Drosophila melanogaster

4 known processes

plx (Dmel_CG42612)

pollux

(Aliases: Dmel_CG14674,CG42612,Dmel\CG42612,CG14674,Dmel_CG1093,Dmel_CG34122,CG34122,CG1093)

plx biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval behavior GO:0030537 42 0.928
single organism behavior GO:0044708 391 0.924
response to abiotic stimulus GO:0009628 341 0.878
respiratory system development GO:0060541 213 0.766
mechanosensory behavior GO:0007638 12 0.751
neurological system process GO:0050877 358 0.672
sensory perception of salty taste GO:0050914 3 0.616
inorganic cation transmembrane transport GO:0098662 61 0.522
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 2 0.520
salt aversion GO:0035199 3 0.482
detection of stimulus GO:0051606 156 0.471
sensory perception of mechanical stimulus GO:0050954 72 0.441
male courtship behavior GO:0008049 63 0.418
open tracheal system development GO:0007424 204 0.405
response to mechanical stimulus GO:0009612 28 0.378
cellular response to abiotic stimulus GO:0071214 58 0.349
inter male aggressive behavior GO:0002121 60 0.347
courtship behavior GO:0007619 68 0.323
epiboly GO:0090504 2 0.288
sensory perception GO:0007600 196 0.280
homeostatic process GO:0042592 199 0.280
ion transmembrane transport GO:0034220 122 0.270
metal ion homeostasis GO:0055065 44 0.250
mating GO:0007618 120 0.240
transmembrane transport GO:0055085 139 0.221
sensory perception of touch GO:0050975 11 0.211
response to light stimulus GO:0009416 124 0.211
cation transmembrane transport GO:0098655 88 0.209
cation homeostasis GO:0055080 51 0.202
locomotory behavior GO:0007626 176 0.198
response to radiation GO:0009314 155 0.179
multi multicellular organism process GO:0044706 123 0.175
synaptic transmission GO:0007268 288 0.172
response to decreased oxygen levels GO:0036293 58 0.156
male mating behavior GO:0060179 70 0.148
sensory perception of pain GO:0019233 4 0.146
metal ion transport GO:0030001 74 0.141
chemical homeostasis GO:0048878 92 0.133
localization of cell GO:0051674 257 0.131
cellular response to water stimulus GO:0071462 2 0.128
behavioral response to pain GO:0048266 3 0.127
feeding behavior GO:0007631 50 0.125
multi organism behavior GO:0051705 175 0.122
water homeostasis GO:0030104 3 0.121
aggressive behavior GO:0002118 63 0.116
ion transport GO:0006811 145 0.116
response to pain GO:0048265 3 0.115
reproductive behavior GO:0019098 122 0.112
morphogenesis of an epithelium GO:0002009 276 0.110
epiboly involved in wound healing GO:0090505 2 0.109
larval locomotory behavior GO:0008345 27 0.108
tissue morphogenesis GO:0048729 297 0.106
response to hypoxia GO:0001666 53 0.105
response to inorganic substance GO:0010035 44 0.102
regulation of ion transport GO:0043269 39 0.094
cognition GO:0050890 141 0.093
detection of stimulus involved in sensory perception GO:0050906 92 0.091
fluid transport GO:0042044 19 0.090
ion homeostasis GO:0050801 55 0.088
negative regulation of response to stimulus GO:0048585 258 0.088
response to temperature stimulus GO:0009266 106 0.087
cellular response to mechanical stimulus GO:0071260 2 0.082
cell migration GO:0016477 238 0.082
rhythmic process GO:0048511 106 0.079
central nervous system development GO:0007417 201 0.078
response to salt stress GO:0009651 11 0.076
taxis GO:0042330 304 0.073
response to oxygen levels GO:0070482 59 0.073
nuclear division GO:0000280 332 0.072
cellular response to organic substance GO:0071310 132 0.071
branching involved in open tracheal system development GO:0060446 45 0.070
regulation of synaptic transmission GO:0050804 69 0.069
regulation of membrane potential GO:0042391 35 0.068
trachea morphogenesis GO:0060439 22 0.068
inorganic ion transmembrane transport GO:0098660 73 0.068
sodium ion transport GO:0006814 22 0.068
sensory perception of chemical stimulus GO:0007606 116 0.067
detection of abiotic stimulus GO:0009582 66 0.066
cellular response to chemical stimulus GO:0070887 199 0.062
terminal branching open tracheal system GO:0007430 17 0.062
response to organic substance GO:0010033 284 0.059
regulation of response to stress GO:0080134 200 0.059
regulation of behavior GO:0050795 75 0.058
forebrain development GO:0030900 2 0.058
small molecule metabolic process GO:0044281 305 0.055
trachea development GO:0060438 29 0.054
response to pheromone GO:0019236 19 0.053
wound healing spreading of epidermal cells GO:0035313 1 0.053
regulation of cellular localization GO:0060341 136 0.051
