Drosophila melanogaster

51 known processes

rk (Dmel_CG8930)

rickets

(Aliases: DLGR2,rk/CG8930,CT25644,BG:DS00180.13,LGR2,CG8930,DLGR-2,Dmel\CG8930)

rk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mating behavior GO:0007617 106 0.918
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.844
positive regulation of macromolecule metabolic process GO:0010604 405 0.824
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.720
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.716
Mouse
developmental maturation GO:0021700 172 0.676
molting cycle process GO:0022404 29 0.655
transcription from rna polymerase ii promoter GO:0006366 368 0.534
adult chitin containing cuticle pigmentation GO:0048085 16 0.446
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.393
male mating behavior GO:0060179 70 0.389
positive regulation of biosynthetic process GO:0009891 316 0.385
Mouse
imaginal disc derived appendage morphogenesis GO:0035114 395 0.363
epithelial cell migration GO:0010631 148 0.336
circadian behavior GO:0048512 76 0.335
digestive tract development GO:0048565 149 0.320
post embryonic appendage morphogenesis GO:0035120 385 0.297
positive regulation of nucleic acid templated transcription GO:1903508 266 0.283
Mouse
regulation of cell cycle GO:0051726 291 0.269
positive regulation of cellular biosynthetic process GO:0031328 316 0.266
Mouse
regulation of developmental pigmentation GO:0048070 24 0.264
positive regulation of rna metabolic process GO:0051254 271 0.257
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.251
Mouse
developmental pigmentation GO:0048066 68 0.242
courtship behavior GO:0007619 68 0.237
embryonic pattern specification GO:0009880 174 0.235
cellular response to chemical stimulus GO:0070887 199 0.230
male courtship behavior GO:0008049 63 0.229
stem cell proliferation GO:0072089 88 0.226
regionalization GO:0003002 416 0.212
male courtship behavior veined wing generated song production GO:0045433 20 0.210
mating GO:0007618 120 0.209
positive regulation of transcription dna templated GO:0045893 266 0.205
Mouse
sensory organ morphogenesis GO:0090596 260 0.204
dendrite development GO:0016358 204 0.203
imaginal disc derived appendage development GO:0048737 399 0.202
chitin based cuticle sclerotization GO:0007593 19 0.202
cellular response to organic substance GO:0071310 132 0.200
molting cycle chitin based cuticle GO:0007591 56 0.193
regulation of cuticle pigmentation GO:0048079 16 0.193
tissue morphogenesis GO:0048729 297 0.191
Mouse
positive regulation of rna biosynthetic process GO:1902680 266 0.190
Mouse
pigmentation GO:0043473 75 0.189
cuticle pigmentation GO:0048067 22 0.185
regulation of protein metabolic process GO:0051246 256 0.181
tissue migration GO:0090130 155 0.175
regulation of anatomical structure morphogenesis GO:0022603 242 0.172
Mouse
chemical homeostasis GO:0048878 92 0.170
molting cycle GO:0042303 56 0.162
leg disc morphogenesis GO:0007478 80 0.155
kidney morphogenesis GO:0060993 3 0.145
Mouse
inter male aggressive behavior GO:0002121 60 0.137
positive regulation of signaling GO:0023056 243 0.134
Mouse
regulation of multicellular organismal development GO:2000026 414 0.133
cuticle development GO:0042335 86 0.131
positive regulation of protein metabolic process GO:0051247 128 0.129
positive regulation of cell communication GO:0010647 250 0.129
Mouse
regulation of immune system process GO:0002682 176 0.127
Mouse
positive regulation of response to stimulus GO:0048584 323 0.123
Mouse
regulation of localization GO:0032879 275 0.121
Mouse
cellular response to growth factor stimulus GO:0071363 30 0.120
digestive tract morphogenesis GO:0048546 127 0.113
imaginal disc derived leg morphogenesis GO:0007480 80 0.112
regulation of cell development GO:0060284 215 0.107
