Drosophila melanogaster

22 known processes

Hsp70Ab (Dmel_CG18743)

Heat-shock-protein-70Ab

(Aliases: Hsp70A,GRP78,HSP70,Hsp70,Hsp70aB,hsp70(87A),DMHSP7A2,hsp-70,hsp70,Hsp70ab,Hsp 70,CG18743,dhsp70,hsp70a,Hsp70-Ab,Dm-hsp70,hsp70 87A,hsp 70,Dmel\CG18743,dHsp70,hsp70A,hs70,hsp70Ab)

Hsp70Ab biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
heat shock mediated polytene chromosome puffing GO:0035080 7 1.000
cellular response to heat GO:0034605 24 0.997
response to heat GO:0009408 63 0.883
determination of adult lifespan GO:0008340 137 0.871
Fly
multicellular organismal aging GO:0010259 140 0.838
Fly
polytene chromosome puffing GO:0035079 7 0.823
aging GO:0007568 143 0.808
Fly
response to temperature stimulus GO:0009266 106 0.791
response to starvation GO:0042594 97 0.768
Fly
chromosome organization GO:0051276 360 0.734
response to organic substance GO:0010033 284 0.698
Fly
response to oxygen containing compound GO:1901700 200 0.577
Fly
response to abiotic stimulus GO:0009628 341 0.556
response to nitrogen compound GO:1901698 90 0.538
Fly
response to nutrient levels GO:0031667 114 0.528
Fly
response to organic cyclic compound GO:0014070 89 0.469
Fly
response to organonitrogen compound GO:0010243 75 0.436
Fly
response to hypoxia GO:0001666 53 0.356
response to decreased oxygen levels GO:0036293 58 0.311
response to endogenous stimulus GO:0009719 119 0.232
Fly
response to acid chemical GO:0001101 25 0.215
Fly
response to methotrexate GO:0031427 11 0.095
Fly
response to oxygen levels GO:0070482 59 0.095
response to extracellular stimulus GO:0009991 116 0.075
Fly
taxis GO:0042330 304 0.060
appendage development GO:0048736 401 0.058
wound healing GO:0042060 75 0.056
lateral inhibition GO:0046331 206 0.055
defense response to bacterium GO:0042742 178 0.054
negative regulation of cellular metabolic process GO:0031324 382 0.052
neurological system process GO:0050877 358 0.051
body morphogenesis GO:0010171 2 0.050
death GO:0016265 284 0.046
regulation of growth GO:0040008 233 0.043
appendage morphogenesis GO:0035107 397 0.041
apoptotic process GO:0006915 159 0.038
ameboidal type cell migration GO:0001667 151 0.037
programmed cell death GO:0012501 257 0.036
wing disc morphogenesis GO:0007472 344 0.036
single organism behavior GO:0044708 391 0.035
epithelial cell migration GO:0010631 148 0.035
negative regulation of cellular biosynthetic process GO:0031327 277 0.034
cellular amino acid metabolic process GO:0006520 61 0.034
imaginal disc derived appendage morphogenesis GO:0035114 395 0.033
response to other organism GO:0051707 293 0.033
imaginal disc derived wing morphogenesis GO:0007476 337 0.033
negative regulation of gene expression GO:0010629 387 0.033
response to external biotic stimulus GO:0043207 293 0.033
negative regulation of biosynthetic process GO:0009890 277 0.033
regulation of cellular ketone metabolic process GO:0010565 3 0.033
sensory organ morphogenesis GO:0090596 260 0.032
defense response to other organism GO:0098542 225 0.032
regulation of cellular component biogenesis GO:0044087 201 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
response to biotic stimulus GO:0009607 294 0.030
tissue death GO:0016271 102 0.030
locomotory behavior GO:0007626 176 0.029
catabolic process GO:0009056 409 0.029
cell motility GO:0048870 251 0.029
vesicle mediated transport GO:0016192 381 0.029
cognition GO:0050890 141 0.029
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.028
cell cell signaling involved in cell fate commitment GO:0045168 210 0.028
organonitrogen compound metabolic process GO:1901564 318 0.028
oxoacid metabolic process GO:0043436 103 0.027
cellular response to chemical stimulus GO:0070887 199 0.027
cellular protein catabolic process GO:0044257 83 0.027
defense response GO:0006952 300 0.026
post embryonic appendage morphogenesis GO:0035120 385 0.026
cellular amine metabolic process GO:0044106 12 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
endocytosis GO:0006897 310 0.024
synapse organization GO:0050808 196 0.024
response to oxidative stress GO:0006979 86 0.024
positive regulation of cell migration GO:0030335 2 0.023
regulation of phosphorus metabolic process GO:0051174 210 0.023
carboxylic acid metabolic process GO:0019752 92 0.023
humoral immune response GO:0006959 117 0.023
cellular ketone metabolic process GO:0042180 24 0.023
response to wounding GO:0009611 94 0.022
phagocytosis GO:0006909 215 0.022
transcription from rna polymerase ii promoter GO:0006366 368 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
homeostatic process GO:0042592 199 0.022
imaginal disc derived appendage development GO:0048737 399 0.021
epithelial cell development GO:0002064 274 0.021
ribonucleoside triphosphate metabolic process GO:0009199 119 0.021
