Drosophila melanogaster

165 known processes

mle (Dmel_CG11680)

maleless

(Aliases: MLE,mll,Dmel\CG11680,mls,nap,CG11680,mak,nap[ts])

mle biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
adult behavior GO:0030534 137 0.975
neuromuscular junction development GO:0007528 149 0.943
synaptic transmission GO:0007268 288 0.913
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.888
synapse organization GO:0050808 196 0.845
establishment of synaptic vesicle localization GO:0097480 50 0.611
synapse assembly GO:0007416 143 0.571
cellular protein modification process GO:0006464 438 0.528
synaptic vesicle transport GO:0048489 50 0.525
regulation of synaptic transmission GO:0050804 69 0.507
synaptic vesicle recycling GO:0036465 28 0.434
regulation of synapse structure and activity GO:0050803 128 0.417
histone h4 acetylation GO:0043967 13 0.413
covalent chromatin modification GO:0016569 106 0.376
synaptic growth at neuromuscular junction GO:0051124 119 0.367
establishment of vesicle localization GO:0051650 51 0.305
histone modification GO:0016570 106 0.297
regulation of synapse assembly GO:0051963 94 0.261
single organism behavior GO:0044708 391 0.251
negative regulation of cellular metabolic process GO:0031324 382 0.248
male mating behavior GO:0060179 70 0.232
metal ion homeostasis GO:0055065 44 0.232
peptidyl lysine modification GO:0018205 57 0.219
positive regulation of synaptic growth at neuromuscular junction GO:0045887 26 0.194
columnar cuboidal epithelial cell development GO:0002066 249 0.188
vesicle localization GO:0051648 55 0.183
chromosome organization GO:0051276 360 0.180
regulation of cellular component biogenesis GO:0044087 201 0.179
cell division GO:0051301 248 0.163
response to organic substance GO:0010033 284 0.161
response to ethanol GO:0045471 59 0.156
locomotory behavior GO:0007626 176 0.155
negative regulation of cell communication GO:0010648 223 0.153
divalent inorganic cation homeostasis GO:0072507 29 0.153
response to temperature stimulus GO:0009266 106 0.143
Mouse
synaptic vesicle endocytosis GO:0048488 28 0.140
positive regulation of growth GO:0045927 75 0.138
protein modification process GO:0036211 438 0.136
protein modification by small protein conjugation GO:0032446 79 0.135
negative regulation of signaling GO:0023057 219 0.130
positive regulation of developmental process GO:0051094 143 0.130
regionalization GO:0003002 416 0.120
establishment of organelle localization GO:0051656 122 0.119
chromosome segregation GO:0007059 157 0.115
phosphorylation GO:0016310 294 0.113
regulation of cell cycle process GO:0010564 181 0.113
establishment of localization in cell GO:0051649 402 0.112
ion transmembrane transport GO:0034220 122 0.109
cellular homeostasis GO:0019725 80 0.108
apoptotic process GO:0006915 159 0.108
cation transmembrane transport GO:0098655 88 0.105
regulation of localization GO:0032879 275 0.102
protein modification by small protein conjugation or removal GO:0070647 106 0.100
g protein coupled receptor signaling pathway GO:0007186 136 0.098
positive regulation of multicellular organismal process GO:0051240 143 0.095
organelle fission GO:0048285 340 0.093
chromatin modification GO:0016568 147 0.093
regulation of developmental growth GO:0048638 174 0.092
cell proliferation GO:0008283 299 0.090
metal ion transport GO:0030001 74 0.089
cellular catabolic process GO:0044248 372 0.088
synaptic vesicle exocytosis GO:0016079 16 0.087
central nervous system development GO:0007417 201 0.086
negative regulation of signal transduction GO:0009968 206 0.086
adult locomotory behavior GO:0008344 76 0.080
cell cycle checkpoint GO:0000075 95 0.080
multi organism reproductive behavior GO:0044705 121 0.078
regulation of neurotransmitter levels GO:0001505 38 0.078
positive regulation of programmed cell death GO:0043068 62 0.077
regulation of transport GO:0051049 181 0.076
