Drosophila melanogaster

48 known processes

Spn6 (Dmel_CG10913)

Serine protease inhibitor 6

(Aliases: sp-6,Spn55B,CG10913,sp6,Dmel\CG10913,Sp6)

Spn6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal development GO:2000026 414 0.079
regulation of cell differentiation GO:0045595 302 0.072
vesicle mediated transport GO:0016192 381 0.069
negative regulation of response to stimulus GO:0048585 258 0.061
Rat Fly
purine nucleoside metabolic process GO:0042278 127 0.052
purine ribonucleoside metabolic process GO:0046128 127 0.052
carbohydrate derivative metabolic process GO:1901135 217 0.052
glycosyl compound metabolic process GO:1901657 127 0.050
nucleoside metabolic process GO:0009116 127 0.049
regulation of nervous system development GO:0051960 248 0.049
kidney development GO:0001822 3 0.048
negative regulation of cellular metabolic process GO:0031324 382 0.048
organic substance catabolic process GO:1901575 308 0.047
immune system process GO:0002376 347 0.046
Fly
immune response GO:0006955 246 0.045
Fly
endocytosis GO:0006897 310 0.045
response to external biotic stimulus GO:0043207 293 0.044
Fly
negative regulation of cell communication GO:0010648 223 0.043
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.042
appendage development GO:0048736 401 0.041
organonitrogen compound metabolic process GO:1901564 318 0.040
Fly
centrosome organization GO:0051297 163 0.038
nucleobase containing small molecule metabolic process GO:0055086 174 0.037
cell division GO:0051301 248 0.036
establishment or maintenance of cell polarity GO:0007163 167 0.036
ribonucleotide metabolic process GO:0009259 145 0.035
antimicrobial humoral response GO:0019730 99 0.035
Fly
enzyme linked receptor protein signaling pathway GO:0007167 179 0.035
response to biotic stimulus GO:0009607 294 0.035
Fly
ribonucleoside metabolic process GO:0009119 127 0.035
negative regulation of signal transduction GO:0009968 206 0.034
Fly
nucleotide metabolic process GO:0009117 161 0.033
phagocytosis GO:0006909 215 0.033
centrosome cycle GO:0007098 137 0.032
protein localization GO:0008104 284 0.032
regionalization GO:0003002 416 0.032
nucleoside triphosphate metabolic process GO:0009141 120 0.031
intracellular signal transduction GO:0035556 300 0.031
regulation of cell cycle GO:0051726 291 0.031
response to other organism GO:0051707 293 0.030
Fly
purine ribonucleotide metabolic process GO:0009150 145 0.030
body morphogenesis GO:0010171 2 0.030
purine nucleotide metabolic process GO:0006163 146 0.029
ribonucleoside triphosphate metabolic process GO:0009199 119 0.029
nucleobase containing compound catabolic process GO:0034655 165 0.029
cellular protein modification process GO:0006464 438 0.029
cellular macromolecule localization GO:0070727 220 0.028
imaginal disc derived appendage morphogenesis GO:0035114 395 0.028
purine containing compound metabolic process GO:0072521 155 0.028
negative regulation of gene expression GO:0010629 387 0.028
nucleotide catabolic process GO:0009166 109 0.028
cellular catabolic process GO:0044248 372 0.028
regulation of intracellular signal transduction GO:1902531 236 0.027
post embryonic appendage morphogenesis GO:0035120 385 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.027
defense response to other organism GO:0098542 225 0.027
Fly
regulation of neurogenesis GO:0050767 158 0.027
ribonucleoside triphosphate catabolic process GO:0009203 108 0.027
imaginal disc derived appendage development GO:0048737 399 0.027
respiratory system development GO:0060541 213 0.026
regulation of response to external stimulus GO:0032101 115 0.026
Rat Fly
cell proliferation GO:0008283 299 0.026
purine nucleoside triphosphate metabolic process GO:0009144 119 0.026
determination of adult lifespan GO:0008340 137 0.025
taxis GO:0042330 304 0.025
purine containing compound catabolic process GO:0072523 112 0.025
catabolic process GO:0009056 409 0.025
glycosyl compound catabolic process GO:1901658 112 0.025
negative regulation of cellular biosynthetic process GO:0031327 277 0.024
ribose phosphate metabolic process GO:0019693 145 0.024
regulation of multi organism process GO:0043900 131 0.024
Fly
single organism cellular localization GO:1902580 180 0.024
nucleoside triphosphate catabolic process GO:0009143 108 0.024
organophosphate metabolic process GO:0019637 195 0.023
single organism catabolic process GO:0044712 228 0.023
chemotaxis GO:0006935 249 0.023
negative regulation of biosynthetic process GO:0009890 277 0.023
negative regulation of signaling GO:0023057 219 0.023
