Drosophila melanogaster

37 known processes

Pros54 (Dmel_CG7619)

Proteasome 54kD subunit

(Aliases: 7619,S5A,Rpn10/p54,CG7619,DmS5a,S5a,Dmel\CG7619,dRpn10,p54,Rpn10,mu-54)

Pros54 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic spindle organization GO:0007052 220 0.976
spindle assembly GO:0051225 80 0.906
proteolysis GO:0006508 192 0.900
spindle assembly involved in mitosis GO:0090307 50 0.809
modification dependent protein catabolic process GO:0019941 78 0.650
Yeast Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.624
mitotic spindle elongation GO:0000022 81 0.621
cellular protein complex assembly GO:0043623 71 0.610
mitotic nuclear division GO:0007067 213 0.608
spindle elongation GO:0051231 83 0.566
regulation of molecular function GO:0065009 217 0.496
modification dependent macromolecule catabolic process GO:0043632 79 0.474
Yeast Worm
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.474
catabolic process GO:0009056 409 0.461
Yeast Worm
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.433
Yeast Worm
ubiquitin dependent protein catabolic process GO:0006511 78 0.413
Yeast Worm
proteasomal protein catabolic process GO:0010498 59 0.384
cellular catabolic process GO:0044248 372 0.347
Yeast Worm
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.336
spindle organization GO:0007051 253 0.323
organelle assembly GO:0070925 198 0.313
chromosome segregation GO:0007059 157 0.312
protein complex assembly GO:0006461 200 0.304
negative regulation of biosynthetic process GO:0009890 277 0.297
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.288
negative regulation of cellular biosynthetic process GO:0031327 277 0.283
protein complex biogenesis GO:0070271 201 0.280
regulation of catabolic process GO:0009894 170 0.272
taxis GO:0042330 304 0.255
positive regulation of molecular function GO:0044093 136 0.247
negative regulation of cellular metabolic process GO:0031324 382 0.245
protein modification by small protein conjugation GO:0032446 79 0.204
protein catabolic process GO:0030163 101 0.196
Yeast Worm
epithelial cell development GO:0002064 274 0.194
negative regulation of signaling GO:0023057 219 0.188
chromosome organization GO:0051276 360 0.174
dna repair GO:0006281 54 0.167
organic substance catabolic process GO:1901575 308 0.166
Yeast Worm
nucleotide metabolic process GO:0009117 161 0.165
organelle fission GO:0048285 340 0.164
protein modification process GO:0036211 438 0.159
mitotic sister chromatid segregation GO:0000070 87 0.152
response to light stimulus GO:0009416 124 0.151
regulation of endopeptidase activity GO:0052548 36 0.140
purine nucleoside triphosphate metabolic process GO:0009144 119 0.138
nuclear division GO:0000280 332 0.137
heterocycle catabolic process GO:0046700 166 0.133
ribose phosphate metabolic process GO:0019693 145 0.132
defense response GO:0006952 300 0.131
nucleoside triphosphate metabolic process GO:0009141 120 0.131
regulation of proteolysis GO:0030162 87 0.130
nucleobase containing small molecule metabolic process GO:0055086 174 0.127
positive regulation of hydrolase activity GO:0051345 78 0.124
purine ribonucleotide catabolic process GO:0009154 109 0.124
positive regulation of macromolecule metabolic process GO:0010604 405 0.117
small molecule metabolic process GO:0044281 305 0.115
protein ubiquitination GO:0016567 70 0.113
hematopoietic or lymphoid organ development GO:0048534 57 0.112
purine containing compound catabolic process GO:0072523 112 0.110
organophosphate catabolic process GO:0046434 112 0.109
protein modification by small protein conjugation or removal GO:0070647 106 0.109
cell migration GO:0016477 238 0.108
nucleotide catabolic process GO:0009166 109 0.108
regulation of cellular protein metabolic process GO:0032268 243 0.108
nucleobase containing compound catabolic process GO:0034655 165 0.107
cell proliferation GO:0008283 299 0.106
nuclear envelope organization GO:0006998 7 0.105
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.103
regulation of cellular catabolic process GO:0031329 157 0.103
regulation of hydrolase activity GO:0051336 97 0.098
centrosome cycle GO:0007098 137 0.096
cellular protein modification process GO:0006464 438 0.096
cellular macromolecule catabolic process GO:0044265 136 0.096
Yeast Worm
columnar cuboidal epithelial cell development GO:0002066 249 0.093
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.090
negative regulation of phosphorus metabolic process GO:0010563 45 0.090
negative regulation of catalytic activity GO:0043086 42 0.090
transcription from rna polymerase ii promoter GO:0006366 368 0.088
regulation of mitotic cell cycle GO:0007346 190 0.087
dna templated transcription elongation GO:0006354 18 0.085
