Drosophila melanogaster

115 known processes

wee (Dmel_CG4488)

CG4488 gene product from transcript CG4488-RA

(Aliases: dwee1,Wee,Dmel\CG4488,CG4488,Wee1,Wee 1,WEE1,dWee1,Dwee,wee1,Dwee1)

wee biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuromuscular junction development GO:0007528 149 0.658
negative regulation of cell cycle GO:0045786 116 0.657
organelle fission GO:0048285 340 0.557
nuclear division GO:0000280 332 0.552
regulation of cell cycle phase transition GO:1901987 130 0.529
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.451
negative regulation of mitotic cell cycle GO:0045930 109 0.449
oocyte development GO:0048599 124 0.419
Mouse
embryo development ending in birth or egg hatching GO:0009792 152 0.395
cell cycle checkpoint GO:0000075 95 0.392
regulation of cell death GO:0010941 173 0.376
regulation of mitotic cell cycle phase transition GO:1901990 130 0.354
immune response GO:0006955 246 0.331
synaptic transmission GO:0007268 288 0.319
negative regulation of cell cycle process GO:0010948 109 0.314
regulation of programmed cell death GO:0043067 152 0.309
regulation of cell differentiation GO:0045595 302 0.303
Mouse
synapse organization GO:0050808 196 0.299
cell division GO:0051301 248 0.294
Mouse
negative regulation of cell cycle phase transition GO:1901988 103 0.291
negative regulation of translation GO:0017148 28 0.290
protein modification process GO:0036211 438 0.267
spindle assembly GO:0051225 80 0.259
larval development GO:0002164 104 0.255
transcription from rna polymerase ii promoter GO:0006366 368 0.250
mitotic dna integrity checkpoint GO:0044774 75 0.247
mitotic cell cycle phase transition GO:0044772 138 0.245
dna integrity checkpoint GO:0031570 81 0.243
positive regulation of macromolecule metabolic process GO:0010604 405 0.230
cell death GO:0008219 279 0.225
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.213
programmed cell death GO:0012501 257 0.210
protein modification by small protein conjugation GO:0032446 79 0.203
single fertilization GO:0007338 24 0.199
Mouse
cellular macromolecule localization GO:0070727 220 0.198
nucleus organization GO:0006997 45 0.175
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.174
oocyte maturation GO:0001556 3 0.169
Mouse
negative regulation of cellular biosynthetic process GO:0031327 277 0.169
regionalization GO:0003002 416 0.169
cellular macromolecule catabolic process GO:0044265 136 0.163
negative regulation of biosynthetic process GO:0009890 277 0.157
tube development GO:0035295 244 0.156
chromosome organization GO:0051276 360 0.137
digestive system development GO:0055123 149 0.130
death GO:0016265 284 0.130
positive regulation of developmental process GO:0051094 143 0.129
cellular protein modification process GO:0006464 438 0.127
dna templated transcription elongation GO:0006354 18 0.126
fertilization GO:0009566 26 0.120
Mouse
negative regulation of cellular metabolic process GO:0031324 382 0.116
negative regulation of neuron death GO:1901215 18 0.114
mitotic dna damage checkpoint GO:0044773 74 0.113
stem cell division GO:0017145 69 0.111
endocytosis GO:0006897 310 0.109
immune system process GO:0002376 347 0.103
protein modification by small protein conjugation or removal GO:0070647 106 0.101
cell proliferation GO:0008283 299 0.101
regulation of cell division GO:0051302 72 0.101
Mouse
regulation of cell cycle process GO:0010564 181 0.100
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 5 0.100
female meiotic division GO:0007143 70 0.100
Mouse
protein complex biogenesis GO:0070271 201 0.097
positive regulation of rna metabolic process GO:0051254 271 0.096
mrna metabolic process GO:0016071 124 0.094
determination of adult lifespan GO:0008340 137 0.092
mitotic spindle organization GO:0007052 220 0.091
taxis GO:0042330 304 0.091
chromosome segregation GO:0007059 157 0.091
single organism biosynthetic process GO:0044711 206 0.086
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.085
regulation of multicellular organismal development GO:2000026 414 0.085
male gamete generation GO:0048232 201 0.084
mitotic sister chromatid segregation GO:0000070 87 0.082
