Drosophila melanogaster

65 known processes

Spn4 (Dmel_CG9453)

Serine protease inhibitor 4

(Aliases: CG9453,Spn4A,Sp4,sp4,Spn42Da,Dmel\CG9453)

Spn4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response GO:0006952 300 0.269
Rat Fly
negative regulation of signaling GO:0023057 219 0.204
Fly
antifungal humoral response GO:0019732 12 0.171
Fly
peptide metabolic process GO:0006518 80 0.160
immune system process GO:0002376 347 0.153
Fly
toll signaling pathway GO:0008063 25 0.151
Fly
establishment of localization in cell GO:0051649 402 0.150
negative regulation of response to stimulus GO:0048585 258 0.122
Rat Fly
regulation of cell proliferation GO:0042127 163 0.110
negative regulation of signal transduction GO:0009968 206 0.108
Fly
immune response GO:0006955 246 0.098
Fly
regulation of localization GO:0032879 275 0.094
negative regulation of cell communication GO:0010648 223 0.094
Fly
wing disc morphogenesis GO:0007472 344 0.090
regulation of multi organism process GO:0043900 131 0.088
Fly
response to fungus GO:0009620 50 0.087
Fly
regionalization GO:0003002 416 0.071
oxoacid metabolic process GO:0043436 103 0.069
cellular amide metabolic process GO:0043603 80 0.065
positive regulation of response to stimulus GO:0048584 323 0.065
death GO:0016265 284 0.064
post embryonic appendage morphogenesis GO:0035120 385 0.062
imaginal disc derived wing morphogenesis GO:0007476 337 0.062
imaginal disc derived appendage development GO:0048737 399 0.059
organic substance transport GO:0071702 257 0.057
vesicle mediated transport GO:0016192 381 0.056
negative regulation of gene expression GO:0010629 387 0.056
imaginal disc derived appendage morphogenesis GO:0035114 395 0.055
response to other organism GO:0051707 293 0.053
Fly
chaeta development GO:0022416 97 0.049
regulation of notch signaling pathway GO:0008593 100 0.047
enzyme linked receptor protein signaling pathway GO:0007167 179 0.046
developmental growth GO:0048589 280 0.045
Rat
proteolysis GO:0006508 192 0.045
secretion by cell GO:0032940 101 0.045
cell death GO:0008219 279 0.045
programmed cell death GO:0012501 257 0.043
response to bacterium GO:0009617 198 0.043
Fly
appendage development GO:0048736 401 0.042
body morphogenesis GO:0010171 2 0.041
gland development GO:0048732 191 0.040
response to abiotic stimulus GO:0009628 341 0.038
immune response regulating signaling pathway GO:0002764 2 0.036
intracellular transport GO:0046907 228 0.035
appendage morphogenesis GO:0035107 397 0.035
carbohydrate derivative biosynthetic process GO:1901137 85 0.035
amino sugar metabolic process GO:0006040 10 0.035
organonitrogen compound biosynthetic process GO:1901566 117 0.035
positive regulation of biosynthetic process GO:0009891 316 0.035
regulation of production of molecular mediator of immune response GO:0002700 44 0.034
Fly
immune response activating signal transduction GO:0002757 2 0.034
regulation of cellular localization GO:0060341 136 0.034
organic substance catabolic process GO:1901575 308 0.033
response to external biotic stimulus GO:0043207 293 0.033
Fly
secretion GO:0046903 109 0.031
protein transport GO:0015031 155 0.030
response to organic substance GO:0010033 284 0.030
regulation of defense response to bacterium GO:1900424 30 0.030
humoral immune response GO:0006959 117 0.030
Fly
protein modification process GO:0036211 438 0.030
regulation of toll signaling pathway GO:0008592 17 0.029
Fly
growth GO:0040007 359 0.029
Rat
aging GO:0007568 143 0.029
cell proliferation GO:0008283 299 0.028
cellular catabolic process GO:0044248 372 0.028
positive regulation of cellular biosynthetic process GO:0031328 316 0.028
developmental programmed cell death GO:0010623 138 0.028
positive regulation of transport GO:0051050 92 0.028
regulation of intracellular signal transduction GO:1902531 236 0.028
catabolic process GO:0009056 409 0.028
positive regulation of cell communication GO:0010647 250 0.028
response to nutrient levels GO:0031667 114 0.028
Rat
positive regulation of signal transduction GO:0009967 223 0.028
small molecule metabolic process GO:0044281 305 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.027
