Drosophila melanogaster

245 known processes

InR (Dmel_CG18402)

Insulin-like receptor

(Aliases: DIHR,Dir-b,Dir-a,inr,insulin/insulin-like growth factor receptor,InsR,dInR,l(3)93Dj,DIR,DILR,CG18402,l(3)05545,DIRbeta,Inr-alpha,INR,dInr,18402,dIRH,dIR,DInR,er10,dInsR,IR,DInr,DIRH,Inr-beta,l(3)er10,Dmel\CG18402,Inr,dINR,dir,dinr)

InR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
growth GO:0040007 359 0.999
learning or memory GO:0007611 141 0.998
Fly
regulation of cell proliferation GO:0042127 163 0.997
regulation of growth GO:0040008 233 0.997
positive regulation of gene expression GO:0010628 290 0.996
axon guidance GO:0007411 233 0.995
cell proliferation GO:0008283 299 0.994
negative regulation of cellular metabolic process GO:0031324 382 0.992
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.991
circadian rhythm GO:0007623 105 0.990
regulation of cell differentiation GO:0045595 302 0.990
Fly
positive regulation of growth GO:0045927 75 0.989
regulation of cell growth GO:0001558 43 0.989
negative regulation of cell communication GO:0010648 223 0.988
Human Mouse Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.988
positive regulation of biosynthetic process GO:0009891 316 0.988
Human Mouse Rat
taxis GO:0042330 304 0.986
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.982
Human Rat
positive regulation of cellular biosynthetic process GO:0031328 316 0.982
Human Mouse Rat
myotube differentiation GO:0014902 46 0.979
positive regulation of cell migration GO:0030335 2 0.977
Human
embryonic morphogenesis GO:0048598 206 0.976
enzyme linked receptor protein signaling pathway GO:0007167 179 0.975
germ line stem cell division GO:0042078 25 0.974
response to organic substance GO:0010033 284 0.974
positive regulation of macromolecule metabolic process GO:0010604 405 0.973
Human Mouse Rat Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.971
positive regulation of rna metabolic process GO:0051254 271 0.969
negative regulation of signal transduction GO:0009968 206 0.969
Human Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.968
Human Rat
positive regulation of developmental growth GO:0048639 62 0.966
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.966
positive regulation of nucleic acid templated transcription GO:1903508 266 0.965
regulation of immune system process GO:0002682 176 0.963
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.963
response to oxygen containing compound GO:1901700 200 0.963
positive regulation of cellular response to insulin stimulus GO:1900078 4 0.962
regulation of cellular localization GO:0060341 136 0.961
Worm
positive regulation of response to stimulus GO:0048584 323 0.957
Human Mouse Fly
cellular response to chemical stimulus GO:0070887 199 0.956
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.953
photoreceptor cell differentiation GO:0046530 170 0.949
Fly
developmental growth GO:0048589 280 0.944
establishment of localization in cell GO:0051649 402 0.942
Worm
aging GO:0007568 143 0.939
feeding behavior GO:0007631 50 0.935
single organism behavior GO:0044708 391 0.935
positive regulation of transcription dna templated GO:0045893 266 0.933
negative regulation of response to stimulus GO:0048585 258 0.930
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.928
regulation of protein metabolic process GO:0051246 256 0.924
Human Zebrafish Rat Fly
negative regulation of signaling GO:0023057 219 0.924
Human Mouse Fly
cell death GO:0008219 279 0.919
Human Zebrafish Rat
transcription from rna polymerase ii promoter GO:0006366 368 0.918
cellular catabolic process GO:0044248 372 0.918
dna metabolic process GO:0006259 227 0.913
Human Rat
regulation of cell development GO:0060284 215 0.908
Fly
multicellular organismal aging GO:0010259 140 0.907
regulation of developmental growth GO:0048638 174 0.906
immune response GO:0006955 246 0.903
Human
chemotaxis GO:0006935 249 0.903
rhythmic process GO:0048511 106 0.900
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.900
brain development GO:0007420 120 0.898
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.897