macromolecular complex assembly GO:0065003 256 0.075
positive regulation of cellular component biogenesis GO:0044089 80 0.071
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.071
cellular protein localization GO:0034613 160 0.070
positive regulation of cellular component organization GO:0051130 156 0.070
catabolic process GO:0009056 409 0.069
organelle localization GO:0051640 148 0.069
regulation of apoptotic process GO:0042981 130 0.069
regulation of cell cycle GO:0051726 291 0.068
positive regulation of macromolecule metabolic process GO:0010604 405 0.068
positive regulation of cell communication GO:0010647 250 0.068
positive regulation of response to stimulus GO:0048584 323 0.067
regulation of neuron projection development GO:0010975 69 0.067
regulation of response to stress GO:0080134 200 0.067
cellular macromolecule catabolic process GO:0044265 136 0.066
cellular divalent inorganic cation homeostasis GO:0072503 23 0.066
macromolecule catabolic process GO:0009057 161 0.065
endocytosis GO:0006897 310 0.064
positive regulation of signal transduction GO:0009967 223 0.063
organonitrogen compound metabolic process GO:1901564 318 0.062
taxis GO:0042330 304 0.062
negative regulation of cellular component organization GO:0051129 108 0.062
protein catabolic process GO:0030163 101 0.060
regulation of cell death GO:0010941 173 0.060
programmed cell death GO:0012501 257 0.060
peptidyl lysine methylation GO:0018022 16 0.059
synaptic vesicle localization GO:0097479 53 0.059
regulation of blood circulation GO:1903522 21 0.058
regulation of dendrite morphogenesis GO:0048814 28 0.058
axon guidance GO:0007411 233 0.056
regulation of phosphorus metabolic process GO:0051174 210 0.055
modification dependent protein catabolic process GO:0019941 78 0.055
regulation of growth GO:0040008 233 0.055
growth GO:0040007 359 0.054
intracellular transport GO:0046907 228 0.054
chemical homeostasis GO:0048878 92 0.053
regulation of nervous system development GO:0051960 248 0.053
neuron projection guidance GO:0097485 241 0.052
response to radiation GO:0009314 155 0.050
axonogenesis GO:0007409 290 0.050
regulation of gene expression epigenetic GO:0040029 128 0.050
meiotic cell cycle GO:0051321 171 0.050
membrane depolarization GO:0051899 4 0.050
ion homeostasis GO:0050801 55 0.049
vesicle mediated transport GO:0016192 381 0.049
regulation of notch signaling pathway GO:0008593 100 0.048
response to starvation GO:0042594 97 0.048
response to abiotic stimulus GO:0009628 341 0.048
Mouse
regulation of intracellular signal transduction GO:1902531 236 0.047
cell motility GO:0048870 251 0.047
neuromuscular synaptic transmission GO:0007274 67 0.047
negative regulation of cell cycle phase transition GO:1901988 103 0.047
stem cell proliferation GO:0072089 88 0.046
cellular macromolecular complex assembly GO:0034622 153 0.046
neurotransmitter secretion GO:0007269 35 0.045
modification dependent macromolecule catabolic process GO:0043632 79 0.045
protein ubiquitination GO:0016567 70 0.045
meiotic cell cycle process GO:1903046 132 0.045
single organism membrane organization GO:0044802 93 0.044
regulation of mitotic cell cycle GO:0007346 190 0.044
intracellular signal transduction GO:0035556 300 0.043
positive regulation of cellular catabolic process GO:0031331 95 0.043
regulation of response to dna damage stimulus GO:2001020 23 0.043
cation homeostasis GO:0055080 51 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.041
actin cytoskeleton organization GO:0030036 206 0.041
actomyosin structure organization GO:0031032 56 0.041
single organism intracellular transport GO:1902582 207 0.041
regulation of synapse organization GO:0050807 110 0.040
histone h4 k16 acetylation GO:0043984 4 0.040
positive regulation of developmental growth GO:0048639 62 0.040
protein phosphorylation GO:0006468 169 0.039
regulation of membrane potential GO:0042391 35 0.039
