Drosophila melanogaster

119 known processes

eIF-4a (Dmel_CG9075)

Eukaryotic initiation factor 4a

(Aliases: 2439,9075,Dm-eIF4A,l(2)k01501,anon26A,eIF4a,l(2)gdh-4,l(2)162,eIF-4A,l(2)26Ac,Eif-4a,eIF4A,l(2L)162,eIF 4A,EiF4A,eIF-4a-I,EIF-4A,l(2)02439,Dmel\CG9075,DmRH2,anon-26Aa,Eif4a,eif-4a,CG9075,Su(dpp)YE9,eif4A)

eIF-4a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nuclear division GO:0000280 332 0.974
axon development GO:0061564 297 0.944
positive regulation of gene expression GO:0010628 290 0.913
cell death GO:0008219 279 0.861
apoptotic process GO:0006915 159 0.847
oocyte development GO:0048599 124 0.845
exocrine system development GO:0035272 162 0.843
death GO:0016265 284 0.824
translation GO:0006412 69 0.753
Yeast
embryo development ending in birth or egg hatching GO:0009792 152 0.743
Worm
oocyte differentiation GO:0009994 145 0.731
programmed cell death GO:0012501 257 0.697
salivary gland morphogenesis GO:0007435 145 0.668
growth GO:0040007 359 0.617
histolysis GO:0007559 102 0.591
organelle fission GO:0048285 340 0.584
organelle assembly GO:0070925 198 0.552
spindle organization GO:0007051 253 0.545
negative regulation of cellular metabolic process GO:0031324 382 0.492
axonogenesis GO:0007409 290 0.467
negative regulation of response to stimulus GO:0048585 258 0.458
catabolic process GO:0009056 409 0.445
Yeast
gland morphogenesis GO:0022612 145 0.424
cell growth GO:0016049 108 0.393
cellular catabolic process GO:0044248 372 0.391
Yeast
mitotic nuclear division GO:0007067 213 0.389
rna processing GO:0006396 147 0.375
chemotaxis GO:0006935 249 0.366
vesicle mediated transport GO:0016192 381 0.353
germarium derived egg chamber formation GO:0007293 101 0.343
developmental programmed cell death GO:0010623 138 0.337
mitotic spindle organization GO:0007052 220 0.336
regulation of growth GO:0040008 233 0.335
negative regulation of signal transduction GO:0009968 206 0.319
endocytosis GO:0006897 310 0.314
negative regulation of apoptotic process GO:0043066 63 0.306
establishment of organelle localization GO:0051656 122 0.304
axon guidance GO:0007411 233 0.276
regulation of apoptotic process GO:0042981 130 0.272
regulation of cell differentiation GO:0045595 302 0.249
regulation of protein metabolic process GO:0051246 256 0.247
enzyme linked receptor protein signaling pathway GO:0007167 179 0.244
establishment of localization in cell GO:0051649 402 0.212
pole plasm mrna localization GO:0019094 49 0.205
oocyte construction GO:0007308 112 0.204
meiotic nuclear division GO:0007126 151 0.193
salivary gland development GO:0007431 162 0.188
reproductive structure development GO:0048608 74 0.187
regulation of cell growth GO:0001558 43 0.185
regulation of cell death GO:0010941 173 0.183
determination of adult lifespan GO:0008340 137 0.183
Worm
positive regulation of response to stimulus GO:0048584 323 0.174
positive regulation of macromolecule metabolic process GO:0010604 405 0.173
nucleobase containing compound catabolic process GO:0034655 165 0.164
Yeast
meiotic cell cycle GO:0051321 171 0.162
regulation of programmed cell death GO:0043067 152 0.154
developmental maturation GO:0021700 172 0.152
embryonic development via the syncytial blastoderm GO:0001700 148 0.151
oocyte axis specification GO:0007309 108 0.151
tissue death GO:0016271 102 0.150
centrosome duplication GO:0051298 121 0.145
salivary gland cell autophagic cell death GO:0035071 83 0.134
ribonucleoprotein complex subunit organization GO:0071826 28 0.132
regulation of organ morphogenesis GO:2000027 78 0.129
salivary gland histolysis GO:0035070 88 0.129
mrna metabolic process GO:0016071 124 0.125
gland development GO:0048732 191 0.124
cardiovascular system development GO:0072358 82 0.116
taxis GO:0042330 304 0.116
positive regulation of translation GO:0045727 12 0.114
microtubule organizing center organization GO:0031023 168 0.110
morphogenesis of an epithelium GO:0002009 276 0.107
muscle structure development GO:0061061 224 0.103
cellular macromolecule catabolic process GO:0044265 136 0.103
establishment or maintenance of cell polarity GO:0007163 167 0.100
modification dependent macromolecule catabolic process GO:0043632 79 0.099
guanosine containing compound metabolic process GO:1901068 74 0.098
proteolysis GO:0006508 192 0.097
organic substance catabolic process GO:1901575 308 0.096
Yeast
