Drosophila melanogaster

48 known processes

MCPH1 (Dmel_CG42572)

Microcephalin

(Aliases: mcph1,CG13184,CG42572,awol,CG8981,CG30038,Dmel_CG8981,Dmel_CG30038,Dmel\CG42572,Dmcph1)

MCPH1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
female meiotic division GO:0007143 70 0.467
mitotic cell cycle phase transition GO:0044772 138 0.339
organelle fission GO:0048285 340 0.337
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.276
nuclear division GO:0000280 332 0.244
dna metabolic process GO:0006259 227 0.222
regulation of organelle organization GO:0033043 196 0.210
regulation of cell cycle GO:0051726 291 0.209
regulation of protein metabolic process GO:0051246 256 0.192
cell maturation GO:0048469 144 0.188
cell death GO:0008219 279 0.176
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.173
negative regulation of cellular biosynthetic process GO:0031327 277 0.167
single fertilization GO:0007338 24 0.156
embryo development ending in birth or egg hatching GO:0009792 152 0.147
death GO:0016265 284 0.145
protein localization GO:0008104 284 0.142
regulation of mitotic cell cycle GO:0007346 190 0.141
regulation of cell cycle process GO:0010564 181 0.138
regulation of cellular protein metabolic process GO:0032268 243 0.131
growth GO:0040007 359 0.129
regulation of mitosis GO:0007088 56 0.123
regulation of cell cycle phase transition GO:1901987 130 0.120
organelle localization GO:0051640 148 0.119
chromosome organization GO:0051276 360 0.118
cell motility GO:0048870 251 0.114
negative regulation of cellular metabolic process GO:0031324 382 0.113
establishment of organelle localization GO:0051656 122 0.111
g2 m transition of mitotic cell cycle GO:0000086 19 0.109
localization of cell GO:0051674 257 0.106
negative regulation of biosynthetic process GO:0009890 277 0.104
negative regulation of cell cycle process GO:0010948 109 0.103
cellular protein modification process GO:0006464 438 0.102
response to radiation GO:0009314 155 0.102
developmental growth GO:0048589 280 0.099
response to abiotic stimulus GO:0009628 341 0.098
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.097
cellular response to dna damage stimulus GO:0006974 223 0.094
chromosome segregation GO:0007059 157 0.092
central nervous system development GO:0007417 201 0.091
oocyte development GO:0048599 124 0.089
cell cycle phase transition GO:0044770 140 0.089
oocyte differentiation GO:0009994 145 0.087
developmental maturation GO:0021700 172 0.086
establishment of cell polarity GO:0030010 40 0.084
regulation of mitotic cell cycle phase transition GO:1901990 130 0.081
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.079
regulation of oocyte development GO:0060281 27 0.077
macromolecular complex assembly GO:0065003 256 0.075
fertilization GO:0009566 26 0.075
cell division GO:0051301 248 0.072
regulation of cellular component biogenesis GO:0044087 201 0.071
negative regulation of cell cycle GO:0045786 116 0.071
cellularization GO:0007349 90 0.071
programmed cell death GO:0012501 257 0.070
regulation of localization GO:0032879 275 0.064
oocyte construction GO:0007308 112 0.061
rho protein signal transduction GO:0007266 14 0.060
transcription from rna polymerase ii promoter GO:0006366 368 0.059
protein complex biogenesis GO:0070271 201 0.059
regulation of multicellular organismal development GO:2000026 414 0.059
double strand break repair via nonhomologous end joining GO:0006303 5 0.058
negative regulation of mitotic cell cycle GO:0045930 109 0.058
response to organic substance GO:0010033 284 0.056
cellular catabolic process GO:0044248 372 0.054
developmental programmed cell death GO:0010623 138 0.054
cell migration GO:0016477 238 0.054
sister chromatid segregation GO:0000819 92 0.053
negative regulation of gene expression GO:0010629 387 0.052
response to uv GO:0009411 24 0.052
response to oxygen containing compound GO:1901700 200 0.050
nucleus organization GO:0006997 45 0.050
small gtpase mediated signal transduction GO:0007264 88 0.050
cellular macromolecule localization GO:0070727 220 0.049
positive regulation of cellular protein metabolic process GO:0032270 118 0.049
determination of adult lifespan GO:0008340 137 0.048
appendage morphogenesis GO:0035107 397 0.047
regulation of nuclear division GO:0051783 58 0.047
enzyme linked receptor protein signaling pathway GO:0007167 179 0.047
taxis GO:0042330 304 0.047
