Drosophila melanogaster

53 known processes

WRNexo (Dmel_CG7670)

WRN exonuclease

(Aliases: CG7670,Dmel\CG7670,DmWRNexo)

WRNexo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome organization GO:0051276 360 0.376
dna repair GO:0006281 54 0.348
negative regulation of gene expression GO:0010629 387 0.335
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.229
negative regulation of biosynthetic process GO:0009890 277 0.228
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.225
negative regulation of rna biosynthetic process GO:1902679 240 0.193
dna conformation change GO:0071103 105 0.192
cellular response to dna damage stimulus GO:0006974 223 0.174
double strand break repair GO:0006302 26 0.155
appendage morphogenesis GO:0035107 397 0.127
negative regulation of gene expression epigenetic GO:0045814 77 0.111
single organism behavior GO:0044708 391 0.111
chromatin silencing GO:0006342 76 0.109
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.108
negative regulation of cellular biosynthetic process GO:0031327 277 0.107
protein complex assembly GO:0006461 200 0.102
negative regulation of transcription dna templated GO:0045892 237 0.092
chromosome segregation GO:0007059 157 0.091
dna packaging GO:0006323 91 0.089
chromosome separation GO:0051304 42 0.088
macromolecular complex assembly GO:0065003 256 0.088
negative regulation of cellular metabolic process GO:0031324 382 0.088
negative regulation of nucleic acid templated transcription GO:1903507 240 0.085
dna metabolic process GO:0006259 227 0.083
regulation of gene expression epigenetic GO:0040029 128 0.080
embryo development ending in birth or egg hatching GO:0009792 152 0.078
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.078
positive regulation of macromolecule metabolic process GO:0010604 405 0.075
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.073
regulation of cellular protein metabolic process GO:0032268 243 0.071
negative regulation of rna metabolic process GO:0051253 251 0.068
establishment of localization in cell GO:0051649 402 0.068
recombinational repair GO:0000725 13 0.066
activation of cysteine type endopeptidase activity GO:0097202 17 0.065
macromolecule catabolic process GO:0009057 161 0.065
death GO:0016265 284 0.065
chromatin remodeling GO:0006338 72 0.063
protein complex biogenesis GO:0070271 201 0.062
protein maturation GO:0051604 71 0.055
cellular macromolecule catabolic process GO:0044265 136 0.054
dna replication GO:0006260 48 0.049
regulation of cell death GO:0010941 173 0.048
eye morphogenesis GO:0048592 260 0.048
regulation of protein metabolic process GO:0051246 256 0.048
organonitrogen compound metabolic process GO:1901564 318 0.047
appendage development GO:0048736 401 0.047
dna dependent dna replication GO:0006261 17 0.047
mitotic nuclear division GO:0007067 213 0.046
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.045
chromatin organization GO:0006325 207 0.043
cell death GO:0008219 279 0.042
regulation of gene silencing GO:0060968 63 0.042
nuclear dna replication GO:0033260 1 0.042
cellular catabolic process GO:0044248 372 0.041
regulation of mitosis GO:0007088 56 0.041
cellular nitrogen compound catabolic process GO:0044270 165 0.041
apoptotic process GO:0006915 159 0.040
sister chromatid segregation GO:0000819 92 0.040
regulation of proteolysis GO:0030162 87 0.039
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.039
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.039
locomotory behavior GO:0007626 176 0.039
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.039
dna duplex unwinding GO:0032508 16 0.038
proteolysis GO:0006508 192 0.038
chromatin modification GO:0016568 147 0.036
multi organism behavior GO:0051705 175 0.034
double strand break repair via homologous recombination GO:0000724 13 0.033
neuron recognition GO:0008038 101 0.033
regulation of hydrolase activity GO:0051336 97 0.032
organelle fission GO:0048285 340 0.032
morphogenesis of an epithelium GO:0002009 276 0.031
transcription from rna polymerase ii promoter GO:0006366 368 0.031
muscle structure development GO:0061061 224 0.031
gene silencing GO:0016458 138 0.030
heterocycle catabolic process GO:0046700 166 0.030
response to organic substance GO:0010033 284 0.030
organic cyclic compound catabolic process GO:1901361 168 0.029
growth GO:0040007 359 0.029
cell cycle g1 s phase transition GO:0044843 31 0.029
organic substance transport GO:0071702 257 0.029
regulation of catabolic process GO:0009894 170 0.029
salivary gland development GO:0007431 162 0.028
positive regulation of molecular function GO:0044093 136 0.028
dendrite development GO:0016358 204 0.028
