Drosophila melanogaster

0 known processes

PyK (Dmel_CG7070)

Pyruvate kinase

(Aliases: CG7070,PYK,Pyk,Dmel\CG7070)

PyK biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
myoblast fusion GO:0007520 43 0.985
syncytium formation by plasma membrane fusion GO:0000768 43 0.983
striated muscle cell differentiation GO:0051146 90 0.903
Worm
somatic muscle development GO:0007525 66 0.902
nad metabolic process GO:0019674 1 0.893
syncytium formation GO:0006949 43 0.871
nicotinamide nucleotide metabolic process GO:0046496 2 0.850
muscle cell differentiation GO:0042692 103 0.840
Worm
muscle structure development GO:0061061 224 0.825
Worm
thioester metabolic process GO:0035383 3 0.779
monocarboxylic acid metabolic process GO:0032787 29 0.582
Yeast Mouse Rat
single organism carbohydrate metabolic process GO:0044723 72 0.560
Yeast Mouse Rat
pyridine nucleotide metabolic process GO:0019362 2 0.559
myotube differentiation GO:0014902 46 0.551
organic acid metabolic process GO:0006082 103 0.473
Yeast Mouse Rat
carbohydrate catabolic process GO:0016052 7 0.452
Yeast Mouse Rat
small molecule metabolic process GO:0044281 305 0.446
Yeast Mouse Rat
organonitrogen compound metabolic process GO:1901564 318 0.389
Rat
oxidoreduction coenzyme metabolic process GO:0006733 2 0.377
nucleotide metabolic process GO:0009117 161 0.327
Rat
catabolic process GO:0009056 409 0.306
Yeast Mouse Rat
pyridine containing compound metabolic process GO:0072524 3 0.305
single organism catabolic process GO:0044712 228 0.259
Yeast Mouse Rat
oxoacid metabolic process GO:0043436 103 0.243
Yeast Mouse Rat
nucleobase containing small molecule metabolic process GO:0055086 174 0.236
Rat
oxidation reduction process GO:0055114 123 0.226
pyruvate metabolic process GO:0006090 7 0.226
Yeast Mouse Rat
organic substance catabolic process GO:1901575 308 0.218
Yeast Mouse Rat
acyl coa metabolic process GO:0006637 3 0.213
carboxylic acid metabolic process GO:0019752 92 0.209
Yeast Mouse Rat
immune response GO:0006955 246 0.193
organophosphate metabolic process GO:0019637 195 0.189
Rat
generation of precursor metabolites and energy GO:0006091 42 0.170
Yeast Mouse Rat
thioester biosynthetic process GO:0035384 2 0.153
citrate metabolic process GO:0006101 0 0.124
negative regulation of cellular metabolic process GO:0031324 382 0.122
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.100
programmed cell death GO:0012501 257 0.100
embryo development ending in birth or egg hatching GO:0009792 152 0.099
Worm
nucleoside metabolic process GO:0009116 127 0.098
Rat
energy derivation by oxidation of organic compounds GO:0015980 32 0.092
purine nucleoside metabolic process GO:0042278 127 0.089
Rat
purine nucleoside monophosphate metabolic process GO:0009126 50 0.086
Rat
response to organic substance GO:0010033 284 0.084
Rat
negative regulation of gene expression GO:0010629 387 0.078
synapse assembly GO:0007416 143 0.078
organophosphate catabolic process GO:0046434 112 0.078
posttranscriptional regulation of gene expression GO:0010608 145 0.077
compound eye development GO:0048749 307 0.073
regulation of protein metabolic process GO:0051246 256 0.073
muscle cell development GO:0055001 50 0.072
Worm
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.070
ribose phosphate metabolic process GO:0019693 145 0.070
Rat
glycolytic process GO:0006096 6 0.069
Yeast Mouse Rat
acyl coa biosynthetic process GO:0071616 2 0.069
response to abiotic stimulus GO:0009628 341 0.069
Rat
purine containing compound metabolic process GO:0072521 155 0.067
Rat
tricarboxylic acid metabolic process GO:0072350 1 0.066
single organism biosynthetic process GO:0044711 206 0.063
Rat
nucleoside catabolic process GO:0009164 112 0.062
negative regulation of cellular biosynthetic process GO:0031327 277 0.060
organic cyclic compound catabolic process GO:1901361 168 0.058
negative regulation of biosynthetic process GO:0009890 277 0.057
regulation of cell cycle GO:0051726 291 0.056
carbohydrate metabolic process GO:0005975 82 0.055
Yeast Mouse Rat
response to monosaccharide GO:0034284 4 0.053
Rat
nucleoside phosphate metabolic process GO:0006753 162 0.053
Rat
nucleobase containing compound catabolic process GO:0034655 165 0.050
heterocycle catabolic process GO:0046700 166 0.050
cellular component assembly involved in morphogenesis GO:0010927 151 0.050
Worm
purine nucleotide metabolic process GO:0006163 146 0.049
Rat
