Drosophila melanogaster

78 known processes

trol (Dmel_CG33950)

terribly reduced optic lobes

(Aliases: ZW-1,l(1)G0374,l(1)zw1,l(1)G0271,l(1)trol,troll,Pcan,CG33950,Dmel\CG33950,zw1,pcan,zw-1,CT23996,EG:BACR25B3.2,EG:BACR25B3.1,GC7891,l(1)zwl,l(1)9-96,l(1)VA51,CG7981,EG:BACR25B3.11,EG:BACR25B3.10,l(1)G0023,Trol,BcDNA:GM02481,l(1)3Ac,anon-WO0153538.72,CG33675,CG12497)

trol biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
motor neuron axon guidance GO:0008045 58 0.884
immune system process GO:0002376 347 0.846
growth GO:0040007 359 0.811
positive regulation of rna metabolic process GO:0051254 271 0.769
tube development GO:0035295 244 0.767
oocyte development GO:0048599 124 0.675
tube morphogenesis GO:0035239 191 0.665
biological adhesion GO:0022610 138 0.625
cell maturation GO:0048469 144 0.594
establishment of localization in cell GO:0051649 402 0.581
neuron projection guidance GO:0097485 241 0.579
regulation of response to stress GO:0080134 200 0.554
membrane organization GO:0061024 112 0.521
positive regulation of macromolecule metabolic process GO:0010604 405 0.460
regulation of immune system process GO:0002682 176 0.438
developmental growth GO:0048589 280 0.432
regulation of localization GO:0032879 275 0.403
response to organic substance GO:0010033 284 0.365
positive regulation of rna biosynthetic process GO:1902680 266 0.361
establishment or maintenance of cell polarity GO:0007163 167 0.360
determination of adult lifespan GO:0008340 137 0.351
cell adhesion GO:0007155 136 0.342
regulation of multicellular organismal development GO:2000026 414 0.337
multicellular organismal aging GO:0010259 140 0.314
response to abiotic stimulus GO:0009628 341 0.286
immune response GO:0006955 246 0.261
blastoderm segmentation GO:0007350 159 0.261
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.250
negative regulation of response to stimulus GO:0048585 258 0.250
mitotic cell cycle checkpoint GO:0007093 88 0.225
protein localization GO:0008104 284 0.212
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.212
cell migration GO:0016477 238 0.210
vesicle mediated transport GO:0016192 381 0.204
negative regulation of cell development GO:0010721 62 0.177
positive regulation of multicellular organismal process GO:0051240 143 0.166
actin filament based process GO:0030029 220 0.164
mitotic cell cycle phase transition GO:0044772 138 0.160
developmental maturation GO:0021700 172 0.158
regulation of developmental growth GO:0048638 174 0.150
regulation of cell projection organization GO:0031344 92 0.149
positive regulation of response to stimulus GO:0048584 323 0.146
peptidyl amino acid modification GO:0018193 105 0.144
regulation of receptor activity GO:0010469 10 0.143
proteolysis GO:0006508 192 0.141
programmed cell death GO:0012501 257 0.140
response to anesthetic GO:0072347 9 0.130
regulation of immune response GO:0050776 118 0.129
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.128
positive regulation of developmental growth GO:0048639 62 0.127
positive regulation of growth GO:0045927 75 0.126
striated muscle cell differentiation GO:0051146 90 0.125
regulation of cell size GO:0008361 63 0.125
embryo development ending in birth or egg hatching GO:0009792 152 0.125
negative regulation of cellular metabolic process GO:0031324 382 0.121
purine nucleotide catabolic process GO:0006195 109 0.121
cellular response to chemical stimulus GO:0070887 199 0.121
positive regulation of cellular biosynthetic process GO:0031328 316 0.119
immune response regulating signaling pathway GO:0002764 2 0.119
cellular protein localization GO:0034613 160 0.118
positive regulation of transport GO:0051050 92 0.117
extracellular structure organization GO:0043062 46 0.116
enzyme linked receptor protein signaling pathway GO:0007167 179 0.114
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.114
regulation of neuron differentiation GO:0045664 103 0.113
gland development GO:0048732 191 0.111
atp metabolic process GO:0046034 49 0.107
regulation of innate immune response GO:0045088 71 0.106
regulation of cellular component size GO:0032535 98 0.104