leg disc development GO:0035218 92 0.107
columnar cuboidal epithelial cell development GO:0002066 249 0.106
single organism cellular localization GO:1902580 180 0.105
cellular response to endogenous stimulus GO:0071495 80 0.104
appendage morphogenesis GO:0035107 397 0.103
growth GO:0040007 359 0.103
segmentation GO:0035282 207 0.099
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.098
positive regulation of signal transduction GO:0009967 223 0.098
Mouse
regulation of cell differentiation GO:0045595 302 0.095
enzyme linked receptor protein signaling pathway GO:0007167 179 0.094
limb development GO:0060173 1 0.091
immune system process GO:0002376 347 0.090
Mouse
digestive system development GO:0055123 149 0.089
urogenital system development GO:0001655 72 0.088
Mouse
catabolic process GO:0009056 409 0.087
cell division GO:0051301 248 0.086
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.086
Mouse
negative regulation of transcription dna templated GO:0045892 237 0.085
Mouse
positive regulation of developmental process GO:0051094 143 0.085
Mouse
positive regulation of hydrolase activity GO:0051345 78 0.083
multi organism reproductive behavior GO:0044705 121 0.083
response to organic substance GO:0010033 284 0.081
ameboidal type cell migration GO:0001667 151 0.080
circadian rhythm GO:0007623 105 0.079
epithelial cell development GO:0002064 274 0.078
single organism behavior GO:0044708 391 0.078
establishment of localization in cell GO:0051649 402 0.077
Mouse
rhythmic behavior GO:0007622 76 0.077
renal system development GO:0072001 72 0.074
Mouse
embryonic morphogenesis GO:0048598 206 0.073
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.072
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.072
negative regulation of cell differentiation GO:0045596 143 0.071
macromolecule catabolic process GO:0009057 161 0.071
morphogenesis of a branching epithelium GO:0061138 45 0.070
Mouse
cell migration GO:0016477 238 0.069
regulation of cellular catabolic process GO:0031329 157 0.069
response to oxygen containing compound GO:1901700 200 0.068
dendrite morphogenesis GO:0048813 199 0.068
regulation of nervous system development GO:0051960 248 0.067
appendage development GO:0048736 401 0.067
stem cell differentiation GO:0048863 117 0.067
axis specification GO:0009798 167 0.066
negative regulation of rna biosynthetic process GO:1902679 240 0.066
Mouse
positive regulation of wnt signaling pathway GO:0030177 25 0.066
Mouse
blastoderm segmentation GO:0007350 159 0.065
response to mechanical stimulus GO:0009612 28 0.063
brain development GO:0007420 120 0.062
negative regulation of signal transduction GO:0009968 206 0.062
Mouse
embryonic organ development GO:0048568 50 0.061
aggressive behavior GO:0002118 63 0.060
protein modification process GO:0036211 438 0.059
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.058
Mouse
cell motility GO:0048870 251 0.058
regulation of response to stress GO:0080134 200 0.057
Mouse
regulation of molecular function GO:0065009 217 0.057
immune response regulating signaling pathway GO:0002764 2 0.056
Mouse
negative regulation of developmental process GO:0051093 201 0.056
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.053
protein localization GO:0008104 284 0.053
Mouse
positive regulation of gene expression GO:0010628 290 0.052
Mouse
small molecule metabolic process GO:0044281 305 0.052
ovarian follicle cell development GO:0030707 248 0.052
neural precursor cell proliferation GO:0061351 75 0.051
carboxylic acid metabolic process GO:0019752 92 0.051
immune response activating signal transduction GO:0002757 2 0.051
Mouse
proteolysis GO:0006508 192 0.050
regulation of catalytic activity GO:0050790 185 0.049
regulation of phosphorus metabolic process GO:0051174 210 0.049