camera type eye development GO:0043010 4 0.049
negative regulation of cellular metabolic process GO:0031324 382 0.049
learning or memory GO:0007611 141 0.048
brain development GO:0007420 120 0.048
establishment of localization in cell GO:0051649 402 0.048
regulation of localization GO:0032879 275 0.048
multicellular organismal aging GO:0010259 140 0.047
organic substance transport GO:0071702 257 0.045
cation transport GO:0006812 110 0.045
cellular response to nitrogen compound GO:1901699 51 0.044
response to organophosphorus GO:0046683 2 0.043
determination of adult lifespan GO:0008340 137 0.043
response to monosaccharide GO:0034284 4 0.041
circulatory system process GO:0003013 37 0.041
mating behavior GO:0007617 106 0.041
response to oxygen containing compound GO:1901700 200 0.040
negative regulation of cell communication GO:0010648 223 0.040
muscle system process GO:0003012 21 0.040
phosphorylation GO:0016310 294 0.040
monovalent inorganic cation transport GO:0015672 40 0.039
sensory perception of taste GO:0050909 25 0.038
defense response GO:0006952 300 0.038
response to glucose GO:0009749 2 0.038
drinking behavior GO:0042756 2 0.037
epithelial cell migration open tracheal system GO:0007427 32 0.037
response to organic cyclic compound GO:0014070 89 0.037
cellular amino acid metabolic process GO:0006520 61 0.037
regulation of transport GO:0051049 181 0.037
catabolic process GO:0009056 409 0.037
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.036
intracellular signal transduction GO:0035556 300 0.036
cellular response to oxygen containing compound GO:1901701 79 0.036
spermatogenesis GO:0007283 200 0.035
organelle fission GO:0048285 340 0.035
regulation of molecular function GO:0065009 217 0.035
regulation of catalytic activity GO:0050790 185 0.034
dendrite development GO:0016358 204 0.034
enzyme linked receptor protein signaling pathway GO:0007167 179 0.033
wound healing spreading of cells GO:0044319 2 0.033
cranial nerve development GO:0021545 1 0.032
mitotic nuclear division GO:0007067 213 0.032
learning GO:0007612 75 0.032
positive regulation of cell communication GO:0010647 250 0.032
regulation of synapse structure and activity GO:0050803 128 0.032
male gamete generation GO:0048232 201 0.031
multi organism reproductive behavior GO:0044705 121 0.031
nitrogen compound transport GO:0071705 85 0.031
circadian rhythm GO:0007623 105 0.031
response to external biotic stimulus GO:0043207 293 0.031
single organism biosynthetic process GO:0044711 206 0.030
protein localization GO:0008104 284 0.030
regulation of phosphorus metabolic process GO:0051174 210 0.029
positive regulation of molecular function GO:0044093 136 0.029
regulation of multicellular organismal development GO:2000026 414 0.029
eye development GO:0001654 323 0.029
regulation of tube architecture open tracheal system GO:0035152 68 0.029
macromolecule catabolic process GO:0009057 161 0.028
cell division GO:0051301 248 0.027
carbohydrate derivative metabolic process GO:1901135 217 0.027
regulation of cell differentiation GO:0045595 302 0.027
regulation of protein metabolic process GO:0051246 256 0.027
positive regulation of response to stimulus GO:0048584 323 0.027
aging GO:0007568 143 0.027
response to nitrogen compound GO:1901698 90 0.027
regulation of cellular catabolic process GO:0031329 157 0.027
negative regulation of signaling GO:0023057 219 0.027
organic cyclic compound catabolic process GO:1901361 168 0.027
body morphogenesis GO:0010171 2 0.026
response to alcohol GO:0097305 95 0.026
detection of external stimulus GO:0009581 66 0.026
positive regulation of signal transduction GO:0009967 223 0.026
multicellular organismal reproductive behavior GO:0033057 110 0.026
single organism carbohydrate metabolic process GO:0044723 72 0.025
heterocycle catabolic process GO:0046700 166 0.025
regulation of cell cycle GO:0051726 291 0.025
potassium ion transport GO:0006813 20 0.025
positive regulation of signaling GO:0023056 243 0.025
kidney development GO:0001822 3 0.025
blood circulation GO:0008015 26 0.024
immune system process GO:0002376 347 0.024
regulation of cellular ketone metabolic process GO:0010565 3 0.024
cellular homeostasis GO:0019725 80 0.024
phagocytosis GO:0006909 215 0.024
rhythmic behavior GO:0007622 76 0.024
regulation of hydrolase activity GO:0051336 97 0.024
mapk cascade GO:0000165 107 0.024
peptidyl amino acid modification GO:0018193 105 0.023
memory GO:0007613 94 0.023
response to wounding GO:0009611 94 0.023