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.096
larval development GO:0002164 104 0.094
Worm
rna catabolic process GO:0006401 37 0.094
regulation of organelle organization GO:0033043 196 0.092
regulation of translation GO:0006417 56 0.091
response to biotic stimulus GO:0009607 294 0.090
centrosome organization GO:0051297 163 0.088
gastrulation GO:0007369 70 0.086
positive regulation of signaling GO:0023056 243 0.086
autophagic cell death GO:0048102 83 0.084
negative regulation of intracellular signal transduction GO:1902532 57 0.084
positive regulation of protein metabolic process GO:0051247 128 0.082
negative regulation of programmed cell death GO:0043069 72 0.081
neuron projection guidance GO:0097485 241 0.081
cell motility GO:0048870 251 0.080
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.079
embryonic morphogenesis GO:0048598 206 0.078
negative regulation of cell communication GO:0010648 223 0.077
forebrain development GO:0030900 2 0.077
cellular macromolecule localization GO:0070727 220 0.076
centrosome cycle GO:0007098 137 0.074
negative regulation of cell death GO:0060548 81 0.074
cell division GO:0051301 248 0.073
cell fate determination GO:0001709 91 0.073
autophagy GO:0006914 108 0.073
positive regulation of signal transduction GO:0009967 223 0.073
nitrogen compound transport GO:0071705 85 0.073
anterior posterior pattern specification GO:0009952 136 0.072
regulation of multicellular organismal development GO:2000026 414 0.072
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.071
embryonic axis specification GO:0000578 107 0.071
regulation of cellular localization GO:0060341 136 0.070
regulation of cellular ketone metabolic process GO:0010565 3 0.070
sex differentiation GO:0007548 81 0.069
signal transduction by phosphorylation GO:0023014 107 0.068
translational elongation GO:0006414 4 0.068
anterior posterior axis specification embryo GO:0008595 103 0.068
appendage morphogenesis GO:0035107 397 0.067
regionalization GO:0003002 416 0.067
regulation of catabolic process GO:0009894 170 0.067
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.066
hemopoiesis GO:0030097 46 0.066
regulation of endopeptidase activity GO:0052548 36 0.066
cellular nitrogen compound catabolic process GO:0044270 165 0.065
Yeast
positive regulation of cell migration GO:0030335 2 0.065
spindle assembly GO:0051225 80 0.065
regulation of cell cycle GO:0051726 291 0.064
nucleotide metabolic process GO:0009117 161 0.063
Yeast
chromosome organization GO:0051276 360 0.063
chromosome segregation GO:0007059 157 0.062
biological adhesion GO:0022610 138 0.062
regulation of mitotic cell cycle GO:0007346 190 0.061
negative regulation of growth GO:0045926 84 0.060
negative regulation of gene expression GO:0010629 387 0.059
single organismal cell cell adhesion GO:0016337 45 0.059
dna replication GO:0006260 48 0.059
heterocycle catabolic process GO:0046700 166 0.058
Yeast
organonitrogen compound metabolic process GO:1901564 318 0.058
Yeast
body morphogenesis GO:0010171 2 0.058
organic cyclic compound catabolic process GO:1901361 168 0.057
Yeast
developmental growth GO:0048589 280 0.057
appendage development GO:0048736 401 0.056
aging GO:0007568 143 0.056
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.056
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.055
maintenance of location GO:0051235 73 0.055
Worm
germarium derived oocyte differentiation GO:0030706 29 0.054
dorsal ventral axis specification GO:0009950 66 0.053
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.052
regulation of endocytosis GO:0030100 37 0.051
embryonic pattern specification GO:0009880 174 0.051
axis specification GO:0009798 167 0.050
morphogenesis of follicular epithelium GO:0016333 36 0.050
positive regulation of developmental growth GO:0048639 62 0.050
positive regulation of cellular protein metabolic process GO:0032270 118 0.050
epithelial cell migration GO:0010631 148 0.049
macromolecule catabolic process GO:0009057 161 0.049
regulation of cysteine type endopeptidase activity GO:2000116 27 0.047
positive regulation of cell death GO:0010942 69 0.047
rna localization GO:0006403 115 0.046
positive regulation of biosynthetic process GO:0009891 316 0.044
positive regulation of developmental process GO:0051094 143 0.044
positive regulation of cellular catabolic process GO:0031331 95 0.044