regulation of catabolic process GO:0009894 170 0.893
regulation of cellular catabolic process GO:0031329 157 0.891
regulation of cell migration GO:0030334 22 0.878
Human
positive regulation of lipid catabolic process GO:0050996 1 0.875
negative regulation of cell proliferation GO:0008285 69 0.873
single organism biosynthetic process GO:0044711 206 0.870
Human Mouse Rat
regulation of apoptotic process GO:0042981 130 0.866
Human Zebrafish Rat
imaginal disc derived appendage development GO:0048737 399 0.864
central nervous system development GO:0007417 201 0.864
Zebrafish Mouse
phosphorylation GO:0016310 294 0.860
ameboidal type cell migration GO:0001667 151 0.852
organic acid metabolic process GO:0006082 103 0.848
Human
cell growth GO:0016049 108 0.845
regulation of multicellular organism growth GO:0040014 40 0.838
dendrite morphogenesis GO:0048813 199 0.838
regulation of organelle organization GO:0033043 196 0.836
Human Mouse Worm
skeletal muscle organ development GO:0060538 48 0.826
organelle fission GO:0048285 340 0.825
Human Mouse
response to oxidative stress GO:0006979 86 0.825
multi organism reproductive behavior GO:0044705 121 0.822
negative regulation of rna metabolic process GO:0051253 251 0.822
imaginal disc derived wing morphogenesis GO:0007476 337 0.816
regulation of phosphate metabolic process GO:0019220 210 0.814
Human Mouse Rat Fly
response to peptide GO:1901652 29 0.813
cardiac cell fate commitment GO:0060911 17 0.812
cellular response to oxygen containing compound GO:1901701 79 0.808
cellular response to peptide GO:1901653 28 0.804
negative regulation of transcription dna templated GO:0045892 237 0.802
death GO:0016265 284 0.798
Human Zebrafish Rat
r7 cell differentiation GO:0045466 43 0.793
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.784
Human Mouse Rat
appendage morphogenesis GO:0035107 397 0.779
response to nitrogen compound GO:1901698 90 0.771
positive regulation of developmental process GO:0051094 143 0.765
regulation of cellular response to insulin stimulus GO:1900076 17 0.740
cell motility GO:0048870 251 0.738
Human Zebrafish
negative regulation of nucleic acid templated transcription GO:1903507 240 0.732
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.731
germ line stem cell maintenance GO:0030718 50 0.723
negative regulation of rna biosynthetic process GO:1902679 240 0.718
regulation of protein kinase activity GO:0045859 51 0.713
Human Fly
appendage development GO:0048736 401 0.711
regulation of cell cycle GO:0051726 291 0.710
Human Mouse Rat
generation of precursor metabolites and energy GO:0006091 42 0.704
Human Mouse
mitochondrion organization GO:0007005 65 0.703
chromosome organization GO:0051276 360 0.700
stem cell development GO:0048864 79 0.694
positive regulation of cell differentiation GO:0045597 64 0.689
Fly
axonogenesis GO:0007409 290 0.671
response to organonitrogen compound GO:0010243 75 0.670
positive regulation of cell motility GO:2000147 3 0.661
Human
positive regulation of lipid metabolic process GO:0045834 4 0.649
Rat
cellular response to hormone stimulus GO:0032870 44 0.644
tube morphogenesis GO:0035239 191 0.643
Zebrafish
regulation of stem cell proliferation GO:0072091 40 0.640
cell division GO:0051301 248 0.633
regulation of cellular protein metabolic process GO:0032268 243 0.627
Human Zebrafish Rat Fly
stem cell proliferation GO:0072089 88 0.622
epithelial cell migration GO:0010631 148 0.621
regulation of nervous system development GO:0051960 248 0.620
Fly
syncytium formation GO:0006949 43 0.617
single organism cellular localization GO:1902580 180 0.612
Worm
oocyte development GO:0048599 124 0.609
meiotic cell cycle GO:0051321 171 0.608
stem cell division GO:0017145 69 0.605
immune system process GO:0002376 347 0.604
Human Fly
compound eye photoreceptor cell differentiation GO:0001751 140 0.604
Fly
small molecule metabolic process GO:0044281 305 0.603
Human
response to ketone GO:1901654 34 0.599
Rat
regulation of cell size GO:0008361 63 0.597
imaginal disc derived appendage morphogenesis GO:0035114 395 0.597
organ growth GO:0035265 56 0.596
cognition GO:0050890 141 0.585