organic substance catabolic process GO:1901575 308 0.028
positive regulation of hydrolase activity GO:0051345 78 0.028
covalent chromatin modification GO:0016569 106 0.028
catabolic process GO:0009056 409 0.028
regulation of apoptotic process GO:0042981 130 0.027
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.027
regulation of mitotic cell cycle GO:0007346 190 0.027
eye development GO:0001654 323 0.027
spindle assembly GO:0051225 80 0.026
positive regulation of transcription dna templated GO:0045893 266 0.026
nuclear division GO:0000280 332 0.026
mitotic sister chromatid segregation GO:0000070 87 0.025
positive regulation of cell death GO:0010942 69 0.025
regulation of cellular ketone metabolic process GO:0010565 3 0.025
regulation of growth GO:0040008 233 0.024
programmed cell death GO:0012501 257 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
positive regulation of catalytic activity GO:0043085 118 0.023
cell recognition GO:0008037 102 0.023
protein modification process GO:0036211 438 0.023
regulation of cellular catabolic process GO:0031329 157 0.023
spindle organization GO:0007051 253 0.022
mitotic cell cycle phase transition GO:0044772 138 0.022
body morphogenesis GO:0010171 2 0.022
single organism biosynthetic process GO:0044711 206 0.022
regulation of cell differentiation GO:0045595 302 0.022
adult behavior GO:0030534 137 0.022
protein processing GO:0016485 68 0.022
cell cycle phase transition GO:0044770 140 0.022
organ growth GO:0035265 56 0.022
response to biotic stimulus GO:0009607 294 0.022
negative regulation of cellular component organization GO:0051129 108 0.021
protein localization GO:0008104 284 0.021
g1 s transition of mitotic cell cycle GO:0000082 31 0.021
imaginal disc derived appendage development GO:0048737 399 0.021
meiotic cell cycle process GO:1903046 132 0.021
aromatic compound catabolic process GO:0019439 166 0.021
regulation of organelle organization GO:0033043 196 0.021
protein transport GO:0015031 155 0.021
positive regulation of peptidase activity GO:0010952 29 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
compound eye development GO:0048749 307 0.021
positive regulation of gene expression GO:0010628 290 0.020
imaginal disc derived appendage morphogenesis GO:0035114 395 0.020
spinal cord development GO:0021510 1 0.020
phagocytosis GO:0006909 215 0.020
tube development GO:0035295 244 0.020
salivary gland morphogenesis GO:0007435 145 0.020
positive regulation of proteolysis GO:0045862 52 0.019
regulation of cell cycle GO:0051726 291 0.019
synaptic target recognition GO:0008039 45 0.019
developmental growth GO:0048589 280 0.019
regulation of molecular function GO:0065009 217 0.019
histone modification GO:0016570 106 0.019
negative regulation of cellular catabolic process GO:0031330 34 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.019
convergent extension GO:0060026 2 0.019
small molecule metabolic process GO:0044281 305 0.018
positive regulation of endopeptidase activity GO:0010950 26 0.018
regulation of endopeptidase activity GO:0052548 36 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.018
positive regulation of programmed cell death GO:0043068 62 0.018
regulation of transcription by chromatin organization GO:0034401 3 0.018
muscle organ development GO:0007517 127 0.018
positive regulation of mitotic cell cycle GO:0045931 34 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.018
cellular ketone metabolic process GO:0042180 24 0.018
dna replication initiation GO:0006270 6 0.017
posttranscriptional regulation of gene expression GO:0010608 145 0.017
regulation of peptidase activity GO:0052547 39 0.017
zymogen activation GO:0031638 20 0.017
meiosis i GO:0007127 59 0.017
regulation of programmed cell death GO:0043067 152 0.017
dna endoreduplication GO:0042023 22 0.016
regulation of proteasomal protein catabolic process GO:0061136 39 0.016
gland morphogenesis GO:0022612 145 0.016
regulation of cysteine type endopeptidase activity GO:2000116 27 0.016
multicellular organismal reproductive behavior GO:0033057 110 0.016
post embryonic appendage morphogenesis GO:0035120 385 0.016
single organism catabolic process GO:0044712 228 0.016
reproductive structure development GO:0048608 74 0.016
ribonucleotide metabolic process GO:0009259 145 0.016
oxoacid metabolic process GO:0043436 103 0.016
regulation of cell cycle phase transition GO:1901987 130 0.016
regulation of cellular protein catabolic process GO:1903362 44 0.016
purine ribonucleotide catabolic process GO:0009154 109 0.016
compound eye morphogenesis GO:0001745 249 0.016
ribonucleoside metabolic process GO:0009119 127 0.016
response to reactive oxygen species GO:0000302 24 0.015