regulation of nuclear division GO:0051783 58 0.043
neurological system process GO:0050877 358 0.043
mapk cascade GO:0000165 107 0.042
modification dependent protein catabolic process GO:0019941 78 0.041
nucleobase containing small molecule metabolic process GO:0055086 174 0.041
Yeast
ribonucleoprotein complex assembly GO:0022618 23 0.040
positive regulation of multicellular organismal process GO:0051240 143 0.039
head development GO:0060322 135 0.039
positive regulation of programmed cell death GO:0043068 62 0.038
actin cytoskeleton organization GO:0030036 206 0.037
small molecule metabolic process GO:0044281 305 0.037
Yeast
response to monosaccharide GO:0034284 4 0.037
intracellular signal transduction GO:0035556 300 0.036
single organism biosynthetic process GO:0044711 206 0.036
tissue morphogenesis GO:0048729 297 0.036
nucleus organization GO:0006997 45 0.036
cellular response to oxygen containing compound GO:1901701 79 0.036
photoreceptor cell differentiation GO:0046530 170 0.036
cell proliferation GO:0008283 299 0.036
homeostatic process GO:0042592 199 0.036
single organism cellular localization GO:1902580 180 0.036
brain development GO:0007420 120 0.035
cell recognition GO:0008037 102 0.035
regulation of cellular component biogenesis GO:0044087 201 0.034
positive regulation of nucleic acid templated transcription GO:1903508 266 0.034
mrna catabolic process GO:0006402 33 0.034
cellular homeostasis GO:0019725 80 0.034
positive regulation of cell motility GO:2000147 3 0.034
detection of stimulus GO:0051606 156 0.033
actin filament based process GO:0030029 220 0.033
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.033
purine nucleoside metabolic process GO:0042278 127 0.033
Yeast
ribonucleoside catabolic process GO:0042454 112 0.032
Yeast
imaginal disc derived wing morphogenesis GO:0007476 337 0.032
detection of external stimulus GO:0009581 66 0.032
male gamete generation GO:0048232 201 0.032
regulation of localization GO:0032879 275 0.031
gene silencing GO:0016458 138 0.031
cognition GO:0050890 141 0.031
single organism intracellular transport GO:1902582 207 0.030
cell maturation GO:0048469 144 0.030
regulation of mitotic cell cycle phase transition GO:1901990 130 0.030
localization of cell GO:0051674 257 0.030
organic substance transport GO:0071702 257 0.030
cellular metal ion homeostasis GO:0006875 31 0.028
digestive tract development GO:0048565 149 0.028
aromatic compound catabolic process GO:0019439 166 0.028
Yeast
spindle assembly involved in mitosis GO:0090307 50 0.028
open tracheal system development GO:0007424 204 0.028
cellular protein localization GO:0034613 160 0.027
fertilization GO:0009566 26 0.027
positive regulation of cell communication GO:0010647 250 0.027
negative regulation of developmental process GO:0051093 201 0.027
cellular response to heat GO:0034605 24 0.027
pronuclear migration GO:0035046 4 0.027
nucleoside phosphate metabolic process GO:0006753 162 0.027
Yeast
regulation of rna splicing GO:0043484 69 0.027
cell cycle checkpoint GO:0000075 95 0.027
nucleoside metabolic process GO:0009116 127 0.027
Yeast
phosphorylation GO:0016310 294 0.027
intracellular transport GO:0046907 228 0.026
regulation of cellular protein metabolic process GO:0032268 243 0.026
positive regulation of proteolysis GO:0045862 52 0.026
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.026
regulation of phosphorylation GO:0042325 147 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.026
regulation of cell cycle phase transition GO:1901987 130 0.026
regulation of response to external stimulus GO:0032101 115 0.026
immune system process GO:0002376 347 0.026
posttranscriptional regulation of gene expression GO:0010608 145 0.025
regulation of immune system process GO:0002682 176 0.025
phagocytosis GO:0006909 215 0.025
dendrite morphogenesis GO:0048813 199 0.025
meiotic cell cycle process GO:1903046 132 0.025
eye development GO:0001654 323 0.025
regulation of catalytic activity GO:0050790 185 0.025
cell adhesion GO:0007155 136 0.025
regulation of cellular catabolic process GO:0031329 157 0.024
imaginal disc derived appendage morphogenesis GO:0035114 395 0.024
regulation of response to stress GO:0080134 200 0.024
segmentation GO:0035282 207 0.024
positive regulation of growth GO:0045927 75 0.024
regulation of molecular function GO:0065009 217 0.023
sister chromatid segregation GO:0000819 92 0.023