organonitrogen compound metabolic process GO:1901564 318 0.048
negative regulation of response to stimulus GO:0048585 258 0.048
Mouse
intracellular signal transduction GO:0035556 300 0.047
epithelium migration GO:0090132 148 0.047
limb morphogenesis GO:0035108 1 0.046
reproductive behavior GO:0019098 122 0.046
multi organism behavior GO:0051705 175 0.046
regulation of proteolysis GO:0030162 87 0.046
malpighian tubule development GO:0072002 64 0.045
cell proliferation GO:0008283 299 0.045
Mouse
renal tubule development GO:0061326 64 0.045
Mouse
organic substance catabolic process GO:1901575 308 0.044
positive regulation of cell differentiation GO:0045597 64 0.044
regulation of anatomical structure size GO:0090066 163 0.044
negative regulation of cellular metabolic process GO:0031324 382 0.044
Mouse
embryo development ending in birth or egg hatching GO:0009792 152 0.044
regulation of chitin based cuticle tanning GO:0007564 14 0.044
lipid biosynthetic process GO:0008610 46 0.043
tripartite regional subdivision GO:0007351 103 0.043
male courtship behavior veined wing extension GO:0048065 22 0.043
positive regulation of cellular catabolic process GO:0031331 95 0.043
regulation of cell fate commitment GO:0010453 29 0.042
cellular catabolic process GO:0044248 372 0.042
regulation of neuron projection development GO:0010975 69 0.042
morphogenesis of an epithelium GO:0002009 276 0.042
Mouse
embryonic hindgut morphogenesis GO:0048619 48 0.042
regulation of multicellular organism growth GO:0040014 40 0.041
nephron tubule development GO:0072080 3 0.041
Mouse
hindgut morphogenesis GO:0007442 58 0.041
mesoderm development GO:0007498 78 0.040
regulation of defense response GO:0031347 102 0.040
Mouse
epithelial cell differentiation GO:0030855 322 0.040
negative regulation of cell cycle GO:0045786 116 0.039
regulation of epithelial cell proliferation GO:0050678 4 0.039
positive regulation of cellular protein metabolic process GO:0032270 118 0.039
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.039
rhythmic process GO:0048511 106 0.039
central nervous system development GO:0007417 201 0.038
lipid metabolic process GO:0006629 121 0.038
cellular protein modification process GO:0006464 438 0.038
locomotor rhythm GO:0045475 56 0.038
regulation of intracellular signal transduction GO:1902531 236 0.038
negative regulation of cell fate specification GO:0009996 15 0.037
autophagy GO:0006914 108 0.037
secretion by cell GO:0032940 101 0.036
Mouse
organic substance transport GO:0071702 257 0.036
Mouse
cellular response to oxygen containing compound GO:1901701 79 0.036
positive regulation of synapse assembly GO:0051965 29 0.036
regulation of organ morphogenesis GO:2000027 78 0.035
Mouse
homeostatic process GO:0042592 199 0.035
regulation of cell proliferation GO:0042127 163 0.033
regulation of response to external stimulus GO:0032101 115 0.033
tube morphogenesis GO:0035239 191 0.032
Mouse
eye antennal disc morphogenesis GO:0007455 34 0.032
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.032
single organism biosynthetic process GO:0044711 206 0.032
regulation of protein localization GO:0032880 76 0.032
Mouse
kidney development GO:0001822 3 0.032
Mouse
positive regulation of catabolic process GO:0009896 105 0.032
secretion GO:0046903 109 0.032
Mouse
positive regulation of multicellular organism growth GO:0040018 21 0.031
renal tubule morphogenesis GO:0061333 44 0.031
Mouse
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.031
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.031
Mouse
regulation of neuron differentiation GO:0045664 103 0.031
negative regulation of cell cycle process GO:0010948 109 0.031
endocytosis GO:0006897 310 0.030
multicellular organismal aging GO:0010259 140 0.030
cellular response to abiotic stimulus GO:0071214 58 0.030
