Drosophila melanogaster

0 known processes

zen2 (Dmel_CG1048)

zerknullt-related

(Aliases: Dmel\CG1048,BG:DS00276.10,zpr,CG1048,z2)

zen2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
detection of stimulus involved in sensory perception GO:0050906 92 0.115
detection of chemical stimulus GO:0009593 93 0.082
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.080
neurological system process GO:0050877 358 0.050
protein heterooligomerization GO:0051291 4 0.045
cell cell signaling involved in cell fate commitment GO:0045168 210 0.044
protein hydroxylation GO:0018126 1 0.041
negative regulation of cellular metabolic process GO:0031324 382 0.040
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.038
Fly
immune response GO:0006955 246 0.038
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.038
Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.035
Fly
axis specification GO:0009798 167 0.034
regionalization GO:0003002 416 0.034
positive regulation of nucleic acid templated transcription GO:1903508 266 0.033
Fly
protein modification process GO:0036211 438 0.033
lateral inhibition GO:0046331 206 0.032
forebrain development GO:0030900 2 0.032
detection of stimulus GO:0051606 156 0.032
endocytosis GO:0006897 310 0.032
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.032
positive regulation of macromolecule metabolic process GO:0010604 405 0.032
Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.031
Fly
cellular protein modification process GO:0006464 438 0.031
transcription from rna polymerase ii promoter GO:0006366 368 0.031
Fly
embryonic pattern specification GO:0009880 174 0.031
sensory perception GO:0007600 196 0.031
positive regulation of rna biosynthetic process GO:1902680 266 0.031
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.031
regulation of localization GO:0032879 275 0.031
phagocytosis GO:0006909 215 0.030
negative regulation of cellular biosynthetic process GO:0031327 277 0.030
Fly
body morphogenesis GO:0010171 2 0.029
Worm
intracellular transport GO:0046907 228 0.029
cell division GO:0051301 248 0.029
positive regulation of rna metabolic process GO:0051254 271 0.029
Fly
cell proliferation GO:0008283 299 0.029
negative regulation of rna biosynthetic process GO:1902679 240 0.028
Fly
segmentation GO:0035282 207 0.028
positive regulation of biosynthetic process GO:0009891 316 0.028
Fly
regulation of multi organism process GO:0043900 131 0.028
establishment of localization in cell GO:0051649 402 0.027
vesicle mediated transport GO:0016192 381 0.027
axonogenesis GO:0007409 290 0.027
Fly
immune system process GO:0002376 347 0.027
compound eye development GO:0048749 307 0.027
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.027
Fly
protein complex assembly GO:0006461 200 0.027
blastoderm segmentation GO:0007350 159 0.027
innate immune response GO:0045087 144 0.027
olfactory behavior GO:0042048 97 0.027
humoral immune response GO:0006959 117 0.026
anterior posterior axis specification embryo GO:0008595 103 0.026
developmental maturation GO:0021700 172 0.026
response to other organism GO:0051707 293 0.026
negative regulation of nucleic acid templated transcription GO:1903507 240 0.026
Fly
response to organic substance GO:0010033 284 0.026
negative regulation of gene expression GO:0010629 387 0.026
Fly
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.026
Fly
negative regulation of biosynthetic process GO:0009890 277 0.025
Fly
peptide metabolic process GO:0006518 80 0.025
positive regulation of cell communication GO:0010647 250 0.025
anterior posterior axis specification GO:0009948 109 0.025
regulation of cell cycle GO:0051726 291 0.025
chemosensory behavior GO:0007635 106 0.025
regulation of gene expression epigenetic GO:0040029 128 0.024
wing disc morphogenesis GO:0007472 344 0.024
sensory perception of chemical stimulus GO:0007606 116 0.024
response to oxygen containing compound GO:1901700 200 0.024
camera type eye development GO:0043010 4 0.024
small molecule metabolic process GO:0044281 305 0.024
appendage development GO:0048736 401 0.024
macromolecular complex assembly GO:0065003 256 0.024
