Drosophila melanogaster

179 known processes

cos (Dmel_CG1708)

costa

(Aliases: cos2,l(2)k16128,COS2,l(2)k16101,l(2)cos[[2]],cos-2,COS[2],l(2)161/28,Dmel\CG1708,Cos2,CG1708,Cos-2,Cos[2])

cos biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regionalization GO:0003002 416 0.997
segmentation GO:0035282 207 0.992
epithelial cell development GO:0002064 274 0.990
embryonic pattern specification GO:0009880 174 0.987
blastoderm segmentation GO:0007350 159 0.982
border follicle cell migration GO:0007298 113 0.981
periodic partitioning GO:0007365 29 0.974
epithelial cell differentiation GO:0030855 322 0.971
segment polarity determination GO:0007367 25 0.964
ovarian follicle cell development GO:0030707 248 0.957
post embryonic appendage morphogenesis GO:0035120 385 0.936
ovarian follicle cell migration GO:0007297 121 0.908
appendage morphogenesis GO:0035107 397 0.877
imaginal disc derived appendage morphogenesis GO:0035114 395 0.864
imaginal disc pattern formation GO:0007447 91 0.811
anterior posterior pattern specification GO:0009952 136 0.744
eye photoreceptor cell differentiation GO:0001754 145 0.739
appendage development GO:0048736 401 0.731
imaginal disc derived appendage development GO:0048737 399 0.694
morphogenesis of an epithelium GO:0002009 276 0.665
establishment of localization in cell GO:0051649 402 0.664
cell migration GO:0016477 238 0.659
columnar cuboidal epithelial cell development GO:0002066 249 0.652
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.612
eye development GO:0001654 323 0.579
negative regulation of response to stimulus GO:0048585 258 0.579
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.562
compound eye photoreceptor cell differentiation GO:0001751 140 0.556
localization of cell GO:0051674 257 0.526
programmed cell death GO:0012501 257 0.510
cell motility GO:0048870 251 0.509
imaginal disc derived wing morphogenesis GO:0007476 337 0.454
regulation of smoothened signaling pathway GO:0008589 28 0.451
axis specification GO:0009798 167 0.444
epithelial cell migration GO:0010631 148 0.434
negative regulation of cell communication GO:0010648 223 0.434
regulation of erbb signaling pathway GO:1901184 42 0.405
smoothened signaling pathway GO:0007224 49 0.392
cell proliferation GO:0008283 299 0.384
negative regulation of signal transduction GO:0009968 206 0.378
retina development in camera type eye GO:0060041 4 0.353
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.352
sensory organ morphogenesis GO:0090596 260 0.347
embryonic organ development GO:0048568 50 0.336
negative regulation of developmental process GO:0051093 201 0.335
negative regulation of cell differentiation GO:0045596 143 0.331
positive regulation of transport GO:0051050 92 0.331
positive regulation of response to stimulus GO:0048584 323 0.323
imaginal disc derived leg morphogenesis GO:0007480 80 0.311
stem cell differentiation GO:0048863 117 0.309
ameboidal type cell migration GO:0001667 151 0.307
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.303
regulation of transport GO:0051049 181 0.293
cellular protein modification process GO:0006464 438 0.288
erbb signaling pathway GO:0038127 58 0.276
positive regulation of macromolecule metabolic process GO:0010604 405 0.269
learning or memory GO:0007611 141 0.262
stem cell development GO:0048864 79 0.261
central nervous system development GO:0007417 201 0.260
negative regulation of wnt signaling pathway GO:0030178 28 0.253
leg disc morphogenesis GO:0007478 80 0.244
signal transduction downstream of smoothened GO:0007227 5 0.242
spinal cord patterning GO:0021511 1 0.239
photoreceptor cell differentiation GO:0046530 170 0.237
positive regulation of gene expression GO:0010628 290 0.227
male gamete generation GO:0048232 201 0.225
compound eye development GO:0048749 307 0.223
leg disc development GO:0035218 92 0.219
positive regulation of cellular biosynthetic process GO:0031328 316 0.216
wing disc pattern formation GO:0035222 66 0.211
segment specification GO:0007379 33 0.210
muscle structure development GO:0061061 224 0.204
neuron recognition GO:0008038 101 0.200
negative regulation of neurogenesis GO:0050768 53 0.194
histone modification GO:0016570 106 0.191
transcription from rna polymerase ii promoter GO:0006366 368 0.186
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.184
positive regulation of signaling GO:0023056 243 0.173
anterior posterior axis specification embryo GO:0008595 103 0.162
