aliases: CG10724,aip1,Dmel\CG10724,Aip1)

flr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
non sensory hair organization GO:0035316 47 0.907
imaginal disc derived wing hair organization GO:0035317 45 0.904
protein depolymerization GO:0051261 31 0.901
actin filament based process GO:0030029 220 0.814
hair cell differentiation GO:0035315 47 0.803
organelle assembly GO:0070925 198 0.614
wing disc morphogenesis GO:0007472 344 0.612
actin filament depolymerization GO:0030042 5 0.609
appendage development GO:0048736 401 0.577
actin cytoskeleton organization GO:0030036 206 0.477
negative regulation of notch signaling pathway GO:0045746 41 0.431
macromolecular complex disassembly GO:0032984 37 0.384
notch signaling pathway GO:0007219 120 0.380
imaginal disc derived appendage development GO:0048737 399 0.351
regulation of notch signaling pathway GO:0008593 100 0.341
regulation of actin cytoskeleton organization GO:0032956 42 0.340
cellular component disassembly GO:0022411 46 0.335
epidermal cell differentiation GO:0009913 51 0.321
cellular protein complex disassembly GO:0043624 35 0.304
imaginal disc derived wing morphogenesis GO:0007476 337 0.297
regulation of actin filament depolymerization GO:0030834 3 0.291
spermatogenesis GO:0007283 200 0.278
negative regulation of actin filament depolymerization GO:0030835 2 0.277
intracellular transport GO:0046907 228 0.255
single organism intracellular transport GO:1902582 207 0.235
establishment of imaginal disc derived wing hair orientation GO:0001737 24 0.235
regulation of lamellipodium assembly GO:0010591 15 0.228
establishment of localization in cell GO:0051649 402 0.228
actin polymerization or depolymerization GO:0008154 31 0.216
vesicle mediated transport GO:0016192 381 0.206
negative regulation of protein polymerization GO:0032272 7 0.188
appendage morphogenesis GO:0035107 397 0.176
imaginal disc derived appendage morphogenesis GO:0035114 395 0.166
male gamete generation GO:0048232 201 0.166
cellular protein modification process GO:0006464 438 0.163
negative regulation of actin filament polymerization GO:0030837 7 0.162
actin filament organization GO:0007015 126 0.156
myofibril assembly GO:0030239 36 0.144
endocytosis GO:0006897 310 0.142
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.137
body morphogenesis GO:0010171 2 0.135
regulation of anatomical structure morphogenesis GO:0022603 242 0.133
regulation of proteolysis GO:0030162 87 0.131
protein modification process GO:0036211 438 0.130
negative regulation of signal transduction GO:0009968 206 0.128
imaginal disc derived wing hair site selection GO:0035320 4 0.125
negative regulation of response to stimulus GO:0048585 258 0.123
epidermis development GO:0008544 65 0.123
regulation of actin filament based process GO:0032970 42 0.119
establishment of planar polarity GO:0001736 87 0.115
actin filament polymerization GO:0030041 27 0.115
post embryonic appendage morphogenesis GO:0035120 385 0.114
spermatid development GO:0007286 98 0.114
dendrite self avoidance GO:0070593 8 0.113
actin filament capping GO:0051693 2 0.109
regulation of actin filament polymerization GO:0030833 25 0.101
chromosome organization GO:0051276 360 0.098
establishment or maintenance of cell polarity GO:0007163 167 0.097
myotube cell development GO:0014904 3 0.097
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.092
regulation of actin filament length GO:0030832 27 0.091
regulation of protein depolymerization GO:1901879 27 0.089
protein complex disassembly GO:0043241 36 0.084
negative regulation of signaling GO:0023057 219 0.079
organic substance transport GO:0071702 257 0.079
negative regulation of cell communication GO:0010648 223 0.077
cellular protein complex assembly GO:0043623 71 0.075
regulation of organelle organization GO:0033043 196 0.073
cellular catabolic process GO:0044248 372 0.072
cuticle pattern formation GO:0035017 27 0.072
cellular macromolecular complex assembly GO:0034622 153 0.071
organelle localization GO:0051640 148 0.071
regulation of endopeptidase activity GO:0052548 36 0.070