Fly
regulation of r7 cell differentiation GO:0045676 15 0.585
Fly
neuron projection guidance GO:0097485 241 0.584
negative regulation of molecular function GO:0044092 51 0.577
Human Zebrafish Mouse Rat
cellular carbohydrate metabolic process GO:0044262 22 0.577
Human Mouse
heart development GO:0007507 82 0.572
Human Zebrafish
forebrain development GO:0030900 2 0.571
response to wounding GO:0009611 94 0.569
Zebrafish
dendrite development GO:0016358 204 0.566
regulation of neurogenesis GO:0050767 158 0.564
Fly
organic substance catabolic process GO:1901575 308 0.563
Human
negative regulation of biosynthetic process GO:0009890 277 0.558
axon development GO:0061564 297 0.555
response to light stimulus GO:0009416 124 0.551
regulation of localization GO:0032879 275 0.546
Human Rat Worm
positive regulation of cell communication GO:0010647 250 0.546
Human Mouse Fly
positive regulation of phosphorus metabolic process GO:0010562 139 0.545
Human Mouse Rat Fly
negative regulation of cell fate specification GO:0009996 15 0.543
positive regulation of lipid biosynthetic process GO:0046889 3 0.542
Rat
regulation of phosphorus metabolic process GO:0051174 210 0.540
Human Mouse Rat Fly
regulation of kinase activity GO:0043549 53 0.538
Human Fly
imaginal disc growth GO:0007446 37 0.537
positive regulation of cell growth GO:0030307 19 0.532
negative regulation of growth GO:0045926 84 0.529
multi organism behavior GO:0051705 175 0.528
response to abiotic stimulus GO:0009628 341 0.526
oxoacid metabolic process GO:0043436 103 0.526
Human
ribose phosphate metabolic process GO:0019693 145 0.520
negative regulation of catalytic activity GO:0043086 42 0.517
Human Zebrafish
regulation of lipid biosynthetic process GO:0046890 6 0.513
Rat
positive regulation of signaling GO:0023056 243 0.510
Human Mouse Fly
neuroblast proliferation GO:0007405 74 0.509
regulation of phosphorylation GO:0042325 147 0.509
Human Mouse Rat Fly
positive regulation of signal transduction GO:0009967 223 0.508
Human Mouse Fly
olfactory behavior GO:0042048 97 0.507
Fly
regulation of cell death GO:0010941 173 0.503
Human Zebrafish Rat
cell fate specification GO:0001708 71 0.502
Fly
chemical homeostasis GO:0048878 92 0.500
Human Rat
response to external biotic stimulus GO:0043207 293 0.498
establishment or maintenance of cell polarity GO:0007163 167 0.496
Rat Fly
determination of adult lifespan GO:0008340 137 0.492
eye photoreceptor cell differentiation GO:0001754 145 0.492
Fly
protein phosphorylation GO:0006468 169 0.489
positive regulation of cell proliferation GO:0008284 47 0.486
muscle structure development GO:0061061 224 0.483
stem cell differentiation GO:0048863 117 0.481
regulation of multicellular organismal development GO:2000026 414 0.481
Human Fly
response to alcohol GO:0097305 95 0.473
Rat
mitotic cell cycle phase transition GO:0044772 138 0.471
negative regulation of intracellular signal transduction GO:1902532 57 0.470
Human Mouse
oocyte differentiation GO:0009994 145 0.469
actin filament based process GO:0030029 220 0.466
Human
positive regulation of organelle organization GO:0010638 65 0.460
Human Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.459
cellular response to nitrogen compound GO:1901699 51 0.457
positive regulation of neurogenesis GO:0050769 41 0.456
Fly
entry into diapause GO:0055115 1 0.451
Worm
tor signaling GO:0031929 32 0.450
dorsal ventral pattern formation GO:0009953 133 0.449
regulation of protein phosphorylation GO:0001932 64 0.447
Human Rat Fly
neurological system process GO:0050877 358 0.446
Fly
regulation of photoreceptor cell differentiation GO:0046532 34 0.445
Fly
negative regulation of cell cycle GO:0045786 116 0.442
cyclic nucleotide metabolic process GO:0009187 28 0.442
negative regulation of phosphorylation GO:0042326 35 0.432
Human Mouse Rat
developmental maturation GO:0021700 172 0.431
compound eye photoreceptor development GO:0042051 78 0.428
Fly
response to peptide hormone GO:0043434 29 0.414
lipid metabolic process GO:0006629 121 0.412
maintenance of location GO:0051235 73 0.410
Worm
negative regulation of gene expression GO:0010629 387 0.410