cell cycle phase transition GO:0044770 140 0.082
organic acid metabolic process GO:0006082 103 0.079
centrosome organization GO:0051297 163 0.078
catabolic process GO:0009056 409 0.078
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.078
intracellular signal transduction GO:0035556 300 0.077
regulation of cell cycle GO:0051726 291 0.076
mitotic cell cycle checkpoint GO:0007093 88 0.076
protein phosphorylation GO:0006468 169 0.075
digestive tract morphogenesis GO:0048546 127 0.074
synapse assembly GO:0007416 143 0.071
dendrite development GO:0016358 204 0.070
digestive tract development GO:0048565 149 0.069
negative regulation of nucleic acid templated transcription GO:1903507 240 0.067
meiotic cell cycle GO:0051321 171 0.067
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.066
meiotic cell cycle process GO:1903046 132 0.065
Mouse
regulation of synapse structure and activity GO:0050803 128 0.065
dendrite morphogenesis GO:0048813 199 0.064
apoptotic process GO:0006915 159 0.064
establishment of localization in cell GO:0051649 402 0.064
pole cell development GO:0007277 26 0.064
positive regulation of multicellular organismal process GO:0051240 143 0.063
phosphorylation GO:0016310 294 0.063
synaptic growth at neuromuscular junction GO:0051124 119 0.062
jnk cascade GO:0007254 50 0.061
cytoplasmic microtubule organization GO:0031122 22 0.060
regulation of apoptotic process GO:0042981 130 0.059
molting cycle GO:0042303 56 0.059
positive regulation of rna biosynthetic process GO:1902680 266 0.059
protein targeting to nucleus GO:0044744 51 0.059
positive regulation of catabolic process GO:0009896 105 0.058
regulation of synapse organization GO:0050807 110 0.058
regulation of molecular function GO:0065009 217 0.057
tube morphogenesis GO:0035239 191 0.057
regulation of mitotic cell cycle GO:0007346 190 0.056
compound eye development GO:0048749 307 0.056
positive regulation of nucleic acid templated transcription GO:1903508 266 0.056
meiotic spindle organization GO:0000212 36 0.055
signal transduction in response to dna damage GO:0042770 3 0.055
single organism intracellular transport GO:1902582 207 0.055
regulation of protein metabolic process GO:0051246 256 0.054
centrosome duplication GO:0051298 121 0.054
regulation of phosphorylation GO:0042325 147 0.053
regulation of mapk cascade GO:0043408 92 0.053
response to biotic stimulus GO:0009607 294 0.052
asymmetric neuroblast division GO:0055059 33 0.051
response to other organism GO:0051707 293 0.051
protein catabolic process GO:0030163 101 0.051
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.050
regulation of meiosis GO:0040020 3 0.050
Mouse
negative regulation of gene expression GO:0010629 387 0.049
spindle assembly involved in female meiosis GO:0007056 14 0.049
regulation of cell development GO:0060284 215 0.049
Mouse
organelle localization GO:0051640 148 0.047
multicellular organismal aging GO:0010259 140 0.047
regulation of nervous system development GO:0051960 248 0.045
response to oxidative stress GO:0006979 86 0.045
regulation of epithelial cell proliferation GO:0050678 4 0.045
intracellular transport GO:0046907 228 0.045
eye morphogenesis GO:0048592 260 0.045
eye development GO:0001654 323 0.044
growth GO:0040007 359 0.044
regulation of stress activated mapk cascade GO:0032872 41 0.044
negative regulation of programmed cell death GO:0043069 72 0.044
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.044
oxoacid metabolic process GO:0043436 103 0.044
proteolysis GO:0006508 192 0.043
vesicle mediated transport GO:0016192 381 0.043
embryonic morphogenesis GO:0048598 206 0.042
spindle organization GO:0007051 253 0.042
response to uv GO:0009411 24 0.042
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.042
hemopoiesis GO:0030097 46 0.041
macromolecule catabolic process GO:0009057 161 0.041
positive regulation of phosphorylation GO:0042327 87 0.040
organic substance catabolic process GO:1901575 308 0.040
negative regulation of chromosome segregation GO:0051985 14 0.040
mitotic nuclear division GO:0007067 213 0.040
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.040
aging GO:0007568 143 0.039
