Drosophila melanogaster

13 known processes

Gie (Dmel_CG7891)

novel GTPase indispensable for equal segregation of chromosomes

(Aliases: Arl8,BcDNA:LD29185,CG7891,Dmel\CG7891)

Gie biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
purine ribonucleoside metabolic process GO:0046128 127 0.507
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.366
positive regulation of macromolecule metabolic process GO:0010604 405 0.331
nucleoside triphosphate metabolic process GO:0009141 120 0.287
defense response to other organism GO:0098542 225 0.275
guanosine containing compound catabolic process GO:1901069 74 0.271
purine nucleotide catabolic process GO:0006195 109 0.270
autophagy GO:0006914 108 0.265
establishment of organelle localization GO:0051656 122 0.231
organelle assembly GO:0070925 198 0.211
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.205
organelle localization GO:0051640 148 0.195
immune system process GO:0002376 347 0.194
vesicle mediated transport GO:0016192 381 0.192
ribonucleoside triphosphate catabolic process GO:0009203 108 0.181
purine nucleoside catabolic process GO:0006152 112 0.179
cell projection assembly GO:0030031 94 0.178
purine nucleoside triphosphate catabolic process GO:0009146 108 0.177
nucleotide catabolic process GO:0009166 109 0.172
ribonucleoside catabolic process GO:0042454 112 0.171
cellular catabolic process GO:0044248 372 0.162
nucleoside catabolic process GO:0009164 112 0.162
nucleoside triphosphate catabolic process GO:0009143 108 0.159
ribonucleotide catabolic process GO:0009261 109 0.150
programmed cell death GO:0012501 257 0.146
purine containing compound catabolic process GO:0072523 112 0.143
nucleoside metabolic process GO:0009116 127 0.143
aromatic compound catabolic process GO:0019439 166 0.139
biological adhesion GO:0022610 138 0.138
growth GO:0040007 359 0.138
regulation of organelle organization GO:0033043 196 0.137
response to biotic stimulus GO:0009607 294 0.135
carbohydrate derivative catabolic process GO:1901136 118 0.134
endocytosis GO:0006897 310 0.134
gtp metabolic process GO:0046039 72 0.133
muscle structure development GO:0061061 224 0.132
regulation of response to stress GO:0080134 200 0.132
nucleoside phosphate catabolic process GO:1901292 110 0.130
cell division GO:0051301 248 0.129
regulation of catabolic process GO:0009894 170 0.121
single organism membrane fusion GO:0044801 42 0.121
positive regulation of cellular component organization GO:0051130 156 0.121
cell proliferation GO:0008283 299 0.118
regulation of cellular catabolic process GO:0031329 157 0.114
morphogenesis of an epithelium GO:0002009 276 0.114
axonogenesis GO:0007409 290 0.114
embryo development ending in birth or egg hatching GO:0009792 152 0.112
proteolysis GO:0006508 192 0.111
dna repair GO:0006281 54 0.111
protein modification process GO:0036211 438 0.108
response to other organism GO:0051707 293 0.107
protein complex biogenesis GO:0070271 201 0.105
response to external biotic stimulus GO:0043207 293 0.105
catabolic process GO:0009056 409 0.103
protein complex assembly GO:0006461 200 0.103
nucleobase containing compound catabolic process GO:0034655 165 0.102
purine ribonucleotide catabolic process GO:0009154 109 0.100
ribonucleoside metabolic process GO:0009119 127 0.097
establishment of vesicle localization GO:0051650 51 0.096
organonitrogen compound catabolic process GO:1901565 128 0.094
purine nucleotide metabolic process GO:0006163 146 0.093
purine ribonucleotide metabolic process GO:0009150 145 0.090
intracellular signal transduction GO:0035556 300 0.090
nucleoside phosphate metabolic process GO:0006753 162 0.089
actin filament based process GO:0030029 220 0.088
negative regulation of cell communication GO:0010648 223 0.087
death GO:0016265 284 0.087
organonitrogen compound metabolic process GO:1901564 318 0.087
ribonucleotide metabolic process GO:0009259 145 0.086
heterocycle catabolic process GO:0046700 166 0.085
purine nucleoside triphosphate metabolic process GO:0009144 119 0.081
defense response GO:0006952 300 0.081
cilium morphogenesis GO:0060271 39 0.081
imaginal disc derived appendage development GO:0048737 399 0.080
negative regulation of response to stimulus GO:0048585 258 0.079
nucleobase containing small molecule metabolic process GO:0055086 174 0.078
