Drosophila melanogaster

20 known processes

l(2)dtl (Dmel_CG11295)

lethal-(2)-denticleless

(Aliases: DTL83,L2DTL,Dmel\CG11295,CG11295)

l(2)dtl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nuclear division GO:0000280 332 0.663
chromosome segregation GO:0007059 157 0.654
meiotic chromosome segregation GO:0045132 59 0.396
spindle organization GO:0007051 253 0.395
dna metabolic process GO:0006259 227 0.294
Human
meiotic nuclear division GO:0007126 151 0.238
single organism biosynthetic process GO:0044711 206 0.218
Human
mitotic spindle organization GO:0007052 220 0.207
dna repair GO:0006281 54 0.198
Human
cellular response to dna damage stimulus GO:0006974 223 0.171
Human Zebrafish
organelle fission GO:0048285 340 0.166
male gamete generation GO:0048232 201 0.158
regulation of cell cycle GO:0051726 291 0.151
dendrite development GO:0016358 204 0.133
mitotic spindle elongation GO:0000022 81 0.130
protein complex biogenesis GO:0070271 201 0.121
chromosome organization GO:0051276 360 0.120
positive regulation of response to stimulus GO:0048584 323 0.117
tube morphogenesis GO:0035239 191 0.113
spermatogenesis GO:0007283 200 0.112
intracellular signal transduction GO:0035556 300 0.109
imaginal disc derived appendage development GO:0048737 399 0.105
cell recognition GO:0008037 102 0.104
male meiosis GO:0007140 52 0.104
response to abiotic stimulus GO:0009628 341 0.099
Human
dna conformation change GO:0071103 105 0.093
regulation of organelle organization GO:0033043 196 0.090
sister chromatid segregation GO:0000819 92 0.083
mitotic nuclear division GO:0007067 213 0.074
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.071
response to light stimulus GO:0009416 124 0.071
Human
locomotory behavior GO:0007626 176 0.068
g2 dna damage checkpoint GO:0031572 69 0.068
Human Zebrafish
regulation of dna metabolic process GO:0051052 34 0.068
protein complex assembly GO:0006461 200 0.068
microtubule organizing center organization GO:0031023 168 0.065
head involution GO:0008258 35 0.064
cell cycle phase transition GO:0044770 140 0.063
Zebrafish
nucleobase containing compound catabolic process GO:0034655 165 0.062
imaginal disc derived appendage morphogenesis GO:0035114 395 0.061
regulation of cell cycle process GO:0010564 181 0.060
Zebrafish
cellular protein complex assembly GO:0043623 71 0.060
meiotic cell cycle process GO:1903046 132 0.057
compound eye development GO:0048749 307 0.057
post embryonic appendage morphogenesis GO:0035120 385 0.057
imaginal disc derived wing morphogenesis GO:0007476 337 0.057
phosphorylation GO:0016310 294 0.056
homeostatic process GO:0042592 199 0.056
cell fate determination GO:0001709 91 0.054
double strand break repair GO:0006302 26 0.053
positive regulation of gene expression GO:0010628 290 0.052
centrosome cycle GO:0007098 137 0.052
regulation of mitotic cell cycle GO:0007346 190 0.052
Zebrafish
taxis GO:0042330 304 0.051
spindle midzone assembly GO:0051255 4 0.050
centrosome organization GO:0051297 163 0.050
spindle elongation GO:0051231 83 0.049
appendage development GO:0048736 401 0.048
mitotic cell cycle phase transition GO:0044772 138 0.047
Zebrafish
regionalization GO:0003002 416 0.047
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.046
organic substance catabolic process GO:1901575 308 0.046
Human
response to organic substance GO:0010033 284 0.046
lipid biosynthetic process GO:0008610 46 0.045
cellular ketone metabolic process GO:0042180 24 0.045
positive regulation of cell communication GO:0010647 250 0.045
positive regulation of signal transduction GO:0009967 223 0.045
meiosis i GO:0007127 59 0.045
chromosome separation GO:0051304 42 0.044
macromolecular complex assembly GO:0065003 256 0.044
axon development GO:0061564 297 0.044
response to temperature stimulus GO:0009266 106 0.042
regulation of microtubule cytoskeleton organization GO:0070507 41 0.041
meiotic cell cycle GO:0051321 171 0.041
dendrite morphogenesis GO:0048813 199 0.041
