Drosophila melanogaster

45 known processes

Pros26.4 (Dmel_CG5289)

Proteasome 26S subunit subunit 4 ATPase

(Aliases: 5289,CG5289,Dm_Rpt2,Rpt2,Dm-S4-1,dRpt2,S4,p54,DmP26S4,P26s4,p56,Dmel\CG5289,pros26.4)

Pros26.4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis GO:0006508 192 0.976
cellular response to dna damage stimulus GO:0006974 223 0.969
protein dna complex assembly GO:0065004 63 0.894
modification dependent macromolecule catabolic process GO:0043632 79 0.889
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.863
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.841
cellular catabolic process GO:0044248 372 0.817
protein complex biogenesis GO:0070271 201 0.785
dna templated transcription initiation GO:0006352 25 0.783
proteasome assembly GO:0043248 2 0.743
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.735
positive regulation of macromolecule metabolic process GO:0010604 405 0.732
protein catabolic process GO:0030163 101 0.681
Worm
proteasomal protein catabolic process GO:0010498 59 0.670
cellular protein catabolic process GO:0044257 83 0.668
protein dna complex subunit organization GO:0071824 86 0.663
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.663
ubiquitin dependent protein catabolic process GO:0006511 78 0.661
catabolic process GO:0009056 409 0.633
Worm
spindle elongation GO:0051231 83 0.620
aging GO:0007568 143 0.601
Worm
macromolecular complex assembly GO:0065003 256 0.599
organelle fission GO:0048285 340 0.598
positive regulation of biosynthetic process GO:0009891 316 0.595
modification dependent protein catabolic process GO:0019941 78 0.586
nuclear division GO:0000280 332 0.585
spindle organization GO:0007051 253 0.573
positive regulation of cellular biosynthetic process GO:0031328 316 0.564
transcription from rna polymerase ii promoter GO:0006366 368 0.541
male gamete generation GO:0048232 201 0.530
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.526
cellular macromolecule catabolic process GO:0044265 136 0.480
macromolecule catabolic process GO:0009057 161 0.478
Worm
positive regulation of nucleic acid templated transcription GO:1903508 266 0.389
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.386
determination of adult lifespan GO:0008340 137 0.386
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.373
positive regulation of peptidase activity GO:0010952 29 0.369
mitotic spindle organization GO:0007052 220 0.364
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.342
spermatogenesis GO:0007283 200 0.338
mitotic spindle elongation GO:0000022 81 0.336
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.323
cell proliferation GO:0008283 299 0.297
positive regulation of protein complex assembly GO:0031334 22 0.297
positive regulation of rna metabolic process GO:0051254 271 0.278
positive regulation of rna biosynthetic process GO:1902680 266 0.268
positive regulation of proteolysis GO:0045862 52 0.258
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.257
protein complex assembly GO:0006461 200 0.245
organic substance catabolic process GO:1901575 308 0.229
Worm
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 1 0.226
positive regulation of transcription dna templated GO:0045893 266 0.219
multicellular organismal aging GO:0010259 140 0.202
Worm
positive regulation of gene expression GO:0010628 290 0.201
mitotic nuclear division GO:0007067 213 0.191
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.177
apoptotic process GO:0006915 159 0.173
positive regulation of cellular component biogenesis GO:0044089 80 0.163
spindle assembly involved in mitosis GO:0090307 50 0.160
cellular protein complex assembly GO:0043623 71 0.159
response to organic substance GO:0010033 284 0.157
regulation of cellular component biogenesis GO:0044087 201 0.155
cell death GO:0008219 279 0.141
regulation of endopeptidase activity GO:0052548 36 0.139
death GO:0016265 284 0.137
larval development GO:0002164 104 0.131
regulation of cellular protein metabolic process GO:0032268 243 0.128
positive regulation of endopeptidase activity GO:0010950 26 0.125
dna repair GO:0006281 54 0.122
positive regulation of protein metabolic process GO:0051247 128 0.118
positive regulation of cellular protein metabolic process GO:0032270 118 0.116
