Drosophila melanogaster

60 known processes

hay (Dmel_CG8019)

haywire

(Aliases: DhXPB,DmXPB,DhR25,XPB,nc2,ERCC3,Xpb/hay,ms(3)nc2,CG8019,i50,TFIIH,hwr,Dmel\CG8019)

hay biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 54 0.997
Human Yeast
cellular response to dna damage stimulus GO:0006974 223 0.988
Human Yeast
meiotic cell cycle GO:0051321 171 0.986
meiotic chromosome segregation GO:0045132 59 0.985
meiotic cell cycle process GO:1903046 132 0.956
meiotic nuclear division GO:0007126 151 0.888
double strand break repair GO:0006302 26 0.888
negative regulation of cell cycle phase transition GO:1901988 103 0.862
mitotic dna damage checkpoint GO:0044773 74 0.859
cell proliferation GO:0008283 299 0.827
regulation of meiosis GO:0040020 3 0.780
chromosome segregation GO:0007059 157 0.769
double strand break repair via synthesis dependent strand annealing GO:0045003 6 0.736
organelle fission GO:0048285 340 0.725
dna metabolic process GO:0006259 227 0.697
Human Yeast Rat
regulation of cell cycle process GO:0010564 181 0.689
Human
ribonucleoside monophosphate catabolic process GO:0009158 39 0.681
Human Yeast Rat
negative regulation of cell cycle GO:0045786 116 0.664
immune system process GO:0002376 347 0.647
dna geometric change GO:0032392 16 0.627
Human Yeast Rat
nucleotide excision repair GO:0006289 8 0.595
Human Yeast
dna recombination GO:0006310 32 0.584
Yeast
mitotic cell cycle checkpoint GO:0007093 88 0.575
dna conformation change GO:0071103 105 0.562
Human Yeast Rat
mitotic cell cycle phase transition GO:0044772 138 0.546
Human
cell division GO:0051301 248 0.497
negative regulation of mitotic cell cycle GO:0045930 109 0.488
postreplication repair GO:0006301 2 0.484
cell cycle checkpoint GO:0000075 95 0.456
chromosome organization GO:0051276 360 0.421
meiosis ii GO:0007135 23 0.418
carbohydrate derivative metabolic process GO:1901135 217 0.416
Human Yeast Rat
programmed cell death GO:0012501 257 0.404
Human
regulation of cell cycle GO:0051726 291 0.370
Human
regulation of cell division GO:0051302 72 0.363
germarium derived egg chamber formation GO:0007293 101 0.321
embryo development ending in birth or egg hatching GO:0009792 152 0.316
Worm
g2 dna damage checkpoint GO:0031572 69 0.293
dna damage checkpoint GO:0000077 78 0.291
regulation of nuclear division GO:0051783 58 0.287
mrna metabolic process GO:0016071 124 0.283
mitotic g2 m transition checkpoint GO:0044818 70 0.281
nucleobase containing compound catabolic process GO:0034655 165 0.279
Human Yeast Rat
mitotic g2 dna damage checkpoint GO:0007095 69 0.266
sex differentiation GO:0007548 81 0.263
immune response GO:0006955 246 0.243
development of primary sexual characteristics GO:0045137 50 0.240
recombinational repair GO:0000725 13 0.239
regulation of mitotic cell cycle phase transition GO:1901990 130 0.235
Human
response to ionizing radiation GO:0010212 32 0.233
dna double strand break processing GO:0000729 3 0.227
rna splicing GO:0008380 83 0.224
dna biosynthetic process GO:0071897 24 0.221
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.220
rna splicing via transesterification reactions GO:0000375 73 0.218
regulation of cell cycle phase transition GO:1901987 130 0.215
Human
protein modification process GO:0036211 438 0.210
Human Yeast Rat
double strand break repair via homologous recombination GO:0000724 13 0.204
determination of adult lifespan GO:0008340 137 0.200
response to abiotic stimulus GO:0009628 341 0.200
organophosphate metabolic process GO:0019637 195 0.197
Human Yeast Rat
purine ribonucleoside metabolic process GO:0046128 127 0.190
Human Yeast Rat
centrosome cycle GO:0007098 137 0.187
larval development GO:0002164 104 0.180
single organism biosynthetic process GO:0044711 206 0.180
purine nucleoside monophosphate catabolic process GO:0009128 38 0.173
Human Yeast Rat
negative regulation of cell cycle process GO:0010948 109 0.171
ribonucleoside catabolic process GO:0042454 112 0.169
Human Yeast Rat
regulation of organelle organization GO:0033043 196 0.163
anterior posterior pattern specification GO:0009952 136 0.156
regulation of dna repair GO:0006282 5 0.148
mrna processing GO:0006397 104 0.148
dna duplex unwinding GO:0032508 16 0.147
Human Yeast Rat
oocyte construction GO:0007308 112 0.147
regulation of meiotic cell cycle GO:0051445 9 0.141
apoptotic process GO:0006915 159 0.139
Human
cell cycle phase transition GO:0044770 140 0.138
Human
dna integrity checkpoint GO:0031570 81 0.135
germarium derived oocyte fate determination GO:0007294 26 0.132