chaeta development GO:0022416 97 0.069
cell projection assembly GO:0030031 94 0.068
positive regulation of signaling GO:0023056 243 0.067
negative regulation of cytoskeleton organization GO:0051494 30 0.067
regulation of anatomical structure size GO:0090066 163 0.067
regulation of actin polymerization or depolymerization GO:0008064 27 0.066
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.065
regulation of vesicle mediated transport GO:0060627 59 0.064
muscle cell differentiation GO:0042692 103 0.061
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.061
regulation of multicellular organismal development GO:2000026 414 0.059
regulation of dendrite morphogenesis GO:0048814 28 0.059
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.058
regulation of protein metabolic process GO:0051246 256 0.058
establishment of body hair or bristle planar orientation GO:0048104 6 0.056
proteasomal protein catabolic process GO:0010498 59 0.055
chaeta morphogenesis GO:0008407 42 0.055
blood circulation GO:0008015 26 0.054
protein polymerization GO:0051258 42 0.054
cellular component assembly involved in morphogenesis GO:0010927 151 0.054
protein localization GO:0008104 284 0.053
skin development GO:0043588 65 0.053
negative regulation of protein complex disassembly GO:0043242 23 0.052
protein transport GO:0015031 155 0.051
positive regulation of organelle organization GO:0010638 65 0.051
regulation of cellular component size GO:0032535 98 0.051
protein maturation GO:0051604 71 0.051
mapk cascade GO:0000165 107 0.050
establishment of proximal distal cell polarity GO:0022606 4 0.049
circulatory system development GO:0072359 82 0.049
asymmetric cell division GO:0008356 37 0.049
synaptic transmission GO:0007268 288 0.046
regulation of protein complex disassembly GO:0043244 29 0.046
retina development in camera type eye GO:0060041 4 0.044
positive regulation of wnt signaling pathway GO:0030177 25 0.044
cilium organization GO:0044782 41 0.044
protein complex biogenesis GO:0070271 201 0.044
cardiovascular system development GO:0072358 82 0.043
spermatid differentiation GO:0048515 114 0.043
wnt signaling pathway GO:0016055 98 0.043
organic substance catabolic process GO:1901575 308 0.042
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.041
positive regulation of cell communication GO:0010647 250 0.040
establishment of tissue polarity GO:0007164 87 0.040
ubiquitin dependent protein catabolic process GO:0006511 78 0.040
kidney development GO:0001822 3 0.040
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.039
phosphorylation GO:0016310 294 0.039
lamellipodium organization GO:0097581 21 0.038
intracellular signal transduction GO:0035556 300 0.038
apoptotic process GO:0006915 159 0.038
protein complex assembly GO:0006461 200 0.037
negative regulation of protein depolymerization GO:1901880 23 0.036
regulation of phosphorylation GO:0042325 147 0.036
regulation of mrna processing GO:0050684 71 0.036
cell division GO:0051301 248 0.036
protein modification by small protein conjugation GO:0032446 79 0.036
regulation of cell cycle process GO:0010564 181 0.035
regionalization GO:0003002 416 0.035
skeletal muscle fiber development GO:0048741 3 0.035
synaptic vesicle localization GO:0097479 53 0.035
regulation of cell projection assembly GO:0060491 30 0.035
regulation of cellular component biogenesis GO:0044087 201 0.034
regulation of neural precursor cell proliferation GO:2000177 35 0.034
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.034
rhabdomere development GO:0042052 38 0.033
cilium assembly GO:0042384 38 0.033
growth GO:0040007 359 0.033
establishment of organelle localization GO:0051656 122 0.033
single organism behavior GO:0044708 391 0.032
macromolecule catabolic process GO:0009057 161 0.032
lamellipodium assembly GO:0030032 21 0.032
proteolysis GO:0006508 192 0.032
protein processing GO:0016485 68 0.032
atp metabolic process GO:0046034 49 0.032
positive regulation of signal transduction GO:0009967 223 0.032
multicellular organismal aging GO:0010259 140 0.032
