Drosophila melanogaster

166 known processes

lic (Dmel_CG12244)

licorne

(Aliases: Dmel\CG12244,p38MAPKK,Mpk3,D-MKK3,DmMKK3,DMKK3,MEK3/MKK3,Mek3,p38,l(1)G0252,DMKK3/lic,Mkk3,MKK3,dMKK3,CG12244,DMEK3)

lic biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna localization GO:0006403 115 0.966
oocyte development GO:0048599 124 0.948
chorion containing eggshell formation GO:0007304 105 0.937
dorsal appendage formation GO:0046843 47 0.927
ovarian follicle cell development GO:0030707 248 0.887
eggshell formation GO:0030703 105 0.866
pole plasm mrna localization GO:0019094 49 0.864
immune response GO:0006955 246 0.811
defense response to other organism GO:0098542 225 0.778
cellular component assembly involved in morphogenesis GO:0010927 151 0.709
defense response GO:0006952 300 0.700
immune system process GO:0002376 347 0.684
defense response to bacterium GO:0042742 178 0.662
innate immune response GO:0045087 144 0.626
response to biotic stimulus GO:0009607 294 0.606
determination of adult lifespan GO:0008340 137 0.582
response to bacterium GO:0009617 198 0.566
phosphorylation GO:0016310 294 0.541
blastoderm segmentation GO:0007350 159 0.490
oocyte differentiation GO:0009994 145 0.467
posttranscriptional regulation of gene expression GO:0010608 145 0.456
epithelial cell development GO:0002064 274 0.452
oocyte anterior posterior axis specification GO:0007314 72 0.437
oocyte microtubule cytoskeleton organization GO:0016325 35 0.415
positive regulation of macromolecule metabolic process GO:0010604 405 0.408
positive regulation of gene expression GO:0010628 290 0.385
oocyte axis specification GO:0007309 108 0.375
fertilization GO:0009566 26 0.371
negative regulation of translation GO:0017148 28 0.367
oocyte construction GO:0007308 112 0.362
intracellular signal transduction GO:0035556 300 0.362
maternal determination of anterior posterior axis embryo GO:0008358 74 0.360
positive regulation of rna biosynthetic process GO:1902680 266 0.349
pole plasm assembly GO:0007315 61 0.327
embryo development ending in birth or egg hatching GO:0009792 152 0.315
aging GO:0007568 143 0.315
regulation of immune response GO:0050776 118 0.308
regulation of response to stress GO:0080134 200 0.291
pole plasm rna localization GO:0007316 52 0.289
multicellular organismal aging GO:0010259 140 0.270
larval development GO:0002164 104 0.266
positive regulation of cell communication GO:0010647 250 0.261
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.249
eggshell chorion assembly GO:0007306 66 0.248
cellularization GO:0007349 90 0.247
negative regulation of cellular metabolic process GO:0031324 382 0.233
embryonic pattern specification GO:0009880 174 0.230
anterior posterior axis specification embryo GO:0008595 103 0.226
response to other organism GO:0051707 293 0.224
regionalization GO:0003002 416 0.220
axis specification GO:0009798 167 0.209
macromolecule catabolic process GO:0009057 161 0.208
tripartite regional subdivision GO:0007351 103 0.191
dna damage checkpoint GO:0000077 78 0.191
cell maturation GO:0048469 144 0.185
positive regulation of transcription dna templated GO:0045893 266 0.184
positive regulation of multicellular organismal process GO:0051240 143 0.177
regulation of cellular localization GO:0060341 136 0.177
cytoplasm organization GO:0007028 64 0.166
positive regulation of rna metabolic process GO:0051254 271 0.165
male gamete generation GO:0048232 201 0.159
anterior posterior axis specification GO:0009948 109 0.155
columnar cuboidal epithelial cell development GO:0002066 249 0.155
negative regulation of signaling GO:0023057 219 0.151
g2 dna damage checkpoint GO:0031572 69 0.149
epithelial cell differentiation GO:0030855 322 0.141
regulation of cell development GO:0060284 215 0.139
spermatogenesis GO:0007283 200 0.136
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.136
dorsal closure GO:0007391 79 0.135
regulation of multicellular organismal development GO:2000026 414 0.135
developmental maturation GO:0021700 172 0.135
regulation of pole plasm oskar mrna localization GO:0007317 27 0.134
protein modification process GO:0036211 438 0.133
