Drosophila melanogaster

40 known processes

eIF-1A (Dmel_CG8053)

Eukaryotic initiation factor 1A

(Aliases: CG8053,eIF1A,Group I,EP(3)0935,group I,EP935,anon-EST:Posey4,eIF-4c,anon-EST:Liang-2.3,clone 2.3,D-eIF4c,D-eIF1A,Dmel\CG8053)

eIF-1A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of gene expression GO:0010628 290 0.301
establishment of localization in cell GO:0051649 402 0.251
intracellular transport GO:0046907 228 0.182
positive regulation of macromolecule metabolic process GO:0010604 405 0.161
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.157
posttranscriptional regulation of gene expression GO:0010608 145 0.155
positive regulation of rna biosynthetic process GO:1902680 266 0.153
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.145
positive regulation of cellular biosynthetic process GO:0031328 316 0.141
positive regulation of nucleic acid templated transcription GO:1903508 266 0.136
dorsal ventral pattern formation GO:0009953 133 0.133
cytoplasmic transport GO:0016482 130 0.119
negative regulation of mitotic cell cycle GO:0045930 109 0.117
modification dependent macromolecule catabolic process GO:0043632 79 0.110
positive regulation of rna metabolic process GO:0051254 271 0.105
positive regulation of transcription dna templated GO:0045893 266 0.103
single organism intracellular transport GO:1902582 207 0.101
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.097
regulation of gene expression epigenetic GO:0040029 128 0.093
macromolecule catabolic process GO:0009057 161 0.092
transcription from rna polymerase ii promoter GO:0006366 368 0.085
immune system process GO:0002376 347 0.084
response to biotic stimulus GO:0009607 294 0.082
organic substance transport GO:0071702 257 0.082
mitotic cell cycle phase transition GO:0044772 138 0.079
positive regulation of biosynthetic process GO:0009891 316 0.076
cellular macromolecule localization GO:0070727 220 0.075
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.075
regulation of cell cycle phase transition GO:1901987 130 0.074
homeostatic process GO:0042592 199 0.072
stem cell differentiation GO:0048863 117 0.072
protein catabolic process GO:0030163 101 0.071
organic substance catabolic process GO:1901575 308 0.071
chemical homeostasis GO:0048878 92 0.070
mitotic dna damage checkpoint GO:0044773 74 0.069
cell cycle phase transition GO:0044770 140 0.069
male gamete generation GO:0048232 201 0.068
cellular response to dna damage stimulus GO:0006974 223 0.066
proteasomal protein catabolic process GO:0010498 59 0.060
positive regulation of transport GO:0051050 92 0.058
organonitrogen compound metabolic process GO:1901564 318 0.057
dna repair GO:0006281 54 0.057
gene silencing GO:0016458 138 0.056
cell cycle checkpoint GO:0000075 95 0.056
negative regulation of cell cycle process GO:0010948 109 0.056
regulation of mitotic cell cycle phase transition GO:1901990 130 0.056
negative regulation of cellular metabolic process GO:0031324 382 0.052
stem cell development GO:0048864 79 0.052
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.051
post embryonic appendage morphogenesis GO:0035120 385 0.050
imaginal disc derived wing morphogenesis GO:0007476 337 0.050
regulation of localization GO:0032879 275 0.049
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.049
negative regulation of cell cycle phase transition GO:1901988 103 0.049
nucleocytoplasmic transport GO:0006913 72 0.049
dna integrity checkpoint GO:0031570 81 0.048
cellular component assembly involved in morphogenesis GO:0010927 151 0.048
stem cell maintenance GO:0019827 67 0.047
rna localization GO:0006403 115 0.047
imaginal disc derived appendage morphogenesis GO:0035114 395 0.046
response to other organism GO:0051707 293 0.046
aging GO:0007568 143 0.046
catabolic process GO:0009056 409 0.045
regulation of transport GO:0051049 181 0.045
cellular macromolecule catabolic process GO:0044265 136 0.045
cell division GO:0051301 248 0.045
imaginal disc derived appendage development GO:0048737 399 0.044
regulation of cell cycle GO:0051726 291 0.044
response to bacterium GO:0009617 198 0.044
eye development GO:0001654 323 0.043
regulation of multicellular organismal development GO:2000026 414 0.043
single organism biosynthetic process GO:0044711 206 0.043
appendage development GO:0048736 401 0.043
negative regulation of developmental process GO:0051093 201 0.042
regulation of anatomical structure morphogenesis GO:0022603 242 0.042
smoothened signaling pathway GO:0007224 49 0.042
regulation of response to stress GO:0080134 200 0.041
negative regulation of cell differentiation GO:0045596 143 0.041
cell migration GO:0016477 238 0.041
growth GO:0040007 359 0.040
epithelial cell development GO:0002064 274 0.040
proteolysis GO:0006508 192 0.040
