Drosophila melanogaster

7 known processes

modSP (Dmel_CG31217)

modular serine protease

(Aliases: ModSP,CT28389,CG10100,W,SP172,Ldlr,LDL,CG17557,Dmel\CG31217,Ser89E,X,SP53,Dm-SP,CG31217)

modSP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
activation of innate immune response GO:0002218 4 0.814
immune response activating signal transduction GO:0002757 2 0.673
pattern recognition receptor signaling pathway GO:0002221 2 0.655
innate immune response activating signal transduction GO:0002758 2 0.628
peptidoglycan catabolic process GO:0009253 3 0.622
immune response GO:0006955 246 0.622
glycosaminoglycan catabolic process GO:0006027 3 0.604
peptidoglycan metabolic process GO:0000270 3 0.558
detection of stimulus GO:0051606 156 0.513
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002816 3 0.486
positive regulation of response to stimulus GO:0048584 323 0.444
immune response regulating signaling pathway GO:0002764 2 0.431
defense response to other organism GO:0098542 225 0.426
immune system process GO:0002376 347 0.391
aminoglycan catabolic process GO:0006026 6 0.384
innate immune response GO:0045087 144 0.379
response to fungus GO:0009620 50 0.358
immune effector process GO:0002252 98 0.345
regulation of immune response GO:0050776 118 0.317
regulation of response to stress GO:0080134 200 0.314
regulation of innate immune response GO:0045088 71 0.313
regulation of defense response GO:0031347 102 0.305
defense response to bacterium GO:0042742 178 0.295
antimicrobial humoral response GO:0019730 99 0.288
defense response to gram positive bacterium GO:0050830 41 0.288
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.222
glycosaminoglycan metabolic process GO:0030203 11 0.220
response to biotic stimulus GO:0009607 294 0.213
antibacterial humoral response GO:0019731 44 0.210
positive regulation of immune response GO:0050778 63 0.208
regulation of antimicrobial humoral response GO:0002759 50 0.188
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.179
humoral immune response GO:0006959 117 0.178
organelle fission GO:0048285 340 0.175
response to bacterium GO:0009617 198 0.171
positive regulation of melanization defense response GO:0035008 1 0.158
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.156
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.152
regulation of immune effector process GO:0002697 52 0.145
antifungal humoral response GO:0019732 12 0.140
regulation of humoral immune response GO:0002920 51 0.140
organonitrogen compound metabolic process GO:1901564 318 0.135
response to external biotic stimulus GO:0043207 293 0.132
regulation of immune system process GO:0002682 176 0.131
regionalization GO:0003002 416 0.130
melanization defense response GO:0035006 45 0.130
positive regulation of defense response GO:0031349 59 0.129
response to other organism GO:0051707 293 0.127
antibacterial peptide biosynthetic process GO:0002780 22 0.123
phenol containing compound metabolic process GO:0018958 57 0.123
defense response GO:0006952 300 0.121
negative regulation of defense response to bacterium GO:1900425 7 0.119
defense response to fungus GO:0050832 48 0.116
antimicrobial peptide production GO:0002775 46 0.110
axis specification GO:0009798 167 0.109
production of molecular mediator of immune response GO:0002440 46 0.106
regulation of defense response to bacterium GO:1900424 30 0.106
detection of chemical stimulus GO:0009593 93 0.106
aminoglycan metabolic process GO:0006022 18 0.105
nuclear division GO:0000280 332 0.094
positive regulation of response to external stimulus GO:0032103 44 0.089
antibacterial peptide production GO:0002778 22 0.087
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.086
positive regulation of cellular biosynthetic process GO:0031328 316 0.086
positive regulation of immune system process GO:0002684 68 0.084
regulation of multi organism process GO:0043900 131 0.082
carbohydrate derivative metabolic process GO:1901135 217 0.081
biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002812 14 0.074
organic substance catabolic process GO:1901575 308 0.072
detection of external biotic stimulus GO:0098581 2 0.072
positive regulation of response to biotic stimulus GO:0002833 31 0.069
cellular amide metabolic process GO:0043603 80 0.067
defense response to gram negative bacterium GO:0050829 94 0.065
biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002815 3 0.062
amide biosynthetic process GO:0043604 42 0.062
response to organic substance GO:0010033 284 0.061
positive regulation of biosynthetic process GO:0009891 316 0.059