Zebrafish Rat
myoblast fusion GO:0007520 43 0.403
synaptic growth at neuromuscular junction GO:0051124 119 0.398
tissue migration GO:0090130 155 0.394
regulation of neuron differentiation GO:0045664 103 0.391
Fly
cellular response to dna damage stimulus GO:0006974 223 0.389
regulation of epithelial cell proliferation GO:0050678 4 0.384
cell maturation GO:0048469 144 0.382
positive regulation of protein metabolic process GO:0051247 128 0.379
Human Rat Fly
regulation of anatomical structure size GO:0090066 163 0.378
negative regulation of cell differentiation GO:0045596 143 0.377
protein catabolic process GO:0030163 101 0.374
cellular response to endogenous stimulus GO:0071495 80 0.373
lipid homeostasis GO:0055088 33 0.365
regulation of lipid metabolic process GO:0019216 15 0.359
Rat
malpighian tubule morphogenesis GO:0007443 44 0.357
regulation of protein modification process GO:0031399 112 0.357
Human Rat Fly
regulation of dna metabolic process GO:0051052 34 0.356
Human Rat
rhythmic behavior GO:0007622 76 0.355
cellular response to organic substance GO:0071310 132 0.353
autophagy GO:0006914 108 0.352
insulin receptor signaling pathway GO:0008286 25 0.346
regulation of programmed cell death GO:0043067 152 0.345
Human Zebrafish Rat
mesoderm development GO:0007498 78 0.344
Fly
regulation of dendrite morphogenesis GO:0048814 28 0.340
epithelial cell development GO:0002064 274 0.339
semaphorin plexin signaling pathway GO:0071526 4 0.335
regulation of cellular ketone metabolic process GO:0010565 3 0.333
negative regulation of kinase activity GO:0033673 16 0.333
Human
response to lipopolysaccharide GO:0032496 4 0.332
cell fate determination GO:0001709 91 0.332
energy derivation by oxidation of organic compounds GO:0015980 32 0.330
Human Mouse
catabolic process GO:0009056 409 0.328
negative regulation of cell cycle process GO:0010948 109 0.328
eye photoreceptor cell development GO:0042462 81 0.327
Fly
cellular amino acid metabolic process GO:0006520 61 0.327
negative regulation of multicellular organismal process GO:0051241 142 0.326
morphogenesis of a branching epithelium GO:0061138 45 0.323
cell migration GO:0016477 238 0.323
Human Zebrafish
meiotic nuclear division GO:0007126 151 0.322
response to endogenous stimulus GO:0009719 119 0.317
open tracheal system development GO:0007424 204 0.317
positive regulation of glycogen biosynthetic process GO:0045725 1 0.312
Human Mouse
regulation of neuroblast proliferation GO:1902692 34 0.310
regulation of immune response GO:0050776 118 0.308
regulation of response to stress GO:0080134 200 0.308
Human Worm
purine ribonucleotide biosynthetic process GO:0009152 28 0.308
positive regulation of cell death GO:0010942 69 0.308
pigment metabolic process GO:0042440 84 0.306
striated muscle cell differentiation GO:0051146 90 0.301
localization of cell GO:0051674 257 0.299
Human Zebrafish
humoral immune response GO:0006959 117 0.292
regulation of muscle organ development GO:0048634 13 0.284
stem cell maintenance GO:0019827 67 0.283
dormancy process GO:0022611 2 0.283
Worm
regulation of neural precursor cell proliferation GO:2000177 35 0.283
asymmetric stem cell division GO:0098722 49 0.282
regulation of insulin receptor signaling pathway GO:0046626 17 0.277
positive regulation of phosphorylation GO:0042327 87 0.277
Human Mouse Rat Fly
sensory organ morphogenesis GO:0090596 260 0.275
Zebrafish Fly
response to biotic stimulus GO:0009607 294 0.270
regulation of catalytic activity GO:0050790 185 0.269
Human Zebrafish Fly
positive regulation of programmed cell death GO:0043068 62 0.267
programmed cell death GO:0012501 257 0.266
Human Zebrafish Rat
signal transduction by phosphorylation GO:0023014 107 0.266
Human Mouse Fly
organonitrogen compound metabolic process GO:1901564 318 0.265
regulation of response to external stimulus GO:0032101 115 0.259
Worm
regulation of small gtpase mediated signal transduction GO:0051056 93 0.258
digestive system development GO:0055123 149 0.258
Mouse Fly
regionalization GO:0003002 416 0.256
Zebrafish
regulation of striated muscle tissue development GO:0016202 5 0.252