regulation of peptidase activity GO:0052547 39 0.031
endosomal transport GO:0016197 44 0.031
establishment of monopolar cell polarity GO:0061162 15 0.031
negative regulation of organelle organization GO:0010639 56 0.031
regulation of mrna 3 end processing GO:0031440 7 0.030
regulation of lamellipodium organization GO:1902743 15 0.030
female germline ring canal formation GO:0007301 9 0.030
sensory perception of chemical stimulus GO:0007606 116 0.030
regulation of proteasomal protein catabolic process GO:0061136 39 0.029
nonmotile primary cilium assembly GO:0035058 8 0.029
modification dependent protein catabolic process GO:0019941 78 0.029
regulation of mitotic cell cycle GO:0007346 190 0.029
intercellular bridge organization GO:0043063 14 0.028
adult somatic muscle development GO:0007527 14 0.028
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.028
phagocytosis GO:0006909 215 0.028
tube development GO:0035295 244 0.028
regulation of blood circulation GO:1903522 21 0.027
regulation of cell projection organization GO:0031344 92 0.027
positive regulation of actin filament polymerization GO:0030838 11 0.026
cell cycle phase transition GO:0044770 140 0.026
organonitrogen compound metabolic process GO:1901564 318 0.026
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 24 0.026
circulatory system process GO:0003013 37 0.026
heart contraction GO:0060047 26 0.025
apical constriction GO:0003383 18 0.025
jnk cascade GO:0007254 50 0.025
posttranscriptional regulation of gene expression GO:0010608 145 0.025
asymmetric neuroblast division GO:0055059 33 0.025
regulation of protein complex assembly GO:0043254 42 0.025
regulation of cysteine type endopeptidase activity GO:2000116 27 0.025
epithelial cell differentiation GO:0030855 322 0.024
notch receptor processing GO:0007220 13 0.024
regulation of protein polymerization GO:0032271 28 0.024
mrna metabolic process GO:0016071 124 0.024
purine nucleoside monophosphate metabolic process GO:0009126 50 0.024
vesicle organization GO:0016050 44 0.023
regulation of smoothened signaling pathway GO:0008589 28 0.023
organic acid metabolic process GO:0006082 103 0.023
regulation of canonical wnt signaling pathway GO:0060828 15 0.023
macromolecular complex assembly GO:0065003 256 0.023
positive regulation of cellular component organization GO:0051130 156 0.023
regulation of cell cycle GO:0051726 291 0.023
actin filament based movement GO:0030048 26 0.023
lateral inhibition GO:0046331 206 0.022
chromosome segregation GO:0007059 157 0.022
regulation of cytoskeleton organization GO:0051493 89 0.022
antennal morphogenesis GO:0048800 14 0.022
negative regulation of programmed cell death GO:0043069 72 0.022
antennal development GO:0007469 25 0.022
positive regulation of axonogenesis GO:0050772 2 0.021
meiotic spindle organization GO:0000212 36 0.021
establishment of epithelial cell polarity GO:0090162 13 0.021
cellular protein localization GO:0034613 160 0.021
regulation of molecular function GO:0065009 217 0.021
protein modification by small protein conjugation or removal GO:0070647 106 0.021
carboxylic acid metabolic process GO:0019752 92 0.021
cell adhesion GO:0007155 136 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.020
striated muscle cell differentiation GO:0051146 90 0.020
regulation of mitotic cell cycle phase transition GO:1901990 130 0.020
muscle attachment GO:0016203 36 0.020
neural precursor cell proliferation GO:0061351 75 0.020
regulation of programmed cell death GO:0043067 152 0.020
morphogenesis of an epithelium GO:0002009 276 0.020
nephron development GO:0072006 3 0.020
neuronal action potential GO:0019228 10 0.020
actin filament bundle organization GO:0061572 28 0.020
maintenance of protein location GO:0045185 28 0.020
regulation of cytokinesis GO:0032465 3 0.020
organic cyclic compound catabolic process GO:1901361 168 0.020
negative regulation of cellular component organization GO:0051129 108 0.019
negative regulation of molecular function GO:0044092 51 0.019
cilium morphogenesis GO:0060271 39 0.019