meiotic nuclear division GO:0007126 151 0.103
negative regulation of signal transduction GO:0009968 206 0.103
regulation of growth GO:0040008 233 0.101
actin filament organization GO:0007015 126 0.096
cellular macromolecule localization GO:0070727 220 0.092
regulation of cell cycle process GO:0010564 181 0.092
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.089
organ growth GO:0035265 56 0.088
endocytosis GO:0006897 310 0.088
protein modification process GO:0036211 438 0.087
purine ribonucleoside metabolic process GO:0046128 127 0.084
regulation of cellular ketone metabolic process GO:0010565 3 0.084
single organism catabolic process GO:0044712 228 0.082
purine nucleoside triphosphate metabolic process GO:0009144 119 0.081
ribonucleoside triphosphate metabolic process GO:0009199 119 0.080
taxis GO:0042330 304 0.079
cellular response to organic substance GO:0071310 132 0.079
macromolecule catabolic process GO:0009057 161 0.078
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.077
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.077
nucleoside triphosphate metabolic process GO:0009141 120 0.076
respiratory system development GO:0060541 213 0.076
stem cell proliferation GO:0072089 88 0.075
cell cycle phase transition GO:0044770 140 0.075
mitotic nuclear division GO:0007067 213 0.073
protein transport GO:0015031 155 0.072
basement membrane organization GO:0071711 10 0.069
meiotic cell cycle process GO:1903046 132 0.067
regulation of neuron projection development GO:0010975 69 0.066
positive regulation of cellular amine metabolic process GO:0033240 0 0.066
negative regulation of decapentaplegic signaling pathway GO:0090099 4 0.065
axonogenesis GO:0007409 290 0.065
body morphogenesis GO:0010171 2 0.064
epidermis development GO:0008544 65 0.064
positive regulation of catabolic process GO:0009896 105 0.060
rho protein signal transduction GO:0007266 14 0.060
kidney development GO:0001822 3 0.059
development of primary sexual characteristics GO:0045137 50 0.059
endomembrane system organization GO:0010256 119 0.059
innate immune response GO:0045087 144 0.059
regulation of cell cycle GO:0051726 291 0.059
larval development GO:0002164 104 0.057
cellular response to dna damage stimulus GO:0006974 223 0.057
positive regulation of nucleoside metabolic process GO:0045979 47 0.055
axon development GO:0061564 297 0.055
oxoacid metabolic process GO:0043436 103 0.055
nucleus localization GO:0051647 34 0.055
reproductive system development GO:0061458 74 0.053
tissue morphogenesis GO:0048729 297 0.053
regulation of anatomical structure size GO:0090066 163 0.052
embryonic pattern specification GO:0009880 174 0.052
cellular protein modification process GO:0006464 438 0.051
morphogenesis of an epithelium GO:0002009 276 0.051
positive regulation of immune response GO:0050778 63 0.050
response to wounding GO:0009611 94 0.050
regulation of glutamate receptor signaling pathway GO:1900449 1 0.050
regulation of cell cycle phase transition GO:1901987 130 0.049
nucleotide metabolic process GO:0009117 161 0.049
negative regulation of mitotic cell cycle GO:0045930 109 0.049
apoptotic process GO:0006915 159 0.048
anterior posterior axis specification GO:0009948 109 0.047
positive regulation of biosynthetic process GO:0009891 316 0.046
response to endogenous stimulus GO:0009719 119 0.045
cell growth GO:0016049 108 0.045
epithelial cell differentiation GO:0030855 322 0.045
regulation of microtubule based process GO:0032886 49 0.045
establishment of protein localization GO:0045184 163 0.044
regulation of cell morphogenesis GO:0022604 163 0.044
positive regulation of developmental process GO:0051094 143 0.044
instar larval development GO:0002168 55 0.044
single organism cellular localization GO:1902580 180 0.043
organic acid metabolic process GO:0006082 103 0.043
skin development GO:0043588 65 0.042
positive regulation of nucleic acid templated transcription GO:1903508 266 0.042
protein catabolic process GO:0030163 101 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.041
meiosis i GO:0007127 59 0.041