histone acetylation GO:0016573 38 0.039
brain development GO:0007420 120 0.039
calcium ion homeostasis GO:0055074 23 0.038
positive regulation of biosynthetic process GO:0009891 316 0.038
inorganic ion transmembrane transport GO:0098660 73 0.038
positive regulation of signaling GO:0023056 243 0.038
oocyte differentiation GO:0009994 145 0.038
regulation of catalytic activity GO:0050790 185 0.038
heterocycle catabolic process GO:0046700 166 0.038
response to decreased oxygen levels GO:0036293 58 0.038
response to extracellular stimulus GO:0009991 116 0.038
developmental growth GO:0048589 280 0.037
protein localization GO:0008104 284 0.037
multicellular organismal reproductive behavior GO:0033057 110 0.035
courtship behavior GO:0007619 68 0.035
regulation of short term neuronal synaptic plasticity GO:0048172 5 0.035
transmission of nerve impulse GO:0019226 12 0.035
positive regulation of synapse assembly GO:0051965 29 0.035
negative regulation of neuron apoptotic process GO:0043524 14 0.035
cellular macromolecule localization GO:0070727 220 0.034
sperm individualization GO:0007291 48 0.034
proteolysis GO:0006508 192 0.034
learning or memory GO:0007611 141 0.034
regulation of response to external stimulus GO:0032101 115 0.034
neuroblast proliferation GO:0007405 74 0.033
meiotic nuclear division GO:0007126 151 0.033
single organism cellular localization GO:1902580 180 0.033
axis specification GO:0009798 167 0.032
cellular cation homeostasis GO:0030003 38 0.032
single organism biosynthetic process GO:0044711 206 0.032
regulation of protein kinase activity GO:0045859 51 0.031
nuclear division GO:0000280 332 0.031
negative regulation of response to stimulus GO:0048585 258 0.031
neurotransmitter transport GO:0006836 37 0.031
rna processing GO:0006396 147 0.031
developmental maturation GO:0021700 172 0.031
regulation of cellular localization GO:0060341 136 0.030
meiotic chromosome segregation GO:0045132 59 0.030
secretion by cell GO:0032940 101 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
negative regulation of chromatin silencing GO:0031936 9 0.029
regulation of programmed cell death GO:0043067 152 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.029
negative regulation of molecular function GO:0044092 51 0.028
response to nutrient levels GO:0031667 114 0.028
regulation of cell division GO:0051302 72 0.028
cellular response to starvation GO:0009267 61 0.028
cytoplasmic transport GO:0016482 130 0.027
small molecule metabolic process GO:0044281 305 0.027
positive regulation of apoptotic process GO:0043065 47 0.027
positive regulation of rna metabolic process GO:0051254 271 0.027
dendrite morphogenesis GO:0048813 199 0.027
anterograde axon cargo transport GO:0008089 6 0.026
negative regulation of cell cycle process GO:0010948 109 0.026
actin filament based process GO:0030029 220 0.026
mitotic cell cycle checkpoint GO:0007093 88 0.025
dendrite development GO:0016358 204 0.025
response to heat GO:0009408 63 0.025
Mouse
regulation of cellular response to stress GO:0080135 89 0.025
response to organic cyclic compound GO:0014070 89 0.025
death GO:0016265 284 0.025
regulation of nuclear division GO:0051783 58 0.025
vesicle organization GO:0016050 44 0.025
ovarian follicle cell development GO:0030707 248 0.024
response to oxidative stress GO:0006979 86 0.024
cellular metal ion homeostasis GO:0006875 31 0.024
organic substance transport GO:0071702 257 0.024
response to endogenous stimulus GO:0009719 119 0.023
regulation of protein metabolic process GO:0051246 256 0.023
cell death GO:0008219 279 0.023
organic substance catabolic process GO:1901575 308 0.023
regulation of neurotransmitter secretion GO:0046928 14 0.023
cellular calcium ion homeostasis GO:0006874 21 0.022
establishment of protein localization GO:0045184 163 0.022