ribonucleoprotein complex biogenesis GO:0022613 31 0.023
macromolecular complex assembly GO:0065003 256 0.023
purine nucleoside triphosphate metabolic process GO:0009144 119 0.023
Yeast
post embryonic appendage morphogenesis GO:0035120 385 0.022
neuron recognition GO:0008038 101 0.022
oocyte microtubule cytoskeleton organization GO:0016325 35 0.022
central nervous system development GO:0007417 201 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.022
tripartite regional subdivision GO:0007351 103 0.022
cytokinesis GO:0000910 90 0.022
cellular response to dna damage stimulus GO:0006974 223 0.022
single organism catabolic process GO:0044712 228 0.022
Yeast
microtubule based transport GO:0010970 42 0.022
positive regulation of apoptotic process GO:0043065 47 0.021
cellular ketone metabolic process GO:0042180 24 0.021
negative regulation of biosynthetic process GO:0009890 277 0.021
reproductive system development GO:0061458 74 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
camera type eye development GO:0043010 4 0.021
positive regulation of phosphorus metabolic process GO:0010562 139 0.020
digestive system development GO:0055123 149 0.020
digestive tract morphogenesis GO:0048546 127 0.020
nuclear transcribed mrna catabolic process GO:0000956 24 0.020
regulation of behavior GO:0050795 75 0.020
maintenance of protein location in cell GO:0032507 26 0.020
motor neuron axon guidance GO:0008045 58 0.020
regulation of mapk cascade GO:0043408 92 0.020
glycosyl compound metabolic process GO:1901657 127 0.020
Yeast
positive regulation of rna biosynthetic process GO:1902680 266 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.019
dendrite development GO:0016358 204 0.019
establishment of cell polarity GO:0030010 40 0.019
ameboidal type cell migration GO:0001667 151 0.019
positive regulation of rna metabolic process GO:0051254 271 0.019
establishment of rna localization GO:0051236 47 0.019
double strand break repair GO:0006302 26 0.019
convergent extension GO:0060026 2 0.019
meiotic cytokinesis GO:0033206 33 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
mitotic spindle elongation GO:0000022 81 0.018
muscle organ development GO:0007517 127 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.018
instar larval development GO:0002168 55 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
regulation of ras protein signal transduction GO:0046578 93 0.018
multicellular organismal aging GO:0010259 140 0.018
Worm
positive regulation of cellular component organization GO:0051130 156 0.018
mitotic cell cycle phase transition GO:0044772 138 0.018
regulation of developmental growth GO:0048638 174 0.018
regulation of cell proliferation GO:0042127 163 0.018
positive regulation of hydrolase activity GO:0051345 78 0.018
oocyte dorsal ventral axis specification GO:0007310 34 0.018
cellular response to lipid GO:0071396 20 0.018
negative regulation of cell cycle process GO:0010948 109 0.017
purine ribonucleoside metabolic process GO:0046128 127 0.017
Yeast
gonad development GO:0008406 50 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
Yeast
nuclear transport GO:0051169 72 0.017
autophagic vacuole assembly GO:0000045 2 0.017
nucleoside biosynthetic process GO:0009163 3 0.017
spermatogenesis GO:0007283 200 0.017
cytoplasmic transport GO:0016482 130 0.017
anterior posterior axis specification GO:0009948 109 0.017
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.017
purine ribonucleotide metabolic process GO:0009150 145 0.016
Yeast
developmental cell growth GO:0048588 52 0.016
organelle localization GO:0051640 148 0.016
purine nucleoside biosynthetic process GO:0042451 3 0.016
spermatid differentiation GO:0048515 114 0.016
regulation of cell projection organization GO:0031344 92 0.016
gene silencing by rna GO:0031047 57 0.016
pole plasm assembly GO:0007315 61 0.016
rna interference GO:0016246 27 0.016
cellular macromolecular complex assembly GO:0034622 153 0.016
negative regulation of translation GO:0017148 28 0.016
nucleotide catabolic process GO:0009166 109 0.015
Yeast
development of primary sexual characteristics GO:0045137 50 0.015
ribosomal large subunit biogenesis GO:0042273 1 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
nucleobase containing compound transport GO:0015931 56 0.015
regulation of proteolysis GO:0030162 87 0.015