response to bacterium GO:0009617 198 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
organic substance catabolic process GO:1901575 308 0.023
response to endogenous stimulus GO:0009719 119 0.023
cellular response to carbohydrate stimulus GO:0071322 4 0.023
oxoacid metabolic process GO:0043436 103 0.022
regulation of response to nutrient levels GO:0032107 18 0.022
transcription from rna polymerase ii promoter GO:0006366 368 0.022
response to organonitrogen compound GO:0010243 75 0.022
protein maturation GO:0051604 71 0.022
vesicle mediated transport GO:0016192 381 0.022
tube morphogenesis GO:0035239 191 0.022
regulation of system process GO:0044057 36 0.022
regulation of feeding behavior GO:0060259 16 0.022
regulation of synaptic activity GO:0060025 9 0.021
cell death GO:0008219 279 0.021
carboxylic acid metabolic process GO:0019752 92 0.021
gliogenesis GO:0042063 80 0.021
cell cell junction assembly GO:0007043 38 0.021
negative regulation of signal transduction GO:0009968 206 0.021
meiotic cell cycle GO:0051321 171 0.021
protein complex assembly GO:0006461 200 0.020
cellular response to external stimulus GO:0071496 66 0.020
action potential GO:0001508 13 0.020
somatic muscle development GO:0007525 66 0.020
intracellular transport GO:0046907 228 0.020
connective tissue development GO:0061448 3 0.020
olfactory behavior GO:0042048 97 0.020
endomembrane system organization GO:0010256 119 0.020
aromatic compound catabolic process GO:0019439 166 0.020
nucleocytoplasmic transport GO:0006913 72 0.020
heart process GO:0003015 37 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.019
regulation of intracellular signal transduction GO:1902531 236 0.019
cell motility GO:0048870 251 0.019
gravitaxis GO:0042332 26 0.019
membrane depolarization GO:0051899 4 0.019
purine ribonucleoside metabolic process GO:0046128 127 0.019
nucleobase containing small molecule metabolic process GO:0055086 174 0.019
branching morphogenesis of an epithelial tube GO:0048754 45 0.019
single organism intracellular transport GO:1902582 207 0.019
purine nucleoside triphosphate catabolic process GO:0009146 108 0.019
death GO:0016265 284 0.019
developmental programmed cell death GO:0010623 138 0.019
intracellular protein transport GO:0006886 104 0.019
ribonucleoside catabolic process GO:0042454 112 0.018
immune response GO:0006955 246 0.018
cellular component assembly involved in morphogenesis GO:0010927 151 0.018
embryo development ending in birth or egg hatching GO:0009792 152 0.018
negative regulation of transcription dna templated GO:0045892 237 0.018
cuticle development GO:0042335 86 0.018
salivary gland morphogenesis GO:0007435 145 0.018
innate immune response GO:0045087 144 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
negative regulation of cell cycle GO:0045786 116 0.017
regulation of anatomical structure size GO:0090066 163 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
response to other organism GO:0051707 293 0.017
response to acid chemical GO:0001101 25 0.017
cellular protein modification process GO:0006464 438 0.017
morphogenesis of a branching structure GO:0001763 45 0.017
organonitrogen compound metabolic process GO:1901564 318 0.017
gene silencing GO:0016458 138 0.017
negative regulation of cell cycle phase transition GO:1901988 103 0.017
positive regulation of macromolecule metabolic process GO:0010604 405 0.017
secretion by cell GO:0032940 101 0.017
protein complex biogenesis GO:0070271 201 0.017
response to hexose GO:0009746 3 0.017
heart contraction GO:0060047 26 0.017
chemosensory behavior GO:0007635 106 0.017
cellular catabolic process GO:0044248 372 0.017
multicellular organismal response to stress GO:0033555 5 0.017
signal transduction by phosphorylation GO:0023014 107 0.017
organic acid metabolic process GO:0006082 103 0.017
cellular response to organonitrogen compound GO:0071417 36 0.017
regulation of cellular response to stress GO:0080135 89 0.017
spindle organization GO:0007051 253 0.017
tissue death GO:0016271 102 0.017
macromolecular complex assembly GO:0065003 256 0.016
regulation of cell cycle process GO:0010564 181 0.016
embryonic morphogenesis GO:0048598 206 0.016
nucleobase containing compound catabolic process GO:0034655 165 0.016
regulation of purine nucleotide catabolic process GO:0033121 48 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
stem cell division GO:0017145 69 0.016
negative regulation of cellular component organization GO:0051129 108 0.016