negative regulation of rna metabolic process GO:0051253 251 0.024
Fly
anterior posterior pattern specification GO:0009952 136 0.024
protein complex biogenesis GO:0070271 201 0.024
taxis GO:0042330 304 0.024
Fly
embryonic axis specification GO:0000578 107 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
telencephalon development GO:0021537 2 0.023
sensory perception of smell GO:0007608 80 0.022
regulation of cell cycle process GO:0010564 181 0.022
epithelial cell development GO:0002064 274 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.022
Fly
defense response GO:0006952 300 0.022
organic substance catabolic process GO:1901575 308 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.022
Fly
regulation of transport GO:0051049 181 0.022
response to abiotic stimulus GO:0009628 341 0.022
organonitrogen compound metabolic process GO:1901564 318 0.022
single organism intracellular transport GO:1902582 207 0.022
eye development GO:0001654 323 0.022
Fly
phosphorylation GO:0016310 294 0.022
multi organism behavior GO:0051705 175 0.022
locomotory behavior GO:0007626 176 0.022
spinal cord development GO:0021510 1 0.021
tripartite regional subdivision GO:0007351 103 0.021
mitotic spindle organization GO:0007052 220 0.021
multi multicellular organism process GO:0044706 123 0.021
regulation of immune system process GO:0002682 176 0.021
response to external biotic stimulus GO:0043207 293 0.021
epithelial cell differentiation GO:0030855 322 0.021
regulation of mitotic cell cycle GO:0007346 190 0.021
neuropeptide signaling pathway GO:0007218 45 0.020
columnar cuboidal epithelial cell development GO:0002066 249 0.020
regulation of nervous system development GO:0051960 248 0.020
Fly
axon development GO:0061564 297 0.020
Fly
proteolysis GO:0006508 192 0.020
sensory organ morphogenesis GO:0090596 260 0.020
kidney development GO:0001822 3 0.020
negative regulation of signaling GO:0023057 219 0.020
organic substance transport GO:0071702 257 0.020
oocyte differentiation GO:0009994 145 0.020
cell maturation GO:0048469 144 0.020
protein localization GO:0008104 284 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
Fly
positive regulation of gene expression GO:0010628 290 0.019
Fly
mitotic nuclear division GO:0007067 213 0.019
imaginal disc derived appendage development GO:0048737 399 0.019
negative regulation of transcription dna templated GO:0045892 237 0.019
Fly
negative regulation of developmental process GO:0051093 201 0.019
Fly
single organism behavior GO:0044708 391 0.019
oxoacid metabolic process GO:0043436 103 0.019
imaginal disc derived wing morphogenesis GO:0007476 337 0.019
cellular response to organic substance GO:0071310 132 0.019
nephron development GO:0072006 3 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
regulation of humoral immune response GO:0002920 51 0.018
organelle fission GO:0048285 340 0.018
retina development in camera type eye GO:0060041 4 0.018
organic acid metabolic process GO:0006082 103 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.018
antimicrobial humoral response GO:0019730 99 0.018
microtubule based transport GO:0010970 42 0.018
spindle organization GO:0007051 253 0.018
imaginal disc derived appendage morphogenesis GO:0035114 395 0.018
oocyte construction GO:0007308 112 0.018
oocyte development GO:0048599 124 0.018
intracellular signal transduction GO:0035556 300 0.018
cellular amide metabolic process GO:0043603 80 0.018
nuclear division GO:0000280 332 0.018
response to biotic stimulus GO:0009607 294 0.018
regulation of response to external stimulus GO:0032101 115 0.018
chromosome organization GO:0051276 360 0.018
organelle assembly GO:0070925 198 0.018
establishment or maintenance of cell polarity GO:0007163 167 0.018
cellular response to chemical stimulus GO:0070887 199 0.018
regulation of anatomical structure size GO:0090066 163 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.017
regulation of embryonic development GO:0045995 68 0.017
regulation of multicellular organismal development GO:2000026 414 0.017
Fly
gene silencing GO:0016458 138 0.017