determination of adult lifespan GO:0008340 137 0.030
olfactory behavior GO:0042048 97 0.029
single organism intracellular transport GO:1902582 207 0.029
actin filament based process GO:0030029 220 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.029
Mouse
regulation of neurogenesis GO:0050767 158 0.029
sensory perception GO:0007600 196 0.029
establishment of tissue polarity GO:0007164 87 0.029
adult behavior GO:0030534 137 0.029
positive regulation of proteolysis GO:0045862 52 0.029
positive regulation of cell proliferation GO:0008284 47 0.029
muscle organ development GO:0007517 127 0.028
muscle structure development GO:0061061 224 0.028
positive regulation of catalytic activity GO:0043085 118 0.027
regulation of cellular localization GO:0060341 136 0.027
Mouse
cellular macromolecule catabolic process GO:0044265 136 0.027
protein targeting to nucleus GO:0044744 51 0.026
posttranscriptional regulation of gene expression GO:0010608 145 0.026
aging GO:0007568 143 0.026
hindgut development GO:0061525 58 0.026
nephron development GO:0072006 3 0.025
Mouse
head development GO:0060322 135 0.025
epithelial cell proliferation GO:0050673 15 0.025
Mouse
somatic muscle development GO:0007525 66 0.025
regulation of cell cycle process GO:0010564 181 0.025
cellular macromolecule localization GO:0070727 220 0.025
apoptotic process involved in morphogenesis GO:0060561 3 0.025
camera type eye development GO:0043010 4 0.025
positive regulation of growth GO:0045927 75 0.025
regulation of epithelial cell differentiation GO:0030856 4 0.025
regulation of cellular protein metabolic process GO:0032268 243 0.025
torso signaling pathway GO:0008293 21 0.025
smoothened signaling pathway GO:0007224 49 0.024
antennal development GO:0007469 25 0.024
signal transduction by phosphorylation GO:0023014 107 0.024
positive regulation of intracellular signal transduction GO:1902533 116 0.024
cellular protein localization GO:0034613 160 0.024
mapk cascade GO:0000165 107 0.024
regulation of cellular response to stress GO:0080135 89 0.024
imaginal disc derived leg segmentation GO:0036011 26 0.023
locomotory behavior GO:0007626 176 0.023
cation transport GO:0006812 110 0.023
skin development GO:0043588 65 0.023
actin cytoskeleton organization GO:0030036 206 0.023
regulation of cellular amine metabolic process GO:0033238 3 0.023
camera type eye morphogenesis GO:0048593 2 0.023
wnt signaling pathway GO:0016055 98 0.023
Mouse
neural retina development GO:0003407 4 0.023
secondary metabolic process GO:0019748 75 0.023
regulation of phosphatase activity GO:0010921 3 0.022
dorsal ventral pattern formation GO:0009953 133 0.022
nephron epithelium morphogenesis GO:0072088 3 0.022
Mouse
nephron epithelium development GO:0072009 3 0.022
Mouse
anterior posterior pattern specification GO:0009952 136 0.022
localization of cell GO:0051674 257 0.022
positive regulation of phosphorus metabolic process GO:0010562 139 0.022
positive regulation of response to external stimulus GO:0032103 44 0.022
wing disc morphogenesis GO:0007472 344 0.021
negative regulation of nucleic acid templated transcription GO:1903507 240 0.021
Mouse
regulation of establishment of planar polarity GO:0090175 22 0.021
multicellular organismal reproductive behavior GO:0033057 110 0.021
negative regulation of gene expression GO:0010629 387 0.021
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.021
single organism carbohydrate metabolic process GO:0044723 72 0.021
anatomical structure homeostasis GO:0060249 97 0.020
nuclear transport GO:0051169 72 0.020
learning or memory GO:0007611 141 0.020
terminal region determination GO:0007362 25 0.020
nephron tubule morphogenesis GO:0072078 3 0.020
Mouse
positive regulation of developmental growth GO:0048639 62 0.020
negative regulation of biosynthetic process GO:0009890 277 0.020
