Drosophila melanogaster

85 known processes

Hr4 (Dmel_CG16902)

CG16902 gene product from transcript CG16902-RC

(Aliases: NR6A2,CG16902,DHR4,GRF,EG:133E12.2,Dmel\CG16902)

Hr4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
circadian rhythm GO:0007623 105 0.746
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.635
Mouse
negative regulation of rna biosynthetic process GO:1902679 240 0.413
Mouse
positive regulation of biosynthetic process GO:0009891 316 0.301
Mouse Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.294
Mouse Fly
growth GO:0040007 359 0.285
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.262
Mouse
gene silencing GO:0016458 138 0.222
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.215
Mouse
cellular ketone metabolic process GO:0042180 24 0.189
positive regulation of rna metabolic process GO:0051254 271 0.188
Mouse Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.170
Mouse Fly
positive regulation of macromolecule metabolic process GO:0010604 405 0.168
Mouse Fly
cell death GO:0008219 279 0.167
regulation of gene expression epigenetic GO:0040029 128 0.165
vesicle mediated transport GO:0016192 381 0.148
negative regulation of cellular metabolic process GO:0031324 382 0.144
Mouse
regulation of immune system process GO:0002682 176 0.138
negative regulation of signal transduction GO:0009968 206 0.131
steroid biosynthetic process GO:0006694 16 0.129
immune system process GO:0002376 347 0.122
negative regulation of rna metabolic process GO:0051253 251 0.120
Mouse
cell fate specification GO:0001708 71 0.115
posttranscriptional regulation of gene expression GO:0010608 145 0.114
rhythmic process GO:0048511 106 0.111
positive regulation of nucleic acid templated transcription GO:1903508 266 0.109
Mouse Fly
eye development GO:0001654 323 0.100
negative regulation of biosynthetic process GO:0009890 277 0.099
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.096
Mouse Fly
organic hydroxy compound metabolic process GO:1901615 83 0.093
programmed cell death GO:0012501 257 0.080
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.080
Mouse
regulation of gene silencing GO:0060968 63 0.077
negative regulation of transcription dna templated GO:0045892 237 0.076
Mouse
apoptotic process GO:0006915 159 0.076
negative regulation of cell communication GO:0010648 223 0.071
eye photoreceptor cell differentiation GO:0001754 145 0.070
positive regulation of developmental growth GO:0048639 62 0.068
positive regulation of rna biosynthetic process GO:1902680 266 0.067
Mouse Fly
negative regulation of nucleic acid templated transcription GO:1903507 240 0.067
Mouse
regulation of programmed cell death GO:0043067 152 0.066
immune response GO:0006955 246 0.065
regionalization GO:0003002 416 0.065
Fly
actin cytoskeleton organization GO:0030036 206 0.064
circadian behavior GO:0048512 76 0.062
endocytosis GO:0006897 310 0.059
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.058
Mouse Fly
regulation of hormone levels GO:0010817 40 0.056
death GO:0016265 284 0.055
cellular protein modification process GO:0006464 438 0.054
regulation of cell death GO:0010941 173 0.052
cellular response to organic substance GO:0071310 132 0.051
Fly
negative regulation of gene expression epigenetic GO:0045814 77 0.049
eye morphogenesis GO:0048592 260 0.048
regulation of chromatin silencing GO:0031935 36 0.048
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.046
Mouse
positive regulation of response to stimulus GO:0048584 323 0.046
regulation of cellular component size GO:0032535 98 0.046
cellular response to nutrient levels GO:0031669 62 0.046
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.046
mesenchymal cell development GO:0014031 1 0.043
cellular response to chemical stimulus GO:0070887 199 0.042
cellular response to dna damage stimulus GO:0006974 223 0.041
cation transport GO:0006812 110 0.041
rhythmic behavior GO:0007622 76 0.040
negative regulation of signaling GO:0023057 219 0.040
regulation of photoreceptor cell differentiation GO:0046532 34 0.039
signal transduction in response to dna damage GO:0042770 3 0.039
cellular response to extracellular stimulus GO:0031668 64 0.038
regulation of protein acetylation GO:1901983 7 0.038
actin filament based process GO:0030029 220 0.037
ion transmembrane transport GO:0034220 122 0.035