negative regulation of cell cycle phase transition GO:1901988 103 0.045
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.045
histone mrna metabolic process GO:0008334 8 0.045
ubiquitin dependent protein catabolic process GO:0006511 78 0.045
protein modification process GO:0036211 438 0.045
organelle assembly GO:0070925 198 0.044
regulation of cell division GO:0051302 72 0.044
cellular protein localization GO:0034613 160 0.043
regulation of pole plasm oskar mrna localization GO:0007317 27 0.043
catabolic process GO:0009056 409 0.042
negative regulation of response to stimulus GO:0048585 258 0.042
positive regulation of response to stimulus GO:0048584 323 0.042
actin filament based process GO:0030029 220 0.042
mitotic sister chromatid segregation GO:0000070 87 0.041
male pronucleus assembly GO:0035039 6 0.041
germ cell migration GO:0008354 43 0.041
dna conformation change GO:0071103 105 0.040
regulation of catabolic process GO:0009894 170 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.040
chemotaxis GO:0006935 249 0.040
response to light stimulus GO:0009416 124 0.039
negative regulation of signal transduction GO:0009968 206 0.039
regulation of embryonic pattern specification GO:1902875 27 0.039
dna repair GO:0006281 54 0.039
male gamete generation GO:0048232 201 0.039
anterior posterior pattern specification GO:0009952 136 0.038
regulation of catalytic activity GO:0050790 185 0.038
maternal determination of anterior posterior axis embryo GO:0008358 74 0.038
regulation of chromosome segregation GO:0051983 32 0.038
chromatin organization GO:0006325 207 0.038
neuron projection guidance GO:0097485 241 0.038
organic substance catabolic process GO:1901575 308 0.037
digestive tract development GO:0048565 149 0.037
embryonic morphogenesis GO:0048598 206 0.037
tube morphogenesis GO:0035239 191 0.037
regulation of cell development GO:0060284 215 0.037
nuclear import GO:0051170 51 0.037
regulation of small gtpase mediated signal transduction GO:0051056 93 0.036
regulation of chromosome organization GO:0033044 64 0.036
meiotic nuclear division GO:0007126 151 0.036
vesicle mediated transport GO:0016192 381 0.036
ribonucleoside triphosphate catabolic process GO:0009203 108 0.036
purine ribonucleotide catabolic process GO:0009154 109 0.035
regulation of cell maturation GO:1903429 27 0.035
spermatogenesis GO:0007283 200 0.035
regulation of cytoskeleton organization GO:0051493 89 0.035
positive regulation of macromolecule metabolic process GO:0010604 405 0.034
negative regulation of transcription dna templated GO:0045892 237 0.034
small molecule metabolic process GO:0044281 305 0.034
establishment of localization in cell GO:0051649 402 0.034
actin mediated cell contraction GO:0070252 21 0.034
pole cell development GO:0007277 26 0.033
maintenance of location GO:0051235 73 0.033
pole cell formation GO:0007279 19 0.033
axis specification GO:0009798 167 0.033
rna processing GO:0006396 147 0.033
ribonucleoside triphosphate metabolic process GO:0009199 119 0.032
stem cell proliferation GO:0072089 88 0.032
nucleotide metabolic process GO:0009117 161 0.032
regulation of dna metabolic process GO:0051052 34 0.032
anterior posterior axis specification GO:0009948 109 0.032
positive regulation of catabolic process GO:0009896 105 0.032
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.031
single organism cellular localization GO:1902580 180 0.031
response to ionizing radiation GO:0010212 32 0.031
positive regulation of hydrolase activity GO:0051345 78 0.031
appendage development GO:0048736 401 0.030
body morphogenesis GO:0010171 2 0.030
actin cytoskeleton organization GO:0030036 206 0.030
positive regulation of cellular component organization GO:0051130 156 0.030
axon development GO:0061564 297 0.029
nucleoside phosphate catabolic process GO:1901292 110 0.029
intracellular signal transduction GO:0035556 300 0.029
tube development GO:0035295 244 0.029
ribose phosphate metabolic process GO:0019693 145 0.029
regulation of molecular function GO:0065009 217 0.029
regulation of ras protein signal transduction GO:0046578 93 0.029
mrna metabolic process GO:0016071 124 0.029
cellular response to organic substance GO:0071310 132 0.029
ribonucleotide metabolic process GO:0009259 145 0.029
establishment of nucleus localization GO:0040023 26 0.029
cellular nitrogen compound catabolic process GO:0044270 165 0.028
positive regulation of developmental process GO:0051094 143 0.028