positive regulation of transcription dna templated GO:0045893 266 0.041
notch signaling pathway GO:0007219 120 0.041
immune response activating signal transduction GO:0002757 2 0.040
intracellular transport GO:0046907 228 0.040
regulation of locomotion GO:0040012 42 0.039
single organism membrane organization GO:0044802 93 0.039
cell cell signaling involved in cell fate commitment GO:0045168 210 0.039
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.038
chromosome segregation GO:0007059 157 0.038
ribonucleoside metabolic process GO:0009119 127 0.038
glycosyl compound catabolic process GO:1901658 112 0.038
cell motility GO:0048870 251 0.037
muscle structure development GO:0061061 224 0.037
immune effector process GO:0002252 98 0.037
actin cytoskeleton organization GO:0030036 206 0.037
chemotaxis GO:0006935 249 0.037
localization of cell GO:0051674 257 0.036
asymmetric stem cell division GO:0098722 49 0.036
positive regulation of immune system process GO:0002684 68 0.036
amine metabolic process GO:0009308 12 0.036
negative regulation of cell communication GO:0010648 223 0.035
regulation of defense response GO:0031347 102 0.035
regulation of catalytic activity GO:0050790 185 0.034
immune system development GO:0002520 57 0.034
positive regulation of protein metabolic process GO:0051247 128 0.034
carboxylic acid metabolic process GO:0019752 92 0.034
transcription from rna polymerase ii promoter GO:0006366 368 0.033
ribonucleoside triphosphate catabolic process GO:0009203 108 0.032
organic substance catabolic process GO:1901575 308 0.032
sister chromatid segregation GO:0000819 92 0.032
positive regulation of cell death GO:0010942 69 0.031
dorsal ventral axis specification GO:0009950 66 0.031
organonitrogen compound metabolic process GO:1901564 318 0.031
cellular macromolecule catabolic process GO:0044265 136 0.031
purine nucleoside metabolic process GO:0042278 127 0.031
positive regulation of axonogenesis GO:0050772 2 0.030
lateral inhibition GO:0046331 206 0.030
brain development GO:0007420 120 0.030
single organism intracellular transport GO:1902582 207 0.030
extracellular matrix organization GO:0030198 32 0.029
activation of ras gtpase activity GO:0032856 6 0.029
modification dependent protein catabolic process GO:0019941 78 0.029
positive regulation of signal transduction GO:0009967 223 0.029
homeostatic process GO:0042592 199 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.028
reproductive structure development GO:0048608 74 0.028
positive regulation of cellular catabolic process GO:0031331 95 0.028
salivary gland cell autophagic cell death GO:0035071 83 0.028
cell death GO:0008219 279 0.027
regulation of mitotic cell cycle GO:0007346 190 0.027
negative regulation of cell cycle process GO:0010948 109 0.026
negative regulation of cell cycle phase transition GO:1901988 103 0.026
mitotic sister chromatid segregation GO:0000070 87 0.026
establishment of nucleus localization GO:0040023 26 0.026
cellular amino acid metabolic process GO:0006520 61 0.026
mitotic dna integrity checkpoint GO:0044774 75 0.025
protein phosphorylation GO:0006468 169 0.025
intracellular protein transport GO:0006886 104 0.025
tripartite regional subdivision GO:0007351 103 0.025
regulation of cellular component movement GO:0051270 42 0.025
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.025
regulation of nervous system development GO:0051960 248 0.025
centrosome organization GO:0051297 163 0.025
negative regulation of nervous system development GO:0051961 92 0.025
positive regulation of cell communication GO:0010647 250 0.024
regulation of intracellular transport GO:0032386 64 0.024
positive regulation of molecular function GO:0044093 136 0.024
oxidation reduction process GO:0055114 123 0.024
positive regulation of cellular protein metabolic process GO:0032270 118 0.024
response to endoplasmic reticulum stress GO:0034976 28 0.024
carbohydrate derivative metabolic process GO:1901135 217 0.023
axis specification GO:0009798 167 0.023
oocyte differentiation GO:0009994 145 0.023
cell cycle checkpoint GO:0000075 95 0.023