single organismal cell cell adhesion GO:0016337 45 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.016
l amino acid import GO:0043092 2 0.016
single organism catabolic process GO:0044712 228 0.016
morphogenesis of a branching epithelium GO:0061138 45 0.016
striated muscle cell development GO:0055002 50 0.016
regulation of metal ion transport GO:0010959 15 0.016
synapse organization GO:0050808 196 0.016
nucleotide metabolic process GO:0009117 161 0.015
cell maturation GO:0048469 144 0.015
response to purine containing compound GO:0014074 12 0.015
cellular response to endogenous stimulus GO:0071495 80 0.015
ribonucleotide catabolic process GO:0009261 109 0.015
response to biotic stimulus GO:0009607 294 0.015
organelle assembly GO:0070925 198 0.015
detection of mechanical stimulus GO:0050982 6 0.015
negative regulation of cell cycle process GO:0010948 109 0.015
cellular response to dna damage stimulus GO:0006974 223 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.015
protein modification process GO:0036211 438 0.015
regulation of catabolic process GO:0009894 170 0.015
regulation of cellular protein metabolic process GO:0032268 243 0.015
wound healing GO:0042060 75 0.015
nucleoside metabolic process GO:0009116 127 0.015
cellular response to hexose stimulus GO:0071331 1 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
imaginal disc derived appendage morphogenesis GO:0035114 395 0.015
nuclear transport GO:0051169 72 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
cellular macromolecule localization GO:0070727 220 0.014
small gtpase mediated signal transduction GO:0007264 88 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
gland development GO:0048732 191 0.014
response to nutrient levels GO:0031667 114 0.014
regulation of immune system process GO:0002682 176 0.014
cellular modified amino acid metabolic process GO:0006575 45 0.014
neuromuscular synaptic transmission GO:0007274 67 0.014
negative regulation of mitotic cell cycle GO:0045930 109 0.014
dna endoreduplication GO:0042023 22 0.014
proteolysis GO:0006508 192 0.014
regulation of ion transmembrane transport GO:0034765 27 0.014
positive regulation of catalytic activity GO:0043085 118 0.014
positive regulation of epithelial cell differentiation GO:0030858 1 0.014
muscle contraction GO:0006936 13 0.014
regulation of excitatory postsynaptic membrane potential GO:0060079 3 0.014
regulation of proteolysis GO:0030162 87 0.014
autophagic cell death GO:0048102 83 0.014
glycosyl compound metabolic process GO:1901657 127 0.014
maintenance of epithelial integrity open tracheal system GO:0035160 12 0.014
negative regulation of gene expression GO:0010629 387 0.014
microtubule polymerization or depolymerization GO:0031109 39 0.014
carbohydrate homeostasis GO:0033500 12 0.014
cellular protein localization GO:0034613 160 0.014
regulation of wnt signaling pathway GO:0030111 68 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
response to extracellular stimulus GO:0009991 116 0.014
head development GO:0060322 135 0.014
protein phosphorylation GO:0006468 169 0.014
liquid clearance open tracheal system GO:0035002 13 0.014
regulation of defense response GO:0031347 102 0.014
glial cell development GO:0021782 27 0.014
epithelial tube morphogenesis GO:0060562 88 0.014
cellular protein catabolic process GO:0044257 83 0.013
epithelial fluid transport GO:0042045 17 0.013
anatomical structure homeostasis GO:0060249 97 0.013
positive regulation of transcription dna templated GO:0045893 266 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
thermosensory behavior GO:0040040 19 0.013
glycosyl compound catabolic process GO:1901658 112 0.013
purine containing compound metabolic process GO:0072521 155 0.013
multicellular organismal signaling GO:0035637 12 0.013
organophosphate catabolic process GO:0046434 112 0.013
salivary gland development GO:0007431 162 0.013
protein transport GO:0015031 155 0.013
regulation of body fluid levels GO:0050878 14 0.013
wing disc morphogenesis GO:0007472 344 0.013
regulation of muscle contraction GO:0006937 5 0.013
negative regulation of multicellular organismal process GO:0051241 142 0.013
defense response to bacterium GO:0042742 178 0.012
segmentation GO:0035282 207 0.012
regulation of nucleotide metabolic process GO:0006140 62 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.012
cellular response to monosaccharide stimulus GO:0071326 2 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