Mouse
phosphorylation GO:0016310 294 0.019
ubiquitin dependent protein catabolic process GO:0006511 78 0.019
eye pigmentation GO:0048069 43 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
cellular ketone metabolic process GO:0042180 24 0.019
immune effector process GO:0002252 98 0.019
response to nitrogen compound GO:1901698 90 0.018
positive regulation of cell migration GO:0030335 2 0.018
regulation of transport GO:0051049 181 0.018
Mouse
protein localization to organelle GO:0033365 82 0.018
positive regulation of autophagy GO:0010508 21 0.018
multi multicellular organism process GO:0044706 123 0.018
cellular response to ionizing radiation GO:0071479 15 0.018
positive regulation of protein modification process GO:0031401 58 0.018
regulation of canonical wnt signaling pathway GO:0060828 15 0.017
Mouse
response to wounding GO:0009611 94 0.017
positive regulation of molecular function GO:0044093 136 0.017
morphogenesis of a polarized epithelium GO:0001738 93 0.017
establishment or maintenance of cell polarity GO:0007163 167 0.017
camera type eye photoreceptor cell differentiation GO:0060219 2 0.017
regulation of wnt signaling pathway GO:0030111 68 0.017
Mouse
positive regulation of cellular component organization GO:0051130 156 0.017
adult locomotory behavior GO:0008344 76 0.017
extrinsic apoptotic signaling pathway GO:0097191 1 0.017
amine metabolic process GO:0009308 12 0.017
transmembrane transport GO:0055085 139 0.016
connective tissue development GO:0061448 3 0.016
negative regulation of cell death GO:0060548 81 0.016
negative regulation of cellular biosynthetic process GO:0031327 277 0.016
Mouse
epithelial tube morphogenesis GO:0060562 88 0.016
Mouse
embryonic axis specification GO:0000578 107 0.016
cellular amine metabolic process GO:0044106 12 0.016
cellular response to lipid GO:0071396 20 0.016
response to endogenous stimulus GO:0009719 119 0.016
phenol containing compound metabolic process GO:0018958 57 0.016
regulation of nucleotide metabolic process GO:0006140 62 0.016
single organism catabolic process GO:0044712 228 0.016
nuclear import GO:0051170 51 0.016
response to external biotic stimulus GO:0043207 293 0.016
cellular response to nitrogen compound GO:1901699 51 0.015
positive regulation of neurogenesis GO:0050769 41 0.015
hormone metabolic process GO:0042445 33 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
organelle localization GO:0051640 148 0.015
anterior posterior axis specification GO:0009948 109 0.015
synaptic transmission GO:0007268 288 0.015
protein phosphorylation GO:0006468 169 0.015
imaginal disc derived leg joint morphogenesis GO:0016348 15 0.015
biological adhesion GO:0022610 138 0.015
eye antennal disc development GO:0035214 60 0.015
branching morphogenesis of an epithelial tube GO:0048754 45 0.015
Mouse
cell maturation GO:0048469 144 0.014
regulation of intracellular protein transport GO:0033157 46 0.014
establishment of planar polarity GO:0001736 87 0.014
regulation of cell morphogenesis GO:0022604 163 0.014
gastrulation GO:0007369 70 0.014
protein processing GO:0016485 68 0.014
taxis GO:0042330 304 0.014
regulation of programmed cell death GO:0043067 152 0.014
regulation of nucleocytoplasmic transport GO:0046822 35 0.014
response to growth factor GO:0070848 31 0.014
vesicle mediated transport GO:0016192 381 0.014
response to biotic stimulus GO:0009607 294 0.014
negative regulation of immune system process GO:0002683 50 0.014
Mouse
single organismal cell cell adhesion GO:0016337 45 0.014
regulation of cellular component size GO:0032535 98 0.013
metal ion homeostasis GO:0055065 44 0.013
regulation of autophagy GO:0010506 62 0.013
regulation of cell projection organization GO:0031344 92 0.013
mesenchymal cell development GO:0014031 1 0.013