dna packaging GO:0006323 91 0.028
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.028
gastrulation GO:0007369 70 0.028
sensory organ morphogenesis GO:0090596 260 0.028
purine nucleoside triphosphate catabolic process GO:0009146 108 0.027
axon guidance GO:0007411 233 0.027
organophosphate catabolic process GO:0046434 112 0.026
regulation of programmed cell death GO:0043067 152 0.026
nucleus localization GO:0051647 34 0.026
compound eye morphogenesis GO:0001745 249 0.026
response to wounding GO:0009611 94 0.026
positive regulation of cellular catabolic process GO:0031331 95 0.026
pole plasm assembly GO:0007315 61 0.026
kidney development GO:0001822 3 0.026
actin filament based movement GO:0030048 26 0.026
oocyte axis specification GO:0007309 108 0.026
cellular component assembly involved in morphogenesis GO:0010927 151 0.025
negative regulation of nucleic acid templated transcription GO:1903507 240 0.025
cytoplasm organization GO:0007028 64 0.025
positive regulation of gtpase activity GO:0043547 43 0.025
phagocytosis GO:0006909 215 0.025
reproductive structure development GO:0048608 74 0.025
positive regulation of multicellular organismal process GO:0051240 143 0.024
dna dependent dna replication GO:0006261 17 0.024
imaginal disc derived appendage development GO:0048737 399 0.024
compound eye development GO:0048749 307 0.024
regulation of cell proliferation GO:0042127 163 0.024
regulation of cell differentiation GO:0045595 302 0.024
protein modification by small protein conjugation or removal GO:0070647 106 0.024
negative regulation of protein metabolic process GO:0051248 85 0.023
meiotic cell cycle GO:0051321 171 0.023
regulation of cellular localization GO:0060341 136 0.023
proteolysis GO:0006508 192 0.023
regulation of protein modification process GO:0031399 112 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.023
head development GO:0060322 135 0.023
reproductive system development GO:0061458 74 0.023
positive regulation of organelle organization GO:0010638 65 0.023
nucleoside triphosphate catabolic process GO:0009143 108 0.022
embryonic pattern specification GO:0009880 174 0.022
positive regulation of ras gtpase activity GO:0032320 36 0.022
mitotic nuclear division GO:0007067 213 0.022
multicellular organismal aging GO:0010259 140 0.022
embryonic development via the syncytial blastoderm GO:0001700 148 0.022
purine ribonucleotide metabolic process GO:0009150 145 0.022
nucleoside metabolic process GO:0009116 127 0.022
non recombinational repair GO:0000726 7 0.022
brain development GO:0007420 120 0.022
purine nucleotide catabolic process GO:0006195 109 0.022
chromatin assembly or disassembly GO:0006333 52 0.022
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.021
positive regulation of cellular component biogenesis GO:0044089 80 0.021
post embryonic appendage morphogenesis GO:0035120 385 0.021
cellular protein complex assembly GO:0043623 71 0.021
ribonucleoside catabolic process GO:0042454 112 0.021
ribonucleoside metabolic process GO:0009119 127 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
negative regulation of signaling GO:0023057 219 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.021
protein catabolic process GO:0030163 101 0.021
atp dependent chromatin remodeling GO:0043044 22 0.021
cell cycle g2 m phase transition GO:0044839 22 0.020
regulation of protein catabolic process GO:0042176 55 0.020
gland morphogenesis GO:0022612 145 0.020
regulation of embryonic development GO:0045995 68 0.020
nucleotide catabolic process GO:0009166 109 0.020
organophosphate metabolic process GO:0019637 195 0.020
negative regulation of cell cycle g2 m phase transition GO:1902750 8 0.019
compound eye photoreceptor cell differentiation GO:0001751 140 0.019
positive regulation of catalytic activity GO:0043085 118 0.019
wing disc morphogenesis GO:0007472 344 0.019
mitotic g2 m transition checkpoint GO:0044818 70 0.019
purine nucleotide metabolic process GO:0006163 146 0.019
negative regulation of rna biosynthetic process GO:1902679 240 0.019
positive regulation of molecular function GO:0044093 136 0.019
embryonic axis specification GO:0000578 107 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
oocyte anterior posterior axis specification GO:0007314 72 0.018
aromatic compound catabolic process GO:0019439 166 0.018
chromosome separation GO:0051304 42 0.018
cellular response to chemical stimulus GO:0070887 199 0.018