organic substance transport GO:0071702 257 0.059
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.058
organonitrogen compound catabolic process GO:1901565 128 0.057
carbohydrate derivative catabolic process GO:1901136 118 0.057
positive regulation of antimicrobial peptide production GO:0002225 28 0.057
melanin metabolic process GO:0006582 47 0.056
meiotic cell cycle GO:0051321 171 0.053
endocytosis GO:0006897 310 0.053
regulation of cellular amide metabolic process GO:0034248 39 0.053
antimicrobial peptide biosynthetic process GO:0002777 38 0.052
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0006965 3 0.052
positive regulation of innate immune response GO:0045089 38 0.052
tissue morphogenesis GO:0048729 297 0.052
regulation of response to external stimulus GO:0032101 115 0.051
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.050
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0006964 12 0.050
macromolecule catabolic process GO:0009057 161 0.048
regulation of production of molecular mediator of immune response GO:0002700 44 0.048
epithelial cell differentiation GO:0030855 322 0.048
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.047
positive regulation of signal transduction GO:0009967 223 0.047
vesicle mediated transport GO:0016192 381 0.047
negative regulation of cellular metabolic process GO:0031324 382 0.047
organonitrogen compound biosynthetic process GO:1901566 117 0.046
meiotic nuclear division GO:0007126 151 0.044
cell adhesion GO:0007155 136 0.044
positive regulation of signaling GO:0023056 243 0.044
establishment of protein localization GO:0045184 163 0.043
negative regulation of signaling GO:0023057 219 0.043
regulation of melanization defense response GO:0035007 6 0.043
catabolic process GO:0009056 409 0.042
defense response to virus GO:0051607 23 0.042
negative regulation of immune response GO:0050777 39 0.040
dorsal ventral axis specification GO:0009950 66 0.040
regulation of antibacterial peptide production GO:0002786 22 0.040
negative regulation of response to stimulus GO:0048585 258 0.040
regulation of antimicrobial peptide production GO:0002784 44 0.039
negative regulation of gene expression GO:0010629 387 0.039
regulation of intracellular signal transduction GO:1902531 236 0.039
negative regulation of immune system process GO:0002683 50 0.038
secondary metabolic process GO:0019748 75 0.037
intracellular signal transduction GO:0035556 300 0.037
phagocytosis GO:0006909 215 0.037
mitotic spindle organization GO:0007052 220 0.037
negative regulation of cell communication GO:0010648 223 0.035
response to wounding GO:0009611 94 0.035
positive regulation of immune effector process GO:0002699 28 0.034
spindle organization GO:0007051 253 0.033
organic hydroxy compound metabolic process GO:1901615 83 0.033
cellular response to organic substance GO:0071310 132 0.033
nucleocytoplasmic transport GO:0006913 72 0.033
epithelial cell development GO:0002064 274 0.033
peptide metabolic process GO:0006518 80 0.032
appendage development GO:0048736 401 0.032
pigment metabolic process GO:0042440 84 0.032
positive regulation of humoral immune response GO:0002922 28 0.031
imaginal disc derived wing morphogenesis GO:0007476 337 0.030
regulation of phosphorus metabolic process GO:0051174 210 0.030
protein transport GO:0015031 155 0.030
mating GO:0007618 120 0.030
protein maturation GO:0051604 71 0.030
locomotory behavior GO:0007626 176 0.030
endomembrane system organization GO:0010256 119 0.029
carboxylic acid metabolic process GO:0019752 92 0.028
protein localization GO:0008104 284 0.028
activation of immune response GO:0002253 5 0.028
protein processing GO:0016485 68 0.028
negative regulation of signal transduction GO:0009968 206 0.028
tube development GO:0035295 244 0.028
response to peptidoglycan GO:0032494 2 0.028
positive regulation of defense response to bacterium GO:1900426 23 0.027
positive regulation of cellular amide metabolic process GO:0034250 26 0.027
protein complex biogenesis GO:0070271 201 0.027
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.026
regulation of response to biotic stimulus GO:0002831 63 0.026
single organism intracellular transport GO:1902582 207 0.026
negative regulation of defense response GO:0031348 35 0.026
cellular protein localization GO:0034613 160 0.026
positive regulation of antibacterial peptide production GO:0002803 20 0.025
regulation of cellular localization GO:0060341 136 0.025
peptide biosynthetic process GO:0043043 42 0.024
determination of adult lifespan GO:0008340 137 0.024
phosphorylation GO:0016310 294 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.024