immune system process GO:0002376 347 0.048
spermatid development GO:0007286 98 0.048
rho protein signal transduction GO:0007266 14 0.048
defense response to gram negative bacterium GO:0050829 94 0.048
aromatic compound catabolic process GO:0019439 166 0.047
tube morphogenesis GO:0035239 191 0.046
vesicle mediated transport GO:0016192 381 0.046
Fly
skeletal muscle fiber development GO:0048741 3 0.045
glycosyl compound metabolic process GO:1901657 127 0.045
Rat
negative regulation of epithelial cell proliferation GO:0050680 4 0.044
ribonucleoside catabolic process GO:0042454 112 0.043
negative regulation of translation GO:0017148 28 0.042
regulation of immune system process GO:0002682 176 0.041
spermatogenesis GO:0007283 200 0.041
purine nucleoside triphosphate metabolic process GO:0009144 119 0.041
Rat
carbohydrate derivative metabolic process GO:1901135 217 0.040
Rat
phagocytosis GO:0006909 215 0.040
Fly
tube development GO:0035295 244 0.038
morphogenesis of a branching structure GO:0001763 45 0.038
translation GO:0006412 69 0.038
organonitrogen compound catabolic process GO:1901565 128 0.037
larval development GO:0002164 104 0.037
Worm
single organism carbohydrate catabolic process GO:0044724 7 0.037
Yeast Mouse Rat
negative regulation of gene expression epigenetic GO:0045814 77 0.036
regulation of developmental growth GO:0048638 174 0.035
response to oxygen containing compound GO:1901700 200 0.035
Rat
aging GO:0007568 143 0.035
Worm
nucleoside triphosphate metabolic process GO:0009141 120 0.035
Rat
regulation of immune response GO:0050776 118 0.034
chaeta development GO:0022416 97 0.034
regulation of cell development GO:0060284 215 0.034
cofactor metabolic process GO:0051186 13 0.034
response to glucose GO:0009749 2 0.034
Rat
anatomical structure homeostasis GO:0060249 97 0.034
regulation of organelle organization GO:0033043 196 0.033
negative regulation of cellular protein metabolic process GO:0032269 85 0.033
apoptotic process GO:0006915 159 0.033
cellular catabolic process GO:0044248 372 0.033
negative regulation of response to stimulus GO:0048585 258 0.033
regulation of response to stress GO:0080134 200 0.033
cellular response to organic substance GO:0071310 132 0.032
Rat
body morphogenesis GO:0010171 2 0.032
nucleoside monophosphate metabolic process GO:0009123 52 0.032
Rat
protein complex biogenesis GO:0070271 201 0.032
Worm
striated muscle cell development GO:0055002 50 0.032
Worm
striated muscle myosin thick filament assembly GO:0071688 3 0.032
Worm
positive regulation of immune system process GO:0002684 68 0.031
regulation of growth GO:0040008 233 0.031
regulation of translation GO:0006417 56 0.031
cellular response to chemical stimulus GO:0070887 199 0.031
Rat
morphogenesis of a branching epithelium GO:0061138 45 0.031
glutamate metabolic process GO:0006536 5 0.030
purine nucleoside monophosphate biosynthetic process GO:0009127 3 0.029
Rat
synapse organization GO:0050808 196 0.029
biological adhesion GO:0022610 138 0.028
salivary gland development GO:0007431 162 0.028
positive regulation of programmed cell death GO:0043068 62 0.027
branching morphogenesis of an epithelial tube GO:0048754 45 0.027
mitotic cell cycle phase transition GO:0044772 138 0.027
regulation of catabolic process GO:0009894 170 0.027
positive regulation of cellular component organization GO:0051130 156 0.027
regulation of programmed cell death GO:0043067 152 0.026
cell death GO:0008219 279 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.026
regulation of cell differentiation GO:0045595 302 0.026
phosphorylation GO:0016310 294 0.026
Yeast Mouse Rat
cytoplasmic microtubule organization GO:0031122 22 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
macromolecule catabolic process GO:0009057 161 0.025
lipid localization GO:0010876 54 0.025
regulation of catalytic activity GO:0050790 185 0.024
positive regulation of cellular component biogenesis GO:0044089 80 0.024
regulation of protein complex assembly GO:0043254 42 0.024
ribonucleoside triphosphate metabolic process GO:0009199 119 0.024
Rat
actin filament based process GO:0030029 220 0.024
Worm
small molecule catabolic process GO:0044282 21 0.024
imaginal disc derived wing morphogenesis GO:0007476 337 0.023
multicellular organismal aging GO:0010259 140 0.023
Worm
glycosyl compound catabolic process GO:1901658 112 0.023
mitotic sister chromatid segregation GO:0000070 87 0.023