positive regulation of cellular biosynthetic process GO:0031328 316 0.021
cell division GO:0051301 248 0.021
learning or memory GO:0007611 141 0.021
regulation of epithelial cell proliferation GO:0050678 4 0.021
organophosphate metabolic process GO:0019637 195 0.021
epithelial cell differentiation GO:0030855 322 0.020
regulation of cellular protein metabolic process GO:0032268 243 0.020
epithelium migration GO:0090132 148 0.020
regulation of cellular amine metabolic process GO:0033238 3 0.020
eye morphogenesis GO:0048592 260 0.020
response to lipopolysaccharide GO:0032496 4 0.020
cellular protein modification process GO:0006464 438 0.020
negative regulation of rna metabolic process GO:0051253 251 0.020
salivary gland development GO:0007431 162 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.020
signal transduction by phosphorylation GO:0023014 107 0.019
neuromuscular junction development GO:0007528 149 0.019
small molecule metabolic process GO:0044281 305 0.019
cellular catabolic process GO:0044248 372 0.019
cellular response to ionizing radiation GO:0071479 15 0.019
forebrain development GO:0030900 2 0.019
salivary gland morphogenesis GO:0007435 145 0.019
organic substance catabolic process GO:1901575 308 0.019
positive regulation of cell communication GO:0010647 250 0.019
proteolysis GO:0006508 192 0.019
camera type eye development GO:0043010 4 0.019
regulation of cellular catabolic process GO:0031329 157 0.019
gland development GO:0048732 191 0.019
cell migration GO:0016477 238 0.019
regulation of anatomical structure morphogenesis GO:0022603 242 0.019
connective tissue development GO:0061448 3 0.019
small gtpase mediated signal transduction GO:0007264 88 0.019
regulation of molecular function GO:0065009 217 0.019
establishment of localization in cell GO:0051649 402 0.019
limb development GO:0060173 1 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.018
compound eye development GO:0048749 307 0.018
single organismal cell cell adhesion GO:0016337 45 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
positive regulation of nucleic acid templated transcription GO:1903508 266 0.018
localization of cell GO:0051674 257 0.018
histolysis GO:0007559 102 0.017
cell adhesion GO:0007155 136 0.017
regulation of cell cycle GO:0051726 291 0.017
response to radiation GO:0009314 155 0.017
camera type eye morphogenesis GO:0048593 2 0.017
respiratory system development GO:0060541 213 0.017
amine metabolic process GO:0009308 12 0.017
actin filament organization GO:0007015 126 0.017
actin cytoskeleton organization GO:0030036 206 0.017
intracellular transport GO:0046907 228 0.017
male gamete generation GO:0048232 201 0.017
purine ribonucleotide catabolic process GO:0009154 109 0.017
response to organophosphorus GO:0046683 2 0.017
positive regulation of cellular component organization GO:0051130 156 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
positive regulation of cellular catabolic process GO:0031331 95 0.016
spermatogenesis GO:0007283 200 0.016
purine nucleoside triphosphate metabolic process GO:0009144 119 0.016
negative regulation of response to stimulus GO:0048585 258 0.016
modification dependent protein catabolic process GO:0019941 78 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.016
nuclear division GO:0000280 332 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
dorsal ventral pattern formation GO:0009953 133 0.016
proteasomal protein catabolic process GO:0010498 59 0.016
regulation of localization GO:0032879 275 0.016
response to light stimulus GO:0009416 124 0.016
autophagy GO:0006914 108 0.016
regionalization GO:0003002 416 0.016
organic substance transport GO:0071702 257 0.016
single organism biosynthetic process GO:0044711 206 0.015
purine ribonucleoside catabolic process GO:0046130 112 0.015
polyol biosynthetic process GO:0046173 3 0.015
cell death GO:0008219 279 0.015
regulation of catabolic process GO:0009894 170 0.015
developmental growth GO:0048589 280 0.015
immune response GO:0006955 246 0.015
positive regulation of signaling GO:0023056 243 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.015
macromolecule catabolic process GO:0009057 161 0.015
exocrine system development GO:0035272 162 0.015
carbohydrate derivative metabolic process GO:1901135 217 0.015
notch signaling pathway GO:0007219 120 0.015
ribose phosphate metabolic process GO:0019693 145 0.015
chemotaxis GO:0006935 249 0.015
xenobiotic catabolic process GO:0042178 1 0.015
developmental programmed cell death GO:0010623 138 0.015
tissue morphogenesis GO:0048729 297 0.015
gland morphogenesis GO:0022612 145 0.015
protein localization GO:0008104 284 0.015
hindbrain development GO:0030902 2 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.015