glycosyl compound metabolic process GO:1901657 127 0.078
appendage morphogenesis GO:0035107 397 0.078
gtp catabolic process GO:0006184 72 0.078
single organism intracellular transport GO:1902582 207 0.077
negative regulation of signaling GO:0023057 219 0.076
negative regulation of cellular biosynthetic process GO:0031327 277 0.076
vesicle localization GO:0051648 55 0.075
cellular nitrogen compound catabolic process GO:0044270 165 0.074
cellular protein modification process GO:0006464 438 0.074
cell death GO:0008219 279 0.074
organic substance catabolic process GO:1901575 308 0.073
purine containing compound metabolic process GO:0072521 155 0.073
regulation of nervous system development GO:0051960 248 0.072
glycosyl compound catabolic process GO:1901658 112 0.071
axon guidance GO:0007411 233 0.071
positive regulation of protein metabolic process GO:0051247 128 0.071
guanosine containing compound metabolic process GO:1901068 74 0.071
regulation of cellular protein metabolic process GO:0032268 243 0.070
response to bacterium GO:0009617 198 0.069
purine nucleoside metabolic process GO:0042278 127 0.069
ribose phosphate metabolic process GO:0019693 145 0.068
nucleotide metabolic process GO:0009117 161 0.068
developmental growth GO:0048589 280 0.066
establishment of localization in cell GO:0051649 402 0.066
imaginal disc derived appendage morphogenesis GO:0035114 395 0.065
regulation of cytoskeleton organization GO:0051493 89 0.065
cytoplasmic transport GO:0016482 130 0.064
single organism catabolic process GO:0044712 228 0.061
regulation of cellular response to stress GO:0080135 89 0.059
apoptotic process GO:0006915 159 0.059
regulation of cell morphogenesis GO:0022604 163 0.057
cytokinesis GO:0000910 90 0.056
tissue morphogenesis GO:0048729 297 0.056
regulation of multi organism process GO:0043900 131 0.055
regulation of cellular component biogenesis GO:0044087 201 0.054
organic substance transport GO:0071702 257 0.054
cellular response to dna damage stimulus GO:0006974 223 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.054
synapse organization GO:0050808 196 0.053
epithelial cell development GO:0002064 274 0.053
negative regulation of signal transduction GO:0009968 206 0.052
transcription from rna polymerase ii promoter GO:0006366 368 0.051
regulation of programmed cell death GO:0043067 152 0.051
cell cell signaling involved in cell fate commitment GO:0045168 210 0.051
regulation of cell shape GO:0008360 113 0.051
regulation of growth GO:0040008 233 0.051
taxis GO:0042330 304 0.051
establishment of protein localization GO:0045184 163 0.050
response to oxygen containing compound GO:1901700 200 0.050
intracellular transport GO:0046907 228 0.049
cell adhesion GO:0007155 136 0.049
ribonucleoside triphosphate metabolic process GO:0009199 119 0.049
organophosphate catabolic process GO:0046434 112 0.049
regulation of protein metabolic process GO:0051246 256 0.049
lateral inhibition GO:0046331 206 0.049
eye development GO:0001654 323 0.048
embryonic organ development GO:0048568 50 0.048
posttranscriptional regulation of gene expression GO:0010608 145 0.047
endosomal transport GO:0016197 44 0.047
single organism membrane organization GO:0044802 93 0.047
purine ribonucleoside catabolic process GO:0046130 112 0.046
single organism cellular localization GO:1902580 180 0.046
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.045
regulation of molecular function GO:0065009 217 0.045
regulation of neurogenesis GO:0050767 158 0.044
macromolecular complex assembly GO:0065003 256 0.043
wing disc morphogenesis GO:0007472 344 0.043
cell cycle checkpoint GO:0000075 95 0.043
compound eye development GO:0048749 307 0.043
regulation of anatomical structure morphogenesis GO:0022603 242 0.042
atp catabolic process GO:0006200 38 0.042
regulation of cell cycle phase transition GO:1901987 130 0.042
protein transport GO:0015031 155 0.041
regulation of cell differentiation GO:0045595 302 0.041
positive regulation of phosphorus metabolic process GO:0010562 139 0.040
regulation of intracellular signal transduction GO:1902531 236 0.040
cell cycle phase transition GO:0044770 140 0.039
positive regulation of biosynthetic process GO:0009891 316 0.039
meiotic cell cycle GO:0051321 171 0.039
regulation of catalytic activity GO:0050790 185 0.038