gene silencing by rna GO:0031047 57 0.013
kidney epithelium development GO:0072073 3 0.013
Mouse
sleep GO:0030431 49 0.013
tube development GO:0035295 244 0.013
Mouse
specification of organ identity GO:0010092 3 0.013
negative regulation of multicellular organismal process GO:0051241 142 0.013
Mouse
retina development in camera type eye GO:0060041 4 0.013
compound eye development GO:0048749 307 0.013
ovarian follicle cell migration GO:0007297 121 0.013
positive regulation of mapk cascade GO:0043410 63 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
regulation of protein localization to nucleus GO:1900180 29 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.012
negative regulation of cell communication GO:0010648 223 0.012
Mouse
regulation of cell fate specification GO:0042659 27 0.012
cellular response to hormone stimulus GO:0032870 44 0.012
regulation of phosphorylation GO:0042325 147 0.012
imaginal disc derived wing morphogenesis GO:0007476 337 0.012
regulation of behavior GO:0050795 75 0.012
open tracheal system development GO:0007424 204 0.012
reproductive structure development GO:0048608 74 0.012
Mouse
regulation of multi organism process GO:0043900 131 0.012
antennal morphogenesis GO:0048800 14 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
regulation of immune response GO:0050776 118 0.012
Mouse
positive regulation of immune response GO:0050778 63 0.012
Mouse
dopamine biosynthetic process GO:0042416 3 0.012
regulation of protein modification process GO:0031399 112 0.012
cognition GO:0050890 141 0.012
response to hypoxia GO:0001666 53 0.012
organic acid metabolic process GO:0006082 103 0.012
positive regulation of cell death GO:0010942 69 0.011
multicellular organism growth GO:0035264 46 0.011
malpighian tubule morphogenesis GO:0007443 44 0.011
negative regulation of cell fate commitment GO:0010454 17 0.011
negative regulation of nervous system development GO:0051961 92 0.011
positive regulation of programmed cell death GO:0043068 62 0.011
hindbrain development GO:0030902 2 0.011
cellular response to mechanical stimulus GO:0071260 2 0.011
regulation of catabolic process GO:0009894 170 0.011
intracellular transport GO:0046907 228 0.011
establishment of protein localization GO:0045184 163 0.011
Mouse
nephron morphogenesis GO:0072028 3 0.011
Mouse
mitotic nuclear division GO:0007067 213 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.011
somatic stem cell division GO:0048103 37 0.011
positive regulation of nervous system development GO:0051962 69 0.011
cell fate specification GO:0001708 71 0.011
apoptotic signaling pathway GO:0097190 27 0.011
regulation of peptidase activity GO:0052547 39 0.011
cell fate determination GO:0001709 91 0.011
positive regulation of cell motility GO:2000147 3 0.010
nucleocytoplasmic transport GO:0006913 72 0.010
glycoprotein metabolic process GO:0009100 41 0.010
carbohydrate metabolic process GO:0005975 82 0.010
aromatic compound catabolic process GO:0019439 166 0.010
cellular nitrogen compound catabolic process GO:0044270 165 0.010
border follicle cell migration GO:0007298 113 0.010
intracellular receptor signaling pathway GO:0030522 19 0.010
necrotic cell death GO:0070265 1 0.010
muscle tissue development GO:0060537 30 0.010
central nervous system neuron differentiation GO:0021953 8 0.010
regulation of protein ubiquitination GO:0031396 22 0.010
stem cell development GO:0048864 79 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
cell aging GO:0007569 2 0.010
stem cell maintenance GO:0019827 67 0.010
regulation of mapk cascade GO:0043408 92 0.010
ion transmembrane transport GO:0034220 122 0.010
programmed cell death GO:0012501 257 0.010
reproductive system development GO:0061458 74 0.010
Mouse

rk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016