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.105
dna metabolic process GO:0006259 227 0.104
negative regulation of gene expression GO:0010629 387 0.103
regulation of proteolysis GO:0030162 87 0.102
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.097
cellular macromolecular complex assembly GO:0034622 153 0.092
regulation of peptidase activity GO:0052547 39 0.089
peroxisome organization GO:0007031 14 0.084
negative regulation of cellular metabolic process GO:0031324 382 0.080
regulation of catabolic process GO:0009894 170 0.077
spindle assembly GO:0051225 80 0.076
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.074
embryo development ending in birth or egg hatching GO:0009792 152 0.073
Worm
programmed cell death GO:0012501 257 0.073
atp metabolic process GO:0046034 49 0.071
nucleoside monophosphate metabolic process GO:0009123 52 0.070
purine nucleoside monophosphate metabolic process GO:0009126 50 0.069
dna templated transcription elongation GO:0006354 18 0.069
chromatin organization GO:0006325 207 0.066
body morphogenesis GO:0010171 2 0.066
regulation of proteasomal protein catabolic process GO:0061136 39 0.063
positive regulation of cellular component organization GO:0051130 156 0.061
regulation of cell differentiation GO:0045595 302 0.060
regulation of protein complex assembly GO:0043254 42 0.060
regulation of gene expression epigenetic GO:0040029 128 0.059
ribonucleoside monophosphate catabolic process GO:0009158 39 0.055
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.055
regulation of locomotion GO:0040012 42 0.054
aromatic compound catabolic process GO:0019439 166 0.053
protein modification by small protein conjugation or removal GO:0070647 106 0.051
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.050
mitotic cell cycle phase transition GO:0044772 138 0.050
ribonucleoside monophosphate metabolic process GO:0009161 51 0.050
regulation of cellular ketone metabolic process GO:0010565 3 0.049
male meiosis GO:0007140 52 0.049
regulation of cell cycle GO:0051726 291 0.049
single organism catabolic process GO:0044712 228 0.048
intracellular signal transduction GO:0035556 300 0.048
establishment of localization in cell GO:0051649 402 0.048
Worm
neurological system process GO:0050877 358 0.048
camera type eye development GO:0043010 4 0.047
negative regulation of signal transduction GO:0009968 206 0.044
spermatid differentiation GO:0048515 114 0.043
response to endogenous stimulus GO:0009719 119 0.042
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.041
autophagy GO:0006914 108 0.041
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.041
epithelial cell differentiation GO:0030855 322 0.041
regulation of protein metabolic process GO:0051246 256 0.040
regulation of multicellular organismal development GO:2000026 414 0.039
negative regulation of biosynthetic process GO:0009890 277 0.039
chemotaxis GO:0006935 249 0.039
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.037
chromosome organization GO:0051276 360 0.036
negative regulation of cellular biosynthetic process GO:0031327 277 0.036
nucleotide excision repair GO:0006289 8 0.035
positive regulation of catabolic process GO:0009896 105 0.035
cellular protein modification process GO:0006464 438 0.035
vesicle mediated transport GO:0016192 381 0.035
negative regulation of nucleic acid templated transcription GO:1903507 240 0.034
negative regulation of rna biosynthetic process GO:1902679 240 0.034
molting cycle GO:0042303 56 0.034
protein ubiquitination GO:0016567 70 0.034
carbohydrate derivative catabolic process GO:1901136 118 0.032
meiotic cell cycle GO:0051321 171 0.031
anterior posterior axis specification embryo GO:0008595 103 0.031
growth GO:0040007 359 0.030
cell migration GO:0016477 238 0.030
appendage development GO:0048736 401 0.030
transmembrane transport GO:0055085 139 0.030
chromatin remodeling GO:0006338 72 0.030
cell cycle phase transition GO:0044770 140 0.029
taxis GO:0042330 304 0.029
regulation of mitotic cell cycle GO:0007346 190 0.029
organonitrogen compound catabolic process GO:1901565 128 0.028
posttranscriptional regulation of gene expression GO:0010608 145 0.028
organic cyclic compound catabolic process GO:1901361 168 0.028
nucleoside metabolic process GO:0009116 127 0.027