regulation of mitotic cell cycle phase transition GO:1901990 130 0.015
positive regulation of cellular protein metabolic process GO:0032270 118 0.015
mrna metabolic process GO:0016071 124 0.015
positive regulation of nucleic acid templated transcription GO:1903508 266 0.015
camera type eye development GO:0043010 4 0.015
mitotic sister chromatid separation GO:0051306 30 0.015
multi multicellular organism process GO:0044706 123 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
wing disc morphogenesis GO:0007472 344 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
sister chromatid cohesion GO:0007062 18 0.014
embryonic morphogenesis GO:0048598 206 0.014
chromatin assembly GO:0031497 48 0.014
positive regulation of lipid metabolic process GO:0045834 4 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
nucleotide metabolic process GO:0009117 161 0.014
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.014
endomembrane system organization GO:0010256 119 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
taxis GO:0042330 304 0.014
positive regulation of catabolic process GO:0009896 105 0.014
cellular macromolecule localization GO:0070727 220 0.014
nucleoside triphosphate catabolic process GO:0009143 108 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
regulation of cytoskeleton organization GO:0051493 89 0.013
response to external biotic stimulus GO:0043207 293 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
histone exchange GO:0043486 21 0.013
dna double strand break processing GO:0000729 3 0.013
actin filament based process GO:0030029 220 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
intracellular transport GO:0046907 228 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
regulation of double strand break repair GO:2000779 3 0.013
positive regulation of apoptotic process GO:0043065 47 0.012
heterochromatin organization GO:0070828 25 0.012
vesicle mediated transport GO:0016192 381 0.012
organophosphate metabolic process GO:0019637 195 0.012
carboxylic acid metabolic process GO:0019752 92 0.012
meiotic chromosome segregation GO:0045132 59 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.012
negative regulation of proteolysis GO:0045861 31 0.012
response to organophosphorus GO:0046683 2 0.012
negative regulation of cytoskeleton organization GO:0051494 30 0.012
nucleoside catabolic process GO:0009164 112 0.012
endocytosis GO:0006897 310 0.012
regulation of catalytic activity GO:0050790 185 0.012
purine containing compound catabolic process GO:0072523 112 0.012
mrna processing GO:0006397 104 0.012
organic acid metabolic process GO:0006082 103 0.012
regulation of protein catabolic process GO:0042176 55 0.012
anatomical structure homeostasis GO:0060249 97 0.012
gtp metabolic process GO:0046039 72 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
exocrine system development GO:0035272 162 0.012
adult locomotory behavior GO:0008344 76 0.012
atp dependent chromatin remodeling GO:0043044 22 0.012
gland development GO:0048732 191 0.012
protein ubiquitination GO:0016567 70 0.012
digestive system development GO:0055123 149 0.012
protein catabolic process GO:0030163 101 0.011
metal ion transport GO:0030001 74 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
cellular amine metabolic process GO:0044106 12 0.011
dendrite morphogenesis GO:0048813 199 0.011
negative regulation of protein processing GO:0010955 31 0.011
positive regulation of rna biosynthetic process GO:1902680 266 0.011
central nervous system development GO:0007417 201 0.011
protein polymerization GO:0051258 42 0.011
positive regulation of transport GO:0051050 92 0.011
guanosine containing compound catabolic process GO:1901069 74 0.011
regulation of anatomical structure size GO:0090066 163 0.011
regulation of transport GO:0051049 181 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
digestive tract development GO:0048565 149 0.011
actin cytoskeleton organization GO:0030036 206 0.011
positive regulation of developmental process GO:0051094 143 0.010
double strand break repair via nonhomologous end joining GO:0006303 5 0.010
mitotic recombination GO:0006312 2 0.010
nucleobase containing compound catabolic process GO:0034655 165 0.010
metaphase anaphase transition of cell cycle GO:0044784 28 0.010
response to abiotic stimulus GO:0009628 341 0.010
negative regulation of chromosome organization GO:2001251 19 0.010
regulation of mitotic sister chromatid segregation GO:0033047 28 0.010
negative regulation of signaling GO:0023057 219 0.010
reproductive behavior GO:0019098 122 0.010
regulation of localization GO:0032879 275 0.010

WRNexo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.015