Fly
purine ribonucleoside catabolic process GO:0046130 112 0.023
regulation of protein metabolic process GO:0051246 256 0.022
carbohydrate derivative catabolic process GO:1901136 118 0.022
nucleoside phosphate metabolic process GO:0006753 162 0.022
regulation of defense response GO:0031347 102 0.022
Rat
negative regulation of developmental process GO:0051093 201 0.022
phosphorylation GO:0016310 294 0.022
regulation of antimicrobial humoral response GO:0002759 50 0.022
Fly
regulation of cell death GO:0010941 173 0.022
centrosome duplication GO:0051298 121 0.021
negative regulation of cellular protein metabolic process GO:0032269 85 0.021
small molecule metabolic process GO:0044281 305 0.021
regulation of programmed cell death GO:0043067 152 0.021
humoral immune response GO:0006959 117 0.021
Fly
cellular protein localization GO:0034613 160 0.021
establishment of localization in cell GO:0051649 402 0.021
regulation of cell proliferation GO:0042127 163 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.020
acyl coa metabolic process GO:0006637 3 0.020
neuron projection guidance GO:0097485 241 0.020
cell death GO:0008219 279 0.020
axon guidance GO:0007411 233 0.020
dendrite development GO:0016358 204 0.020
atp metabolic process GO:0046034 49 0.020
chromosome organization GO:0051276 360 0.020
positive regulation of biosynthetic process GO:0009891 316 0.019
apoptotic process GO:0006915 159 0.019
mitotic nuclear division GO:0007067 213 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.019
axon development GO:0061564 297 0.019
intracellular transport GO:0046907 228 0.019
nucleoside catabolic process GO:0009164 112 0.019
axonogenesis GO:0007409 290 0.019
transcription from rna polymerase ii promoter GO:0006366 368 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.018
forebrain development GO:0030900 2 0.018
regulation of anatomical structure morphogenesis GO:0022603 242 0.018
wing disc morphogenesis GO:0007472 344 0.018
ras protein signal transduction GO:0007265 88 0.018
regulation of molecular function GO:0065009 217 0.018
regulation of localization GO:0032879 275 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
proteolysis GO:0006508 192 0.017
regulation of phosphate metabolic process GO:0019220 210 0.017
purine nucleoside catabolic process GO:0006152 112 0.017
regulation of response to stress GO:0080134 200 0.017
Rat
sensory organ morphogenesis GO:0090596 260 0.016
cytoskeleton dependent cytokinesis GO:0061640 81 0.016
cytokinesis GO:0000910 90 0.016
membrane organization GO:0061024 112 0.016
negative regulation of rna biosynthetic process GO:1902679 240 0.016
regulation of response to biotic stimulus GO:0002831 63 0.016
Fly
oxoacid metabolic process GO:0043436 103 0.016
appendage morphogenesis GO:0035107 397 0.016
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
nuclear division GO:0000280 332 0.016
regulation of hormone levels GO:0010817 40 0.016
Fly
eye development GO:0001654 323 0.016
dendrite morphogenesis GO:0048813 199 0.016
positive regulation of cellular biosynthetic process GO:0031328 316 0.016
negative regulation of transcription dna templated GO:0045892 237 0.016
regulation of immune response GO:0050776 118 0.016
Fly
tube morphogenesis GO:0035239 191 0.016
neuronal action potential GO:0019228 10 0.016
programmed cell death GO:0012501 257 0.016
purine nucleoside triphosphate catabolic process GO:0009146 108 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.016
Fly
chromosome segregation GO:0007059 157 0.016
regulation of cellular protein metabolic process GO:0032268 243 0.016
regulation of immune system process GO:0002682 176 0.015
Fly
positive regulation of signaling GO:0023056 243 0.015
regulation of cellular ketone metabolic process GO:0010565 3 0.015
single organism intracellular transport GO:1902582 207 0.015
cytoplasmic transport GO:0016482 130 0.015
establishment of protein localization GO:0045184 163 0.015
connective tissue development GO:0061448 3 0.015
regulation of membrane potential GO:0042391 35 0.015
epithelial cell development GO:0002064 274 0.015
wound healing GO:0042060 75 0.015
Rat
defense response GO:0006952 300 0.015
Rat Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
wnt signaling pathway GO:0016055 98 0.015
organic cyclic compound catabolic process GO:1901361 168 0.014
organic substance transport GO:0071702 257 0.014
small gtpase mediated signal transduction GO:0007264 88 0.014
regulation of catalytic activity GO:0050790 185 0.014