positive regulation of cell motility GO:2000147 3 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
negative regulation of rna biosynthetic process GO:1902679 240 0.015
glycosyl compound metabolic process GO:1901657 127 0.015
growth GO:0040007 359 0.015
regulation of tube size GO:0035150 46 0.015
cell proliferation GO:0008283 299 0.015
embryonic morphogenesis GO:0048598 206 0.014
sterol homeostasis GO:0055092 4 0.014
salivary gland histolysis GO:0035070 88 0.014
regulation of multicellular organismal development GO:2000026 414 0.014
tissue migration GO:0090130 155 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
fat soluble vitamin biosynthetic process GO:0042362 1 0.014
ras protein signal transduction GO:0007265 88 0.014
antimicrobial humoral response GO:0019730 99 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
macromolecular complex assembly GO:0065003 256 0.014
purine ribonucleotide metabolic process GO:0009150 145 0.014
protein catabolic process GO:0030163 101 0.014
synapse assembly GO:0007416 143 0.014
regulation of transport GO:0051049 181 0.014
regulation of cell cycle phase transition GO:1901987 130 0.014
nucleoside phosphate catabolic process GO:1901292 110 0.014
olfactory behavior GO:0042048 97 0.014
negative regulation of nucleic acid templated transcription GO:1903507 240 0.014
positive regulation of signal transduction GO:0009967 223 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
salivary gland cell autophagic cell death GO:0035071 83 0.014
chemosensory behavior GO:0007635 106 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
neuron projection guidance GO:0097485 241 0.014
positive regulation of nucleotide metabolic process GO:0045981 55 0.013
meiosis i GO:0007127 59 0.013
positive regulation of catabolic process GO:0009896 105 0.013
muscle organ development GO:0007517 127 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
learning GO:0007612 75 0.013
limb morphogenesis GO:0035108 1 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
cellular response to oxygen containing compound GO:1901701 79 0.013
posttranscriptional regulation of gene expression GO:0010608 145 0.013
intracellular signal transduction GO:0035556 300 0.013
regulation of cell cycle process GO:0010564 181 0.013
small molecule biosynthetic process GO:0044283 37 0.013
regulation of catalytic activity GO:0050790 185 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
aromatic compound catabolic process GO:0019439 166 0.013
sensory perception of chemical stimulus GO:0007606 116 0.013
morphogenesis of an epithelium GO:0002009 276 0.013
regulation of cell differentiation GO:0045595 302 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.013
positive regulation of apoptotic signaling pathway GO:2001235 4 0.013
negative regulation of transcription dna templated GO:0045892 237 0.013
peptidyl lysine modification GO:0018205 57 0.013
negative regulation of signal transduction GO:0009968 206 0.013
response to glucose GO:0009749 2 0.013
microtubule organizing center organization GO:0031023 168 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.012
meiotic cell cycle GO:0051321 171 0.012
molting cycle chitin based cuticle GO:0007591 56 0.012
single organism catabolic process GO:0044712 228 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
rrna processing GO:0006364 3 0.012
phosphorylation GO:0016310 294 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
actin filament based process GO:0030029 220 0.012
nucleoside catabolic process GO:0009164 112 0.012
mating GO:0007618 120 0.012
immune system process GO:0002376 347 0.012
organelle assembly GO:0070925 198 0.012
regulation of rna splicing GO:0043484 69 0.012
regulation of organelle organization GO:0033043 196 0.012
regulation of anatomical structure size GO:0090066 163 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
biological adhesion GO:0022610 138 0.012
regulation of cell morphogenesis GO:0022604 163 0.012
autophagic cell death GO:0048102 83 0.012
mesenchymal cell development GO:0014031 1 0.012
imaginal disc pattern formation GO:0007447 91 0.012
cellular response to abiotic stimulus GO:0071214 58 0.012
compound eye morphogenesis GO:0001745 249 0.012
behavioral response to ethanol GO:0048149 49 0.012
mitotic cell cycle phase transition GO:0044772 138 0.012
regulation of apoptotic process GO:0042981 130 0.012
mrna processing GO:0006397 104 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
regulation of protein metabolic process GO:0051246 256 0.012
protein complex biogenesis GO:0070271 201 0.012
mesenchymal cell differentiation GO:0048762 1 0.012
regulation of response to stress GO:0080134 200 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
positive regulation of transcription dna templated GO:0045893 266 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