cellular amine metabolic process GO:0044106 12 0.250
macromolecule catabolic process GO:0009057 161 0.248
positive regulation of catabolic process GO:0009896 105 0.248
Human
regulation of embryonic development GO:0045995 68 0.247
Human
regulation of cell cycle phase transition GO:1901987 130 0.246
response to insulin GO:0032868 29 0.245
regulation of organ growth GO:0046620 42 0.245
response to organic cyclic compound GO:0014070 89 0.244
eye morphogenesis GO:0048592 260 0.243
Fly
cellular response to insulin stimulus GO:0032869 28 0.242
response to monosaccharide GO:0034284 4 0.239
Rat
peptidyl threonine phosphorylation GO:0018107 2 0.236
response to hexose GO:0009746 3 0.236
Rat
regulation of protein localization GO:0032880 76 0.234
Worm
regulation of behavior GO:0050795 75 0.233
response to hormone GO:0009725 45 0.231
syncytium formation by plasma membrane fusion GO:0000768 43 0.229
regulation of hormone levels GO:0010817 40 0.227
Rat
apoptotic process GO:0006915 159 0.226
Human Zebrafish Rat
positive regulation of cell development GO:0010720 61 0.223
Fly
embryonic development via the syncytial blastoderm GO:0001700 148 0.219
negative regulation of protein metabolic process GO:0051248 85 0.216
Human Zebrafish Rat
neuron fate commitment GO:0048663 50 0.212
Fly
wing disc morphogenesis GO:0007472 344 0.212
regulation of mitotic cell cycle phase transition GO:1901990 130 0.211
regulation of imaginal disc growth GO:0045570 26 0.208
head development GO:0060322 135 0.208
Mouse
cardioblast differentiation GO:0010002 20 0.207
regulation of protein transport GO:0051223 57 0.204
Worm
negative regulation of programmed cell death GO:0043069 72 0.202
Human Zebrafish Rat
regulation of ras protein signal transduction GO:0046578 93 0.201
mating GO:0007618 120 0.201
ras protein signal transduction GO:0007265 88 0.198
response to bacterium GO:0009617 198 0.197
protein targeting to nucleus GO:0044744 51 0.197
Worm
associative learning GO:0008306 65 0.196
Fly
adult chitin containing cuticle pigmentation GO:0048085 16 0.196
translation GO:0006412 69 0.193
embryonic hemopoiesis GO:0035162 26 0.193
skeletal muscle tissue development GO:0007519 13 0.193
regulation of malpighian tubule diameter GO:0035297 3 0.192
negative regulation of insulin secretion GO:0046676 1 0.192
genital disc development GO:0035215 44 0.190
lipid biosynthetic process GO:0008610 46 0.189
Rat
exocrine system development GO:0035272 162 0.188
Mouse
single organismal cell cell adhesion GO:0016337 45 0.187
skeletal muscle fiber development GO:0048741 3 0.185
intracellular transport GO:0046907 228 0.184
Worm
hemopoiesis GO:0030097 46 0.182
regulation of locomotion GO:0040012 42 0.181
Human
response to radiation GO:0009314 155 0.178
biological adhesion GO:0022610 138 0.177
learning GO:0007612 75 0.175
Fly
response to glucose GO:0009749 2 0.173
Rat
regulation of cell motility GO:2000145 23 0.173
Human
positive regulation of cellular protein metabolic process GO:0032270 118 0.173
Human Fly
positive regulation of protein phosphorylation GO:0001934 34 0.171
Human Fly
post embryonic appendage morphogenesis GO:0035120 385 0.171
intracellular signal transduction GO:0035556 300 0.171
Human Mouse Fly
circulatory system development GO:0072359 82 0.170
Human Zebrafish
male gamete generation GO:0048232 201 0.170
chemosensory behavior GO:0007635 106 0.169
Fly
circulatory system process GO:0003013 37 0.168
cell cycle phase transition GO:0044770 140 0.167
myotube cell development GO:0014904 3 0.167
regulation of epithelial cell migration GO:0010632 12 0.166
negative regulation of photoreceptor cell differentiation GO:0046533 8 0.166
malpighian tubule development GO:0072002 64 0.164
chromatin organization GO:0006325 207 0.163
cellular protein modification process GO:0006464 438 0.162
positive regulation of muscle organ development GO:0048636 6 0.160
carboxylic acid metabolic process GO:0019752 92 0.160
Human
oocyte axis specification GO:0007309 108 0.160
homeostatic process GO:0042592 199 0.159
regulation of mitotic cell cycle GO:0007346 190 0.154
Human Mouse