positive regulation of rna biosynthetic process GO:1902680 266 0.161
regulation of neurogenesis GO:0050767 158 0.158
positive regulation of transcription dna templated GO:0045893 266 0.156
compound eye morphogenesis GO:0001745 249 0.152
endocytosis GO:0006897 310 0.147
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.145
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.143
tissue migration GO:0090130 155 0.143
canonical wnt signaling pathway GO:0060070 21 0.143
secretion GO:0046903 109 0.143
negative regulation of signaling GO:0023057 219 0.142
positive regulation of rna metabolic process GO:0051254 271 0.141
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.139
epidermal growth factor receptor signaling pathway GO:0007173 58 0.137
immune system process GO:0002376 347 0.137
dorsal ventral pattern formation GO:0009953 133 0.137
anterior posterior axis specification GO:0009948 109 0.132
regulation of neuron differentiation GO:0045664 103 0.131
imaginal disc derived wing vein specification GO:0007474 48 0.130
respiratory system development GO:0060541 213 0.129
axon development GO:0061564 297 0.128
regulation of nucleocytoplasmic transport GO:0046822 35 0.127
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.126
regulation of epithelial cell proliferation GO:0050678 4 0.123
spermatogenesis GO:0007283 200 0.122
camera type eye development GO:0043010 4 0.120
positive regulation of cell differentiation GO:0045597 64 0.108
regulation of cell differentiation GO:0045595 302 0.108
forebrain development GO:0030900 2 0.104
neuron fate commitment GO:0048663 50 0.103
protein localization to organelle GO:0033365 82 0.102
open tracheal system development GO:0007424 204 0.101
inter male aggressive behavior GO:0002121 60 0.097
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.096
maintenance of location in cell GO:0051651 28 0.096
protein modification by small protein conjugation GO:0032446 79 0.095
brain development GO:0007420 120 0.094
tissue morphogenesis GO:0048729 297 0.094
eye morphogenesis GO:0048592 260 0.093
enzyme linked receptor protein signaling pathway GO:0007167 179 0.091
molting cycle GO:0042303 56 0.091
multicellular organism growth GO:0035264 46 0.089
chromosome organization GO:0051276 360 0.089
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.088
connective tissue development GO:0061448 3 0.088
negative regulation of biosynthetic process GO:0009890 277 0.087
retinal ganglion cell axon guidance GO:0031290 12 0.085
regulation of wnt signaling pathway GO:0030111 68 0.085
single organism intracellular transport GO:1902582 207 0.085
wing disc morphogenesis GO:0007472 344 0.084
eggshell formation GO:0030703 105 0.083
growth GO:0040007 359 0.083
formation of primary germ layer GO:0001704 24 0.079
cognition GO:0050890 141 0.079
chromatin modification GO:0016568 147 0.077
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.077
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.074
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.074
protein catabolic process GO:0030163 101 0.073
organic substance transport GO:0071702 257 0.073
protein localization GO:0008104 284 0.073
mitotic cell cycle phase transition GO:0044772 138 0.072
positive regulation of protein localization to nucleus GO:1900182 21 0.071
intraciliary transport GO:0042073 8 0.071
regulation of multicellular organismal development GO:2000026 414 0.069
stem cell maintenance GO:0019827 67 0.068
gland development GO:0048732 191 0.066
negative regulation of nucleic acid templated transcription GO:1903507 240 0.066
mesenchymal cell differentiation GO:0048762 1 0.064
positive regulation of signal transduction GO:0009967 223 0.063
anterior posterior pattern specification imaginal disc GO:0007448 16 0.063
regulation of cell proliferation GO:0042127 163 0.063
negative regulation of smoothened signaling pathway GO:0045879 16 0.063
negative regulation of cell development GO:0010721 62 0.062
olfactory learning GO:0008355 56 0.061
regulation of immune response GO:0050776 118 0.061
morphogenesis of follicular epithelium GO:0016333 36 0.060
positive regulation of multi organism process GO:0043902 40 0.059
epithelial tube morphogenesis GO:0060562 88 0.057
regulation of cell development GO:0060284 215 0.056
negative regulation of rna metabolic process GO:0051253 251 0.054
germarium derived female germ line cyst encapsulation GO:0030708 8 0.054