proteasomal protein catabolic process GO:0010498 59 0.039
response to external biotic stimulus GO:0043207 293 0.039
cellular response to chemical stimulus GO:0070887 199 0.037
axon guidance GO:0007411 233 0.037
positive regulation of cell proliferation GO:0008284 47 0.037
positive regulation of cell death GO:0010942 69 0.036
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.036
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.036
positive regulation of phosphorus metabolic process GO:0010562 139 0.036
histoblast morphogenesis GO:0007488 9 0.035
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.035
single organism nuclear import GO:1902593 51 0.034
lateral inhibition GO:0046331 206 0.034
response to abiotic stimulus GO:0009628 341 0.034
cell type specific apoptotic process GO:0097285 38 0.033
regulation of transferase activity GO:0051338 58 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.033
developmental maturation GO:0021700 172 0.033
Mouse
nucleocytoplasmic transport GO:0006913 72 0.032
dorsal ventral pattern formation GO:0009953 133 0.031
spindle assembly involved in mitosis GO:0090307 50 0.031
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.031
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.031
positive regulation of phosphate metabolic process GO:0045937 139 0.031
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.031
positive regulation of transcription dna templated GO:0045893 266 0.031
peptidyl amino acid modification GO:0018193 105 0.031
homeostatic process GO:0042592 199 0.030
protein ubiquitination GO:0016567 70 0.030
mitotic sister chromatid separation GO:0051306 30 0.030
regulation of ras protein signal transduction GO:0046578 93 0.030
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.030
regulation of cellular localization GO:0060341 136 0.030
regulation of chromosome segregation GO:0051983 32 0.030
positive regulation of proteolysis GO:0045862 52 0.030
nuclear transport GO:0051169 72 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.030
protein localization GO:0008104 284 0.029
compound eye morphogenesis GO:0001745 249 0.029
protein complex assembly GO:0006461 200 0.029
asymmetric stem cell division GO:0098722 49 0.029
membrane organization GO:0061024 112 0.029
cellular catabolic process GO:0044248 372 0.028
positive regulation of cell cycle GO:0045787 43 0.028
regulation of transport GO:0051049 181 0.028
positive regulation of protein catabolic process GO:0045732 34 0.028
regulation of kinase activity GO:0043549 53 0.028
dna metabolic process GO:0006259 227 0.028
modification dependent protein catabolic process GO:0019941 78 0.028
regulation of phosphate metabolic process GO:0019220 210 0.027
cell maturation GO:0048469 144 0.027
Mouse
sensory organ morphogenesis GO:0090596 260 0.027
karyogamy GO:0000741 4 0.027
g2 m transition of mitotic cell cycle GO:0000086 19 0.027
regulation of immune response GO:0050776 118 0.026
cellular nitrogen compound catabolic process GO:0044270 165 0.026
mitotic g2 m transition checkpoint GO:0044818 70 0.026
nuclear envelope organization GO:0006998 7 0.026
regulation of multi organism process GO:0043900 131 0.026
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.026
single organism cellular localization GO:1902580 180 0.026
sister chromatid segregation GO:0000819 92 0.026
negative regulation of cell death GO:0060548 81 0.025
segmentation GO:0035282 207 0.025
cellular protein localization GO:0034613 160 0.025
apoptotic signaling pathway GO:0097190 27 0.025
translation GO:0006412 69 0.024
regulation of immune system process GO:0002682 176 0.024
negative regulation of apoptotic process GO:0043066 63 0.024
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.024
intracellular protein transport GO:0006886 104 0.024
signal transduction by p53 class mediator GO:0072331 6 0.024
membrane disassembly GO:0030397 4 0.024
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
cellular protein catabolic process GO:0044257 83 0.023
pole cell formation GO:0007279 19 0.023
mitotic cell cycle embryonic GO:0045448 38 0.023
cellular protein complex assembly GO:0043623 71 0.022