sister chromatid segregation GO:0000819 92 0.027
synaptic transmission GO:0007268 288 0.027
regulation of transport GO:0051049 181 0.027
gene silencing GO:0016458 138 0.027
ribonucleotide metabolic process GO:0009259 145 0.027
cell motility GO:0048870 251 0.027
meiotic cell cycle process GO:1903046 132 0.026
appendage morphogenesis GO:0035107 397 0.026
regulation of catalytic activity GO:0050790 185 0.026
regulation of molecular function GO:0065009 217 0.026
lipid metabolic process GO:0006629 121 0.026
chromosome separation GO:0051304 42 0.026
positive regulation of molecular function GO:0044093 136 0.026
ribose phosphate metabolic process GO:0019693 145 0.026
regulation of mitosis GO:0007088 56 0.026
negative regulation of signaling GO:0023057 219 0.025
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.025
chromosome segregation GO:0007059 157 0.025
endomembrane system organization GO:0010256 119 0.025
response to metal ion GO:0010038 23 0.024
regulation of hydrolase activity GO:0051336 97 0.024
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.024
cellular response to organic substance GO:0071310 132 0.024
purine nucleoside monophosphate catabolic process GO:0009128 38 0.024
regulation of apoptotic process GO:0042981 130 0.024
lipid modification GO:0030258 24 0.024
regulation of protein modification process GO:0031399 112 0.024
negative regulation of cell communication GO:0010648 223 0.023
heterocycle catabolic process GO:0046700 166 0.023
homeostatic process GO:0042592 199 0.023
embryonic morphogenesis GO:0048598 206 0.023
response to abiotic stimulus GO:0009628 341 0.022
meiotic nuclear division GO:0007126 151 0.022
regulation of programmed cell death GO:0043067 152 0.022
purine ribonucleotide metabolic process GO:0009150 145 0.022
negative regulation of transcription dna templated GO:0045892 237 0.021
rna catabolic process GO:0006401 37 0.021
nucleoside monophosphate catabolic process GO:0009125 39 0.021
organonitrogen compound metabolic process GO:1901564 318 0.020
purine nucleoside triphosphate metabolic process GO:0009144 119 0.020
protein modification by small protein conjugation GO:0032446 79 0.020
small molecule metabolic process GO:0044281 305 0.020
regulation of dna templated transcription elongation GO:0032784 17 0.020
ion transmembrane transport GO:0034220 122 0.020
negative regulation of multicellular organismal process GO:0051241 142 0.020
regulation of cell cycle process GO:0010564 181 0.019
cellular nitrogen compound catabolic process GO:0044270 165 0.019
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
regulation of nuclear division GO:0051783 58 0.019
purine containing compound metabolic process GO:0072521 155 0.019
wing disc morphogenesis GO:0007472 344 0.019
oxoacid metabolic process GO:0043436 103 0.019
membrane organization GO:0061024 112 0.019
purine nucleoside catabolic process GO:0006152 112 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
mitotic sister chromatid segregation GO:0000070 87 0.019
cellular ketone metabolic process GO:0042180 24 0.019
mapk cascade GO:0000165 107 0.019
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.019
protein localization GO:0008104 284 0.019
Worm
phosphorylation GO:0016310 294 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.019
imaginal disc derived appendage morphogenesis GO:0035114 395 0.018
cell division GO:0051301 248 0.018
negative regulation of developmental process GO:0051093 201 0.018
cell maturation GO:0048469 144 0.018
purine ribonucleotide catabolic process GO:0009154 109 0.018
protein modification process GO:0036211 438 0.018
regulation of growth GO:0040008 233 0.018
positive regulation of catalytic activity GO:0043085 118 0.018
fatty acid metabolic process GO:0006631 20 0.018
cell adhesion GO:0007155 136 0.018
cellular homeostasis GO:0019725 80 0.018
protein deubiquitination GO:0016579 17 0.018
organophosphate catabolic process GO:0046434 112 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.018
gene silencing by rna GO:0031047 57 0.018
forebrain development GO:0030900 2 0.018
developmental maturation GO:0021700 172 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.018
intracellular transport GO:0046907 228 0.017
regulation of cell development GO:0060284 215 0.017