regulation of apoptotic process GO:0042981 130 0.019
heart development GO:0007507 82 0.019
mrna processing GO:0006397 104 0.019
apical junction assembly GO:0043297 32 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.019
nucleus localization GO:0051647 34 0.019
biological adhesion GO:0022610 138 0.019
muscle organ development GO:0007517 127 0.019
ribonucleoside metabolic process GO:0009119 127 0.019
response to temperature stimulus GO:0009266 106 0.019
catabolic process GO:0009056 409 0.019
kidney epithelium development GO:0072073 3 0.018
protein catabolic process GO:0030163 101 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.018
adult behavior GO:0030534 137 0.018
receptor mediated endocytosis GO:0006898 21 0.018
negative regulation of catalytic activity GO:0043086 42 0.018
positive regulation of response to stimulus GO:0048584 323 0.018
ion transport GO:0006811 145 0.017
regulation of cell morphogenesis GO:0022604 163 0.017
wound healing GO:0042060 75 0.017
cation transport GO:0006812 110 0.017
cellular macromolecule catabolic process GO:0044265 136 0.017
metal ion transport GO:0030001 74 0.017
spinal cord patterning GO:0021511 1 0.017
positive regulation of cell migration GO:0030335 2 0.017
cytokinesis GO:0000910 90 0.017
axonal fasciculation GO:0007413 12 0.017
cellularization GO:0007349 90 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
modification dependent macromolecule catabolic process GO:0043632 79 0.017
camera type eye development GO:0043010 4 0.017
single organism catabolic process GO:0044712 228 0.016
ovarian nurse cell to oocyte transport GO:0007300 27 0.016
ribosomal large subunit biogenesis GO:0042273 1 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
nuclear transport GO:0051169 72 0.016
adherens junction organization GO:0034332 27 0.016
organelle fusion GO:0048284 46 0.016
actomyosin structure organization GO:0031032 56 0.016
stress activated mapk cascade GO:0051403 52 0.016
somatic stem cell division GO:0048103 37 0.016
regulation of cellular protein catabolic process GO:1903362 44 0.016
establishment of spindle localization GO:0051293 22 0.016
morphogenesis of a branching structure GO:0001763 45 0.016
regulation of transport GO:0051049 181 0.016
stress activated protein kinase signaling cascade GO:0031098 55 0.016
dephosphorylation GO:0016311 51 0.015
regulation of phosphorus metabolic process GO:0051174 210 0.015
regulation of stress activated mapk cascade GO:0032872 41 0.015
regulation of jnk cascade GO:0046328 40 0.015
rna 3 end processing GO:0031123 45 0.015
negative regulation of neural precursor cell proliferation GO:2000178 27 0.015
establishment of cell polarity GO:0030010 40 0.015
memory GO:0007613 94 0.015
oocyte construction GO:0007308 112 0.015
single organism cellular localization GO:1902580 180 0.015
axonogenesis GO:0007409 290 0.015
regulation of catalytic activity GO:0050790 185 0.015
regulation of mrna metabolic process GO:1903311 72 0.015
regulation of wnt signaling pathway GO:0030111 68 0.015
vesicle localization GO:0051648 55 0.015
branching morphogenesis of an epithelial tube GO:0048754 45 0.015
nucleoside catabolic process GO:0009164 112 0.015
mushroom body development GO:0016319 70 0.014
cytoskeleton dependent cytokinesis GO:0061640 81 0.014
regulation of establishment of planar polarity GO:0090175 22 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
multi organism behavior GO:0051705 175 0.014
dorsal ventral pattern formation GO:0009953 133 0.014
protein dephosphorylation GO:0006470 27 0.014
action potential GO:0001508 13 0.014
positive regulation of establishment of protein localization to plasma membrane GO:0090004 3 0.014
negative regulation of cell death GO:0060548 81 0.014
regulation of cell death GO:0010941 173 0.014
nucleocytoplasmic transport GO:0006913 72 0.014
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.014
mesodermal cell migration GO:0008078 7 0.014
nitrogen compound transport GO:0071705 85 0.014
nucleobase containing compound catabolic process GO:0034655 165 0.014