multi organism reproductive behavior GO:0044705 121 0.054
wnt signaling pathway GO:0016055 98 0.053
imaginal disc growth GO:0007446 37 0.053
compound eye photoreceptor fate commitment GO:0001752 36 0.053
limb morphogenesis GO:0035108 1 0.052
dorsal appendage formation GO:0046843 47 0.052
single organism behavior GO:0044708 391 0.052
eye photoreceptor cell development GO:0042462 81 0.052
carbohydrate metabolic process GO:0005975 82 0.051
positive regulation of hh target transcription factor activity GO:0007228 5 0.051
ovarian follicle cell stalk formation GO:0030713 17 0.051
tissue homeostasis GO:0001894 36 0.049
proteolysis GO:0006508 192 0.047
regulation of mitotic cell cycle GO:0007346 190 0.047
regulation of intracellular transport GO:0032386 64 0.046
positive regulation of cell communication GO:0010647 250 0.044
regulation of response to stress GO:0080134 200 0.044
regulation of compound eye photoreceptor development GO:0045314 12 0.044
embryonic axis specification GO:0000578 107 0.044
intracellular signal transduction GO:0035556 300 0.044
body morphogenesis GO:0010171 2 0.044
regulation of cellular localization GO:0060341 136 0.044
chorion containing eggshell formation GO:0007304 105 0.043
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.043
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.043
apoptotic process GO:0006915 159 0.043
regulation of eye photoreceptor cell development GO:0042478 13 0.042
regulation of response to gamma radiation GO:2001228 4 0.042
epithelium migration GO:0090132 148 0.042
chromatin mediated maintenance of transcription GO:0048096 7 0.041
cytokinesis GO:0000910 90 0.040
imaginal disc derived leg segmentation GO:0036011 26 0.040
regulation of cell cycle GO:0051726 291 0.040
homeostatic process GO:0042592 199 0.039
catabolic process GO:0009056 409 0.038
rna localization GO:0006403 115 0.038
regulation of growth GO:0040008 233 0.038
protein modification by small protein conjugation or removal GO:0070647 106 0.037
neuron maturation GO:0042551 31 0.037
positive regulation of protein transport GO:0051222 37 0.036
positive regulation of transcription factor import into nucleus GO:0042993 19 0.036
positive regulation of cellular component organization GO:0051130 156 0.036
protein glycosylation GO:0006486 32 0.036
compound eye photoreceptor development GO:0042051 78 0.036
reproductive structure development GO:0048608 74 0.036
secretion by cell GO:0032940 101 0.035
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.035
negative regulation of erbb signaling pathway GO:1901185 29 0.035
regulation of sister chromatid cohesion GO:0007063 2 0.035
negative regulation of cellular metabolic process GO:0031324 382 0.034
regulation of protein localization to nucleus GO:1900180 29 0.034
cuticle pattern formation GO:0035017 27 0.034
negative regulation of transcription factor import into nucleus GO:0042992 4 0.034
nuclear division GO:0000280 332 0.034
regulation of rna splicing GO:0043484 69 0.034
contractile actin filament bundle assembly GO:0030038 1 0.034
negative regulation of multicellular organismal process GO:0051241 142 0.033
nuclear transport GO:0051169 72 0.033
spinal cord dorsal ventral patterning GO:0021513 1 0.032
photoreceptor cell development GO:0042461 96 0.032
regulation of sequence specific dna binding transcription factor activity GO:0051090 12 0.032
developmental pigmentation GO:0048066 68 0.032
cellular macromolecule localization GO:0070727 220 0.032
eggshell chorion assembly GO:0007306 66 0.031
germarium derived egg chamber formation GO:0007293 101 0.031
intracellular transport GO:0046907 228 0.031
glycoprotein metabolic process GO:0009100 41 0.031
positive regulation of protein import into nucleus GO:0042307 21 0.031
regulation of protein stability GO:0031647 43 0.030
covalent chromatin modification GO:0016569 106 0.030
peptidyl threonine phosphorylation GO:0018107 2 0.030
positive regulation of developmental growth GO:0048639 62 0.030
synaptic target recognition GO:0008039 45 0.030
positive regulation of nucleic acid templated transcription GO:1903508 266 0.030
germ line cyst encapsulation GO:0048138 8 0.029
myoblast migration GO:0051451 2 0.029
chromatin organization GO:0006325 207 0.029
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.029
protein alkylation GO:0008213 43 0.029
sex differentiation GO:0007548 81 0.029
negative regulation of cellular protein metabolic process GO:0032269 85 0.029