reproductive structure development GO:0048608 74 0.131
reproductive system development GO:0061458 74 0.130
mitotic dna integrity checkpoint GO:0044774 75 0.129
carbohydrate derivative catabolic process GO:1901136 118 0.126
Human Yeast Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.126
Human
non recombinational repair GO:0000726 7 0.124
gonad development GO:0008406 50 0.123
aromatic compound catabolic process GO:0019439 166 0.118
Human Yeast Rat
nucleoside monophosphate catabolic process GO:0009125 39 0.117
Human Yeast Rat
positive regulation of cellular biosynthetic process GO:0031328 316 0.111
Human
ribonucleoside triphosphate catabolic process GO:0009203 108 0.109
Human Yeast Rat
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.107
atp metabolic process GO:0046034 49 0.106
Human Yeast Rat
cellular protein modification process GO:0006464 438 0.105
Human Yeast Rat
purine ribonucleoside catabolic process GO:0046130 112 0.102
Human Yeast Rat
signal transduction in response to dna damage GO:0042770 3 0.100
genitalia development GO:0048806 26 0.096
translesion synthesis GO:0019985 2 0.094
telomere maintenance via recombination GO:0000722 1 0.092
nucleobase containing small molecule metabolic process GO:0055086 174 0.092
Human Yeast Rat
multicellular organismal reproductive behavior GO:0033057 110 0.091
cellular amino acid metabolic process GO:0006520 61 0.091
purine nucleotide catabolic process GO:0006195 109 0.091
Human Yeast Rat
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.090
Human
negative regulation of cell division GO:0051782 17 0.089
gene silencing GO:0016458 138 0.089
regulation of response to dna damage stimulus GO:2001020 23 0.088
endocytosis GO:0006897 310 0.088
dna dependent dna replication GO:0006261 17 0.086
regionalization GO:0003002 416 0.085
nuclear division GO:0000280 332 0.085
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.078
atp catabolic process GO:0006200 38 0.078
Human Yeast Rat
dna replication GO:0006260 48 0.077
negative regulation of biosynthetic process GO:0009890 277 0.076
response to other organism GO:0051707 293 0.076
glycoprotein metabolic process GO:0009100 41 0.075
meiosis i GO:0007127 59 0.075
purine nucleoside triphosphate catabolic process GO:0009146 108 0.074
Human Yeast Rat
protein maturation GO:0051604 71 0.074
glycosyl compound catabolic process GO:1901658 112 0.072
Human Yeast Rat
nucleoside triphosphate metabolic process GO:0009141 120 0.072
Human Yeast Rat
oocyte differentiation GO:0009994 145 0.069
carbohydrate derivative biosynthetic process GO:1901137 85 0.068
axis specification GO:0009798 167 0.067
centrosome duplication GO:0051298 121 0.064
glycosyl compound metabolic process GO:1901657 127 0.064
Human Yeast Rat
small molecule metabolic process GO:0044281 305 0.062
Human Yeast Rat
cellular macromolecule catabolic process GO:0044265 136 0.058
response to radiation GO:0009314 155 0.058
ribose phosphate metabolic process GO:0019693 145 0.057
Human Yeast Rat
ribonucleoside metabolic process GO:0009119 127 0.056
Human Yeast Rat
lateral inhibition GO:0046331 206 0.056
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.056
purine nucleoside monophosphate metabolic process GO:0009126 50 0.056
Human Yeast Rat
cellular catabolic process GO:0044248 372 0.055
Human Yeast Rat
ribonucleotide catabolic process GO:0009261 109 0.055
Human Yeast Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.054
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.054
Human Yeast Rat
purine nucleoside metabolic process GO:0042278 127 0.053
Human Yeast Rat
glycoprotein biosynthetic process GO:0009101 41 0.053
nucleoside phosphate catabolic process GO:1901292 110 0.052
Human Yeast Rat
protein processing GO:0016485 68 0.051
oocyte fate determination GO:0030716 27 0.050
segmentation GO:0035282 207 0.049
positive regulation of rna metabolic process GO:0051254 271 0.049
Human
proteolysis GO:0006508 192 0.048
regulation of cell proliferation GO:0042127 163 0.046
purine ribonucleotide catabolic process GO:0009154 109 0.046
Human Yeast Rat
nucleoside triphosphate catabolic process GO:0009143 108 0.045
Human Yeast Rat
single organism catabolic process GO:0044712 228 0.044
Human Yeast Rat
female meiotic division GO:0007143 70 0.044
organonitrogen compound metabolic process GO:1901564 318 0.042
Human Yeast Rat
dna packaging GO:0006323 91 0.042
carboxylic acid metabolic process GO:0019752 92 0.041
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.040