cellular amino acid metabolic process GO:0006520 61 0.017
cellular catabolic process GO:0044248 372 0.017
eggshell formation GO:0030703 105 0.017
cellular component assembly involved in morphogenesis GO:0010927 151 0.017
reproductive behavior GO:0019098 122 0.017
positive regulation of signaling GO:0023056 243 0.017
regulation of protein metabolic process GO:0051246 256 0.017
hindgut development GO:0061525 58 0.017
negative regulation of cell communication GO:0010648 223 0.017
protein processing GO:0016485 68 0.017
regulation of response to stress GO:0080134 200 0.016
tissue morphogenesis GO:0048729 297 0.016
tube morphogenesis GO:0035239 191 0.016
Fly
chemotaxis GO:0006935 249 0.016
Fly
hindbrain development GO:0030902 2 0.016
axon guidance GO:0007411 233 0.016
Fly
negative regulation of signal transduction GO:0009968 206 0.016
positive regulation of signal transduction GO:0009967 223 0.016
notch signaling pathway GO:0007219 120 0.016
oocyte axis specification GO:0007309 108 0.016
regulation of immune response GO:0050776 118 0.016
digestive tract morphogenesis GO:0048546 127 0.016
Fly
cytoplasm organization GO:0007028 64 0.016
regulation of phosphorus metabolic process GO:0051174 210 0.016
cellular response to dna damage stimulus GO:0006974 223 0.016
cytoskeleton dependent intracellular transport GO:0030705 44 0.016
catabolic process GO:0009056 409 0.016
regulation of phosphorylation GO:0042325 147 0.016
acylglycerol catabolic process GO:0046464 3 0.016
connective tissue development GO:0061448 3 0.016
regulation of notch signaling pathway GO:0008593 100 0.015
single organism cellular localization GO:1902580 180 0.015
immune effector process GO:0002252 98 0.015
single organism catabolic process GO:0044712 228 0.015
response to wounding GO:0009611 94 0.015
stem cell differentiation GO:0048863 117 0.015
Fly
regulation of gene silencing GO:0060968 63 0.015
synaptic transmission GO:0007268 288 0.015
negative regulation of response to stimulus GO:0048585 258 0.015
wound healing GO:0042060 75 0.015
embryo development ending in birth or egg hatching GO:0009792 152 0.015
Worm
peptidyl proline modification GO:0018208 3 0.015
rna processing GO:0006396 147 0.015
appendage morphogenesis GO:0035107 397 0.015
compound eye morphogenesis GO:0001745 249 0.015
microtubule based movement GO:0007018 51 0.015
embryonic morphogenesis GO:0048598 206 0.015
Fly
monocarboxylic acid transport GO:0015718 3 0.015
negative regulation of mitotic cell cycle GO:0045930 109 0.015
regulation of cellular localization GO:0060341 136 0.015
negative regulation of cell cycle process GO:0010948 109 0.015
maternal determination of anterior posterior axis embryo GO:0008358 74 0.015
regulation of cell proliferation GO:0042127 163 0.015
regulation of anatomical structure morphogenesis GO:0022603 242 0.015
Fly
endodermal cell differentiation GO:0035987 3 0.015
mesenchymal cell differentiation GO:0048762 1 0.015
regulation of behavior GO:0050795 75 0.014
eye morphogenesis GO:0048592 260 0.014
negative regulation of gene expression epigenetic GO:0045814 77 0.014
negative regulation of nervous system development GO:0051961 92 0.014
cellular macromolecule localization GO:0070727 220 0.014
chorion containing eggshell formation GO:0007304 105 0.014
signal transduction by phosphorylation GO:0023014 107 0.014
cation transport GO:0006812 110 0.014
localization of cell GO:0051674 257 0.014
neuron projection guidance GO:0097485 241 0.014
Fly
single organism biosynthetic process GO:0044711 206 0.014
dorsal ventral axis specification GO:0009950 66 0.014
regulation of epithelial cell differentiation GO:0030856 4 0.014
cell motility GO:0048870 251 0.014
chromatin silencing GO:0006342 76 0.014
homeostatic process GO:0042592 199 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
Fly
negative regulation of cell cycle GO:0045786 116 0.014
protein maturation GO:0051604 71 0.014
regulation of production of molecular mediator of immune response GO:0002700 44 0.014
mating GO:0007618 120 0.014
embryonic development via the syncytial blastoderm GO:0001700 148 0.014