positive regulation of molecular function GO:0044093 136 0.022
ubiquitin dependent protein catabolic process GO:0006511 78 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.022
single organism carbohydrate metabolic process GO:0044723 72 0.022
regulation of nuclear division GO:0051783 58 0.022
Mouse
organic substance transport GO:0071702 257 0.022
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.022
positive regulation of apoptotic process GO:0043065 47 0.021
gastrulation GO:0007369 70 0.021
regulation of developmental growth GO:0048638 174 0.021
response to organic substance GO:0010033 284 0.021
regulation of mitosis GO:0007088 56 0.021
pronuclear fusion GO:0007344 4 0.020
positive regulation of protein modification process GO:0031401 58 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
chemotaxis GO:0006935 249 0.020
positive regulation of transport GO:0051050 92 0.020
regulation of protein catabolic process GO:0042176 55 0.020
organophosphate metabolic process GO:0019637 195 0.020
dorsal closure GO:0007391 79 0.019
mitotic g2 dna damage checkpoint GO:0007095 69 0.019
negative regulation of transcription dna templated GO:0045892 237 0.019
carboxylic acid metabolic process GO:0019752 92 0.019
positive regulation of neurogenesis GO:0050769 41 0.019
negative regulation of rna biosynthetic process GO:1902679 240 0.019
negative regulation of response to stimulus GO:0048585 258 0.019
cytoplasmic transport GO:0016482 130 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
asymmetric cell division GO:0008356 37 0.018
regulation of localization GO:0032879 275 0.018
meiosis ii GO:0007135 23 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.018
regulation of protein modification process GO:0031399 112 0.018
nuclear import GO:0051170 51 0.018
oocyte differentiation GO:0009994 145 0.018
Mouse
spermatogenesis GO:0007283 200 0.018
embryonic development via the syncytial blastoderm GO:0001700 148 0.018
positive regulation of protein phosphorylation GO:0001934 34 0.018
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.017
positive regulation of cellular component organization GO:0051130 156 0.017
positive regulation of transferase activity GO:0051347 26 0.017
regulation of synapse assembly GO:0051963 94 0.017
response to organic cyclic compound GO:0014070 89 0.017
central nervous system formation GO:0021556 5 0.017
modification dependent macromolecule catabolic process GO:0043632 79 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.016
synaptic vesicle endocytosis GO:0048488 28 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.016
establishment of protein localization GO:0045184 163 0.016
body morphogenesis GO:0010171 2 0.016
regulation of embryonic development GO:0045995 68 0.016
regulation of neuron death GO:1901214 26 0.016
regulation of ubiquitin protein transferase activity GO:0051438 4 0.016
stem cell maintenance GO:0019827 67 0.016
positive regulation of protein transport GO:0051222 37 0.016
protein import into nucleus GO:0006606 51 0.015
positive regulation of protein metabolic process GO:0051247 128 0.015
response to alcohol GO:0097305 95 0.015
neuroblast proliferation GO:0007405 74 0.015
regulation of nf kappab import into nucleus GO:0042345 1 0.015
female meiosis i GO:0007144 8 0.015
meiotic nuclear division GO:0007126 151 0.015
Mouse
cellular response to organic substance GO:0071310 132 0.015
regulation of meiotic cell cycle GO:0051445 9 0.015
Mouse
negative regulation of oskar mrna translation GO:0007319 5 0.015
macromolecular complex assembly GO:0065003 256 0.015
regulation of cellular catabolic process GO:0031329 157 0.015
regulation of protein phosphorylation GO:0001932 64 0.015
regulation of sister chromatid cohesion GO:0007063 2 0.015
developmental growth GO:0048589 280 0.015
unidimensional cell growth GO:0009826 15 0.014
cell activation GO:0001775 9 0.014
positive regulation of transcription factor import into nucleus GO:0042993 19 0.014
endomembrane system organization GO:0010256 119 0.014
positive regulation of signal transduction GO:0009967 223 0.014
stress activated protein kinase signaling cascade GO:0031098 55 0.014
