Drosophila melanogaster

93 known processes

Pk92B (Dmel_CG4720)

Protein kinase at 92B

(Aliases: Ask1,Dmel\CG4720,DPk92B/ASK1,CG4720,DASK1,DASK,MEKK5/ASK1,ASK1,dASK)

Pk92B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of intracellular signal transduction GO:1902531 236 0.316
immune response GO:0006955 246 0.233
organonitrogen compound catabolic process GO:1901565 128 0.199
post embryonic appendage morphogenesis GO:0035120 385 0.192
glycosyl compound catabolic process GO:1901658 112 0.182
imaginal disc derived appendage morphogenesis GO:0035114 395 0.168
regulation of response to stress GO:0080134 200 0.166
homeostatic process GO:0042592 199 0.160
catabolic process GO:0009056 409 0.147
purine ribonucleoside metabolic process GO:0046128 127 0.141
establishment of localization in cell GO:0051649 402 0.133
imaginal disc derived wing morphogenesis GO:0007476 337 0.132
appendage morphogenesis GO:0035107 397 0.129
cell proliferation GO:0008283 299 0.124
defense response to other organism GO:0098542 225 0.124
cellular nitrogen compound catabolic process GO:0044270 165 0.123
ribonucleoside triphosphate catabolic process GO:0009203 108 0.120
positive regulation of response to stimulus GO:0048584 323 0.116
heterocycle catabolic process GO:0046700 166 0.116
negative regulation of signal transduction GO:0009968 206 0.115
positive regulation of signaling GO:0023056 243 0.115
positive regulation of immune response GO:0050778 63 0.114
ribonucleotide catabolic process GO:0009261 109 0.114
nucleotide catabolic process GO:0009166 109 0.113
organophosphate metabolic process GO:0019637 195 0.113
purine nucleoside catabolic process GO:0006152 112 0.108
tube morphogenesis GO:0035239 191 0.104
organic substance catabolic process GO:1901575 308 0.104
regulation of mapk cascade GO:0043408 92 0.104
defense response GO:0006952 300 0.104
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.103
immune response regulating signaling pathway GO:0002764 2 0.102
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.102
single organism behavior GO:0044708 391 0.101
stress activated mapk cascade GO:0051403 52 0.101
macromolecular complex assembly GO:0065003 256 0.100
purine nucleoside triphosphate metabolic process GO:0009144 119 0.098
nucleoside triphosphate metabolic process GO:0009141 120 0.096
small molecule metabolic process GO:0044281 305 0.095
positive regulation of biosynthetic process GO:0009891 316 0.091
imaginal disc derived appendage development GO:0048737 399 0.090
ribose phosphate metabolic process GO:0019693 145 0.090
cell division GO:0051301 248 0.089
morphogenesis of an epithelium GO:0002009 276 0.088
cellular response to chemical stimulus GO:0070887 199 0.087
Human Mouse
organonitrogen compound metabolic process GO:1901564 318 0.087
regulation of cellular response to stress GO:0080135 89 0.084
wing disc morphogenesis GO:0007472 344 0.084
glycosyl compound metabolic process GO:1901657 127 0.084
nucleobase containing compound catabolic process GO:0034655 165 0.084
carbohydrate derivative metabolic process GO:1901135 217 0.083
phosphorylation GO:0016310 294 0.082
response to abiotic stimulus GO:0009628 341 0.082
ribonucleoside triphosphate metabolic process GO:0009199 119 0.081
regulation of purine nucleotide metabolic process GO:1900542 62 0.080
organic cyclic compound catabolic process GO:1901361 168 0.079
purine ribonucleotide metabolic process GO:0009150 145 0.079
response to organic substance GO:0010033 284 0.079
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.077
purine containing compound metabolic process GO:0072521 155 0.076
ribonucleotide metabolic process GO:0009259 145 0.075
gtp metabolic process GO:0046039 72 0.075
cell maturation GO:0048469 144 0.074
negative regulation of gene expression GO:0010629 387 0.072
positive regulation of signal transduction GO:0009967 223 0.072
stem cell differentiation GO:0048863 117 0.071
nucleoside phosphate catabolic process GO:1901292 110 0.070
carbohydrate derivative catabolic process GO:1901136 118 0.070
intracellular signal transduction GO:0035556 300 0.070
transcription from rna polymerase ii promoter GO:0006366 368 0.070
organic substance transport GO:0071702 257 0.070
nucleobase containing small molecule metabolic process GO:0055086 174 0.070
positive regulation of gene expression GO:0010628 290 0.069
ras protein signal transduction GO:0007265 88 0.069
regulation of localization GO:0032879 275 0.068
immune system process GO:0002376 347 0.067