purine ribonucleoside metabolic process GO:0046128 127 0.018
dna replication GO:0006260 48 0.018
centrosome organization GO:0051297 163 0.018
metaphase anaphase transition of cell cycle GO:0044784 28 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
negative regulation of developmental process GO:0051093 201 0.018
pole plasm mrna localization GO:0019094 49 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.018
epithelial cell development GO:0002064 274 0.018
pole plasm rna localization GO:0007316 52 0.018
macromolecule catabolic process GO:0009057 161 0.017
carbohydrate derivative metabolic process GO:1901135 217 0.017
mitotic sister chromatid separation GO:0051306 30 0.017
nucleoside phosphate metabolic process GO:0006753 162 0.017
nucleoside catabolic process GO:0009164 112 0.017
homeostatic process GO:0042592 199 0.017
regulation of cell size GO:0008361 63 0.017
retina development in camera type eye GO:0060041 4 0.017
protein complex assembly GO:0006461 200 0.017
regulation of protein localization GO:0032880 76 0.017
blastoderm segmentation GO:0007350 159 0.017
pole plasm protein localization GO:0007318 10 0.017
positive regulation of protein metabolic process GO:0051247 128 0.017
positive regulation of transcription dna templated GO:0045893 266 0.016
regionalization GO:0003002 416 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.016
cellular macromolecular complex assembly GO:0034622 153 0.016
regulation of reproductive process GO:2000241 54 0.016
glycosyl compound metabolic process GO:1901657 127 0.016
single organism biosynthetic process GO:0044711 206 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.016
wnt signaling pathway GO:0016055 98 0.016
regulation of sister chromatid segregation GO:0033045 28 0.016
purine nucleoside triphosphate metabolic process GO:0009144 119 0.016
meiotic cell cycle process GO:1903046 132 0.016
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.015
positive regulation of rna metabolic process GO:0051254 271 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
positive regulation of nucleic acid templated transcription GO:1903508 266 0.015
sex differentiation GO:0007548 81 0.015
circulatory system development GO:0072359 82 0.015
eye morphogenesis GO:0048592 260 0.015
regulation of actin filament based process GO:0032970 42 0.015
pole plasm oskar mrna localization GO:0045451 46 0.015
cuticle development GO:0042335 86 0.015
spindle assembly GO:0051225 80 0.015
nephron development GO:0072006 3 0.015
single organism catabolic process GO:0044712 228 0.015
protein transport GO:0015031 155 0.015
regulation of actin cytoskeleton organization GO:0032956 42 0.015
chromatin modification GO:0016568 147 0.015
regulation of intracellular signal transduction GO:1902531 236 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
negative regulation of translation GO:0017148 28 0.015
ribonucleotide catabolic process GO:0009261 109 0.015
intracellular protein transport GO:0006886 104 0.015
regulation of proteolysis GO:0030162 87 0.015
tripartite regional subdivision GO:0007351 103 0.015
positive regulation of growth GO:0045927 75 0.014
positive regulation of phosphate metabolic process GO:0045937 139 0.014
regulation of transport GO:0051049 181 0.014
glycosyl compound catabolic process GO:1901658 112 0.014
chromatin remodeling GO:0006338 72 0.014
histone modification GO:0016570 106 0.014
regulation of transferase activity GO:0051338 58 0.014
male meiosis cytokinesis GO:0007112 26 0.014
eye photoreceptor cell differentiation GO:0001754 145 0.014
mrna processing GO:0006397 104 0.014
axonogenesis GO:0007409 290 0.014
organonitrogen compound metabolic process GO:1901564 318 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.014
positive regulation of cell motility GO:2000147 3 0.014
negative regulation of rna metabolic process GO:0051253 251 0.014
establishment of protein localization GO:0045184 163 0.014
pronuclear fusion GO:0007344 4 0.014
aging GO:0007568 143 0.014
oocyte microtubule cytoskeleton organization GO:0016325 35 0.013
camera type eye morphogenesis GO:0048593 2 0.013
gtp catabolic process GO:0006184 72 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
regulation of translation GO:0006417 56 0.013
maintenance of protein location in cell GO:0032507 26 0.013
eye development GO:0001654 323 0.013
forebrain development GO:0030900 2 0.013