synapse assembly GO:0007416 143 0.151
photoreceptor cell development GO:0042461 96 0.150
Fly
cytoplasmic transport GO:0016482 130 0.149
Worm
g protein coupled receptor signaling pathway GO:0007186 136 0.149
Human
regulation of cell fate commitment GO:0010453 29 0.148
anterior posterior pattern specification GO:0009952 136 0.147
Zebrafish
organophosphate biosynthetic process GO:0090407 46 0.146
response to other organism GO:0051707 293 0.146
regulation of response to nutrient levels GO:0032107 18 0.145
Worm
cellular response to organonitrogen compound GO:0071417 36 0.144
regulation of chemotaxis GO:0050920 12 0.142
regulation of establishment of protein localization GO:0070201 61 0.142
Worm
positive regulation of cellular component organization GO:0051130 156 0.141
Human Mouse
regulation of protein serine threonine kinase activity GO:0071900 25 0.141
Human Fly
regulation of intracellular protein transport GO:0033157 46 0.139
Worm
regulation of cellular component movement GO:0051270 42 0.138
Human
positive regulation of apoptotic process GO:0043065 47 0.137
negative regulation of apoptotic process GO:0043066 63 0.137
Human Zebrafish Rat
locomotor rhythm GO:0045475 56 0.135
immune system development GO:0002520 57 0.135
digestive tract development GO:0048565 149 0.135
Fly
protein localization to organelle GO:0033365 82 0.134
Worm
response to ethanol GO:0045471 59 0.134
Rat
positive regulation of molecular function GO:0044093 136 0.134
Human Fly
response to uv GO:0009411 24 0.134
pigmentation GO:0043473 75 0.132
positive regulation of nervous system development GO:0051962 69 0.130
Fly
response to oxygen levels GO:0070482 59 0.129
cellular glucan metabolic process GO:0006073 6 0.128
Human Mouse
spermatogenesis GO:0007283 200 0.127
tripartite regional subdivision GO:0007351 103 0.126
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.126
neuron death GO:0070997 27 0.125
mesoderm morphogenesis GO:0048332 22 0.124
cell type specific apoptotic process GO:0097285 38 0.124
Rat
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 1 0.124
negative regulation of neuroblast proliferation GO:0007406 27 0.122
regulation of tor signaling GO:0032006 21 0.121
small gtpase mediated signal transduction GO:0007264 88 0.121
regulation of transport GO:0051049 181 0.120
Human Rat Worm
lipid localization GO:0010876 54 0.120
Worm
locomotory behavior GO:0007626 176 0.120
positive regulation of protein modification process GO:0031401 58 0.120
Human Fly
regulation of glucan biosynthetic process GO:0010962 1 0.119
Human Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.119
cell projection assembly GO:0030031 94 0.118
establishment of protein localization to organelle GO:0072594 62 0.118
Worm
negative regulation of mitotic cell cycle GO:0045930 109 0.117
negative regulation of insulin receptor signaling pathway GO:0046627 11 0.117
activation of protein kinase activity GO:0032147 12 0.117
Human Fly
regulation of cell cycle process GO:0010564 181 0.116
Human Mouse Rat
gastrulation GO:0007369 70 0.116
negative regulation of cell migration GO:0030336 5 0.115
developmental pigmentation GO:0048066 68 0.113
chorion containing eggshell formation GO:0007304 105 0.113
cellular response to lipopolysaccharide GO:0071222 3 0.112
regulation of transferase activity GO:0051338 58 0.111
Human Fly
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 0.111
regulation of heart contraction GO:0008016 21 0.111
epithelial cell migration open tracheal system GO:0007427 32 0.111
regulation of cellular component size GO:0032535 98 0.111
response to extracellular stimulus GO:0009991 116 0.110
Rat Worm
regulation of autophagy GO:0010506 62 0.110
epithelium migration GO:0090132 148 0.110
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.107
Mouse
nucleobase containing small molecule metabolic process GO:0055086 174 0.107
positive regulation of cellular catabolic process GO:0031331 95 0.107
Human
regulation of map kinase activity GO:0043405 17 0.106
Human Fly
positive regulation of cell size GO:0045793 21 0.106
memory GO:0007613 94 0.105
positive regulation of behavior GO:0048520 19 0.104