lateral inhibition GO:0046331 206 0.029
memory GO:0007613 94 0.028
regulation of protein transport GO:0051223 57 0.028
regulation of apoptotic process GO:0042981 130 0.028
meiosis i GO:0007127 59 0.028
anatomical structure homeostasis GO:0060249 97 0.028
regulation of imaginal disc growth GO:0045570 26 0.028
tripartite regional subdivision GO:0007351 103 0.028
cell cycle phase transition GO:0044770 140 0.028
positive regulation of developmental process GO:0051094 143 0.027
negative regulation of nervous system development GO:0051961 92 0.027
response to abiotic stimulus GO:0009628 341 0.026
head development GO:0060322 135 0.026
hindgut development GO:0061525 58 0.026
single organism carbohydrate metabolic process GO:0044723 72 0.026
embryo development ending in birth or egg hatching GO:0009792 152 0.026
reproductive behavior GO:0019098 122 0.025
negative regulation of cell proliferation GO:0008285 69 0.025
neurological system process GO:0050877 358 0.024
cellular amino acid metabolic process GO:0006520 61 0.024
muscle system process GO:0003012 21 0.024
negative regulation of transcription dna templated GO:0045892 237 0.024
organelle assembly GO:0070925 198 0.023
regulation of rho gtpase activity GO:0032319 20 0.023
regulation of canonical wnt signaling pathway GO:0060828 15 0.023
renal system development GO:0072001 72 0.023
multicellular organismal reproductive behavior GO:0033057 110 0.023
response to organic cyclic compound GO:0014070 89 0.022
organic acid metabolic process GO:0006082 103 0.022
nuclear import GO:0051170 51 0.022
spindle organization GO:0007051 253 0.022
glycoprotein biosynthetic process GO:0009101 41 0.022
olfactory behavior GO:0042048 97 0.022
liposaccharide metabolic process GO:1903509 8 0.022
positive regulation of protein metabolic process GO:0051247 128 0.022
larval development GO:0002164 104 0.022
mesoderm development GO:0007498 78 0.022
smoothened signaling pathway involved in ventral spinal cord patterning GO:0021910 0 0.022
cellular response to abiotic stimulus GO:0071214 58 0.022
retina morphogenesis in camera type eye GO:0060042 2 0.021
dna metabolic process GO:0006259 227 0.021
single organism cellular localization GO:1902580 180 0.021
cellular amine metabolic process GO:0044106 12 0.021
spermatid differentiation GO:0048515 114 0.021
immune system development GO:0002520 57 0.021
foregut morphogenesis GO:0007440 10 0.020
nucleocytoplasmic transport GO:0006913 72 0.020
negative regulation of epithelial cell proliferation GO:0050680 4 0.020
protein modification process GO:0036211 438 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
multi organism behavior GO:0051705 175 0.020
hemopoiesis GO:0030097 46 0.020
cellular response to chemical stimulus GO:0070887 199 0.020
cell fate specification GO:0001708 71 0.020
amine metabolic process GO:0009308 12 0.020
kidney development GO:0001822 3 0.020
regulation of protein metabolic process GO:0051246 256 0.019
pupal development GO:0035209 11 0.019
cellular response to ionizing radiation GO:0071479 15 0.019
chaeta development GO:0022416 97 0.019
receptor clustering GO:0043113 3 0.019
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 9 0.019
hematopoietic or lymphoid organ development GO:0048534 57 0.019
torso signaling pathway GO:0008293 21 0.018
phagocytosis GO:0006909 215 0.018
protein methylation GO:0006479 43 0.018
developmental maturation GO:0021700 172 0.018
tube development GO:0035295 244 0.018
proteasomal protein catabolic process GO:0010498 59 0.018
locomotor rhythm GO:0045475 56 0.018
endomembrane system organization GO:0010256 119 0.018
positive regulation of biosynthetic process GO:0009891 316 0.018
chemosensory behavior GO:0007635 106 0.018
protein ubiquitination GO:0016567 70 0.018
regulation of cytoplasmic transport GO:1903649 47 0.017
cellular response to radiation GO:0071478 52 0.017
female germ line cyst encapsulation GO:0048139 8 0.017
regulation of programmed cell death GO:0043067 152 0.017
camera type eye morphogenesis GO:0048593 2 0.017
oviposition GO:0018991 19 0.017
eye photoreceptor cell fate commitment GO:0042706 37 0.017
neuron projection guidance GO:0097485 241 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
regulation of localization GO:0032879 275 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.017
regulation of intracellular protein transport GO:0033157 46 0.017
multi multicellular organism process GO:0044706 123 0.017