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.038
regulation of protein stability GO:0031647 43 0.038
cellular protein localization GO:0034613 160 0.037
larval development GO:0002164 104 0.037
cellular response to chemical stimulus GO:0070887 199 0.037
phagocytosis GO:0006909 215 0.037
wnt signaling pathway GO:0016055 98 0.037
positive regulation of phosphate metabolic process GO:0045937 139 0.037
positive regulation of cellular biosynthetic process GO:0031328 316 0.037
cellular protein complex assembly GO:0043623 71 0.037
regulation of cell cycle GO:0051726 291 0.036
muscle cell differentiation GO:0042692 103 0.036
appendage development GO:0048736 401 0.035
actin cytoskeleton organization GO:0030036 206 0.035
stress activated protein kinase signaling cascade GO:0031098 55 0.034
gland development GO:0048732 191 0.033
defense response to bacterium GO:0042742 178 0.033
sensory organ morphogenesis GO:0090596 260 0.032
membrane organization GO:0061024 112 0.032
regulation of response to external stimulus GO:0032101 115 0.032
ribonucleoside monophosphate catabolic process GO:0009158 39 0.032
cilium assembly GO:0042384 38 0.032
positive regulation of multicellular organismal process GO:0051240 143 0.031
stem cell differentiation GO:0048863 117 0.031
regulation of multicellular organismal development GO:2000026 414 0.031
mitotic cell cycle phase transition GO:0044772 138 0.031
carbohydrate derivative metabolic process GO:1901135 217 0.031
regulation of phosphate metabolic process GO:0019220 210 0.031
cellular macromolecule localization GO:0070727 220 0.030
positive regulation of cellular catabolic process GO:0031331 95 0.030
body morphogenesis GO:0010171 2 0.030
small molecule metabolic process GO:0044281 305 0.030
regulation of cell proliferation GO:0042127 163 0.030
positive regulation of catalytic activity GO:0043085 118 0.029
regionalization GO:0003002 416 0.029
positive regulation of catabolic process GO:0009896 105 0.029
post embryonic appendage morphogenesis GO:0035120 385 0.029
response to organic substance GO:0010033 284 0.029
dna integrity checkpoint GO:0031570 81 0.029
regulation of response to biotic stimulus GO:0002831 63 0.028
regulation of phosphorus metabolic process GO:0051174 210 0.028
regulation of cell cycle process GO:0010564 181 0.028
synaptic transmission GO:0007268 288 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.027
membrane fusion GO:0061025 42 0.027
digestive system development GO:0055123 149 0.027
protein localization GO:0008104 284 0.027
response to abiotic stimulus GO:0009628 341 0.027
neurotransmitter transport GO:0006836 37 0.027
epithelial cell differentiation GO:0030855 322 0.027
regulation of proteolysis GO:0030162 87 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.026
negative regulation of cell cycle phase transition GO:1901988 103 0.026
immune effector process GO:0002252 98 0.026
positive regulation of lyase activity GO:0051349 10 0.025
vesicle organization GO:0016050 44 0.025
regulation of cell development GO:0060284 215 0.024
cilium organization GO:0044782 41 0.024
regulation of neuron differentiation GO:0045664 103 0.024
hematopoietic or lymphoid organ development GO:0048534 57 0.024
protein catabolic process GO:0030163 101 0.024
dna metabolic process GO:0006259 227 0.024
meiotic nuclear division GO:0007126 151 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
nitrogen compound transport GO:0071705 85 0.023
chromosome organization GO:0051276 360 0.023
centrosome cycle GO:0007098 137 0.023
response to nitrogen compound GO:1901698 90 0.023
embryonic morphogenesis GO:0048598 206 0.023
ovarian follicle cell development GO:0030707 248 0.023
stress activated mapk cascade GO:0051403 52 0.023
positive regulation of cellular component biogenesis GO:0044089 80 0.023
actin filament organization GO:0007015 126 0.022
regulation of developmental growth GO:0048638 174 0.022
imaginal disc derived wing morphogenesis GO:0007476 337 0.022
gland morphogenesis GO:0022612 145 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.021
regulation of cell death GO:0010941 173 0.021
negative regulation of cell proliferation GO:0008285 69 0.021
negative regulation of developmental process GO:0051093 201 0.021
stem cell development GO:0048864 79 0.021
chemotaxis GO:0006935 249 0.021