single organismal cell cell adhesion GO:0016337 45 0.023
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.023
cellular response to endogenous stimulus GO:0071495 80 0.023
nucleoside catabolic process GO:0009164 112 0.023
positive regulation of nucleotide catabolic process GO:0030813 46 0.022
regulation of cell growth GO:0001558 43 0.022
peptidyl threonine phosphorylation GO:0018107 2 0.022
positive regulation of gtpase activity GO:0043547 43 0.022
terminal region determination GO:0007362 25 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.022
nuclear division GO:0000280 332 0.022
cytoplasmic transport GO:0016482 130 0.022
neurotransmitter gated ion channel clustering GO:0072578 2 0.022
positive regulation of catalytic activity GO:0043085 118 0.022
negative regulation of nucleic acid templated transcription GO:1903507 240 0.021
regulation of phosphorus metabolic process GO:0051174 210 0.021
cellular ketone metabolic process GO:0042180 24 0.021
cellular catabolic process GO:0044248 372 0.021
regulation of mitotic cell cycle phase transition GO:1901990 130 0.021
purine containing compound catabolic process GO:0072523 112 0.021
dna integrity checkpoint GO:0031570 81 0.021
ribonucleotide catabolic process GO:0009261 109 0.021
oocyte maturation GO:0001556 3 0.021
cellular amine metabolic process GO:0044106 12 0.020
axon guidance GO:0007411 233 0.020
modification dependent macromolecule catabolic process GO:0043632 79 0.020
regulation of protein metabolic process GO:0051246 256 0.020
regulation of neurogenesis GO:0050767 158 0.020
regulation of protein catabolic process GO:0042176 55 0.020
regulation of cellular protein metabolic process GO:0032268 243 0.020
peptidyl threonine modification GO:0018210 3 0.020
organic cyclic compound catabolic process GO:1901361 168 0.019
establishment of organelle localization GO:0051656 122 0.019
molting cycle GO:0042303 56 0.019
regulation of hydrolase activity GO:0051336 97 0.019
protein targeting GO:0006605 64 0.019
defense response GO:0006952 300 0.019
negative regulation of epithelial cell proliferation GO:0050680 4 0.019
negative regulation of growth GO:0045926 84 0.018
oviposition GO:0018991 19 0.018
cellular protein catabolic process GO:0044257 83 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.018
macromolecular complex assembly GO:0065003 256 0.018
endothelial cell development GO:0001885 6 0.018
gland morphogenesis GO:0022612 145 0.018
mesenchymal cell development GO:0014031 1 0.018
aging GO:0007568 143 0.018
nephron development GO:0072006 3 0.018
organic substance transport GO:0071702 257 0.018
nucleoside phosphate catabolic process GO:1901292 110 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.017
regulation of anatomical structure morphogenesis GO:0022603 242 0.017
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.017
open tracheal system development GO:0007424 204 0.017
protein complex biogenesis GO:0070271 201 0.017
plasma membrane organization GO:0007009 26 0.016
organelle localization GO:0051640 148 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.016
cation homeostasis GO:0055080 51 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.016
regulation of response to external stimulus GO:0032101 115 0.016
positive regulation of hydrolase activity GO:0051345 78 0.016
purine nucleoside catabolic process GO:0006152 112 0.016
peptidyl lysine modification GO:0018205 57 0.016
glycosyl compound metabolic process GO:1901657 127 0.015
epithelial cell development GO:0002064 274 0.015
negative regulation of notch signaling pathway GO:0045746 41 0.015
response to radiation GO:0009314 155 0.015
regulation of protein localization GO:0032880 76 0.015
regulation of response to wounding GO:1903034 19 0.015
ribose phosphate metabolic process GO:0019693 145 0.015
secretion GO:0046903 109 0.015
small molecule metabolic process GO:0044281 305 0.015
regulation of protein modification process GO:0031399 112 0.015
peripheral nervous system development GO:0007422 52 0.015
ubiquitin dependent protein catabolic process GO:0006511 78 0.014