regulation of multicellular organismal development GO:2000026 414 0.026
defense response to gram positive bacterium GO:0050830 41 0.026
endocytosis GO:0006897 310 0.026
cellular ketone metabolic process GO:0042180 24 0.026
homeostatic process GO:0042592 199 0.026
regulation of immune response GO:0050776 118 0.026
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.025
cellular macromolecule localization GO:0070727 220 0.025
endomembrane system organization GO:0010256 119 0.025
axis specification GO:0009798 167 0.024
regulation of hormone levels GO:0010817 40 0.024
multi organism behavior GO:0051705 175 0.024
regulation of defense response GO:0031347 102 0.024
Rat
rna processing GO:0006396 147 0.024
regulation of phosphorus metabolic process GO:0051174 210 0.024
macromolecule catabolic process GO:0009057 161 0.024
gland morphogenesis GO:0022612 145 0.024
multicellular organismal aging GO:0010259 140 0.023
single organism biosynthetic process GO:0044711 206 0.023
extracellular matrix constituent secretion GO:0070278 4 0.023
open tracheal system development GO:0007424 204 0.023
connective tissue development GO:0061448 3 0.022
regulation of response to stress GO:0080134 200 0.022
Rat
regulation of programmed cell death GO:0043067 152 0.022
antimicrobial humoral response GO:0019730 99 0.022
Fly
response to light stimulus GO:0009416 124 0.021
regulation of protein metabolic process GO:0051246 256 0.020
regulation of secretion GO:0051046 44 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
salivary gland morphogenesis GO:0007435 145 0.020
maintenance of location GO:0051235 73 0.020
regulation of immune system process GO:0002682 176 0.020
Fly
kidney development GO:0001822 3 0.020
negative regulation of cellular metabolic process GO:0031324 382 0.020
positive regulation of signaling GO:0023056 243 0.019
positive regulation of rna biosynthetic process GO:1902680 266 0.019
notch signaling pathway GO:0007219 120 0.019
immune effector process GO:0002252 98 0.019
Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.019
spermatogenesis GO:0007283 200 0.019
regulation of antimicrobial humoral response GO:0002759 50 0.019
Fly
phagocytosis GO:0006909 215 0.019
epithelial cell differentiation GO:0030855 322 0.019
regulation of cell cycle GO:0051726 291 0.019
cellular protein modification process GO:0006464 438 0.018
lipid metabolic process GO:0006629 121 0.018
determination of adult lifespan GO:0008340 137 0.018
positive regulation of immune system process GO:0002684 68 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.018
response to alcohol GO:0097305 95 0.018
cholesterol transport GO:0030301 2 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.017
respiratory system development GO:0060541 213 0.017
tissue death GO:0016271 102 0.017
defense response to bacterium GO:0042742 178 0.017
Fly
negative regulation of neural precursor cell proliferation GO:2000178 27 0.017
organic acid metabolic process GO:0006082 103 0.016
dorsal ventral pattern formation GO:0009953 133 0.016
organonitrogen compound metabolic process GO:1901564 318 0.016
cholesterol homeostasis GO:0042632 3 0.016
phosphorylation GO:0016310 294 0.016
cellular response to starvation GO:0009267 61 0.016
salivary gland cell autophagic cell death GO:0035071 83 0.016
response to radiation GO:0009314 155 0.016
positive regulation of transcription dna templated GO:0045893 266 0.015
steroid metabolic process GO:0008202 20 0.015
segmentation GO:0035282 207 0.015
cellular protein localization GO:0034613 160 0.015
positive regulation of gene expression GO:0010628 290 0.015
protein localization GO:0008104 284 0.015
positive regulation of nucleic acid templated transcription GO:1903508 266 0.015
chemical homeostasis GO:0048878 92 0.015
wound healing GO:0042060 75 0.015
Rat
dorsal ventral axis specification GO:0009950 66 0.015
response to lipopolysaccharide GO:0032496 4 0.015
regulation of cell adhesion GO:0030155 27 0.015
Rat
dendrite development GO:0016358 204 0.015
embryo development ending in birth or egg hatching GO:0009792 152 0.015
positive regulation of cellular component organization GO:0051130 156 0.014
regulation of cell death GO:0010941 173 0.014