Human Yeast Rat
response to external biotic stimulus GO:0043207 293 0.039
organophosphate catabolic process GO:0046434 112 0.039
Human Yeast Rat
oocyte maturation GO:0001556 3 0.039
regulation of protein catabolic process GO:0042176 55 0.038
ribonucleotide metabolic process GO:0009259 145 0.038
Human Yeast Rat
spindle organization GO:0007051 253 0.037
growth GO:0040007 359 0.037
cell cell signaling involved in cell fate commitment GO:0045168 210 0.037
protein complex biogenesis GO:0070271 201 0.037
peptidyl amino acid modification GO:0018193 105 0.037
ribonucleoside monophosphate metabolic process GO:0009161 51 0.037
Human Yeast Rat
tripartite regional subdivision GO:0007351 103 0.037
purine containing compound catabolic process GO:0072523 112 0.036
Human Yeast Rat
cell death GO:0008219 279 0.036
Human
death GO:0016265 284 0.035
Human
humoral immune response GO:0006959 117 0.035
double strand break repair via nonhomologous end joining GO:0006303 5 0.034
anterior posterior axis specification GO:0009948 109 0.034
oxoacid metabolic process GO:0043436 103 0.034
positive regulation of signaling GO:0023056 243 0.033
regulation of spindle organization GO:0090224 17 0.033
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.033
regulation of hemocyte proliferation GO:0035206 37 0.032
purine nucleoside catabolic process GO:0006152 112 0.032
Human Yeast Rat
chromosome condensation GO:0030261 41 0.031
regulation of catalytic activity GO:0050790 185 0.030
organic cyclic compound catabolic process GO:1901361 168 0.030
Human Yeast Rat
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.030
Human
body morphogenesis GO:0010171 2 0.029
regulation of mitotic cell cycle GO:0007346 190 0.029
Human
positive regulation of transcription dna templated GO:0045893 266 0.028
Human
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.028
purine nucleoside triphosphate metabolic process GO:0009144 119 0.027
Human Yeast Rat
dorsal ventral pattern formation GO:0009953 133 0.027
response to biotic stimulus GO:0009607 294 0.027
vesicle mediated transport GO:0016192 381 0.027
anatomical structure homeostasis GO:0060249 97 0.027
nucleoside catabolic process GO:0009164 112 0.026
Human Yeast Rat
actin cytoskeleton organization GO:0030036 206 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.026
Human Yeast Rat
regulation of catabolic process GO:0009894 170 0.025
nucleoside phosphate metabolic process GO:0006753 162 0.025
Human Yeast Rat
negative regulation of cellular component organization GO:0051129 108 0.025
organic substance catabolic process GO:1901575 308 0.025
Human Yeast Rat
chromosome separation GO:0051304 42 0.025
regulation of cellular catabolic process GO:0031329 157 0.024
organonitrogen compound catabolic process GO:1901565 128 0.024
Human Yeast Rat
catabolic process GO:0009056 409 0.024
Human Yeast Rat
ribonucleoside triphosphate metabolic process GO:0009199 119 0.024
Human Yeast Rat
multicellular organismal aging GO:0010259 140 0.023
pigmentation GO:0043473 75 0.023
negative regulation of cell death GO:0060548 81 0.022
negative regulation of organelle organization GO:0010639 56 0.022
negative regulation of gene expression GO:0010629 387 0.022
embryonic axis specification GO:0000578 107 0.022
aging GO:0007568 143 0.021
modification dependent protein catabolic process GO:0019941 78 0.021
organic acid metabolic process GO:0006082 103 0.021
response to organic cyclic compound GO:0014070 89 0.021
dna synthesis involved in dna repair GO:0000731 5 0.021
defense response GO:0006952 300 0.021
protein glycosylation GO:0006486 32 0.021
regulation of multi organism process GO:0043900 131 0.021
response to light stimulus GO:0009416 124 0.020
cellular macromolecule localization GO:0070727 220 0.020
cellular amide metabolic process GO:0043603 80 0.020
positive regulation of biosynthetic process GO:0009891 316 0.020
Human
negative regulation of sister chromatid segregation GO:0033046 13 0.020
regulation of protein complex assembly GO:0043254 42 0.020
lipid metabolic process GO:0006629 121 0.020
embryonic pattern specification GO:0009880 174 0.019
regulation of immune response GO:0050776 118 0.019
regulation of programmed cell death GO:0043067 152 0.019
Human
positive regulation of signal transduction GO:0009967 223 0.019
meiosis ii cytokinesis GO:0007111 11 0.019
nucleotide metabolic process GO:0009117 161 0.019
Human Yeast Rat
regulation of phosphatase activity GO:0010921 3 0.019
telomere maintenance GO:0000723 21 0.018