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.067
ribonucleoside metabolic process GO:0009119 127 0.066
regulation of phosphorus metabolic process GO:0051174 210 0.066
appendage development GO:0048736 401 0.066
mapk cascade GO:0000165 107 0.065
nucleoside metabolic process GO:0009116 127 0.065
developmental maturation GO:0021700 172 0.063
response to endogenous stimulus GO:0009719 119 0.063
regulation of epithelial cell proliferation GO:0050678 4 0.062
positive regulation of cell communication GO:0010647 250 0.062
tissue morphogenesis GO:0048729 297 0.062
regulation of multi organism process GO:0043900 131 0.062
regulation of phosphate metabolic process GO:0019220 210 0.061
positive regulation of nucleic acid templated transcription GO:1903508 266 0.061
central nervous system development GO:0007417 201 0.060
regulation of molecular function GO:0065009 217 0.060
Human Mouse
transmembrane transport GO:0055085 139 0.059
purine ribonucleotide catabolic process GO:0009154 109 0.059
nucleotide metabolic process GO:0009117 161 0.059
positive regulation of cellular biosynthetic process GO:0031328 316 0.058
stress activated protein kinase signaling cascade GO:0031098 55 0.058
regulation of phosphorylation GO:0042325 147 0.057
compound eye development GO:0048749 307 0.057
negative regulation of cell communication GO:0010648 223 0.057
molting cycle GO:0042303 56 0.057
nucleoside triphosphate catabolic process GO:0009143 108 0.057
regulation of nucleotide metabolic process GO:0006140 62 0.057
purine nucleotide metabolic process GO:0006163 146 0.056
regulation of nucleoside metabolic process GO:0009118 50 0.056
stem cell maintenance GO:0019827 67 0.056
negative regulation of signaling GO:0023057 219 0.056
positive regulation of catalytic activity GO:0043085 118 0.054
Human Mouse
dna metabolic process GO:0006259 227 0.053
negative regulation of response to stimulus GO:0048585 258 0.053
gtp catabolic process GO:0006184 72 0.052
response to other organism GO:0051707 293 0.052
oocyte development GO:0048599 124 0.051
nucleoside catabolic process GO:0009164 112 0.051
hindgut morphogenesis GO:0007442 58 0.050
negative regulation of developmental process GO:0051093 201 0.049
gland morphogenesis GO:0022612 145 0.047
positive regulation of rna metabolic process GO:0051254 271 0.047
hindgut development GO:0061525 58 0.046
purine ribonucleoside catabolic process GO:0046130 112 0.046
signal transduction by phosphorylation GO:0023014 107 0.046
biological adhesion GO:0022610 138 0.046
neuron projection guidance GO:0097485 241 0.046
purine nucleoside triphosphate catabolic process GO:0009146 108 0.046
aging GO:0007568 143 0.045
regulation of immune system process GO:0002682 176 0.045
positive regulation of phosphate metabolic process GO:0045937 139 0.045
aromatic compound catabolic process GO:0019439 166 0.045
axonogenesis GO:0007409 290 0.045
regulation of developmental pigmentation GO:0048070 24 0.044
dendrite development GO:0016358 204 0.044
purine nucleotide catabolic process GO:0006195 109 0.044
organophosphate catabolic process GO:0046434 112 0.041
dendrite morphogenesis GO:0048813 199 0.041
developmental programmed cell death GO:0010623 138 0.041
regulation of catalytic activity GO:0050790 185 0.041
Human Mouse
nucleoside phosphate metabolic process GO:0006753 162 0.040
regulation of immune response GO:0050776 118 0.040
small gtpase mediated signal transduction GO:0007264 88 0.040
purine containing compound catabolic process GO:0072523 112 0.040
molting cycle chitin based cuticle GO:0007591 56 0.039
cellular protein complex assembly GO:0043623 71 0.039
anterior posterior pattern specification GO:0009952 136 0.039
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.038
cellular catabolic process GO:0044248 372 0.038
cellular macromolecule localization GO:0070727 220 0.038
mitotic nuclear division GO:0007067 213 0.037
regionalization GO:0003002 416 0.037
chemotaxis GO:0006935 249 0.035
response to gravity GO:0009629 26 0.035
cellular response to growth factor stimulus GO:0071363 30 0.035
positive regulation of phosphorus metabolic process GO:0010562 139 0.035
hindbrain development GO:0030902 2 0.035
guanosine containing compound metabolic process GO:1901068 74 0.035
regulation of innate immune response GO:0045088 71 0.034
negative regulation of biosynthetic process GO:0009890 277 0.034
response to bacterium GO:0009617 198 0.034
germarium derived egg chamber formation GO:0007293 101 0.033
organelle fission GO:0048285 340 0.033