detection of molecule of fungal origin GO:0032491 1 0.024
proteolysis GO:0006508 192 0.023
positive regulation of transcription factor import into nucleus GO:0042993 19 0.023
intracellular transport GO:0046907 228 0.023
positive regulation of intracellular signal transduction GO:1902533 116 0.023
regulation of mrna metabolic process GO:1903311 72 0.022
regulation of cell shape GO:0008360 113 0.022
cellular response to lipopolysaccharide GO:0071222 3 0.022
imaginal disc derived appendage morphogenesis GO:0035114 395 0.022
response to lipopolysaccharide GO:0032496 4 0.022
cellular response to chemical stimulus GO:0070887 199 0.021
regulation of mapk cascade GO:0043408 92 0.021
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.021
single organism cellular localization GO:1902580 180 0.021
positive regulation of cell communication GO:0010647 250 0.020
toll signaling pathway GO:0008063 25 0.020
regulation of cell morphogenesis GO:0022604 163 0.020
wound healing GO:0042060 75 0.020
melanotic encapsulation of foreign target GO:0035011 30 0.020
rna processing GO:0006396 147 0.019
meiotic cell cycle process GO:1903046 132 0.019
negative regulation of innate immune response GO:0045824 30 0.019
mrna metabolic process GO:0016071 124 0.019
embryonic pattern specification GO:0009880 174 0.019
mapk cascade GO:0000165 107 0.019
regulation of anatomical structure morphogenesis GO:0022603 242 0.019
positive regulation of cell migration GO:0030335 2 0.019
appendage morphogenesis GO:0035107 397 0.019
body morphogenesis GO:0010171 2 0.019
actin filament based process GO:0030029 220 0.019
regulation of localization GO:0032879 275 0.019
positive regulation of cellular component organization GO:0051130 156 0.019
establishment of localization in cell GO:0051649 402 0.019
tube morphogenesis GO:0035239 191 0.018
regulation of multicellular organismal development GO:2000026 414 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
spermatogenesis GO:0007283 200 0.018
imaginal disc derived appendage development GO:0048737 399 0.018
response to oxygen containing compound GO:1901700 200 0.018
eye morphogenesis GO:0048592 260 0.018
stem cell differentiation GO:0048863 117 0.018
jnk cascade GO:0007254 50 0.018
cellular catabolic process GO:0044248 372 0.018
muscle organ development GO:0007517 127 0.017
rna localization GO:0006403 115 0.017
actin cytoskeleton organization GO:0030036 206 0.017
positive regulation of antimicrobial humoral response GO:0002760 28 0.017
stress activated protein kinase signaling cascade GO:0031098 55 0.017
positive regulation of multi organism process GO:0043902 40 0.017
signal transduction by phosphorylation GO:0023014 107 0.017
response to organophosphorus GO:0046683 2 0.017
nucleotide metabolic process GO:0009117 161 0.016
response to molecule of fungal origin GO:0002238 1 0.016
segmentation GO:0035282 207 0.016
multicellular organismal aging GO:0010259 140 0.016
nuclear transport GO:0051169 72 0.016
cellular protein modification process GO:0006464 438 0.016
wing disc morphogenesis GO:0007472 344 0.016
protein modification process GO:0036211 438 0.016
mesenchymal cell differentiation GO:0048762 1 0.016
regulation of transport GO:0051049 181 0.016
morphogenesis of an epithelium GO:0002009 276 0.015
post embryonic appendage morphogenesis GO:0035120 385 0.015
membrane organization GO:0061024 112 0.015
organelle assembly GO:0070925 198 0.015
organic acid metabolic process GO:0006082 103 0.015
small molecule metabolic process GO:0044281 305 0.015
positive regulation of protein transport GO:0051222 37 0.015
male meiosis GO:0007140 52 0.015
response to nitrogen compound GO:1901698 90 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.015
regulation of protein transport GO:0051223 57 0.015
nitrogen compound transport GO:0071705 85 0.015
mitotic nuclear division GO:0007067 213 0.015
oxoacid metabolic process GO:0043436 103 0.015
cell cell signaling involved in cell fate commitment GO:0045168 210 0.015
regulation of secondary metabolic process GO:0043455 7 0.015
epithelial tube morphogenesis GO:0060562 88 0.015
ion transport GO:0006811 145 0.014
aggressive behavior GO:0002118 63 0.014
stress activated mapk cascade GO:0051403 52 0.014
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.014
cytoplasmic transport GO:0016482 130 0.014
regulation of stress activated mapk cascade GO:0032872 41 0.014
cellular macromolecule localization GO:0070727 220 0.014
negative regulation of biosynthetic process GO:0009890 277 0.014
negative regulation of response to external stimulus GO:0032102 22 0.014