regulation of immune system process GO:0002682 176 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.018
regulation of cellular protein catabolic process GO:1903362 44 0.018
purine nucleotide metabolic process GO:0006163 146 0.018
Human Yeast Rat
macromolecular complex assembly GO:0065003 256 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.018
Human Yeast Rat
negative regulation of dna dependent dna replication GO:2000104 2 0.018
maintenance of location GO:0051235 73 0.017
immune effector process GO:0002252 98 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.017
Human
positive regulation of immune response GO:0050778 63 0.017
establishment of protein localization GO:0045184 163 0.017
negative regulation of mitotic sister chromatid segregation GO:0033048 13 0.017
regulation of double strand break repair GO:2000779 3 0.017
heterocycle catabolic process GO:0046700 166 0.017
Human Yeast Rat
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.016
positive regulation of immune system process GO:0002684 68 0.016
regulation of proteolysis GO:0030162 87 0.016
spindle stabilization GO:0043146 14 0.016
imaginal disc derived appendage morphogenesis GO:0035114 395 0.016
regulation of protein processing GO:0070613 32 0.016
nucleoside monophosphate metabolic process GO:0009123 52 0.015
Human Yeast Rat
cuticle development GO:0042335 86 0.015
modification dependent macromolecule catabolic process GO:0043632 79 0.015
protein catabolic process GO:0030163 101 0.015
negative regulation of nucleic acid templated transcription GO:1903507 240 0.015
germarium derived oocyte differentiation GO:0030706 29 0.015
cytokinesis GO:0000910 90 0.015
regulation of innate immune response GO:0045088 71 0.015
negative regulation of chromosome segregation GO:0051985 14 0.014
digestive tract morphogenesis GO:0048546 127 0.014
oocyte development GO:0048599 124 0.014
negative regulation of cellular metabolic process GO:0031324 382 0.014
positive regulation of gene expression GO:0010628 290 0.014
Human
spindle checkpoint GO:0031577 11 0.014
positive regulation of nucleic acid templated transcription GO:1903508 266 0.013
Human
cell aging GO:0007569 2 0.013
amine metabolic process GO:0009308 12 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
nucleotide catabolic process GO:0009166 109 0.013
Human Yeast Rat
protein complex assembly GO:0006461 200 0.013
columnar cuboidal epithelial cell development GO:0002066 249 0.013
epidermis development GO:0008544 65 0.013
Human
negative regulation of rna metabolic process GO:0051253 251 0.013
innate immune response GO:0045087 144 0.013
actin filament based process GO:0030029 220 0.012
organelle assembly GO:0070925 198 0.012
cellular response to ionizing radiation GO:0071479 15 0.012
positive regulation of mapk cascade GO:0043410 63 0.012
negative regulation of gene expression epigenetic GO:0045814 77 0.012
germarium derived female germ line cyst formation GO:0030727 42 0.012
regulation of response to stress GO:0080134 200 0.012
homeostatic process GO:0042592 199 0.012
membrane organization GO:0061024 112 0.012
regulation of mitosis GO:0007088 56 0.012
rna processing GO:0006396 147 0.011
regulation of protein complex disassembly GO:0043244 29 0.011
hatching GO:0035188 4 0.011
regulation of dna templated transcription elongation GO:0032784 17 0.011
response to x ray GO:0010165 8 0.011
phagocytosis GO:0006909 215 0.011
taxis GO:0042330 304 0.011
cell maturation GO:0048469 144 0.011
meiosis i cytokinesis GO:0007110 12 0.011
positive regulation of response to stimulus GO:0048584 323 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
Human Yeast Rat
wound healing GO:0042060 75 0.011
anterior posterior axis specification embryo GO:0008595 103 0.011
regulation of protein metabolic process GO:0051246 256 0.011
mitotic spindle organization GO:0007052 220 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
protein dna complex subunit organization GO:0071824 86 0.010
Yeast
mrna splicing via spliceosome GO:0000398 73 0.010
divalent inorganic cation homeostasis GO:0072507 29 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
male meiosis chromosome segregation GO:0007060 10 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.010
regulation of mrna processing GO:0050684 71 0.010
cellular nitrogen compound catabolic process GO:0044270 165 0.010
Human Yeast Rat
regulation of dna recombination GO:0000018 4 0.010
Yeast

hay disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.013
disease of anatomical entity DOID:7 0 0.013