response to lipopolysaccharide GO:0032496 4 0.014
macromolecule catabolic process GO:0009057 161 0.014
mrna metabolic process GO:0016071 124 0.013
developmental growth GO:0048589 280 0.013
dna metabolic process GO:0006259 227 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
hindgut morphogenesis GO:0007442 58 0.013
growth GO:0040007 359 0.013
establishment of protein localization GO:0045184 163 0.013
regulation of intracellular signal transduction GO:1902531 236 0.013
antimicrobial peptide production GO:0002775 46 0.013
central nervous system development GO:0007417 201 0.013
regulation of response to biotic stimulus GO:0002831 63 0.013
mesenchymal cell development GO:0014031 1 0.013
peptide biosynthetic process GO:0043043 42 0.013
regulation of chromatin silencing GO:0031935 36 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
Fly
regulation of reproductive process GO:2000241 54 0.013
dorsal ventral pattern formation GO:0009953 133 0.013
digestive system development GO:0055123 149 0.013
Fly
rna localization GO:0006403 115 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
spindle elongation GO:0051231 83 0.013
endomembrane system organization GO:0010256 119 0.013
chromosome segregation GO:0007059 157 0.013
cellular response to carbohydrate stimulus GO:0071322 4 0.013
digestive tract development GO:0048565 149 0.013
Fly
adult behavior GO:0030534 137 0.013
defense response to other organism GO:0098542 225 0.012
dendrite morphogenesis GO:0048813 199 0.012
regulation of organelle organization GO:0033043 196 0.012
production of molecular mediator of immune response GO:0002440 46 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
Fly
positive regulation of cell motility GO:2000147 3 0.012
cell death GO:0008219 279 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
Fly
behavioral response to pain GO:0048266 3 0.012
regulation of defense response GO:0031347 102 0.012
positive regulation of transport GO:0051050 92 0.012
gland development GO:0048732 191 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
regulation of synapse structure and activity GO:0050803 128 0.012
regulation of immune effector process GO:0002697 52 0.012
ovarian follicle cell development GO:0030707 248 0.012
positive regulation of cell migration GO:0030335 2 0.012
regulation of antimicrobial humoral response GO:0002759 50 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
camera type eye morphogenesis GO:0048593 2 0.012
mapk cascade GO:0000165 107 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.012
cell cycle phase transition GO:0044770 140 0.012
defense response to bacterium GO:0042742 178 0.012
regulation of cellular amide metabolic process GO:0034248 39 0.012
regulation of cell development GO:0060284 215 0.012
Fly
regulation of mapk cascade GO:0043408 92 0.012
response to alcohol GO:0097305 95 0.012
response to extracellular stimulus GO:0009991 116 0.012
response to organophosphorus GO:0046683 2 0.012
regulation of mitotic cell cycle phase transition GO:1901990 130 0.012
positive regulation of antimicrobial humoral response GO:0002760 28 0.012
regulation of molecular function GO:0065009 217 0.012
regulation of antimicrobial peptide production GO:0002784 44 0.012
regulation of cell division GO:0051302 72 0.012
actin filament organization GO:0007015 126 0.012
sterol homeostasis GO:0055092 4 0.012
somatic muscle development GO:0007525 66 0.012
peptidyl proline hydroxylation GO:0019511 1 0.012
cytokinesis GO:0000910 90 0.012
death GO:0016265 284 0.012
regulation of cell shape GO:0008360 113 0.012
nephron epithelium development GO:0072009 3 0.012
cellular amine metabolic process GO:0044106 12 0.012
regulation of cell differentiation GO:0045595 302 0.011
Fly
adult locomotory behavior GO:0008344 76 0.011
cholesterol homeostasis GO:0042632 3 0.011
actin cytoskeleton organization GO:0030036 206 0.011
pole plasm rna localization GO:0007316 52 0.011
pole plasm assembly GO:0007315 61 0.011
regulation of cell death GO:0010941 173 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
cellular response to ethanol GO:0071361 4 0.011