ribonucleoside monophosphate biosynthetic process GO:0009156 3 0.015
regulation of notch signaling pathway GO:0008593 100 0.015
regulation of mitosis GO:0007088 56 0.015
regulation of phosphatase activity GO:0010921 3 0.015
cellularization GO:0007349 90 0.015
imaginal disc derived appendage development GO:0048737 399 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.015
larval midgut cell programmed cell death GO:0035096 19 0.015
response to hexose GO:0009746 3 0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.015
response to oxygen containing compound GO:1901700 200 0.014
regulation of anatomical structure morphogenesis GO:0022603 242 0.014
cuticle development GO:0042335 86 0.014
regulation of neurogenesis GO:0050767 158 0.014
oxoacid metabolic process GO:0043436 103 0.014
retina development in camera type eye GO:0060041 4 0.014
actomyosin structure organization GO:0031032 56 0.014
chemical homeostasis GO:0048878 92 0.014
receptor mediated endocytosis GO:0006898 21 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.014
positive regulation of transcription dna templated GO:0045893 266 0.014
negative regulation of catalytic activity GO:0043086 42 0.014
negative regulation of molecular function GO:0044092 51 0.014
substrate adhesion dependent cell spreading GO:0034446 2 0.014
detection of abiotic stimulus GO:0009582 66 0.013
negative regulation of cell cycle phase transition GO:1901988 103 0.013
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.013
purine containing compound catabolic process GO:0072523 112 0.013
Yeast
proteasomal protein catabolic process GO:0010498 59 0.013
positive regulation of cell differentiation GO:0045597 64 0.013
cell migration GO:0016477 238 0.013
germarium derived oocyte fate determination GO:0007294 26 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
cellular protein catabolic process GO:0044257 83 0.013
carbohydrate derivative metabolic process GO:1901135 217 0.013
Yeast
circulatory system development GO:0072359 82 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
Yeast
rna transport GO:0050658 46 0.013
respiratory system development GO:0060541 213 0.012
carbohydrate homeostasis GO:0033500 12 0.012
notch signaling pathway GO:0007219 120 0.012
positive regulation of molecular function GO:0044093 136 0.012
nuclear export GO:0051168 24 0.012
stem cell division GO:0017145 69 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.012
Yeast
ribonucleoside metabolic process GO:0009119 127 0.012
Yeast
purine containing compound metabolic process GO:0072521 155 0.012
Yeast
protein localization GO:0008104 284 0.012
response to organic substance GO:0010033 284 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
Yeast
response to ecdysone GO:0035075 34 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.012
Yeast
regulation of cell development GO:0060284 215 0.012
negative regulation of transcription dna templated GO:0045892 237 0.012
negative regulation of mapk cascade GO:0043409 23 0.012
oocyte fate determination GO:0030716 27 0.012
dorsal closure GO:0007391 79 0.012
protein catabolic process GO:0030163 101 0.011
carbohydrate metabolic process GO:0005975 82 0.011
regulation of neuron projection development GO:0010975 69 0.011
regulation of cellular response to stress GO:0080135 89 0.011
mesoderm development GO:0007498 78 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
Yeast
response to other organism GO:0051707 293 0.011
chromatin silencing GO:0006342 76 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
axon extension GO:0048675 32 0.011
maintenance of protein location GO:0045185 28 0.011
protein modification process GO:0036211 438 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
regulation of hydrolase activity GO:0051336 97 0.011
response to heat GO:0009408 63 0.011
single fertilization GO:0007338 24 0.011
axon cargo transport GO:0008088 29 0.011
heart morphogenesis GO:0003007 32 0.011
regulation of mrna metabolic process GO:1903311 72 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
Yeast
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.010
cell type specific apoptotic process GO:0097285 38 0.010
stem cell development GO:0048864 79 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.010
convergent extension involved in gastrulation GO:0060027 2 0.010

eIF-4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org