negative regulation of gene expression GO:0010629 387 0.035
Mouse
positive regulation of gene expression GO:0010628 290 0.034
Mouse Fly
muscle organ development GO:0007517 127 0.034
instar larval development GO:0002168 55 0.032
multi multicellular organism process GO:0044706 123 0.032
gene silencing by mirna GO:0035195 22 0.032
regulation of intracellular signal transduction GO:1902531 236 0.031
cell cycle phase transition GO:0044770 140 0.031
homeostatic process GO:0042592 199 0.031
Fly
regulation of mitotic cell cycle phase transition GO:1901990 130 0.030
organic acid metabolic process GO:0006082 103 0.030
chromatin silencing GO:0006342 76 0.029
proteasomal protein catabolic process GO:0010498 59 0.029
negative regulation of response to stimulus GO:0048585 258 0.029
secretion by cell GO:0032940 101 0.029
organic substance catabolic process GO:1901575 308 0.028
small molecule metabolic process GO:0044281 305 0.028
regulation of apoptotic process GO:0042981 130 0.028
regulation of anatomical structure morphogenesis GO:0022603 242 0.028
response to extracellular stimulus GO:0009991 116 0.027
regulation of cellular localization GO:0060341 136 0.027
regulation of response to stress GO:0080134 200 0.026
photoreceptor cell development GO:0042461 96 0.025
cell motility GO:0048870 251 0.025
regulation of catalytic activity GO:0050790 185 0.025
locomotor rhythm GO:0045475 56 0.025
developmental growth GO:0048589 280 0.025
translation GO:0006412 69 0.025
cellular protein localization GO:0034613 160 0.025
positive regulation of chromosome segregation GO:0051984 10 0.024
regulation of protein metabolic process GO:0051246 256 0.023
positive regulation of growth GO:0045927 75 0.023
positive regulation of multicellular organismal process GO:0051240 143 0.023
Worm
response to sterol GO:0036314 34 0.023
dendrite development GO:0016358 204 0.023
Fly
molting cycle GO:0042303 56 0.023
positive regulation of transcription dna templated GO:0045893 266 0.023
Mouse Fly
cell fate determination GO:0001709 91 0.022
regulation of notch signaling pathway GO:0008593 100 0.022
regulation of steroid metabolic process GO:0019218 2 0.022
lipid biosynthetic process GO:0008610 46 0.022
protein modification process GO:0036211 438 0.022
chitin based cuticle development GO:0040003 49 0.022
alcohol metabolic process GO:0006066 25 0.021
positive regulation of cellular biosynthetic process GO:0031328 316 0.021
Mouse Fly
dna metabolic process GO:0006259 227 0.021
modification dependent protein catabolic process GO:0019941 78 0.021
chromosome organization GO:0051276 360 0.021
photoreceptor cell differentiation GO:0046530 170 0.020
regulation of cellular ketone metabolic process GO:0010565 3 0.020
developmental programmed cell death GO:0010623 138 0.020
negative regulation of cell death GO:0060548 81 0.020
notch signaling pathway GO:0007219 120 0.020
negative regulation of mitotic cell cycle GO:0045930 109 0.020
transcription from rna polymerase ii promoter GO:0006366 368 0.020
nitrogen compound transport GO:0071705 85 0.019
regulation of organ morphogenesis GO:2000027 78 0.019
regulation of cell fate specification GO:0042659 27 0.019
regulation of cell cycle process GO:0010564 181 0.019
sensory organ morphogenesis GO:0090596 260 0.019
compound eye morphogenesis GO:0001745 249 0.019
sex differentiation GO:0007548 81 0.019
positive regulation of signaling GO:0023056 243 0.019
organic hydroxy compound biosynthetic process GO:1901617 21 0.019
positive regulation of molecular function GO:0044093 136 0.019
innate immune response GO:0045087 144 0.018
negative regulation of cell differentiation GO:0045596 143 0.018
positive regulation of cell death GO:0010942 69 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.017
Mouse
positive regulation of immune response GO:0050778 63 0.017
transition metal ion homeostasis GO:0055076 17 0.017
protein complex biogenesis GO:0070271 201 0.017
phagocytosis GO:0006909 215 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
positive regulation of multicellular organism growth GO:0040018 21 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
regulation of molecular function GO:0065009 217 0.017
larval development GO:0002164 104 0.016
Worm
regulation of localization GO:0032879 275 0.016
posttranscriptional gene silencing GO:0016441 46 0.016