purine ribonucleotide metabolic process GO:0009150 145 0.084
determination of adult lifespan GO:0008340 137 0.083
Worm
macromolecule catabolic process GO:0009057 161 0.083
Yeast Worm
ribonucleoside metabolic process GO:0009119 127 0.083
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.082
response to radiation GO:0009314 155 0.082
regulation of catalytic activity GO:0050790 185 0.082
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.080
centrosome organization GO:0051297 163 0.080
purine nucleoside triphosphate catabolic process GO:0009146 108 0.078
regulation of proteasomal protein catabolic process GO:0061136 39 0.077
cellular response to dna damage stimulus GO:0006974 223 0.075
negative regulation of multicellular organismal process GO:0051241 142 0.075
Worm
multicellular organismal aging GO:0010259 140 0.075
Worm
organic cyclic compound catabolic process GO:1901361 168 0.074
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.073
positive regulation of catabolic process GO:0009896 105 0.072
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.072
negative regulation of molecular function GO:0044092 51 0.072
sister chromatid segregation GO:0000819 92 0.070
negative regulation of signal transduction GO:0009968 206 0.070
response to inorganic substance GO:0010035 44 0.070
secretion by cell GO:0032940 101 0.069
larval development GO:0002164 104 0.069
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.069
regulation of mitosis GO:0007088 56 0.069
negative regulation of gene expression GO:0010629 387 0.067
Worm
ribonucleoside triphosphate metabolic process GO:0009199 119 0.065
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.062
neurological system process GO:0050877 358 0.061
microtubule based transport GO:0010970 42 0.061
cellular protein catabolic process GO:0044257 83 0.061
Yeast Worm
anterior posterior pattern specification GO:0009952 136 0.061
regulation of protein metabolic process GO:0051246 256 0.059
purine ribonucleoside catabolic process GO:0046130 112 0.059
establishment of cell polarity GO:0030010 40 0.059
organonitrogen compound metabolic process GO:1901564 318 0.059
neuron projection guidance GO:0097485 241 0.059
epithelial cell differentiation GO:0030855 322 0.059
wnt signaling pathway GO:0016055 98 0.057
cellular macromolecular complex assembly GO:0034622 153 0.056
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.055
purine nucleotide catabolic process GO:0006195 109 0.054
cell death GO:0008219 279 0.054
regulation of mitotic sister chromatid segregation GO:0033047 28 0.054
response to organic substance GO:0010033 284 0.053
nucleoside phosphate catabolic process GO:1901292 110 0.053
negative regulation of cellular protein metabolic process GO:0032269 85 0.053
embryo development ending in birth or egg hatching GO:0009792 152 0.052
lymph gland development GO:0048542 28 0.052
positive regulation of gene expression GO:0010628 290 0.051
ribonucleotide catabolic process GO:0009261 109 0.050
purine nucleoside catabolic process GO:0006152 112 0.049
ribonucleoside catabolic process GO:0042454 112 0.049
carbohydrate derivative catabolic process GO:1901136 118 0.049
immune response GO:0006955 246 0.049
nucleoside metabolic process GO:0009116 127 0.048
cellular nitrogen compound catabolic process GO:0044270 165 0.047
regulation of nucleoside metabolic process GO:0009118 50 0.045
ribonucleotide metabolic process GO:0009259 145 0.044
negative regulation of response to stimulus GO:0048585 258 0.043
regulation of protein modification process GO:0031399 112 0.043
single organism catabolic process GO:0044712 228 0.043
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.042
lateral inhibition GO:0046331 206 0.042
nucleoside phosphate metabolic process GO:0006753 162 0.042
cellular response to chemical stimulus GO:0070887 199 0.042
ribonucleoside triphosphate catabolic process GO:0009203 108 0.042
head development GO:0060322 135 0.041
regulation of gtpase activity GO:0043087 44 0.041
multi organism behavior GO:0051705 175 0.041
regulation of peptidase activity GO:0052547 39 0.041
mitotic cell cycle phase transition GO:0044772 138 0.040
purine nucleoside metabolic process GO:0042278 127 0.040
organonitrogen compound catabolic process GO:1901565 128 0.039
organophosphate metabolic process GO:0019637 195 0.039
cell type specific apoptotic process GO:0097285 38 0.038
regulation of response to stress GO:0080134 200 0.038
establishment of spindle localization GO:0051293 22 0.038
central nervous system development GO:0007417 201 0.037
glycosyl compound catabolic process GO:1901658 112 0.037
wing disc morphogenesis GO:0007472 344 0.037
aromatic compound catabolic process GO:0019439 166 0.036