centrosome duplication GO:0051298 121 0.041
protein modification process GO:0036211 438 0.041
Human
positive regulation of signaling GO:0023056 243 0.040
protein dna complex subunit organization GO:0071824 86 0.040
positive regulation of macromolecule metabolic process GO:0010604 405 0.039
aging GO:0007568 143 0.038
regulation of phosphate metabolic process GO:0019220 210 0.038
appendage morphogenesis GO:0035107 397 0.037
morphogenesis of an epithelium GO:0002009 276 0.037
cell death GO:0008219 279 0.037
neuron recognition GO:0008038 101 0.037
regulation of tube size GO:0035150 46 0.036
positive regulation of rna biosynthetic process GO:1902680 266 0.036
regulation of dna recombination GO:0000018 4 0.036
axonogenesis GO:0007409 290 0.036
cellular response to radiation GO:0071478 52 0.036
organelle assembly GO:0070925 198 0.035
programmed cell death GO:0012501 257 0.035
gastrulation with mouth forming first GO:0001703 36 0.035
dna packaging GO:0006323 91 0.034
nucleosome organization GO:0034728 59 0.034
dna damage checkpoint GO:0000077 78 0.033
Human Zebrafish
dna biosynthetic process GO:0071897 24 0.032
Human
small molecule metabolic process GO:0044281 305 0.032
single organism cellular localization GO:1902580 180 0.032
protein catabolic process GO:0030163 101 0.032
Human
organelle localization GO:0051640 148 0.031
protein localization GO:0008104 284 0.031
regulation of response to dna damage stimulus GO:2001020 23 0.031
death GO:0016265 284 0.031
cuticle development GO:0042335 86 0.031
protein phosphorylation GO:0006468 169 0.031
response to monosaccharide GO:0034284 4 0.030
ribonucleotide metabolic process GO:0009259 145 0.030
cellular catabolic process GO:0044248 372 0.030
Human
dna integrity checkpoint GO:0031570 81 0.029
Human Zebrafish
positive regulation of molecular function GO:0044093 136 0.029
dna recombination GO:0006310 32 0.029
mitotic spindle midzone assembly GO:0051256 1 0.029
mrna processing GO:0006397 104 0.028
response to radiation GO:0009314 155 0.028
Human
regulation of molecular function GO:0065009 217 0.027
positive regulation of cellular biosynthetic process GO:0031328 316 0.027
regulation of intracellular signal transduction GO:1902531 236 0.027
ion transport GO:0006811 145 0.027
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.027
compound eye morphogenesis GO:0001745 249 0.026
regulation of ras protein signal transduction GO:0046578 93 0.026
single organism catabolic process GO:0044712 228 0.026
cellular macromolecule localization GO:0070727 220 0.025
response to biotic stimulus GO:0009607 294 0.025
cellular macromolecular complex assembly GO:0034622 153 0.025
epithelial tube morphogenesis GO:0060562 88 0.025
organic cyclic compound catabolic process GO:1901361 168 0.025
sensory organ morphogenesis GO:0090596 260 0.025
immune response GO:0006955 246 0.024
wing disc morphogenesis GO:0007472 344 0.024
male meiosis chromosome segregation GO:0007060 10 0.024
establishment of cell polarity GO:0030010 40 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.024
regulation of transport GO:0051049 181 0.024
branching morphogenesis of an epithelial tube GO:0048754 45 0.024
inorganic cation transmembrane transport GO:0098662 61 0.024
compound eye photoreceptor development GO:0042051 78 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.023
heterocycle catabolic process GO:0046700 166 0.023
regulation of cellular response to stress GO:0080135 89 0.023
actin cytoskeleton organization GO:0030036 206 0.023
determination of adult lifespan GO:0008340 137 0.023
regulation of chromatin silencing GO:0031935 36 0.023
single organism behavior GO:0044708 391 0.023
immune system process GO:0002376 347 0.022
regulation of mitotic cell cycle phase transition GO:1901990 130 0.022
Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 151 0.022
purine containing compound metabolic process GO:0072521 155 0.022
carboxylic acid metabolic process GO:0019752 92 0.022