methylation GO:0032259 47 0.017
multicellular organismal aging GO:0010259 140 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.016
wing disc dorsal ventral pattern formation GO:0048190 47 0.016
maintenance of gastrointestinal epithelium GO:0030277 3 0.016
telencephalon development GO:0021537 2 0.016
peptidyl amino acid modification GO:0018193 105 0.016
protein import into nucleus GO:0006606 51 0.016
histone methylation GO:0016571 40 0.016
cytoplasmic transport GO:0016482 130 0.016
macromolecule catabolic process GO:0009057 161 0.015
positive regulation of nf kappab import into nucleus GO:0042346 1 0.015
morphogenesis of a branching epithelium GO:0061138 45 0.015
oocyte microtubule cytoskeleton organization GO:0016325 35 0.015
positive regulation of wnt signaling pathway GO:0030177 25 0.015
response to oxygen containing compound GO:1901700 200 0.015
cellular macromolecule catabolic process GO:0044265 136 0.015
regulation of mitosis GO:0007088 56 0.015
cellular protein catabolic process GO:0044257 83 0.015
negative regulation of notch signaling pathway GO:0045746 41 0.015
positive regulation of intracellular transport GO:0032388 42 0.015
spermatid development GO:0007286 98 0.015
imaginal disc derived leg joint morphogenesis GO:0016348 15 0.015
response to ionizing radiation GO:0010212 32 0.014
chromosome segregation GO:0007059 157 0.014
purine nucleoside monophosphate metabolic process GO:0009126 50 0.014
cell fate determination GO:0001709 91 0.014
establishment of protein localization GO:0045184 163 0.014
negative regulation of rna biosynthetic process GO:1902679 240 0.014
regulation of stem cell proliferation GO:0072091 40 0.014
stress activated mapk cascade GO:0051403 52 0.014
histone h3 k4 methylation GO:0051568 16 0.013
regulation of chromatin organization GO:1902275 32 0.013
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 0.013
negative regulation of gene expression GO:0010629 387 0.013
reproductive system development GO:0061458 74 0.013
regulation of nervous system development GO:0051960 248 0.013
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.013
modification dependent protein catabolic process GO:0019941 78 0.013
regulation of protein import into nucleus GO:0042306 28 0.013
cell death GO:0008219 279 0.013
regulation of epidermal growth factor activated receptor activity GO:0007176 4 0.013
response to wounding GO:0009611 94 0.013
positive regulation of intracellular protein transport GO:0090316 30 0.012
response to radiation GO:0009314 155 0.012
mushroom body development GO:0016319 70 0.012
regulation of cell death GO:0010941 173 0.012
endoderm formation GO:0001706 3 0.012
neuroblast fate commitment GO:0014017 19 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.012
protein processing GO:0016485 68 0.012
regulation of secretion GO:0051046 44 0.012
positive regulation of neurogenesis GO:0050769 41 0.011
induction of programmed cell death by ecdysone GO:0035078 12 0.011
regulation of establishment of planar polarity GO:0090175 22 0.011
positive regulation of molecular function GO:0044093 136 0.011
positive regulation of reproductive process GO:2000243 7 0.011
small molecule metabolic process GO:0044281 305 0.011
regulation of organ growth GO:0046620 42 0.011
embryonic morphogenesis GO:0048598 206 0.011
regulation of protein export from nucleus GO:0046825 3 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
torc1 signaling GO:0038202 12 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
sulfur compound metabolic process GO:0006790 59 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.011
regulation of cellular component biogenesis GO:0044087 201 0.011
regulation of cell junction assembly GO:1901888 2 0.011
negative regulation of intracellular signal transduction GO:1902532 57 0.010
meiotic chromosome segregation GO:0045132 59 0.010
regulation of cell substrate adhesion GO:0010810 2 0.010
immune response GO:0006955 246 0.010
cellular protein complex assembly GO:0043623 71 0.010
decapentaplegic signaling pathway GO:0008101 19 0.010
carboxylic acid metabolic process GO:0019752 92 0.010
phosphorylation GO:0016310 294 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.010
eye antennal disc development GO:0035214 60 0.010
pole plasm assembly GO:0007315 61 0.010

cos disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.092
disease of cellular proliferation DOID:14566 0 0.092
organ system cancer DOID:0050686 0 0.092