positive regulation of apoptotic signaling pathway GO:2001235 4 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.022
organic cyclic compound catabolic process GO:1901361 168 0.022
spermatid differentiation GO:0048515 114 0.022
response to oxygen levels GO:0070482 59 0.022
microtubule based transport GO:0010970 42 0.021
cell cycle phase transition GO:0044770 140 0.021
synaptic transmission cholinergic GO:0007271 9 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
signal transduction in response to dna damage GO:0042770 3 0.021
regulation of cellular amine metabolic process GO:0033238 3 0.021
aging GO:0007568 143 0.021
defense response to other organism GO:0098542 225 0.020
peptidyl lysine acetylation GO:0018394 39 0.020
cytoplasmic microtubule organization GO:0031122 22 0.020
anterior posterior axis specification GO:0009948 109 0.020
negative regulation of nervous system development GO:0051961 92 0.020
wound healing GO:0042060 75 0.020
peripheral nervous system development GO:0007422 52 0.020
cellular ketone metabolic process GO:0042180 24 0.019
short term memory GO:0007614 19 0.019
regulation of transferase activity GO:0051338 58 0.019
ribonucleotide metabolic process GO:0009259 145 0.018
anterior posterior axis specification embryo GO:0008595 103 0.018
neuronal action potential GO:0019228 10 0.018
phagocytosis GO:0006909 215 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
mitotic sister chromatid separation GO:0051306 30 0.018
exocytosis GO:0006887 28 0.018
negative regulation of gene expression GO:0010629 387 0.017
Worm
cellularization GO:0007349 90 0.017
regulation of cell development GO:0060284 215 0.017
homeostatic process GO:0042592 199 0.017
regulation of cell proliferation GO:0042127 163 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
regulation of mapk cascade GO:0043408 92 0.017
ubiquitin dependent protein catabolic process GO:0006511 78 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 38 0.017
spermatogenesis GO:0007283 200 0.016
regulation of organelle organization GO:0033043 196 0.016
mitotic dna integrity checkpoint GO:0044774 75 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
reproductive behavior GO:0019098 122 0.016
response to hypoxia GO:0001666 53 0.016
regulation of multicellular organismal development GO:2000026 414 0.016
gene silencing by rna GO:0031047 57 0.016
forebrain development GO:0030900 2 0.016
axon cargo transport GO:0008088 29 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
positive regulation of nervous system development GO:0051962 69 0.016
regulation of synaptic vesicle exocytosis GO:2000300 3 0.016
positive regulation of proteolysis GO:0045862 52 0.016
cellular response to dna damage stimulus GO:0006974 223 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.015
regulation of meiosis GO:0040020 3 0.015
bmp signaling pathway GO:0030509 27 0.015
mrna metabolic process GO:0016071 124 0.015
multicellular organismal signaling GO:0035637 12 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
organophosphate metabolic process GO:0019637 195 0.015
neuron neuron synaptic transmission GO:0007270 14 0.015
regulation of synaptic plasticity GO:0048167 14 0.015
chemotaxis GO:0006935 249 0.015
regulation of immune system process GO:0002682 176 0.015
nucleoside catabolic process GO:0009164 112 0.015
gliogenesis GO:0042063 80 0.015
maternal determination of anterior posterior axis embryo GO:0008358 74 0.015
secretion GO:0046903 109 0.015
negative regulation of rna biosynthetic process GO:1902679 240 0.015
positive regulation of cell death GO:0010942 69 0.014
regulation of secretion by cell GO:1903530 39 0.014
terminal button organization GO:0072553 19 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
determination of adult lifespan GO:0008340 137 0.014
regulation of phosphatase activity GO:0010921 3 0.014
segmentation GO:0035282 207 0.014
positive regulation of catabolic process GO:0009896 105 0.014