antimicrobial peptide production GO:0002775 46 0.014
Fly
protein complex biogenesis GO:0070271 201 0.014
innate immune response GO:0045087 144 0.014
telencephalon development GO:0021537 2 0.014
positive regulation of rna metabolic process GO:0051254 271 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
cognition GO:0050890 141 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
oxidation reduction process GO:0055114 123 0.013
regulation of transport GO:0051049 181 0.013
positive regulation of multicellular organismal process GO:0051240 143 0.013
synapse assembly GO:0007416 143 0.013
positive regulation of cell migration GO:0030335 2 0.013
regulation of response to external stimulus GO:0032101 115 0.013
Rat Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
positive regulation of multi organism process GO:0043902 40 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
aminoglycan metabolic process GO:0006022 18 0.013
embryonic axis specification GO:0000578 107 0.013
cellular response to organic substance GO:0071310 132 0.013
histolysis GO:0007559 102 0.013
regulation of cellular amide metabolic process GO:0034248 39 0.013
response to organic cyclic compound GO:0014070 89 0.013
response to biotic stimulus GO:0009607 294 0.013
Fly
anterior posterior axis specification embryo GO:0008595 103 0.013
regulation of antimicrobial peptide production GO:0002784 44 0.013
Fly
regulation of secretion by cell GO:1903530 39 0.013
negative regulation of molecular function GO:0044092 51 0.013
macromolecular complex assembly GO:0065003 256 0.012
response to endogenous stimulus GO:0009719 119 0.012
dendrite morphogenesis GO:0048813 199 0.012
taxis GO:0042330 304 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
male gamete generation GO:0048232 201 0.012
salivary gland histolysis GO:0035070 88 0.012
positive regulation of cell motility GO:2000147 3 0.012
neurological system process GO:0050877 358 0.012
mitotic spindle organization GO:0007052 220 0.012
protein localization to organelle GO:0033365 82 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
protein polymerization GO:0051258 42 0.012
autophagic cell death GO:0048102 83 0.012
negative regulation of rna metabolic process GO:0051253 251 0.012
cation homeostasis GO:0055080 51 0.012
cell motility GO:0048870 251 0.012
negative regulation of cell development GO:0010721 62 0.012
positive regulation of secretion GO:0051047 22 0.011
positive regulation of defense response GO:0031349 59 0.011
amine metabolic process GO:0009308 12 0.011
cellular response to external stimulus GO:0071496 66 0.011
intracellular protein transport GO:0006886 104 0.011
chromosome organization GO:0051276 360 0.011
anatomical structure homeostasis GO:0060249 97 0.011
learning GO:0007612 75 0.011
single organism intracellular transport GO:1902582 207 0.011
regulation of anatomical structure size GO:0090066 163 0.011
forebrain development GO:0030900 2 0.011
inter male aggressive behavior GO:0002121 60 0.011
spindle organization GO:0007051 253 0.011
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
sterol homeostasis GO:0055092 4 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
establishment of protein localization GO:0045184 163 0.011
positive regulation of catabolic process GO:0009896 105 0.010
peptide hormone processing GO:0016486 2 0.010
positive regulation of defense response to bacterium GO:1900426 23 0.010
detection of stimulus GO:0051606 156 0.010
developmental maturation GO:0021700 172 0.010
regulation of organ morphogenesis GO:2000027 78 0.010
regulation of phosphate metabolic process GO:0019220 210 0.010
regulation of lipid transport GO:0032368 3 0.010
associative learning GO:0008306 65 0.010
cellular macromolecular complex assembly GO:0034622 153 0.010
response to organophosphorus GO:0046683 2 0.010
regulation of molecular function GO:0065009 217 0.010

Spn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.053
disease of anatomical entity DOID:7 0 0.036
inherited metabolic disorder DOID:655 0 0.013
nervous system disease DOID:863 0 0.013
urinary system disease DOID:18 0 0.012
acquired metabolic disease DOID:0060158 0 0.011