open tracheal system development GO:0007424 204 0.013
protein phosphorylation GO:0006468 169 0.013
nuclear migration GO:0007097 20 0.013
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.013
nephron epithelium development GO:0072009 3 0.013
negative regulation of cell communication GO:0010648 223 0.013
protein polymerization GO:0051258 42 0.013
ribonucleoside monophosphate catabolic process GO:0009158 39 0.013
cuticle pattern formation GO:0035017 27 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
regulation of epithelial cell differentiation GO:0030856 4 0.013
cellular protein catabolic process GO:0044257 83 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
microtubule organizing center organization GO:0031023 168 0.013
organic acid metabolic process GO:0006082 103 0.013
regulation of cellular protein catabolic process GO:1903362 44 0.013
mitotic cell cycle embryonic GO:0045448 38 0.012
positive regulation of proteolysis GO:0045862 52 0.012
imaginal disc derived wing morphogenesis GO:0007476 337 0.012
positive regulation of gene expression GO:0010628 290 0.012
covalent chromatin modification GO:0016569 106 0.012
karyogamy GO:0000741 4 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
purine containing compound catabolic process GO:0072523 112 0.012
cilium morphogenesis GO:0060271 39 0.012
positive regulation of cell communication GO:0010647 250 0.012
positive regulation of signaling GO:0023056 243 0.012
peptidyl amino acid modification GO:0018193 105 0.012
apoptotic process GO:0006915 159 0.012
mrna 3 end processing GO:0031124 28 0.012
negative regulation of synapse assembly GO:0051964 39 0.012
protein targeting GO:0006605 64 0.012
regulation of cellular component size GO:0032535 98 0.012
carboxylic acid metabolic process GO:0019752 92 0.012
anterior posterior axis specification embryo GO:0008595 103 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
endocytosis GO:0006897 310 0.012
microtubule polymerization or depolymerization GO:0031109 39 0.012
notch signaling pathway GO:0007219 120 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
gonad development GO:0008406 50 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
ras protein signal transduction GO:0007265 88 0.011
response to organic cyclic compound GO:0014070 89 0.011
regulation of proteasomal protein catabolic process GO:0061136 39 0.011
positive regulation of transport GO:0051050 92 0.011
modification dependent macromolecule catabolic process GO:0043632 79 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
positive regulation of developmental growth GO:0048639 62 0.011
cell proliferation GO:0008283 299 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
regulation of response to stress GO:0080134 200 0.011
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.011
maintenance of location in cell GO:0051651 28 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.011
actin filament organization GO:0007015 126 0.011
cellular response to abiotic stimulus GO:0071214 58 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.011
regulation of apoptotic process GO:0042981 130 0.011
regulation of cellular response to stress GO:0080135 89 0.011
centrosome duplication GO:0051298 121 0.011
negative regulation of cell development GO:0010721 62 0.011
negative regulation of nervous system development GO:0051961 92 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
kidney epithelium development GO:0072073 3 0.011
gtp metabolic process GO:0046039 72 0.011
positive regulation of cytoskeleton organization GO:0051495 21 0.011
hindbrain development GO:0030902 2 0.010
cellular ketone metabolic process GO:0042180 24 0.010
protein deubiquitination GO:0016579 17 0.010
gland development GO:0048732 191 0.010
positive regulation of signal transduction GO:0009967 223 0.010
regulation of nervous system development GO:0051960 248 0.010
telencephalon development GO:0021537 2 0.010
histolysis GO:0007559 102 0.010
development of primary sexual characteristics GO:0045137 50 0.010
kidney morphogenesis GO:0060993 3 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.010
heterocycle catabolic process GO:0046700 166 0.010
spindle organization GO:0007051 253 0.010

MCPH1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.027
disease of cellular proliferation DOID:14566 0 0.027
organ system cancer DOID:0050686 0 0.027
disease of anatomical entity DOID:7 0 0.014