defense response to other organism GO:0098542 225 0.014
oocyte construction GO:0007308 112 0.014
purine ribonucleoside catabolic process GO:0046130 112 0.014
cell proliferation GO:0008283 299 0.014
regulation of notch signaling pathway GO:0008593 100 0.014
cellular response to oxygen containing compound GO:1901701 79 0.014
regulation of cellular localization GO:0060341 136 0.014
catechol containing compound biosynthetic process GO:0009713 3 0.014
molting cycle chitin based cuticle GO:0007591 56 0.014
response to oxidative stress GO:0006979 86 0.014
negative regulation of cell cycle GO:0045786 116 0.014
positive regulation of signaling GO:0023056 243 0.014
sex differentiation GO:0007548 81 0.014
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.014
death GO:0016265 284 0.013
digestive tract morphogenesis GO:0048546 127 0.013
positive regulation of cellular component organization GO:0051130 156 0.013
protein complex assembly GO:0006461 200 0.013
response to other organism GO:0051707 293 0.013
positive regulation of gene expression GO:0010628 290 0.013
segmentation GO:0035282 207 0.013
germarium derived egg chamber formation GO:0007293 101 0.013
regulation of intracellular protein transport GO:0033157 46 0.013
response to oxygen containing compound GO:1901700 200 0.013
secretion by cell GO:0032940 101 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
hemopoiesis GO:0030097 46 0.013
striated muscle myosin thick filament assembly GO:0071688 3 0.013
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.013
neuromuscular junction development GO:0007528 149 0.013
head development GO:0060322 135 0.013
mitotic g2 m transition checkpoint GO:0044818 70 0.013
regulation of dendrite development GO:0050773 37 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
regulation of cell differentiation GO:0045595 302 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
renal tubule development GO:0061326 64 0.012
positive regulation of chromosome segregation GO:0051984 10 0.012
protein autophosphorylation GO:0046777 15 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.012
regulation of molecular function GO:0065009 217 0.012
regulation of viral genome replication GO:0045069 4 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
production of molecular mediator of immune response GO:0002440 46 0.012
hatching GO:0035188 4 0.012
gtp catabolic process GO:0006184 72 0.012
regulation of intracellular signal transduction GO:1902531 236 0.011
ion homeostasis GO:0050801 55 0.011
icosanoid biosynthetic process GO:0046456 1 0.011
catabolic process GO:0009056 409 0.011
establishment of protein localization to organelle GO:0072594 62 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
regulation of transferase activity GO:0051338 58 0.011
cell cycle arrest GO:0007050 4 0.011
organelle inheritance GO:0048308 2 0.011
digestive tract development GO:0048565 149 0.011
negative regulation of immune system process GO:0002683 50 0.011
imaginal disc growth GO:0007446 37 0.011
activation of innate immune response GO:0002218 4 0.011
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.011
regulation of organelle organization GO:0033043 196 0.011
regulation of reproductive process GO:2000241 54 0.011
stem cell division GO:0017145 69 0.011
dna damage checkpoint GO:0000077 78 0.011
organophosphate metabolic process GO:0019637 195 0.010
nucleoside metabolic process GO:0009116 127 0.010
regulation of cell division GO:0051302 72 0.010
phagocytosis GO:0006909 215 0.010
cellular response to nitrogen compound GO:1901699 51 0.010
metal ion homeostasis GO:0055065 44 0.010
mushroom body development GO:0016319 70 0.010
response to nitrogen compound GO:1901698 90 0.010
regulation of cell proliferation GO:0042127 163 0.010
negative regulation of signal transduction by p53 class mediator GO:1901797 1 0.010
negative regulation of cellular component organization GO:0051129 108 0.010
chemical homeostasis GO:0048878 92 0.010

trol disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
disease of anatomical entity DOID:7 0 0.014