protein complex assembly GO:0006461 200 0.016
r3 r4 cell differentiation GO:0048056 12 0.016
organic cyclic compound catabolic process GO:1901361 168 0.016
developmental maturation GO:0021700 172 0.016
wnt signaling pathway GO:0016055 98 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.015
axis specification GO:0009798 167 0.015
positive regulation of developmental process GO:0051094 143 0.015
Worm
positive regulation of proteolysis GO:0045862 52 0.015
regulation of organelle organization GO:0033043 196 0.015
negative regulation of cell fate commitment GO:0010454 17 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
positive regulation of synapse assembly GO:0051965 29 0.015
ecdysteroid metabolic process GO:0045455 19 0.015
protein transport GO:0015031 155 0.015
neuropeptide signaling pathway GO:0007218 45 0.015
mesenchymal cell differentiation GO:0048762 1 0.014
chaeta development GO:0022416 97 0.014
regulation of cell size GO:0008361 63 0.014
response to ecdysone GO:0035075 34 0.014
multicellular organism growth GO:0035264 46 0.014
macromolecular complex assembly GO:0065003 256 0.014
positive regulation of cell communication GO:0010647 250 0.014
regulation of growth GO:0040008 233 0.014
intracellular signal transduction GO:0035556 300 0.014
negative regulation of molecular function GO:0044092 51 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
gene silencing by rna GO:0031047 57 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.013
positive regulation of hydrolase activity GO:0051345 78 0.013
hormone metabolic process GO:0042445 33 0.013
regulation of cell proliferation GO:0042127 163 0.013
modification dependent macromolecule catabolic process GO:0043632 79 0.013
cellular protein catabolic process GO:0044257 83 0.013
establishment of protein localization GO:0045184 163 0.013
macromolecule catabolic process GO:0009057 161 0.013
cellular catabolic process GO:0044248 372 0.013
regulation of protein modification process GO:0031399 112 0.013
defense response GO:0006952 300 0.013
cell adhesion GO:0007155 136 0.013
response to oxygen containing compound GO:1901700 200 0.012
single organism cellular localization GO:1902580 180 0.012
cellular hormone metabolic process GO:0034754 23 0.012
establishment or maintenance of cell polarity GO:0007163 167 0.012
sterol metabolic process GO:0016125 12 0.012
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
small molecule biosynthetic process GO:0044283 37 0.012
cell cell signaling involved in cell fate commitment GO:0045168 210 0.012
aromatic compound catabolic process GO:0019439 166 0.012
nucleoside catabolic process GO:0009164 112 0.012
actin filament organization GO:0007015 126 0.012
negative regulation of cell fate specification GO:0009996 15 0.012
cuticle development GO:0042335 86 0.012
regulation of hydrolase activity GO:0051336 97 0.011
zinc ion homeostasis GO:0055069 6 0.011
cellular response to organic cyclic compound GO:0071407 32 0.011
cellular amine metabolic process GO:0044106 12 0.011
protein secretion GO:0009306 45 0.011
negative regulation of programmed cell death GO:0043069 72 0.011
regulation of immune response GO:0050776 118 0.011
histolysis GO:0007559 102 0.011
chemical homeostasis GO:0048878 92 0.011
Fly
striated muscle adaptation GO:0014888 1 0.011
regulation of multicellular organism growth GO:0040014 40 0.011
cellular homeostasis GO:0019725 80 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
tissue death GO:0016271 102 0.011
response to endogenous stimulus GO:0009719 119 0.011
Fly
centrosome organization GO:0051297 163 0.011
response to endoplasmic reticulum stress GO:0034976 28 0.011
cellular macromolecule catabolic process GO:0044265 136 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
locomotory behavior GO:0007626 176 0.010
cell maturation GO:0048469 144 0.010
nucleobase containing compound catabolic process GO:0034655 165 0.010
positive regulation of apoptotic process GO:0043065 47 0.010
dendrite morphogenesis GO:0048813 199 0.010
Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.010
regulation of translation GO:0006417 56 0.010
ubiquitin dependent protein catabolic process GO:0006511 78 0.010
humoral immune response GO:0006959 117 0.010
salivary gland development GO:0007431 162 0.010

Hr4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.013