regulation of cell proliferation GO:0042127 163 0.012
chromatin organization GO:0006325 207 0.012
axis specification GO:0009798 167 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
purine containing compound metabolic process GO:0072521 155 0.011
kidney development GO:0001822 3 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
regulation of mrna splicing via spliceosome GO:0048024 64 0.011
regulation of chromosome organization GO:0033044 64 0.011
multi multicellular organism process GO:0044706 123 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
regulation of programmed cell death GO:0043067 152 0.011
steroid catabolic process GO:0006706 1 0.011
larval behavior GO:0030537 42 0.011
phosphatidylethanolamine metabolic process GO:0046337 1 0.011
negative regulation of cell communication GO:0010648 223 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
cellular response to organic substance GO:0071310 132 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
axon development GO:0061564 297 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
protein modification process GO:0036211 438 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
heterocycle catabolic process GO:0046700 166 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.011
cellular protein localization GO:0034613 160 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
stem cell differentiation GO:0048863 117 0.011
mrna metabolic process GO:0016071 124 0.011
modification dependent macromolecule catabolic process GO:0043632 79 0.011
cellularization GO:0007349 90 0.011
nephron epithelium development GO:0072009 3 0.011
mitotic dna integrity checkpoint GO:0044774 75 0.011
protein transmembrane transport GO:0071806 4 0.011
cell fate determination GO:0001709 91 0.011
organelle fission GO:0048285 340 0.011
organophosphate catabolic process GO:0046434 112 0.011
cellular response to dna damage stimulus GO:0006974 223 0.011
tube morphogenesis GO:0035239 191 0.011
cuticle development GO:0042335 86 0.011
tube development GO:0035295 244 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
positive regulation of gene expression GO:0010628 290 0.011
meiotic nuclear division GO:0007126 151 0.011
medium chain fatty acid metabolic process GO:0051791 1 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
telencephalon development GO:0021537 2 0.011
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.011
cell cycle phase transition GO:0044770 140 0.011
sensory perception GO:0007600 196 0.011
anterior posterior pattern specification GO:0009952 136 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.010
organic acid metabolic process GO:0006082 103 0.010
male meiosis GO:0007140 52 0.010
organonitrogen compound catabolic process GO:1901565 128 0.010
regulation of response to external stimulus GO:0032101 115 0.010
muscle structure development GO:0061061 224 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.010
regulation of intracellular transport GO:0032386 64 0.010
cellular protein complex assembly GO:0043623 71 0.010
spermatid differentiation GO:0048515 114 0.010
response to alcohol GO:0097305 95 0.010
cell projection assembly GO:0030031 94 0.010
regulation of lipid transport GO:0032368 3 0.010
intracellular protein transport GO:0006886 104 0.010
anatomical structure homeostasis GO:0060249 97 0.010
positive regulation of molecular function GO:0044093 136 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.010
spermatid development GO:0007286 98 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
response to monosaccharide GO:0034284 4 0.010
negative regulation of growth GO:0045926 84 0.010
regulation of cell growth GO:0001558 43 0.010
positive regulation of biosynthetic process GO:0009891 316 0.010
sensory perception of smell GO:0007608 80 0.010
negative regulation of cellular protein metabolic process GO:0032269 85 0.010
alternative mrna splicing via spliceosome GO:0000380 60 0.010
regulation of cellular response to stress GO:0080135 89 0.010
single organism intracellular transport GO:1902582 207 0.010

Hsp70Ab disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
cardiovascular system disease DOID:1287 0 0.024
central nervous system disease DOID:331 0 0.018
neurodegenerative disease DOID:1289 0 0.018
nervous system disease DOID:863 0 0.018
motor neuron disease DOID:231 0 0.018
musculoskeletal system disease DOID:17 0 0.016
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
artery disease DOID:0050828 0 0.013
vascular disease DOID:178 0 0.013
neuromuscular disease DOID:440 0 0.012
charcot marie tooth disease type 2 DOID:0050539 0 0.012
charcot marie tooth disease DOID:10595 0 0.012
neuropathy DOID:870 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.011