wound healing GO:0042060 75 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.021
negative regulation of cell cycle process GO:0010948 109 0.021
Zebrafish
catabolic process GO:0009056 409 0.021
Human
negative regulation of cell cycle GO:0045786 116 0.021
Zebrafish
regulation of microtubule depolymerization GO:0031114 24 0.021
multicellular organismal aging GO:0010259 140 0.021
mitotic sister chromatid segregation GO:0000070 87 0.020
branching involved in open tracheal system development GO:0060446 45 0.020
cell division GO:0051301 248 0.020
dna replication GO:0006260 48 0.020
chemical homeostasis GO:0048878 92 0.019
mitotic g2 m transition checkpoint GO:0044818 70 0.019
Zebrafish
digestive tract morphogenesis GO:0048546 127 0.019
photoreceptor cell development GO:0042461 96 0.019
purine nucleotide metabolic process GO:0006163 146 0.019
establishment or maintenance of cell polarity GO:0007163 167 0.019
sensory perception GO:0007600 196 0.018
positive regulation of phosphate metabolic process GO:0045937 139 0.018
eye development GO:0001654 323 0.018
eye photoreceptor cell development GO:0042462 81 0.018
response to organophosphorus GO:0046683 2 0.018
purine nucleoside triphosphate metabolic process GO:0009144 119 0.018
response to lipopolysaccharide GO:0032496 4 0.018
regulation of cell cycle phase transition GO:1901987 130 0.018
Zebrafish
regulation of hormone levels GO:0010817 40 0.017
apoptotic process GO:0006915 159 0.017
phagocytosis GO:0006909 215 0.017
enzyme linked receptor protein signaling pathway GO:0007167 179 0.017
lipid metabolic process GO:0006629 121 0.017
tube development GO:0035295 244 0.017
establishment of organelle localization GO:0051656 122 0.017
negative regulation of microtubule depolymerization GO:0007026 21 0.017
organic acid metabolic process GO:0006082 103 0.017
eye photoreceptor cell differentiation GO:0001754 145 0.016
segmentation GO:0035282 207 0.016
positive regulation of cell cycle process GO:0090068 28 0.016
mrna metabolic process GO:0016071 124 0.016
regulation of cytokinesis GO:0032465 3 0.016
ras protein signal transduction GO:0007265 88 0.016
intracellular mrna localization GO:0008298 66 0.016
atp metabolic process GO:0046034 49 0.016
axon guidance GO:0007411 233 0.015
mitotic chromosome condensation GO:0007076 22 0.015
cellular response to nutrient levels GO:0031669 62 0.015
positive regulation of rna metabolic process GO:0051254 271 0.015
establishment of localization in cell GO:0051649 402 0.015
regulation of anatomical structure size GO:0090066 163 0.015
hindgut morphogenesis GO:0007442 58 0.015
protein dna complex assembly GO:0065004 63 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
negative regulation of mitotic cell cycle GO:0045930 109 0.015
Zebrafish
small gtpase mediated signal transduction GO:0007264 88 0.015
regulation of double strand break repair GO:2000779 3 0.015
vesicle mediated transport GO:0016192 381 0.014
Worm
positive regulation of intracellular signal transduction GO:1902533 116 0.014
chromatin organization GO:0006325 207 0.014
cilium morphogenesis GO:0060271 39 0.014
purine containing compound catabolic process GO:0072523 112 0.014
cellular protein localization GO:0034613 160 0.014
gland morphogenesis GO:0022612 145 0.014
maintenance of location GO:0051235 73 0.014
connective tissue development GO:0061448 3 0.014
tissue migration GO:0090130 155 0.014
asymmetric protein localization involved in cell fate determination GO:0045167 9 0.014
establishment of planar polarity GO:0001736 87 0.014
regulation of protein depolymerization GO:1901879 27 0.014
transmembrane transport GO:0055085 139 0.014
dna endoreduplication GO:0042023 22 0.014
mitotic cytokinesis GO:0000281 50 0.014
nucleoside phosphate metabolic process GO:0006753 162 0.014
positive regulation of cell cycle GO:0045787 43 0.014
salivary gland morphogenesis GO:0007435 145 0.014
regulation of cell death GO:0010941 173 0.013