negative regulation of stem cell proliferation GO:2000647 30 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.014
peptidyl amino acid modification GO:0018193 105 0.014
regulation of cell cycle phase transition GO:1901987 130 0.013
mitotic chromosome condensation GO:0007076 22 0.013
positive regulation of transcription dna templated GO:0045893 266 0.013
negative regulation of organelle organization GO:0010639 56 0.013
single organism catabolic process GO:0044712 228 0.013
chromatin organization GO:0006325 207 0.013
learning GO:0007612 75 0.013
negative regulation of response to oxidative stress GO:1902883 1 0.013
mitotic cytokinesis GO:0000281 50 0.013
camera type eye development GO:0043010 4 0.013
regulation of terminal button organization GO:2000331 11 0.013
internal peptidyl lysine acetylation GO:0018393 38 0.013
receptor recycling GO:0001881 2 0.013
negative regulation of neuron death GO:1901215 18 0.013
spinal cord development GO:0021510 1 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
epithelial cell development GO:0002064 274 0.013
regulation of neurogenesis GO:0050767 158 0.013
purine containing compound metabolic process GO:0072521 155 0.013
membrane organization GO:0061024 112 0.013
regulation of cellular response to oxidative stress GO:1900407 4 0.013
lipid metabolic process GO:0006629 121 0.012
regulation of neuronal synaptic plasticity GO:0048168 8 0.012
chromosome separation GO:0051304 42 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
protein localization to organelle GO:0033365 82 0.012
morphogenesis of an epithelium GO:0002009 276 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
cellular response to external stimulus GO:0071496 66 0.012
regulation of behavior GO:0050795 75 0.012
neural precursor cell proliferation GO:0061351 75 0.012
spindle checkpoint GO:0031577 11 0.012
aromatic compound catabolic process GO:0019439 166 0.012
negative regulation of catalytic activity GO:0043086 42 0.012
signal release GO:0023061 49 0.012
apoptotic signaling pathway GO:0097190 27 0.011
regulation of protein localization GO:0032880 76 0.011
autophagic vacuole assembly GO:0000045 2 0.011
mitotic g2 dna damage checkpoint GO:0007095 69 0.011
neuroblast division GO:0055057 35 0.011
regulation of multi organism process GO:0043900 131 0.011
ribonucleoprotein complex subunit organization GO:0071826 28 0.011
organic acid metabolic process GO:0006082 103 0.011
regulation of protein catabolic process GO:0042176 55 0.011
g1 s transition of mitotic cell cycle GO:0000082 31 0.011
regulation of mitotic cell cycle phase transition GO:1901990 130 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
ribonucleoprotein complex biogenesis GO:0022613 31 0.011
regulation of anatomical structure size GO:0090066 163 0.011
male gamete generation GO:0048232 201 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
Human
protein transport GO:0015031 155 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.010
negative regulation of synapse assembly GO:0051964 39 0.010
nucleotide metabolic process GO:0009117 161 0.010
negative regulation of nucleic acid templated transcription GO:1903507 240 0.010
action potential GO:0001508 13 0.010
cellular response to chemical stimulus GO:0070887 199 0.010
proteasomal protein catabolic process GO:0010498 59 0.010
nucleobase containing compound catabolic process GO:0034655 165 0.010
nucleoside triphosphate catabolic process GO:0009143 108 0.010
nucleoside phosphate catabolic process GO:1901292 110 0.010
synaptic vesicle fusion to presynaptic membrane GO:0031629 7 0.010
positive regulation of notch signaling pathway GO:0045747 34 0.010
mitotic nuclear division GO:0007067 213 0.010

mle disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.017
disease of cellular proliferation DOID:14566 0 0.013
central nervous system disease DOID:331 0 0.011