establishment of planar polarity GO:0001736 87 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.020
organic cyclic compound catabolic process GO:1901361 168 0.020
enzyme linked receptor protein signaling pathway GO:0007167 179 0.020
leg disc development GO:0035218 92 0.020
negative regulation of nucleic acid templated transcription GO:1903507 240 0.020
regulation of protein modification process GO:0031399 112 0.020
positive regulation of signaling GO:0023056 243 0.020
regulation of transport GO:0051049 181 0.020
chromatin modification GO:0016568 147 0.020
immune system development GO:0002520 57 0.020
dna damage checkpoint GO:0000077 78 0.020
compound eye morphogenesis GO:0001745 249 0.020
cellular component assembly involved in morphogenesis GO:0010927 151 0.019
negative regulation of biosynthetic process GO:0009890 277 0.019
positive regulation of nervous system development GO:0051962 69 0.019
tor signaling GO:0031929 32 0.019
positive regulation of proteolysis GO:0045862 52 0.019
cellular response to oxygen containing compound GO:1901701 79 0.019
establishment or maintenance of cell polarity GO:0007163 167 0.019
positive regulation of developmental process GO:0051094 143 0.019
cellular macromolecular complex assembly GO:0034622 153 0.019
positive regulation of cellular protein metabolic process GO:0032270 118 0.019
homeostatic process GO:0042592 199 0.019
establishment of tissue polarity GO:0007164 87 0.019
intracellular protein transport GO:0006886 104 0.018
positive regulation of hydrolase activity GO:0051345 78 0.018
covalent chromatin modification GO:0016569 106 0.018
negative regulation of cell cycle GO:0045786 116 0.018
positive regulation of molecular function GO:0044093 136 0.018
response to endogenous stimulus GO:0009719 119 0.018
jnk cascade GO:0007254 50 0.018
membrane budding GO:0006900 4 0.018
regulation of notch signaling pathway GO:0008593 100 0.018
cell cycle g1 s phase transition GO:0044843 31 0.018
negative regulation of transcription dna templated GO:0045892 237 0.017
positive regulation of cell communication GO:0010647 250 0.017
meiotic cell cycle process GO:1903046 132 0.017
negative regulation of cellular protein metabolic process GO:0032269 85 0.017
cellular macromolecule catabolic process GO:0044265 136 0.017
regulation of mitotic cell cycle GO:0007346 190 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.017
cortical actin cytoskeleton organization GO:0030866 24 0.017
cellular protein catabolic process GO:0044257 83 0.017
neurotransmitter secretion GO:0007269 35 0.017
negative regulation of cellular metabolic process GO:0031324 382 0.017
axon development GO:0061564 297 0.017
nuclear division GO:0000280 332 0.017
regulation of protein phosphorylation GO:0001932 64 0.017
regulation of nucleoside metabolic process GO:0009118 50 0.017
exocytosis GO:0006887 28 0.017
neuron projection guidance GO:0097485 241 0.016
regulation of hydrolase activity GO:0051336 97 0.016
columnar cuboidal epithelial cell development GO:0002066 249 0.016
response to organonitrogen compound GO:0010243 75 0.016
salivary gland development GO:0007431 162 0.016
secretion GO:0046903 109 0.016
regulation of synapse structure and activity GO:0050803 128 0.016
epidermal growth factor receptor signaling pathway GO:0007173 58 0.016
erbb signaling pathway GO:0038127 58 0.016
localization of cell GO:0051674 257 0.016
regulation of cell projection organization GO:0031344 92 0.016
negative regulation of intracellular signal transduction GO:1902532 57 0.016
regulation of hemocyte proliferation GO:0035206 37 0.016
regulation of apoptotic process GO:0042981 130 0.015
purine nucleoside monophosphate catabolic process GO:0009128 38 0.015
eye morphogenesis GO:0048592 260 0.015
reproductive structure development GO:0048608 74 0.015
regulation of immune system process GO:0002682 176 0.015
protein modification by small protein conjugation or removal GO:0070647 106 0.015
neuron remodeling GO:0016322 29 0.015
vesicle fusion GO:0006906 19 0.015
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.015
macromolecule catabolic process GO:0009057 161 0.015
synapse assembly GO:0007416 143 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.014
negative regulation of rna metabolic process GO:0051253 251 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.014