regulation of chromosome organization GO:0033044 64 0.013
regulation of cell shape GO:0008360 113 0.013
organonitrogen compound catabolic process GO:1901565 128 0.013
digestive tract development GO:0048565 149 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
anatomical structure homeostasis GO:0060249 97 0.013
cell cycle checkpoint GO:0000075 95 0.013
Human Zebrafish
regulation of multicellular organismal development GO:2000026 414 0.013
Worm
response to other organism GO:0051707 293 0.013
salivary gland development GO:0007431 162 0.013
embryonic morphogenesis GO:0048598 206 0.013
renal tubule development GO:0061326 64 0.013
negative regulation of organelle organization GO:0010639 56 0.013
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.013
developmental growth GO:0048589 280 0.013
Worm
aromatic compound catabolic process GO:0019439 166 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.013
regulation of dna repair GO:0006282 5 0.013
gastrulation GO:0007369 70 0.013
regulation of phosphorus metabolic process GO:0051174 210 0.012
axis specification GO:0009798 167 0.012
cellular response to abiotic stimulus GO:0071214 58 0.012
mitotic dna integrity checkpoint GO:0044774 75 0.012
Zebrafish
negative regulation of cell communication GO:0010648 223 0.012
regulation of tube size open tracheal system GO:0035151 43 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
cell type specific apoptotic process GO:0097285 38 0.012
hormone biosynthetic process GO:0042446 20 0.012
cellular response to organic substance GO:0071310 132 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
organic substance transport GO:0071702 257 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
blastoderm segmentation GO:0007350 159 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
regulation of programmed cell death GO:0043067 152 0.012
protein targeting GO:0006605 64 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
cellular amine metabolic process GO:0044106 12 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.011
mitotic g2 dna damage checkpoint GO:0007095 69 0.011
Zebrafish
photoreceptor cell differentiation GO:0046530 170 0.011
cellular lipid metabolic process GO:0044255 83 0.011
regulation of sister chromatid cohesion GO:0007063 2 0.011
rna 3 end processing GO:0031123 45 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
regulation of neuron projection development GO:0010975 69 0.011
cellular protein catabolic process GO:0044257 83 0.011
Human
establishment of protein localization GO:0045184 163 0.011
ecdysteroid biosynthetic process GO:0045456 15 0.011
cell adhesion GO:0007155 136 0.011
cellular protein modification process GO:0006464 438 0.011
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.011
mitotic dna damage checkpoint GO:0044773 74 0.011
Zebrafish
ribonucleoside catabolic process GO:0042454 112 0.011
proteasomal protein catabolic process GO:0010498 59 0.011
body morphogenesis GO:0010171 2 0.011
regulation of transferase activity GO:0051338 58 0.011
amine metabolic process GO:0009308 12 0.011
antimicrobial humoral response GO:0019730 99 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
asymmetric protein localization GO:0008105 33 0.010
gene silencing GO:0016458 138 0.010
proteolysis GO:0006508 192 0.010
Human
protein complex disassembly GO:0043241 36 0.010
regulation of cellular component size GO:0032535 98 0.010
regulation of response to biotic stimulus GO:0002831 63 0.010
response to bacterium GO:0009617 198 0.010
response to external biotic stimulus GO:0043207 293 0.010
aggressive behavior GO:0002118 63 0.010
ribonucleoside triphosphate metabolic process GO:0009199 119 0.010
cation transport GO:0006812 110 0.010
regulation of dna dependent dna replication GO:0090329 6 0.010

l(2)dtl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
organ system cancer DOID:0050686 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
cancer DOID:162 0 0.025