negative regulation of cell differentiation GO:0045596 143 0.130
response to abiotic stimulus GO:0009628 341 0.130
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.125
mrna metabolic process GO:0016071 124 0.121
nuclear division GO:0000280 332 0.118
response to organic substance GO:0010033 284 0.117
positive regulation of biosynthetic process GO:0009891 316 0.115
embryonic axis specification GO:0000578 107 0.112
oxoacid metabolic process GO:0043436 103 0.111
tor signaling GO:0031929 32 0.108
positive regulation of growth GO:0045927 75 0.107
mitotic g2 dna damage checkpoint GO:0007095 69 0.107
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.101
rna processing GO:0006396 147 0.100
lipid storage GO:0019915 38 0.100
response to nutrient levels GO:0031667 114 0.100
negative regulation of transposition GO:0010529 12 0.099
unidimensional cell growth GO:0009826 15 0.096
enzyme linked receptor protein signaling pathway GO:0007167 179 0.095
regulation of translation GO:0006417 56 0.094
defense response to gram negative bacterium GO:0050829 94 0.093
response to oxidative stress GO:0006979 86 0.092
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.091
regulation of nurse cell apoptotic process GO:0045477 9 0.086
translation GO:0006412 69 0.085
cellular response to chemical stimulus GO:0070887 199 0.085
cellular response to heat GO:0034605 24 0.081
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.081
germarium derived oocyte differentiation GO:0030706 29 0.080
mrna catabolic process GO:0006402 33 0.079
protein phosphorylation GO:0006468 169 0.079
embryonic development via the syncytial blastoderm GO:0001700 148 0.078
germarium derived oocyte fate determination GO:0007294 26 0.078
bmp signaling pathway GO:0030509 27 0.073
programmed cell death GO:0012501 257 0.073
regulation of embryonic development GO:0045995 68 0.072
apoptotic process GO:0006915 159 0.071
regulation of defense response GO:0031347 102 0.071
maintenance of location GO:0051235 73 0.070
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.070
cell cycle checkpoint GO:0000075 95 0.067
reproductive system development GO:0061458 74 0.067
segmentation GO:0035282 207 0.066
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.065
death GO:0016265 284 0.065
cell death GO:0008219 279 0.063
dna integrity checkpoint GO:0031570 81 0.062
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.062
regulation of cell maturation GO:1903429 27 0.061
protein import into nucleus GO:0006606 51 0.060
immune response regulating signaling pathway GO:0002764 2 0.058
stem cell development GO:0048864 79 0.057
female germline ring canal formation GO:0007301 9 0.057
protein targeting to nucleus GO:0044744 51 0.057
cellular response to unfolded protein GO:0034620 9 0.057
positive regulation of signal transduction GO:0009967 223 0.056
regulation of multi organism process GO:0043900 131 0.053
regulation of oocyte development GO:0060281 27 0.052
cellular response to arsenic containing substance GO:0071243 6 0.052
organelle assembly GO:0070925 198 0.051
response to extracellular stimulus GO:0009991 116 0.049
respiratory system development GO:0060541 213 0.049
positive regulation of signaling GO:0023056 243 0.049
oocyte dorsal ventral axis specification GO:0007310 34 0.048
multi multicellular organism process GO:0044706 123 0.047
response to temperature stimulus GO:0009266 106 0.047
cellular response to dna damage stimulus GO:0006974 223 0.047
regulation of immune system process GO:0002682 176 0.047
negative regulation of rna biosynthetic process GO:1902679 240 0.046
production of sirna involved in rna interference GO:0030422 11 0.046
response to heat GO:0009408 63 0.046
carboxylic acid metabolic process GO:0019752 92 0.046
anterior posterior pattern specification GO:0009952 136 0.046
chromatin remodeling GO:0006338 72 0.046
mushroom body development GO:0016319 70 0.045
establishment of localization in cell GO:0051649 402 0.045
immune response activating signal transduction GO:0002757 2 0.044
gonad development GO:0008406 50 0.043
organic substance transport GO:0071702 257 0.042