negative regulation of rna biosynthetic process GO:1902679 240 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
cellular response to nutrient levels GO:0031669 62 0.014
cellular response to endogenous stimulus GO:0071495 80 0.014
cell motility GO:0048870 251 0.014
organophosphate metabolic process GO:0019637 195 0.014
response to extracellular stimulus GO:0009991 116 0.014
cytoskeleton dependent cytokinesis GO:0061640 81 0.014
developmental maturation GO:0021700 172 0.014
negative regulation of protein metabolic process GO:0051248 85 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
spermatid differentiation GO:0048515 114 0.013
macroautophagy GO:0016236 42 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
striated muscle cell differentiation GO:0051146 90 0.013
pronuclear migration GO:0035046 4 0.013
circulatory system development GO:0072359 82 0.013
mitotic cytokinesis GO:0000281 50 0.013
regulation of neuron projection development GO:0010975 69 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.013
notch signaling pathway GO:0007219 120 0.013
signal release GO:0023061 49 0.013
regulation of nucleotide metabolic process GO:0006140 62 0.013
positive regulation of response to stimulus GO:0048584 323 0.013
production of molecular mediator of immune response GO:0002440 46 0.013
regulation of nucleotide catabolic process GO:0030811 48 0.013
negative regulation of phosphorylation GO:0042326 35 0.013
protein dna complex subunit organization GO:0071824 86 0.013
mitotic dna integrity checkpoint GO:0044774 75 0.013
g1 s transition of mitotic cell cycle GO:0000082 31 0.013
regulation of meiosis GO:0040020 3 0.012
centrosome organization GO:0051297 163 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
golgi vesicle transport GO:0048193 27 0.012
cell growth GO:0016049 108 0.012
positive regulation of developmental growth GO:0048639 62 0.012
phosphorylation GO:0016310 294 0.012
protein phosphorylation GO:0006468 169 0.012
response to lipopolysaccharide GO:0032496 4 0.012
negative regulation of gene expression GO:0010629 387 0.012
positive regulation of cell cycle GO:0045787 43 0.012
organelle fission GO:0048285 340 0.012
negative regulation of organelle organization GO:0010639 56 0.012
response to nutrient levels GO:0031667 114 0.012
spermatid development GO:0007286 98 0.012
positive regulation of gtp catabolic process GO:0033126 43 0.012
regulation of humoral immune response GO:0002920 51 0.012
heart development GO:0007507 82 0.012
camera type eye development GO:0043010 4 0.012
gliogenesis GO:0042063 80 0.012
ras protein signal transduction GO:0007265 88 0.012
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
axoneme assembly GO:0035082 18 0.011
dendrite self avoidance GO:0070593 8 0.011
epithelial tube morphogenesis GO:0060562 88 0.011
modification dependent macromolecule catabolic process GO:0043632 79 0.011
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.011
positive regulation of gene expression GO:0010628 290 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
response to radiation GO:0009314 155 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
regulation of chromosome organization GO:0033044 64 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
negative regulation of apoptotic process GO:0043066 63 0.011
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
leg disc morphogenesis GO:0007478 80 0.011
secretion by cell GO:0032940 101 0.011
nucleoside monophosphate catabolic process GO:0009125 39 0.011
dorsal closure GO:0007391 79 0.011
molting cycle GO:0042303 56 0.011
response to decreased oxygen levels GO:0036293 58 0.011
exocrine system development GO:0035272 162 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.011
cellular response to nitrogen compound GO:1901699 51 0.010
stem cell fate commitment GO:0048865 25 0.010
tube morphogenesis GO:0035239 191 0.010
mitotic spindle organization GO:0007052 220 0.010
salivary gland morphogenesis GO:0007435 145 0.010
positive regulation of signal transduction GO:0009967 223 0.010
regulation of vesicle mediated transport GO:0060627 59 0.010
regulation of synapse organization GO:0050807 110 0.010
digestive tract development GO:0048565 149 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.010

Gie disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035