regulation of stress activated mapk cascade GO:0032872 41 0.033
single organism catabolic process GO:0044712 228 0.032
ribonucleoside catabolic process GO:0042454 112 0.032
cation transport GO:0006812 110 0.032
positive regulation of mapk cascade GO:0043410 63 0.031
single organism intracellular transport GO:1902582 207 0.031
macromolecule catabolic process GO:0009057 161 0.031
regulation of apoptotic process GO:0042981 130 0.031
Human Mouse
establishment of protein localization GO:0045184 163 0.031
gene silencing GO:0016458 138 0.030
positive regulation of hydrolase activity GO:0051345 78 0.030
Human
response to oxygen containing compound GO:1901700 200 0.030
Human
regulation of nucleotide catabolic process GO:0030811 48 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.030
regulation of anatomical structure morphogenesis GO:0022603 242 0.030
cell migration GO:0016477 238 0.030
positive regulation of transcription dna templated GO:0045893 266 0.029
phagocytosis GO:0006909 215 0.029
positive regulation of histone deacetylation GO:0031065 2 0.029
adherens junction organization GO:0034332 27 0.029
positive regulation of molecular function GO:0044093 136 0.029
Human Mouse
spinal cord development GO:0021510 1 0.029
stem cell proliferation GO:0072089 88 0.029
gland development GO:0048732 191 0.028
purine nucleoside metabolic process GO:0042278 127 0.028
stem cell division GO:0017145 69 0.028
renal system development GO:0072001 72 0.028
immune response activating signal transduction GO:0002757 2 0.028
protein localization GO:0008104 284 0.028
regulation of cellular catabolic process GO:0031329 157 0.028
intracellular transport GO:0046907 228 0.027
regulation of gtp catabolic process GO:0033124 44 0.027
defense response to gram negative bacterium GO:0050829 94 0.027
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.027
negative regulation of cell differentiation GO:0045596 143 0.027
pigmentation GO:0043473 75 0.027
cellular response to endogenous stimulus GO:0071495 80 0.027
regulation of cell shape GO:0008360 113 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.026
actin cytoskeleton organization GO:0030036 206 0.026
regulation of programmed cell death GO:0043067 152 0.026
Human Mouse
gastrulation with mouth forming first GO:0001703 36 0.026
humoral immune response GO:0006959 117 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.025
jnk cascade GO:0007254 50 0.025
regulation of ras gtpase activity GO:0032318 38 0.025
exocrine system development GO:0035272 162 0.025
response to growth factor GO:0070848 31 0.024
cellular response to oxygen containing compound GO:1901701 79 0.024
Human
regulation of jnk cascade GO:0046328 40 0.024
memory GO:0007613 94 0.024
negative regulation of protein metabolic process GO:0051248 85 0.024
regulation of cell death GO:0010941 173 0.024
Human Mouse
growth GO:0040007 359 0.024
regulation of ras protein signal transduction GO:0046578 93 0.024
actin filament organization GO:0007015 126 0.024
response to oxidative stress GO:0006979 86 0.024
Human Mouse
positive regulation of cell differentiation GO:0045597 64 0.024
actin filament based process GO:0030029 220 0.024
spermatogenesis GO:0007283 200 0.023
regulation of cell proliferation GO:0042127 163 0.023
neurological system process GO:0050877 358 0.023
programmed cell death GO:0012501 257 0.023
Human Mouse
positive regulation of developmental process GO:0051094 143 0.023
positive regulation of phosphorylation GO:0042327 87 0.023
protein complex assembly GO:0006461 200 0.023
positive regulation of cell motility GO:2000147 3 0.023
leg disc development GO:0035218 92 0.023
positive regulation of rna biosynthetic process GO:1902680 266 0.023
anatomical structure homeostasis GO:0060249 97 0.023
salivary gland morphogenesis GO:0007435 145 0.022
positive regulation of defense response GO:0031349 59 0.022
death GO:0016265 284 0.022
Human Mouse
response to external biotic stimulus GO:0043207 293 0.022
regulation of cell differentiation GO:0045595 302 0.022
ameboidal type cell migration GO:0001667 151 0.022
regulation of cellular localization GO:0060341 136 0.022
regulation of cell cycle GO:0051726 291 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.022
protein transport GO:0015031 155 0.022
proteolysis GO:0006508 192 0.022
Human
germ line stem cell maintenance GO:0030718 50 0.021
gonad development GO:0008406 50 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
negative regulation of epithelial cell proliferation GO:0050680 4 0.021