negative regulation of response to stimulus GO:0048585 258 0.042
axonogenesis GO:0007409 290 0.042
protein localization to organelle GO:0033365 82 0.042
regulation of bmp signaling pathway GO:0030510 23 0.041
oxidation reduction process GO:0055114 123 0.040
rna splicing GO:0008380 83 0.040
positive regulation of cellular protein metabolic process GO:0032270 118 0.039
actin filament based process GO:0030029 220 0.039
regulation of cell differentiation GO:0045595 302 0.039
dorsal ventral axis specification ovarian follicular epithelium GO:0008069 13 0.038
regulation of hemocyte differentiation GO:0045610 22 0.038
ovarian fusome organization GO:0030723 11 0.037
regulation of rna splicing GO:0043484 69 0.036
mrna splicing via spliceosome GO:0000398 73 0.036
cell motility GO:0048870 251 0.036
protein localization to nucleus GO:0034504 55 0.036
negative regulation of immune system process GO:0002683 50 0.036
molting cycle GO:0042303 56 0.036
chemotaxis GO:0006935 249 0.035
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.035
regulation of innate immune response GO:0045088 71 0.035
intracellular mrna localization GO:0008298 66 0.034
ncrna metabolic process GO:0034660 43 0.034
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0030722 6 0.034
gene silencing by rna GO:0031047 57 0.033
positive regulation of nucleic acid templated transcription GO:1903508 266 0.033
cellular response to organic substance GO:0071310 132 0.033
embryonic morphogenesis GO:0048598 206 0.032
epithelial cell migration GO:0010631 148 0.032
negative regulation of developmental process GO:0051093 201 0.032
synaptic transmission GO:0007268 288 0.032
actin cytoskeleton organization GO:0030036 206 0.032
cellular macromolecule localization GO:0070727 220 0.031
response to virus GO:0009615 28 0.031
regulation of cellular response to stress GO:0080135 89 0.031
response to external biotic stimulus GO:0043207 293 0.030
epithelial cell morphogenesis involved in gastrulation GO:0003381 7 0.030
central nervous system development GO:0007417 201 0.030
mitotic dna integrity checkpoint GO:0044774 75 0.030
response to oxygen radical GO:0000305 3 0.030
striated muscle myosin thick filament assembly GO:0071688 3 0.029
nitrogen compound transport GO:0071705 85 0.029
regulation of protein metabolic process GO:0051246 256 0.029
reproductive behavior GO:0019098 122 0.028
defense response to gram positive bacterium GO:0050830 41 0.028
head involution GO:0008258 35 0.028
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.028
regulation of mrna metabolic process GO:1903311 72 0.027
protein complex biogenesis GO:0070271 201 0.027
sex differentiation GO:0007548 81 0.027
protein localization GO:0008104 284 0.027
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.027
protein import GO:0017038 55 0.027
regulation of phosphorus metabolic process GO:0051174 210 0.027
nucleobase containing compound transport GO:0015931 56 0.027
positive regulation of response to stimulus GO:0048584 323 0.026
morphogenesis of a branching epithelium GO:0061138 45 0.026
negative regulation of cell communication GO:0010648 223 0.025
positive regulation of phosphate metabolic process GO:0045937 139 0.025
spindle organization GO:0007051 253 0.025
catabolic process GO:0009056 409 0.024
tube morphogenesis GO:0035239 191 0.024
gastrulation GO:0007369 70 0.024
organic acid metabolic process GO:0006082 103 0.024
regulation of response to oxidative stress GO:1902882 4 0.024
nuclear transcribed mrna catabolic process GO:0000956 24 0.024
epithelial cell morphogenesis GO:0003382 25 0.024
adherens junction organization GO:0034332 27 0.024
chromatin organization GO:0006325 207 0.023
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.023
posttranscriptional gene silencing by rna GO:0035194 45 0.023
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 8 0.023
cell migration GO:0016477 238 0.023
humoral immune response GO:0006959 117 0.023
post embryonic appendage morphogenesis GO:0035120 385 0.023
imaginal disc derived appendage morphogenesis GO:0035114 395 0.023
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.023