mrna splicing via spliceosome GO:0000398 73 0.014
stem cell proliferation GO:0072089 88 0.014
anterior posterior axis specification embryo GO:0008595 103 0.014
dendrite development GO:0016358 204 0.014
positive regulation of intracellular protein transport GO:0090316 30 0.014
mesenchymal cell development GO:0014031 1 0.014
macromolecular complex assembly GO:0065003 256 0.014
sleep GO:0030431 49 0.014
developmental maturation GO:0021700 172 0.013
regulation of cellular response to stress GO:0080135 89 0.013
cell migration GO:0016477 238 0.013
maintenance of location GO:0051235 73 0.013
negative regulation of developmental process GO:0051093 201 0.013
lateral inhibition GO:0046331 206 0.013
non sensory hair organization GO:0035316 47 0.013
compound eye development GO:0048749 307 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
response to glucose GO:0009749 2 0.013
biological adhesion GO:0022610 138 0.013
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.013
homeostatic process GO:0042592 199 0.013
mrna processing GO:0006397 104 0.013
organophosphate metabolic process GO:0019637 195 0.013
growth GO:0040007 359 0.013
chromosome organization GO:0051276 360 0.013
eye development GO:0001654 323 0.013
very long chain fatty acid metabolic process GO:0000038 4 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
regulation of cell differentiation GO:0045595 302 0.012
negative regulation of mapk cascade GO:0043409 23 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.012
female meiotic division GO:0007143 70 0.012
organelle localization GO:0051640 148 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
regulation of organ morphogenesis GO:2000027 78 0.012
positive regulation of transport GO:0051050 92 0.012
wnt signaling pathway GO:0016055 98 0.012
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.012
chemotaxis GO:0006935 249 0.012
regulation of intracellular protein transport GO:0033157 46 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
rna splicing GO:0008380 83 0.012
gene silencing by rna GO:0031047 57 0.012
heterocycle catabolic process GO:0046700 166 0.012
spindle assembly GO:0051225 80 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
g protein coupled receptor signaling pathway GO:0007186 136 0.012
ras protein signal transduction GO:0007265 88 0.012
regulation of cell cycle process GO:0010564 181 0.012
regulation of proteolysis GO:0030162 87 0.012
regulation of jnk cascade GO:0046328 40 0.011
regulation of peptidase activity GO:0052547 39 0.011
cell cycle phase transition GO:0044770 140 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
purine containing compound metabolic process GO:0072521 155 0.011
positive regulation of molecular function GO:0044093 136 0.011
morphogenesis of a branching structure GO:0001763 45 0.011
regulation of toll signaling pathway GO:0008592 17 0.011
cellular response to dna damage stimulus GO:0006974 223 0.011
regulation of cellular component biogenesis GO:0044087 201 0.011
cellular response to lipid GO:0071396 20 0.011
response to organic cyclic compound GO:0014070 89 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.011
cellular macromolecular complex assembly GO:0034622 153 0.011
response to endogenous stimulus GO:0009719 119 0.011
regulation of nervous system development GO:0051960 248 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
skeletal muscle fiber development GO:0048741 3 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
negative regulation of rna biosynthetic process GO:1902679 240 0.011
synaptic transmission GO:0007268 288 0.011
positive regulation of cell motility GO:2000147 3 0.011
neurological system process GO:0050877 358 0.011
ovarian follicle cell development GO:0030707 248 0.011
regulation of molecular function GO:0065009 217 0.011
regulation of cell development GO:0060284 215 0.011
response to mechanical stimulus GO:0009612 28 0.010
camera type eye development GO:0043010 4 0.010
extrinsic apoptotic signaling pathway GO:0097191 1 0.010
regulation of cytoplasmic transport GO:1903649 47 0.010
imaginal disc pattern formation GO:0007447 91 0.010
glycosyl compound metabolic process GO:1901657 127 0.010
cellular protein complex assembly GO:0043623 71 0.010
regulation of nucleocytoplasmic transport GO:0046822 35 0.010
regulation of cell substrate adhesion GO:0010810 2 0.010
intracellular protein transport GO:0006886 104 0.010
retina development in camera type eye GO:0060041 4 0.010
cell maturation GO:0048469 144 0.010

modSP disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013