regulation of endocytosis GO:0030100 37 0.014
determination of adult lifespan GO:0008340 137 0.013
oocyte anterior posterior axis specification GO:0007314 72 0.013
negative regulation of protein processing GO:0010955 31 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.013
spinal cord development GO:0021510 1 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
negative regulation of cell cycle GO:0045786 116 0.013
hindbrain development GO:0030902 2 0.013
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.013
positive regulation of cell projection organization GO:0031346 29 0.013
cell death GO:0008219 279 0.013
acid secretion GO:0046717 1 0.013
cuticle development GO:0042335 86 0.013
ribonucleoside monophosphate metabolic process GO:0009161 51 0.013
positive regulation of macromolecule metabolic process GO:0010604 405 0.013
multicellular organismal signaling GO:0035637 12 0.013
response to alcohol GO:0097305 95 0.013
ameboidal type cell migration GO:0001667 151 0.013
response to organophosphorus GO:0046683 2 0.013
single organism biosynthetic process GO:0044711 206 0.012
cell junction assembly GO:0034329 42 0.012
intracellular protein transmembrane transport GO:0065002 4 0.012
positive regulation of cell motility GO:2000147 3 0.012
germarium derived egg chamber formation GO:0007293 101 0.012
negative regulation of cellular metabolic process GO:0031324 382 0.012
mitotic cell cycle phase transition GO:0044772 138 0.012
membrane organization GO:0061024 112 0.012
regulation of protein catabolic process GO:0042176 55 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
neuromuscular synaptic transmission GO:0007274 67 0.012
actin mediated cell contraction GO:0070252 21 0.012
mrna polyadenylation GO:0006378 11 0.012
establishment of nucleus localization GO:0040023 26 0.012
response to external biotic stimulus GO:0043207 293 0.012
germline ring canal formation GO:0030725 13 0.012
rna localization GO:0006403 115 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.012
protein ubiquitination GO:0016567 70 0.011
nephron epithelium development GO:0072009 3 0.011
tissue morphogenesis GO:0048729 297 0.011
establishment or maintenance of monopolar cell polarity GO:0061339 15 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.011
regulation of cell shape GO:0008360 113 0.011
positive regulation of protein localization to plasma membrane GO:1903078 3 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
actin filament bundle assembly GO:0051017 26 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
oocyte development GO:0048599 124 0.011
larval development GO:0002164 104 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
establishment of protein localization GO:0045184 163 0.011
epithelium migration GO:0090132 148 0.011
programmed cell death GO:0012501 257 0.011
intracellular protein transport GO:0006886 104 0.011
compound eye morphogenesis GO:0001745 249 0.011
anterior posterior pattern specification GO:0009952 136 0.011
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.011
karyosome formation GO:0030717 22 0.011
response to other organism GO:0051707 293 0.011
purine containing compound metabolic process GO:0072521 155 0.011
integrin mediated signaling pathway GO:0007229 3 0.011
rna polyadenylation GO:0043631 12 0.011
morphogenesis of a polarized epithelium GO:0001738 93 0.011
establishment of synaptic vesicle localization GO:0097480 50 0.010
cellular homeostasis GO:0019725 80 0.010
embryonic morphogenesis GO:0048598 206 0.010
convergent extension GO:0060026 2 0.010
endomembrane system organization GO:0010256 119 0.010
nucleotide metabolic process GO:0009117 161 0.010
cell recognition GO:0008037 102 0.010

flr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.055
nervous system disease DOID:863 0 0.029
auditory system disease DOID:2742 0 0.016
nonsyndromic deafness DOID:0050563 0 0.016
sensory system disease DOID:0050155 0 0.016
cardiovascular system disease DOID:1287 0 0.011
artery disease DOID:0050828 0 0.011
vascular disease DOID:178 0 0.011