organic substance catabolic process GO:1901575 308 0.023
lamellocyte differentiation GO:0035171 9 0.023
single organism nuclear import GO:1902593 51 0.023
establishment of rna localization GO:0051236 47 0.023
ribonucleoprotein complex biogenesis GO:0022613 31 0.022
nuclear migration GO:0007097 20 0.022
response to dsrna GO:0043331 15 0.022
pole plasm protein localization GO:0007318 10 0.022
mitotic dna damage checkpoint GO:0044773 74 0.022
dorsal ventral axis specification GO:0009950 66 0.022
localization of cell GO:0051674 257 0.022
nuclear transport GO:0051169 72 0.022
heterocycle catabolic process GO:0046700 166 0.021
muscle system process GO:0003012 21 0.021
negative regulation of transcription dna templated GO:0045892 237 0.021
immune system development GO:0002520 57 0.021
single organism biosynthetic process GO:0044711 206 0.021
cellular protein modification process GO:0006464 438 0.021
positive regulation of multicellular organism growth GO:0040018 21 0.021
single organism cellular localization GO:1902580 180 0.021
regulation of antifungal peptide biosynthetic process GO:0002810 5 0.021
transcription from rna polymerase ii promoter GO:0006366 368 0.021
stem cell maintenance GO:0019827 67 0.021
ubiquitin dependent protein catabolic process GO:0006511 78 0.021
post embryonic hemopoiesis GO:0035166 17 0.020
negative regulation of cell cycle phase transition GO:1901988 103 0.020
cell projection assembly GO:0030031 94 0.020
pole cell formation GO:0007279 19 0.020
compound eye development GO:0048749 307 0.020
golgi vesicle transport GO:0048193 27 0.020
aromatic compound catabolic process GO:0019439 166 0.020
negative regulation of erbb signaling pathway GO:1901185 29 0.019
rna transport GO:0050658 46 0.019
germ line stem cell division GO:0042078 25 0.019
nuclear import GO:0051170 51 0.019
homeostatic process GO:0042592 199 0.019
positive regulation of immune response GO:0050778 63 0.019
negative regulation of gene expression GO:0010629 387 0.019
regulation of establishment of protein localization GO:0070201 61 0.019
regulation of tor signaling GO:0032006 21 0.019
salivary gland development GO:0007431 162 0.018
organelle localization GO:0051640 148 0.018
negative regulation of immune response GO:0050777 39 0.018
cilium assembly GO:0042384 38 0.018
myotube cell development GO:0014904 3 0.018
positive regulation of defense response GO:0031349 59 0.018
cytokinesis GO:0000910 90 0.018
imaginal disc derived appendage development GO:0048737 399 0.018
macromolecular complex assembly GO:0065003 256 0.018
regulation of nf kappab import into nucleus GO:0042345 1 0.018
chromosome organization GO:0051276 360 0.018
intracellular steroid hormone receptor signaling pathway GO:0030518 12 0.018
mitotic cell cycle checkpoint GO:0007093 88 0.018
oocyte localization involved in germarium derived egg chamber formation GO:0030720 12 0.018
pole plasm oskar mrna localization GO:0045451 46 0.018
compound eye retinal cell programmed cell death GO:0046667 23 0.017
regulation of intracellular transport GO:0032386 64 0.017
regulation of embryonic pattern specification GO:1902875 27 0.017
response to transforming growth factor beta GO:0071559 18 0.017
instar larval development GO:0002168 55 0.017
dna metabolic process GO:0006259 227 0.017
maintenance of gastrointestinal epithelium GO:0030277 3 0.017
chorion containing eggshell pattern formation GO:0030381 11 0.017
centrosome organization GO:0051297 163 0.016
apical constriction involved in gastrulation GO:0003384 7 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.016
tissue morphogenesis GO:0048729 297 0.016
extrinsic apoptotic signaling pathway GO:0097191 1 0.016
negative regulation of signal transduction GO:0009968 206 0.016
microtubule organizing center organization GO:0031023 168 0.016
rna catabolic process GO:0006401 37 0.016
cell division GO:0051301 248 0.016
regulation of intracellular signal transduction GO:1902531 236 0.016
imaginal disc fusion GO:0046528 19 0.016
oviposition GO:0018991 19 0.016
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.016
growth GO:0040007 359 0.016
negative regulation of protein tyrosine kinase activity GO:0061099 5 0.016