regulation of purine nucleotide catabolic process GO:0033121 48 0.021
locomotory behavior GO:0007626 176 0.021
stem cell development GO:0048864 79 0.021
intracellular protein transport GO:0006886 104 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
rho protein signal transduction GO:0007266 14 0.021
olfactory behavior GO:0042048 97 0.021
sensory organ morphogenesis GO:0090596 260 0.021
oocyte differentiation GO:0009994 145 0.021
adult behavior GO:0030534 137 0.020
segmentation GO:0035282 207 0.020
oocyte construction GO:0007308 112 0.020
innate immune response GO:0045087 144 0.020
neural precursor cell proliferation GO:0061351 75 0.020
cell cell junction organization GO:0045216 55 0.020
embryonic organ development GO:0048568 50 0.020
establishment or maintenance of cell polarity GO:0007163 167 0.020
regulation of defense response GO:0031347 102 0.020
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 9 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.020
single organism membrane organization GO:0044802 93 0.019
response to heat GO:0009408 63 0.019
regulation of cell cycle process GO:0010564 181 0.019
response to nitrogen compound GO:1901698 90 0.019
Mouse
positive regulation of cell death GO:0010942 69 0.019
Human Mouse
positive regulation of gtpase activity GO:0043547 43 0.019
positive regulation of cellular catabolic process GO:0031331 95 0.019
vesicle mediated transport GO:0016192 381 0.019
negative regulation of immune system process GO:0002683 50 0.019
muscle organ development GO:0007517 127 0.018
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.018
protein modification by small protein conjugation or removal GO:0070647 106 0.018
response to extracellular stimulus GO:0009991 116 0.018
positive regulation of nucleotide metabolic process GO:0045981 55 0.018
male gamete generation GO:0048232 201 0.018
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.018
apoptotic process GO:0006915 159 0.018
Human Mouse
regulation of multicellular organismal development GO:2000026 414 0.018
body morphogenesis GO:0010171 2 0.018
positive regulation of immune system process GO:0002684 68 0.018
cellular protein modification process GO:0006464 438 0.018
Human Mouse
positive regulation of nucleoside metabolic process GO:0045979 47 0.018
defense response to bacterium GO:0042742 178 0.018
salivary gland development GO:0007431 162 0.018
negative regulation of rna metabolic process GO:0051253 251 0.018
oocyte axis specification GO:0007309 108 0.018
negative regulation of cellular protein metabolic process GO:0032269 85 0.018
digestive tract morphogenesis GO:0048546 127 0.017
regulation of dna metabolic process GO:0051052 34 0.017
positive regulation of nucleotide catabolic process GO:0030813 46 0.017
embryonic hindgut morphogenesis GO:0048619 48 0.017
regulation of gtpase activity GO:0043087 44 0.017
negative regulation of transcription dna templated GO:0045892 237 0.017
adult chitin containing cuticle pigmentation GO:0048085 16 0.017
compound eye morphogenesis GO:0001745 249 0.017
cell death GO:0008219 279 0.017
Human Mouse
cell fate determination GO:0001709 91 0.017
axon guidance GO:0007411 233 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
cellular response to lipopolysaccharide GO:0071222 3 0.017
wnt signaling pathway GO:0016055 98 0.016
endocytosis GO:0006897 310 0.016
protein modification process GO:0036211 438 0.016
Human Mouse
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.016
cytoplasmic transport GO:0016482 130 0.016
cuticle pigmentation GO:0048067 22 0.016
eye development GO:0001654 323 0.016
negative regulation of dna dependent dna replication GO:2000104 2 0.016
urogenital system development GO:0001655 72 0.015
cellular response to organic substance GO:0071310 132 0.015
regulation of protein deacetylation GO:0090311 2 0.015
cellular protein localization GO:0034613 160 0.015
response to hormone GO:0009725 45 0.015
hematopoietic progenitor cell differentiation GO:0002244 1 0.015
regulation of protein localization GO:0032880 76 0.015
spindle organization GO:0007051 253 0.015
positive regulation of ras gtpase activity GO:0032320 36 0.015
antimicrobial humoral response GO:0019730 99 0.015
muscle structure development GO:0061061 224 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
Human Mouse
ovarian follicle cell development GO:0030707 248 0.015
malpighian tubule development GO:0072002 64 0.014
localization of cell GO:0051674 257 0.014
lipid metabolic process GO:0006629 121 0.014