locomotory behavior GO:0007626 176 0.035
dna packaging GO:0006323 91 0.035
growth GO:0040007 359 0.035
synaptic vesicle recycling GO:0036465 28 0.035
sensory organ morphogenesis GO:0090596 260 0.034
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.034
positive regulation of proteolysis GO:0045862 52 0.033
purine ribonucleoside metabolic process GO:0046128 127 0.033
regulation of multicellular organismal development GO:2000026 414 0.032
Worm
gene silencing GO:0016458 138 0.032
Worm
regulation of cell cycle GO:0051726 291 0.032
positive regulation of transcription dna templated GO:0045893 266 0.032
positive regulation of cellular catabolic process GO:0031331 95 0.031
regulation of cellular component biogenesis GO:0044087 201 0.031
gtp metabolic process GO:0046039 72 0.031
detection of stimulus GO:0051606 156 0.031
developmental growth GO:0048589 280 0.030
anterior posterior axis specification GO:0009948 109 0.030
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.029
regulation of synapse assembly GO:0051963 94 0.029
neuromuscular synaptic transmission GO:0007274 67 0.029
cellular component assembly involved in morphogenesis GO:0010927 151 0.029
regulation of protein complex assembly GO:0043254 42 0.028
regulation of phosphate metabolic process GO:0019220 210 0.028
body morphogenesis GO:0010171 2 0.028
purine nucleotide metabolic process GO:0006163 146 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.026
imaginal disc derived appendage morphogenesis GO:0035114 395 0.026
regulation of protein catabolic process GO:0042176 55 0.026
aging GO:0007568 143 0.026
Worm
nucleoside catabolic process GO:0009164 112 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.026
regulation of organ morphogenesis GO:2000027 78 0.026
ovarian follicle cell development GO:0030707 248 0.026
response to peptide GO:1901652 29 0.025
blastoderm segmentation GO:0007350 159 0.025
chemotaxis GO:0006935 249 0.025
positive regulation of endopeptidase activity GO:0010950 26 0.025
negative regulation of phosphate metabolic process GO:0045936 45 0.024
double strand break repair GO:0006302 26 0.024
nucleoside triphosphate catabolic process GO:0009143 108 0.024
axon cargo transport GO:0008088 29 0.024
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.024
guanosine containing compound catabolic process GO:1901069 74 0.024
negative regulation of rna biosynthetic process GO:1902679 240 0.023
positive regulation of nucleoside metabolic process GO:0045979 47 0.023
cellular response to endogenous stimulus GO:0071495 80 0.023
positive regulation of protein metabolic process GO:0051247 128 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
negative regulation of nucleic acid templated transcription GO:1903507 240 0.023
dna metabolic process GO:0006259 227 0.023
positive regulation of cellular protein metabolic process GO:0032270 118 0.023
regulation of gtp catabolic process GO:0033124 44 0.022
embryonic axis specification GO:0000578 107 0.022
regulation of apoptotic process GO:0042981 130 0.022
telencephalon development GO:0021537 2 0.022
negative regulation of developmental growth GO:0048640 64 0.022
fertilization GO:0009566 26 0.022
death GO:0016265 284 0.022
positive regulation of biosynthetic process GO:0009891 316 0.021
programmed cell death GO:0012501 257 0.021
negative regulation of cell communication GO:0010648 223 0.021
chaperone mediated protein folding GO:0061077 2 0.021
vesicle mediated transport GO:0016192 381 0.021
protein deubiquitination GO:0016579 17 0.021
appendage morphogenesis GO:0035107 397 0.021
positive regulation of catalytic activity GO:0043085 118 0.021
regulation of purine nucleotide catabolic process GO:0033121 48 0.021
protein maturation GO:0051604 71 0.020
axon guidance GO:0007411 233 0.020
cell motility GO:0048870 251 0.020
positive regulation of protein catabolic process GO:0045732 34 0.020
eye development GO:0001654 323 0.020
protein processing GO:0016485 68 0.019
tripartite regional subdivision GO:0007351 103 0.019
anterior posterior axis specification embryo GO:0008595 103 0.019
response to peptide hormone GO:0043434 29 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
mitotic g2 dna damage checkpoint GO:0007095 69 0.018
regulation of nucleotide metabolic process GO:0006140 62 0.018
lipid localization GO:0010876 54 0.018
glycosyl compound metabolic process GO:1901657 127 0.018
purine nucleoside monophosphate metabolic process GO:0009126 50 0.018
mitotic sister chromatid separation GO:0051306 30 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.017
regulation of growth GO:0040008 233 0.016
organelle localization GO:0051640 148 0.016