macromolecule catabolic process GO:0009057 161 0.014
positive regulation of phosphate metabolic process GO:0045937 139 0.014
death GO:0016265 284 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
positive regulation of rna metabolic process GO:0051254 271 0.014
heterocycle catabolic process GO:0046700 166 0.014
negative regulation of rna metabolic process GO:0051253 251 0.014
tissue morphogenesis GO:0048729 297 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
estrogen metabolic process GO:0008210 1 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
protein modification process GO:0036211 438 0.014
protein transport GO:0015031 155 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
antimicrobial peptide production GO:0002775 46 0.013
Fly
positive regulation of catabolic process GO:0009896 105 0.013
cellular response to high light intensity GO:0071486 1 0.013
negative regulation of defense response GO:0031348 35 0.013
Rat
negative regulation of cell differentiation GO:0045596 143 0.013
regulation of cell development GO:0060284 215 0.013
positive regulation of signal transduction GO:0009967 223 0.013
ribonucleoside monophosphate metabolic process GO:0009161 51 0.013
heart development GO:0007507 82 0.013
multi organism reproductive behavior GO:0044705 121 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.013
regulation of transport GO:0051049 181 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
regulation of cellular component size GO:0032535 98 0.013
transmission of nerve impulse GO:0019226 12 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
negative regulation of immune system process GO:0002683 50 0.013
regulation of neuron differentiation GO:0045664 103 0.013
microtubule organizing center organization GO:0031023 168 0.013
mitotic cytokinesis GO:0000281 50 0.013
positive regulation of cell differentiation GO:0045597 64 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
embryonic pattern specification GO:0009880 174 0.012
ribonucleoside catabolic process GO:0042454 112 0.012
regulation of organelle organization GO:0033043 196 0.012
organic acid metabolic process GO:0006082 103 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
reproductive behavior GO:0019098 122 0.012
epithelial cell differentiation GO:0030855 322 0.012
regulation of phosphorylation GO:0042325 147 0.012
compound eye development GO:0048749 307 0.012
establishment of tissue polarity GO:0007164 87 0.012
positive regulation of transcription dna templated GO:0045893 266 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
regulation of humoral immune response GO:0002920 51 0.012
Fly
multicellular organismal signaling GO:0035637 12 0.012
establishment of planar polarity GO:0001736 87 0.011
organophosphate catabolic process GO:0046434 112 0.011
protein phosphorylation GO:0006468 169 0.011
intracellular protein transport GO:0006886 104 0.011
positive regulation of molecular function GO:0044093 136 0.011
open tracheal system development GO:0007424 204 0.011
regulation of rna splicing GO:0043484 69 0.011
camera type eye development GO:0043010 4 0.011
neuron recognition GO:0008038 101 0.011
positive regulation of cell communication GO:0010647 250 0.011
hormone metabolic process GO:0042445 33 0.011
Fly
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.011
multicellular organismal homeostasis GO:0048871 41 0.011
positive regulation of developmental process GO:0051094 143 0.011
regulation of wnt signaling pathway GO:0030111 68 0.011
transmembrane transport GO:0055085 139 0.011
response to lipopolysaccharide GO:0032496 4 0.010
single organism nuclear import GO:1902593 51 0.010
eye morphogenesis GO:0048592 260 0.010
establishment of protein localization to organelle GO:0072594 62 0.010
purine nucleoside monophosphate metabolic process GO:0009126 50 0.010
positive regulation of macromolecule metabolic process GO:0010604 405 0.010
gtp catabolic process GO:0006184 72 0.010
negative regulation of response to external stimulus GO:0032102 22 0.010
Rat
cell motility GO:0048870 251 0.010
regulation of cellular component biogenesis GO:0044087 201 0.010
negative regulation of cell death GO:0060548 81 0.010
positive regulation of nucleic acid templated transcription GO:1903508 266 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
leg disc development GO:0035218 92 0.010

Spn6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015
disease of metabolism DOID:0014667 0 0.014
nervous system disease DOID:863 0 0.011
musculoskeletal system disease DOID:17 0 0.010