embryonic pattern specification GO:0009880 174 0.014
axon development GO:0061564 297 0.014
epithelial cell migration open tracheal system GO:0007427 32 0.014
ion transport GO:0006811 145 0.014
activation of innate immune response GO:0002218 4 0.014
regulation of gene expression epigenetic GO:0040029 128 0.014
nitrogen compound transport GO:0071705 85 0.014
mrna processing GO:0006397 104 0.014
regulation of notch signaling pathway GO:0008593 100 0.014
response to biotic stimulus GO:0009607 294 0.014
leg disc morphogenesis GO:0007478 80 0.014
gene silencing by rna GO:0031047 57 0.014
forebrain development GO:0030900 2 0.014
ribonucleoside monophosphate metabolic process GO:0009161 51 0.014
protein processing GO:0016485 68 0.014
Human
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
secretion by cell GO:0032940 101 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
Human Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.014
epithelial cell differentiation GO:0030855 322 0.014
positive regulation of cell migration GO:0030335 2 0.014
epithelial cell development GO:0002064 274 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.013
dorsal closure GO:0007391 79 0.013
morphogenesis of a branching structure GO:0001763 45 0.013
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.013
cellular homeostasis GO:0019725 80 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
head development GO:0060322 135 0.013
epidermis development GO:0008544 65 0.013
tripartite regional subdivision GO:0007351 103 0.013
response to lipopolysaccharide GO:0032496 4 0.013
camera type eye development GO:0043010 4 0.013
negative regulation of intracellular signal transduction GO:1902532 57 0.013
organelle assembly GO:0070925 198 0.013
molting cycle process GO:0022404 29 0.013
cell adhesion GO:0007155 136 0.013
peptide metabolic process GO:0006518 80 0.012
regulation of mitotic cell cycle GO:0007346 190 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
renal tubule morphogenesis GO:0061333 44 0.012
negative regulation of cellular biosynthetic process GO:0031327 277 0.012
connective tissue development GO:0061448 3 0.012
regulation of phosphatase activity GO:0010921 3 0.012
membrane organization GO:0061024 112 0.012
determination of adult lifespan GO:0008340 137 0.012
positive regulation of programmed cell death GO:0043068 62 0.012
Human Mouse
regulation of establishment of protein localization GO:0070201 61 0.012
developmental pigmentation GO:0048066 68 0.012
protein catabolic process GO:0030163 101 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
tissue death GO:0016271 102 0.012
response to organic cyclic compound GO:0014070 89 0.012
cellular component assembly involved in morphogenesis GO:0010927 151 0.012
protein phosphorylation GO:0006468 169 0.011
Human Mouse
autophagic cell death GO:0048102 83 0.011
eye morphogenesis GO:0048592 260 0.011
nucleoside monophosphate metabolic process GO:0009123 52 0.011
nuclear division GO:0000280 332 0.011
taxis GO:0042330 304 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.011
regulation of histone deacetylation GO:0031063 2 0.011
negative regulation of multicellular organismal process GO:0051241 142 0.011
regulation of hydrolase activity GO:0051336 97 0.011
Human
positive regulation of catabolic process GO:0009896 105 0.011
positive regulation of jun kinase activity GO:0043507 4 0.011
carboxylic acid metabolic process GO:0019752 92 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
negative regulation of cell proliferation GO:0008285 69 0.011
response to wounding GO:0009611 94 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
positive regulation of stress activated mapk cascade GO:0032874 17 0.011
protein secretion GO:0009306 45 0.011
cellular response to lipid GO:0071396 20 0.010
regulation of transport GO:0051049 181 0.010
regulation of catabolic process GO:0009894 170 0.010
single organism cellular localization GO:1902580 180 0.010
cellular amide metabolic process GO:0043603 80 0.010
negative regulation of cell death GO:0060548 81 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.010
negative regulation of dna endoreduplication GO:0032876 2 0.010
secretion GO:0046903 109 0.010
catechol containing compound biosynthetic process GO:0009713 3 0.010
regulation of cell division GO:0051302 72 0.010

Pk92B disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.020
disease of metabolism DOID:0014667 0 0.015
disease of cellular proliferation DOID:14566 0 0.011