negative regulation of cell cycle GO:0045786 116 0.016
cellular response to organic cyclic compound GO:0071407 32 0.015
regulation of localization GO:0032879 275 0.015
response to starvation GO:0042594 97 0.015
apical constriction GO:0003383 18 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
mitotic g2 m transition checkpoint GO:0044818 70 0.015
spermatid differentiation GO:0048515 114 0.015
epidermal cell differentiation GO:0009913 51 0.015
regulation of mapk cascade GO:0043408 92 0.015
imaginal disc derived wing vein specification GO:0007474 48 0.015
sperm individualization GO:0007291 48 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.014
antimicrobial humoral response GO:0019730 99 0.014
body morphogenesis GO:0010171 2 0.014
stress activated mapk cascade GO:0051403 52 0.014
germline ring canal formation GO:0030725 13 0.014
meiotic nuclear division GO:0007126 151 0.014
positive regulation of apoptotic signaling pathway GO:2001235 4 0.014
segment polarity determination GO:0007367 25 0.014
centrosome cycle GO:0007098 137 0.014
mitotic spindle organization GO:0007052 220 0.013
innate immune response activating signal transduction GO:0002758 2 0.013
dendrite morphogenesis GO:0048813 199 0.013
response to superoxide GO:0000303 3 0.013
regulation of phosphatase activity GO:0010921 3 0.013
regulation of mrna splicing via spliceosome GO:0048024 64 0.013
chromatin modification GO:0016568 147 0.013
regulation of membrane potential GO:0042391 35 0.013
reproductive structure development GO:0048608 74 0.013
negative regulation of cell death GO:0060548 81 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
alternative mrna splicing via spliceosome GO:0000380 60 0.013
negative regulation of innate immune response GO:0045824 30 0.013
posttranscriptional gene silencing GO:0016441 46 0.013
cellular macromolecular complex assembly GO:0034622 153 0.013
initiation of dorsal closure GO:0007392 12 0.013
protein transport GO:0015031 155 0.013
mitotic cell cycle embryonic GO:0045448 38 0.013
regulation of cellular response to oxidative stress GO:1900407 4 0.013
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.013
fusome organization GO:0045478 13 0.012
neuroblast proliferation GO:0007405 74 0.012
lipid localization GO:0010876 54 0.012
organonitrogen compound metabolic process GO:1901564 318 0.012
nephron development GO:0072006 3 0.012
positive regulation of cellular biosynthetic process GO:0031328 316 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
negative regulation of lamellocyte differentiation GO:0035204 5 0.011
appendage morphogenesis GO:0035107 397 0.011
positive regulation of translation GO:0045727 12 0.011
establishment of protein localization to organelle GO:0072594 62 0.011
development of primary sexual characteristics GO:0045137 50 0.011
actin filament based movement GO:0030048 26 0.011
somatic muscle development GO:0007525 66 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
tube development GO:0035295 244 0.011
muscle organ development GO:0007517 127 0.011
regulation of lamellocyte differentiation GO:0035203 6 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
regulation of jnk cascade GO:0046328 40 0.011
protein catabolic process GO:0030163 101 0.011
regulation of transposition GO:0010528 13 0.011
oocyte maturation GO:0001556 3 0.011
establishment of protein localization GO:0045184 163 0.011
muscle structure development GO:0061061 224 0.011
rna interference GO:0016246 27 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
mrna processing GO:0006397 104 0.011
multicellular organismal reproductive behavior GO:0033057 110 0.011
chromosome segregation GO:0007059 157 0.011
multi organism reproductive behavior GO:0044705 121 0.011
regulation of synapse assembly GO:0051963 94 0.010
negative regulation of cellular biosynthetic process GO:0031327 277 0.010
regulation of defense response to virus by host GO:0050691 10 0.010
regulation of reproductive process GO:2000241 54 0.010
appendage development GO:0048736 401 0.010

lic disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014