response to bacterium GO:0009617 198 0.011
rhythmic behavior GO:0007622 76 0.011
neuroblast proliferation GO:0007405 74 0.011
glycerolipid catabolic process GO:0046503 3 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
regulation of mitosis GO:0007088 56 0.011
benzene containing compound metabolic process GO:0042537 3 0.011
response to monosaccharide GO:0034284 4 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
antimicrobial peptide biosynthetic process GO:0002777 38 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.011
pole plasm oskar mrna localization GO:0045451 46 0.011
amine metabolic process GO:0009308 12 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
stem cell proliferation GO:0072089 88 0.011
oocyte anterior posterior axis specification GO:0007314 72 0.011
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.011
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.011
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.011
ras protein signal transduction GO:0007265 88 0.011
anatomical structure homeostasis GO:0060249 97 0.011
mrna processing GO:0006397 104 0.011
regulation of catalytic activity GO:0050790 185 0.011
regulation of cellular component size GO:0032535 98 0.011
protein phosphorylation GO:0006468 169 0.011
cellular protein localization GO:0034613 160 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
leg disc development GO:0035218 92 0.011
respiratory system development GO:0060541 213 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.011
ion transmembrane transport GO:0034220 122 0.011
ion transport GO:0006811 145 0.011
cell migration GO:0016477 238 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
regulation of innate immune response GO:0045088 71 0.011
actin filament based process GO:0030029 220 0.011
response to heat GO:0009408 63 0.011
establishment of tissue polarity GO:0007164 87 0.010
cell fate specification GO:0001708 71 0.010
Fly
regulation of apoptotic process GO:0042981 130 0.010
male gamete generation GO:0048232 201 0.010
rna splicing via transesterification reactions GO:0000375 73 0.010
positive regulation of multicellular organismal process GO:0051240 143 0.010
small gtpase mediated signal transduction GO:0007264 88 0.010
positive regulation of cellular protein metabolic process GO:0032270 118 0.010
regulation of programmed cell death GO:0043067 152 0.010
response to hexose GO:0009746 3 0.010
establishment of planar polarity GO:0001736 87 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
intracellular mrna localization GO:0008298 66 0.010
positive regulation of intracellular signal transduction GO:1902533 116 0.010
nephron morphogenesis GO:0072028 3 0.010
salivary gland development GO:0007431 162 0.010
organelle localization GO:0051640 148 0.010
compound eye photoreceptor cell differentiation GO:0001751 140 0.010
photoreceptor cell differentiation GO:0046530 170 0.010
neural precursor cell proliferation GO:0061351 75 0.010
spermatogenesis GO:0007283 200 0.010
nephron tubule development GO:0072080 3 0.010
anion homeostasis GO:0055081 3 0.010
epiboly involved in wound healing GO:0090505 2 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
morphogenesis of a polarized epithelium GO:0001738 93 0.010
secretion GO:0046903 109 0.010
mitotic spindle elongation GO:0000022 81 0.010
aromatic compound catabolic process GO:0019439 166 0.010
cell fate determination GO:0001709 91 0.010
sensory perception of pain GO:0019233 4 0.010
chromatin organization GO:0006325 207 0.010
cuticle development GO:0042335 86 0.010
g2 dna damage checkpoint GO:0031572 69 0.010

zen2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.049
nervous system disease DOID:863 0 0.017
disease of metabolism DOID:0014667 0 0.017
renal tubular transport disease DOID:447 0 0.014
urinary system disease DOID:18 0 0.014
kidney disease DOID:557 0 0.014
inherited metabolic disorder DOID:655 0 0.013
musculoskeletal system disease DOID:17 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
acquired metabolic disease DOID:0060158 0 0.011
carbohydrate metabolism disease DOID:0050013 0 0.010