negative regulation of protein metabolic process GO:0051248 85 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
endocytosis GO:0006897 310 0.016
chromosome separation GO:0051304 42 0.016
protein neddylation GO:0045116 5 0.016
regulation of innate immune response GO:0045088 71 0.016
detection of stimulus involved in sensory perception GO:0050906 92 0.016
protein transport GO:0015031 155 0.016
regulation of wnt signaling pathway GO:0030111 68 0.015
positive regulation of peptidase activity GO:0010952 29 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
positive regulation of cell death GO:0010942 69 0.015
axon development GO:0061564 297 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
microtubule organizing center organization GO:0031023 168 0.015
striated muscle cell differentiation GO:0051146 90 0.015
regulation of mitotic sister chromatid separation GO:0010965 28 0.015
ras protein signal transduction GO:0007265 88 0.015
larval behavior GO:0030537 42 0.015
regulation of ras protein signal transduction GO:0046578 93 0.015
cellular response to nitrogen compound GO:1901699 51 0.015
axis specification GO:0009798 167 0.015
protein phosphorylation GO:0006468 169 0.015
macromolecular complex assembly GO:0065003 256 0.015
imaginal disc derived appendage development GO:0048737 399 0.014
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.014
maternal determination of anterior posterior axis embryo GO:0008358 74 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.014
metaphase anaphase transition of cell cycle GO:0044784 28 0.014
centriole assembly GO:0098534 24 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.014
positive regulation of nucleotide metabolic process GO:0045981 55 0.014
male gamete generation GO:0048232 201 0.013
Worm
positive regulation of cellular biosynthetic process GO:0031328 316 0.013
eye morphogenesis GO:0048592 260 0.013
organic substance transport GO:0071702 257 0.013
response to endogenous stimulus GO:0009719 119 0.013
compound eye development GO:0048749 307 0.013
establishment of protein localization GO:0045184 163 0.013
regulation of programmed cell death GO:0043067 152 0.013
chromatin organization GO:0006325 207 0.013
transition metal ion transport GO:0000041 16 0.013
positive regulation of rna metabolic process GO:0051254 271 0.013
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.013
compound eye morphogenesis GO:0001745 249 0.013
protein modification by small protein removal GO:0070646 28 0.013
regulation of chromosome organization GO:0033044 64 0.013
positive regulation of gtp catabolic process GO:0033126 43 0.013
sex differentiation GO:0007548 81 0.012
regionalization GO:0003002 416 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.012
brain development GO:0007420 120 0.012
positive regulation of cellular component biogenesis GO:0044089 80 0.012
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 20 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
innate immune response GO:0045087 144 0.012
axonogenesis GO:0007409 290 0.012
reproductive system development GO:0061458 74 0.012
cell maturation GO:0048469 144 0.012
tube development GO:0035295 244 0.012
regulation of striated muscle contraction GO:0006942 2 0.012
negative regulation of cell death GO:0060548 81 0.012
regulation of developmental growth GO:0048638 174 0.012
protein alkylation GO:0008213 43 0.012
forebrain development GO:0030900 2 0.011
rhabdomere development GO:0042052 38 0.011
tube morphogenesis GO:0035239 191 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.011
cellular response to organic substance GO:0071310 132 0.011
negative regulation of protein phosphorylation GO:0001933 17 0.011
protein secretion GO:0009306 45 0.011
cell division GO:0051301 248 0.011
negative regulation of defense response GO:0031348 35 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
cellular component maintenance GO:0043954 23 0.011
protein polymerization GO:0051258 42 0.011
ion transport GO:0006811 145 0.011
imaginal disc derived wing morphogenesis GO:0007476 337 0.011
centriole replication GO:0007099 24 0.011
positive regulation of gtpase activity GO:0043547 43 0.011
dephosphorylation GO:0016311 51 0.011
establishment of organelle localization GO:0051656 122 0.011
protein localization GO:0008104 284 0.011
histone lysine methylation GO:0034968 32 0.011
apoptotic process involved in morphogenesis GO:0060561 3 0.010
regulation of organelle organization GO:0033043 196 0.010
establishment of localization in cell GO:0051649 402 0.010
purine nucleoside monophosphate catabolic process GO:0009128 38 0.010
regulation of immune response GO:0050776 118 0.010

Pros54 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org