brain development GO:0007420 120 0.014
dna damage checkpoint GO:0000077 78 0.014
positive regulation of mapk cascade GO:0043410 63 0.014
response to growth factor GO:0070848 31 0.014
immune effector process GO:0002252 98 0.014
regulation of cell proliferation GO:0042127 163 0.014
negative regulation of epithelial cell proliferation GO:0050680 4 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.013
pronuclear migration GO:0035046 4 0.013
positive regulation of immune response GO:0050778 63 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
regulation of cellular protein catabolic process GO:1903362 44 0.013
positive regulation of programmed cell death GO:0043068 62 0.013
regulation of chromatin binding GO:0035561 3 0.013
positive regulation of biosynthetic process GO:0009891 316 0.013
regulation of histone deacetylation GO:0031063 2 0.013
microtubule polymerization or depolymerization GO:0031109 39 0.013
cell aging GO:0007569 2 0.013
central nervous system development GO:0007417 201 0.013
regulation of protein localization to nucleus GO:1900180 29 0.013
spindle checkpoint GO:0031577 11 0.013
hematopoietic or lymphoid organ development GO:0048534 57 0.013
negative regulation of signal transduction GO:0009968 206 0.013
positive regulation of protein localization to nucleus GO:1900182 21 0.012
lipid localization GO:0010876 54 0.012
epithelial cell migration open tracheal system GO:0007427 32 0.012
positive regulation of mitotic metaphase anaphase transition GO:0045842 10 0.012
centrosome cycle GO:0007098 137 0.012
protein import GO:0017038 55 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
aromatic compound catabolic process GO:0019439 166 0.012
positive regulation of cellular catabolic process GO:0031331 95 0.012
anatomical structure homeostasis GO:0060249 97 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
innate immune response GO:0045087 144 0.012
positive regulation of jun kinase activity GO:0043507 4 0.012
developmental programmed cell death GO:0010623 138 0.012
maintenance of location GO:0051235 73 0.012
neuron projection guidance GO:0097485 241 0.012
stem cell proliferation GO:0072089 88 0.012
regulation of response to stress GO:0080134 200 0.012
oocyte microtubule cytoskeleton organization GO:0016325 35 0.012
regulation of hemocyte proliferation GO:0035206 37 0.011
nuclear transcribed mrna catabolic process GO:0000956 24 0.011
peptidyl threonine modification GO:0018210 3 0.011
regulation of mrna 3 end processing GO:0031440 7 0.011
negative regulation of rna metabolic process GO:0051253 251 0.011
oocyte construction GO:0007308 112 0.011
inorganic cation transmembrane transport GO:0098662 61 0.011
mapk cascade GO:0000165 107 0.011
vesicle localization GO:0051648 55 0.011
positive regulation of dendrite development GO:1900006 9 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
regulation of organ morphogenesis GO:2000027 78 0.011
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 1 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
Mouse
negative regulation of signaling GO:0023057 219 0.011
ras protein signal transduction GO:0007265 88 0.011
rna localization GO:0006403 115 0.011
positive regulation of nervous system development GO:0051962 69 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
positive regulation of protein kinase activity GO:0045860 25 0.011
regulation of dna metabolic process GO:0051052 34 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
glycerolipid metabolic process GO:0046486 34 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
sister chromatid cohesion GO:0007062 18 0.011
head development GO:0060322 135 0.011
development of primary sexual characteristics GO:0045137 50 0.011
defense response GO:0006952 300 0.010
response to radiation GO:0009314 155 0.010
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.010
cellular response to growth factor stimulus GO:0071363 30 0.010
positive regulation of mitotic cell cycle GO:0045931 34 0.010
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.010
mrna processing GO:0006397 104 0.010

wee disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.013