gene silencing GO:0016458 138 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.023
Rat
negative regulation of protein metabolic process GO:0051248 85 0.023
negative regulation of multicellular organismal process GO:0051241 142 0.022
purine containing compound catabolic process GO:0072523 112 0.022
eye development GO:0001654 323 0.022
positive regulation of developmental growth GO:0048639 62 0.022
male gamete generation GO:0048232 201 0.022
neurotransmitter receptor metabolic process GO:0045213 3 0.022
cellular macromolecular complex assembly GO:0034622 153 0.022
Worm
cellular amino acid metabolic process GO:0006520 61 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.021
lateral inhibition GO:0046331 206 0.021
developmental growth GO:0048589 280 0.021
Rat
organic acid transport GO:0015849 18 0.021
determination of adult lifespan GO:0008340 137 0.021
Worm
epithelial tube morphogenesis GO:0060562 88 0.021
purine ribonucleoside catabolic process GO:0046130 112 0.020
extrinsic apoptotic signaling pathway GO:0097191 1 0.020
tissue morphogenesis GO:0048729 297 0.020
cellular protein complex assembly GO:0043623 71 0.020
Worm
heart development GO:0007507 82 0.020
wing disc pattern formation GO:0035222 66 0.020
camera type eye development GO:0043010 4 0.020
regulation of anatomical structure size GO:0090066 163 0.020
ribonucleoside metabolic process GO:0009119 127 0.020
Rat
purine ribonucleotide catabolic process GO:0009154 109 0.020
response to oxidative stress GO:0006979 86 0.020
regulation of cellular catabolic process GO:0031329 157 0.020
purine ribonucleotide metabolic process GO:0009150 145 0.020
Rat
development of primary sexual characteristics GO:0045137 50 0.019
myofibril assembly GO:0030239 36 0.019
Worm
positive regulation of developmental process GO:0051094 143 0.019
purine ribonucleoside metabolic process GO:0046128 127 0.019
Rat
response to organophosphorus GO:0046683 2 0.019
Rat
regulation of apoptotic process GO:0042981 130 0.019
response to decreased oxygen levels GO:0036293 58 0.019
Rat
single organism intracellular transport GO:1902582 207 0.018
acetaldehyde metabolic process GO:0006117 5 0.018
eye antennal disc development GO:0035214 60 0.018
regulation of neurogenesis GO:0050767 158 0.017
nucleoside triphosphate catabolic process GO:0009143 108 0.017
growth GO:0040007 359 0.017
Rat
organic substance transport GO:0071702 257 0.017
regulation of hydrolase activity GO:0051336 97 0.017
regulation of multicellular organismal development GO:2000026 414 0.017
kidney development GO:0001822 3 0.017
glucose metabolic process GO:0006006 5 0.017
Rat
cell cycle phase transition GO:0044770 140 0.016
ribonucleotide catabolic process GO:0009261 109 0.016
positive regulation of peptidase activity GO:0010952 29 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
cell aging GO:0007569 2 0.016
negative regulation of signal transduction GO:0009968 206 0.016
response to endogenous stimulus GO:0009719 119 0.016
Rat
ribonucleoside biosynthetic process GO:0042455 3 0.016
Rat
proteolysis GO:0006508 192 0.016
lipid storage GO:0019915 38 0.016
mitotic nuclear division GO:0007067 213 0.016
dendrite morphogenesis GO:0048813 199 0.016
negative regulation of signaling GO:0023057 219 0.016
regulation of cell death GO:0010941 173 0.016
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
cell cell signaling involved in cell fate commitment GO:0045168 210 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
carbohydrate derivative biosynthetic process GO:1901137 85 0.016
Rat
cell motility GO:0048870 251 0.016
macromolecular complex assembly GO:0065003 256 0.015
Worm
sex differentiation GO:0007548 81 0.015
cellular carbohydrate catabolic process GO:0044275 2 0.015
cell adhesion GO:0007155 136 0.015
regulation of nervous system development GO:0051960 248 0.015
morphogenesis of an epithelium GO:0002009 276 0.015
negative regulation of neurogenesis GO:0050768 53 0.015
regulation of cell proliferation GO:0042127 163 0.014
urogenital system development GO:0001655 72 0.014
purine nucleotide catabolic process GO:0006195 109 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.014
response to nitrogen compound GO:1901698 90 0.014
Rat
homeostatic process GO:0042592 199 0.014
imaginal disc derived appendage development GO:0048737 399 0.014
monovalent inorganic cation transport GO:0015672 40 0.014
neurological system process GO:0050877 358 0.014