cellular response to chemical stimulus GO:0070887 199 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.017
response to radiation GO:0009314 155 0.016
ovarian follicle cell development GO:0030707 248 0.016
regulation of phosphate metabolic process GO:0019220 210 0.016
regionalization GO:0003002 416 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
eye development GO:0001654 323 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.015
positive regulation of cell communication GO:0010647 250 0.015
nucleus organization GO:0006997 45 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
centrosome organization GO:0051297 163 0.015
carboxylic acid metabolic process GO:0019752 92 0.015
nucleoside phosphate metabolic process GO:0006753 162 0.015
positive regulation of response to stimulus GO:0048584 323 0.014
ribonucleoside catabolic process GO:0042454 112 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.014
positive regulation of cellular catabolic process GO:0031331 95 0.014
intracellular mrna localization GO:0008298 66 0.014
nucleoside triphosphate metabolic process GO:0009141 120 0.014
enzyme linked receptor protein signaling pathway GO:0007167 179 0.014
single organism behavior GO:0044708 391 0.014
nucleobase containing compound catabolic process GO:0034655 165 0.014
regulation of cellular protein catabolic process GO:1903362 44 0.014
rna interference GO:0016246 27 0.014
purine nucleotide metabolic process GO:0006163 146 0.014
gonad development GO:0008406 50 0.013
regulation of cell division GO:0051302 72 0.013
cell recognition GO:0008037 102 0.013
response to hexose GO:0009746 3 0.013
response to oxygen containing compound GO:1901700 200 0.013
atp catabolic process GO:0006200 38 0.013
imaginal disc derived wing vein specification GO:0007474 48 0.013
nucleoside triphosphate catabolic process GO:0009143 108 0.013
positive regulation of cell death GO:0010942 69 0.013
regulation of phosphorus metabolic process GO:0051174 210 0.013
purine ribonucleoside catabolic process GO:0046130 112 0.013
nucleotide catabolic process GO:0009166 109 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.012
posttranscriptional gene silencing by rna GO:0035194 45 0.012
response to organonitrogen compound GO:0010243 75 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
regulation of protein catabolic process GO:0042176 55 0.012
response to organic cyclic compound GO:0014070 89 0.012
organic acid metabolic process GO:0006082 103 0.012
response to wounding GO:0009611 94 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
single organism cellular localization GO:1902580 180 0.012
regulation of meiosis GO:0040020 3 0.012
regulation of organelle organization GO:0033043 196 0.012
positive regulation of signaling GO:0023056 243 0.012
cellular macromolecule localization GO:0070727 220 0.012
protein neddylation GO:0045116 5 0.011
protein processing GO:0016485 68 0.011
tube development GO:0035295 244 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
development of primary sexual characteristics GO:0045137 50 0.011
endocytosis GO:0006897 310 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
embryonic axis specification GO:0000578 107 0.011
regulation of reproductive process GO:2000241 54 0.011
organophosphate metabolic process GO:0019637 195 0.011
sensory perception GO:0007600 196 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
regulation of cell death GO:0010941 173 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
mitotic sister chromatid separation GO:0051306 30 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
regulation of nervous system development GO:0051960 248 0.011
regulation of anatomical structure size GO:0090066 163 0.011
cellular lipid metabolic process GO:0044255 83 0.011
single organism intracellular transport GO:1902582 207 0.011
ion transport GO:0006811 145 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
localization of cell GO:0051674 257 0.010
protein destabilization GO:0031648 2 0.010
wound healing GO:0042060 75 0.010
epithelial cell development GO:0002064 274 0.010
posttranscriptional gene silencing GO:0016441 46 0.010

Pros26.4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
nervous system disease DOID:863 0 0.018