cellular protein complex assembly GO:0043623 71 0.012
g2 dna damage checkpoint GO:0031572 69 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
protein catabolic process GO:0030163 101 0.012
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.012
imaginal disc derived wing morphogenesis GO:0007476 337 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
protein modification by small protein conjugation or removal GO:0070647 106 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
cellular response to acid chemical GO:0071229 8 0.012
organ growth GO:0035265 56 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
divalent metal ion transport GO:0070838 26 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.012
programmed cell death GO:0012501 257 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
developmental maturation GO:0021700 172 0.012
oocyte maturation GO:0001556 3 0.012
cellular chemical homeostasis GO:0055082 40 0.012
sulfur compound metabolic process GO:0006790 59 0.011
regulation of heart contraction GO:0008016 21 0.011
specification of organ identity GO:0010092 3 0.011
hindbrain development GO:0030902 2 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
meiotic nuclear division GO:0007126 151 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
cellular response to organic cyclic compound GO:0071407 32 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.011
chitin based cuticle development GO:0040003 49 0.011
dna integrity checkpoint GO:0031570 81 0.011
syncytium formation by plasma membrane fusion GO:0000768 43 0.011
nucleoside catabolic process GO:0009164 112 0.011
adult behavior GO:0030534 137 0.011
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
mitotic spindle organization GO:0007052 220 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
carbohydrate metabolic process GO:0005975 82 0.011
biological adhesion GO:0022610 138 0.011
cellular ketone metabolic process GO:0042180 24 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
response to carbohydrate GO:0009743 15 0.011
cellular amine metabolic process GO:0044106 12 0.011
glandular epithelial cell differentiation GO:0002067 1 0.011
establishment of protein localization GO:0045184 163 0.011
defense response to other organism GO:0098542 225 0.011
purine containing compound catabolic process GO:0072523 112 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
positive regulation of peptidase activity GO:0010952 29 0.011
amine metabolic process GO:0009308 12 0.010
regulation of establishment of protein localization GO:0070201 61 0.010
imaginal disc derived appendage development GO:0048737 399 0.010
regionalization GO:0003002 416 0.010
regulation of protein localization GO:0032880 76 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.010
regulation of innate immune response GO:0045088 71 0.010
organonitrogen compound catabolic process GO:1901565 128 0.010
endocytosis GO:0006897 310 0.010
synapse assembly GO:0007416 143 0.010
establishment of rna localization GO:0051236 47 0.010
oocyte differentiation GO:0009994 145 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
olfactory learning GO:0008355 56 0.010
negative regulation of phosphate metabolic process GO:0045936 45 0.010
positive regulation of mapk cascade GO:0043410 63 0.010
mitotic cell cycle phase transition GO:0044772 138 0.010

plx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
respiratory system disease DOID:1579 0 0.735
lower respiratory tract disease DOID:0050161 0 0.735
bronchial disease DOID:1176 0 0.735
disease of anatomical entity DOID:7 0 0.735
liddle syndrome DOID:0050477 0 0.568
renal tubular transport disease DOID:447 0 0.568
kidney disease DOID:557 0 0.568
urinary system disease DOID:18 0 0.568
bronchiectasis DOID:9563 0 0.251
disease of metabolism DOID:0014667 0 0.034
inherited metabolic disorder DOID:655 0 0.034
nervous system disease DOID:863 0 0.030
carbohydrate metabolism disease DOID:0050013 0 0.028
glucose metabolism disease DOID:4194 0 0.028
acquired metabolic disease DOID:0060158 0 0.028
heart conduction disease DOID:10273 0 0.025
cardiovascular system disease DOID:1287 0 0.025
musculoskeletal system disease DOID:17 0 0.020
bone disease DOID:0080001 0 0.019
connective tissue disease DOID:65 0 0.019
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
diabetes mellitus DOID:9351 0 0.013
artery disease DOID:0050828 0 0.012
vascular disease DOID:178 0 0.012