regulation of innate immune response GO:0045088 71 0.014
organic anion transport GO:0015711 28 0.014
microtubule organizing center organization GO:0031023 168 0.014
chromatin silencing GO:0006342 76 0.014
regulation of cell cycle phase transition GO:1901987 130 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.013
regulation of cellular component movement GO:0051270 42 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
notch signaling pathway GO:0007219 120 0.013
neuron death GO:0070997 27 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
positive regulation of molecular function GO:0044093 136 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
Rat
negative regulation of cell cycle GO:0045786 116 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
appendage morphogenesis GO:0035107 397 0.013
positive regulation of growth GO:0045927 75 0.013
protein complex assembly GO:0006461 200 0.013
Worm
renal system development GO:0072001 72 0.013
wing disc morphogenesis GO:0007472 344 0.013
cellular respiration GO:0045333 26 0.013
regulation of cytoskeleton organization GO:0051493 89 0.012
negative regulation of developmental process GO:0051093 201 0.012
maintenance of location GO:0051235 73 0.012
membrane organization GO:0061024 112 0.012
positive regulation of signal transduction GO:0009967 223 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
carbohydrate biosynthetic process GO:0016051 17 0.012
ubiquitin dependent protein catabolic process GO:0006511 78 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
regulation of nucleotide catabolic process GO:0030811 48 0.012
sulfur compound biosynthetic process GO:0044272 16 0.012
centrosome organization GO:0051297 163 0.012
ion transport GO:0006811 145 0.012
regulation of cell cycle process GO:0010564 181 0.012
positive regulation of cell communication GO:0010647 250 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
response to oxygen levels GO:0070482 59 0.012
Rat
nucleotide catabolic process GO:0009166 109 0.011
cellular carbohydrate metabolic process GO:0044262 22 0.011
regulation of cellular component size GO:0032535 98 0.011
muscle system process GO:0003012 21 0.011
positive regulation of cell motility GO:2000147 3 0.011
gland development GO:0048732 191 0.011
Rat
sister chromatid segregation GO:0000819 92 0.011
regulation of proteolysis GO:0030162 87 0.011
integrin mediated signaling pathway GO:0007229 3 0.011
spermatid differentiation GO:0048515 114 0.011
detection of external stimulus GO:0009581 66 0.011
endocytosis GO:0006897 310 0.011
Fly
negative regulation of neural precursor cell proliferation GO:2000178 27 0.011
glucan biosynthetic process GO:0009250 2 0.011
negative regulation of immune response GO:0050777 39 0.011
adherens junction organization GO:0034332 27 0.011
cellular protein catabolic process GO:0044257 83 0.011
cellular aldehyde metabolic process GO:0006081 10 0.011
establishment of protein localization GO:0045184 163 0.011
negative regulation of cellular component organization GO:0051129 108 0.011
positive regulation of multicellular organism growth GO:0040018 21 0.011
response to biotic stimulus GO:0009607 294 0.011
salivary gland morphogenesis GO:0007435 145 0.011
defense response to bacterium GO:0042742 178 0.010
response to other organism GO:0051707 293 0.010
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.010
Rat
gland morphogenesis GO:0022612 145 0.010
cellular protein modification process GO:0006464 438 0.010
purine nucleoside catabolic process GO:0006152 112 0.010
embryonic morphogenesis GO:0048598 206 0.010
organonitrogen compound biosynthetic process GO:1901566 117 0.010
Rat
negative regulation of transcription dna templated GO:0045892 237 0.010
reproductive system development GO:0061458 74 0.010
negative regulation of cell development GO:0010721 62 0.010
cellular homeostasis GO:0019725 80 0.010

PyK disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.090
disease of metabolism DOID:0014667 0 0.029
inherited metabolic disorder DOID:655 0 0.029
carbohydrate metabolism disease DOID:0050013 0 0.023
glucose metabolism disease DOID:4194 0 0.023
acquired metabolic disease DOID:0060158 0 0.023
sensory system disease DOID:0050155 0 0.019
eye and adnexa disease DOID:1492 0 0.019
nervous system disease DOID:863 0 0.019
disease of cellular proliferation DOID:14566 0 0.013
kidney disease DOID:557 0 0.011
urinary system disease DOID:18 0 0.011