defense response GO:0006952 300 0.103
positive regulation of phosphate metabolic process GO:0045937 139 0.103
Human Mouse Rat Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.102
blood circulation GO:0008015 26 0.102
cytoplasm organization GO:0007028 64 0.101
regulation of cell division GO:0051302 72 0.100
Human Mouse Rat
cellular response to peptide hormone stimulus GO:0071375 28 0.100
negative regulation of cell death GO:0060548 81 0.100
Human Zebrafish Rat
regulation of nuclear division GO:0051783 58 0.099
Human Mouse
somatic muscle development GO:0007525 66 0.099
cell activation GO:0001775 9 0.099
organophosphate metabolic process GO:0019637 195 0.098
response to lipid GO:0033993 38 0.097
Rat
muscle organ development GO:0007517 127 0.097
Fly
telencephalon development GO:0021537 2 0.096
neural precursor cell proliferation GO:0061351 75 0.096
axis specification GO:0009798 167 0.096
regulation of cellular amine metabolic process GO:0033238 3 0.095
blastoderm segmentation GO:0007350 159 0.095
response to hypoxia GO:0001666 53 0.095
negative regulation of developmental growth GO:0048640 64 0.094
ribonucleotide metabolic process GO:0009259 145 0.094
protein complex biogenesis GO:0070271 201 0.094
Human Rat
protein import into nucleus GO:0006606 51 0.094
Worm
extrinsic apoptotic signaling pathway GO:0097191 1 0.092
cellular ketone metabolic process GO:0042180 24 0.092
cellular response to organic cyclic compound GO:0071407 32 0.091
embryonic axis specification GO:0000578 107 0.090
lateral inhibition GO:0046331 206 0.089
regulation of intracellular transport GO:0032386 64 0.088
Worm
negative regulation of epithelial cell migration GO:0010633 1 0.088
carbohydrate metabolic process GO:0005975 82 0.087
carbohydrate derivative metabolic process GO:1901135 217 0.086
Rat
negative regulation of autophagy GO:0010507 16 0.085
border follicle cell migration GO:0007298 113 0.085
single organism catabolic process GO:0044712 228 0.085
Human Worm
nuclear transport GO:0051169 72 0.084
Worm
regulation of carbohydrate metabolic process GO:0006109 10 0.083
Human Mouse
negative regulation of epithelial cell proliferation GO:0050680 4 0.083
regulation of synapse structure and activity GO:0050803 128 0.082
cell cycle g1 s phase transition GO:0044843 31 0.082
germ band shortening GO:0007390 19 0.081
regulation of chromosome organization GO:0033044 64 0.081
heart contraction GO:0060047 26 0.081
oocyte microtubule cytoskeleton organization GO:0016325 35 0.080
positive regulation of immune system process GO:0002684 68 0.080
regulation of cellular component biogenesis GO:0044087 201 0.080
Worm
proteolysis GO:0006508 192 0.080
Zebrafish
axon midline choice point recognition GO:0016199 26 0.080
cellular response to lipid GO:0071396 20 0.079
regulation of multi organism process GO:0043900 131 0.079
heart process GO:0003015 37 0.079
gland development GO:0048732 191 0.079
Mouse
negative regulation of cellular component organization GO:0051129 108 0.077
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.076
antimicrobial humoral response GO:0019730 99 0.075
negative regulation of developmental process GO:0051093 201 0.073
regulation of molecular function GO:0065009 217 0.073
Human Zebrafish Mouse Rat Fly
eye pigmentation GO:0048069 43 0.072
regulation of dendrite development GO:0050773 37 0.072
hindgut morphogenesis GO:0007442 58 0.071
negative regulation of gene expression epigenetic GO:0045814 77 0.071
activin receptor signaling pathway GO:0032924 6 0.071
positive regulation of nitric oxide biosynthetic process GO:0045429 1 0.071
Human
anterior posterior axis specification GO:0009948 109 0.071
hematopoietic or lymphoid organ development GO:0048534 57 0.070
negative regulation of stem cell proliferation GO:2000647 30 0.070
positive regulation of mitotic cell cycle GO:0045931 34 0.069
Human Mouse
organic hydroxy compound metabolic process GO:1901615 83 0.069
reactive oxygen species metabolic process GO:0072593 22 0.068

InR disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.091
Human
acquired metabolic disease DOID:0060158 0 0.091