columnar cuboidal epithelial cell development GO:0002066 249 0.040
negative regulation of cellular biosynthetic process GO:0031327 277 0.039
rna processing GO:0006396 147 0.039
epithelial cell differentiation GO:0030855 322 0.039
secretion GO:0046903 109 0.039
mitotic dna integrity checkpoint GO:0044774 75 0.039
mitotic nuclear division GO:0007067 213 0.038
embryo development ending in birth or egg hatching GO:0009792 152 0.038
imaginal disc derived wing vein specification GO:0007474 48 0.038
protein transport GO:0015031 155 0.038
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.038
mrna metabolic process GO:0016071 124 0.038
regulation of cell cycle process GO:0010564 181 0.037
nitrogen compound transport GO:0071705 85 0.037
mitotic cell cycle checkpoint GO:0007093 88 0.036
translation GO:0006412 69 0.036
cell proliferation GO:0008283 299 0.035
appendage morphogenesis GO:0035107 397 0.035
compound eye morphogenesis GO:0001745 249 0.034
muscle structure development GO:0061061 224 0.034
negative regulation of cell cycle GO:0045786 116 0.034
body morphogenesis GO:0010171 2 0.033
negative regulation of gene expression GO:0010629 387 0.033
cellular catabolic process GO:0044248 372 0.033
sensory organ morphogenesis GO:0090596 260 0.033
regulation of mitotic cell cycle GO:0007346 190 0.032
response to external biotic stimulus GO:0043207 293 0.032
endocytosis GO:0006897 310 0.032
compound eye development GO:0048749 307 0.031
defense response to bacterium GO:0042742 178 0.031
response to light stimulus GO:0009416 124 0.031
protein modification process GO:0036211 438 0.031
dendrite morphogenesis GO:0048813 199 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.031
negative regulation of rna biosynthetic process GO:1902679 240 0.031
imaginal disc derived leg morphogenesis GO:0007480 80 0.030
ubiquitin dependent protein catabolic process GO:0006511 78 0.030
dna damage checkpoint GO:0000077 78 0.030
cation homeostasis GO:0055080 51 0.030
dna metabolic process GO:0006259 227 0.030
negative regulation of nucleic acid templated transcription GO:1903507 240 0.030
carbohydrate derivative metabolic process GO:1901135 217 0.029
modification dependent protein catabolic process GO:0019941 78 0.029
macromolecular complex disassembly GO:0032984 37 0.029
ovarian follicle cell development GO:0030707 248 0.029
dna conformation change GO:0071103 105 0.029
organelle fission GO:0048285 340 0.029
secretion by cell GO:0032940 101 0.029
regulation of cellular response to stress GO:0080135 89 0.028
jak stat cascade GO:0007259 49 0.028
cellular protein modification process GO:0006464 438 0.028
regulation of notch signaling pathway GO:0008593 100 0.028
eggshell formation GO:0030703 105 0.027
imaginal disc pattern formation GO:0007447 91 0.027
single organism carbohydrate metabolic process GO:0044723 72 0.027
leg disc morphogenesis GO:0007478 80 0.027
regulation of epithelial cell proliferation GO:0050678 4 0.027
chorion containing eggshell formation GO:0007304 105 0.027
protein localization GO:0008104 284 0.027
regionalization GO:0003002 416 0.027
detection of stimulus GO:0051606 156 0.026
chaeta morphogenesis GO:0008407 42 0.026
regulation of developmental growth GO:0048638 174 0.026
chromosome organization GO:0051276 360 0.025
mitotic spindle elongation GO:0000022 81 0.025
defense response GO:0006952 300 0.025
nuclear division GO:0000280 332 0.025
cellular protein complex disassembly GO:0043624 35 0.024
protein modification by small protein conjugation GO:0032446 79 0.024
biological adhesion GO:0022610 138 0.023
cell motility GO:0048870 251 0.023
eye morphogenesis GO:0048592 260 0.023
multicellular organismal aging GO:0010259 140 0.023
microtubule based movement GO:0007018 51 0.023
cellular protein catabolic process GO:0044257 83 0.023
spindle elongation GO:0051231 83 0.022
negative regulation of biosynthetic process GO:0009890 277 0.022
adult behavior GO:0030534 137 0.022
carbohydrate metabolic process GO:0005975 82 0.022
response to organic substance GO:0010033 284 0.022
cell death GO:0008219 279 0.022
organelle assembly GO:0070925 198 0.022
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.022
gland development GO:0048732 191 0.022
rrna processing GO:0006364 3 0.022
organonitrogen compound biosynthetic process GO:1901566 117 0.021
regulation of cytoplasmic transport GO:1903649 47 0.021
regulation of cellular localization GO:0060341 136 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.021
regulation of immune system process GO:0002682 176 0.021
intracellular protein transmembrane import GO:0044743 4 0.021
oocyte development GO:0048599 124 0.021
response to lipopolysaccharide GO:0032496 4 0.021
cell cell signaling involved in cell fate commitment GO:0045168 210 0.021
mitotic g2 dna damage checkpoint GO:0007095 69 0.021
single organism behavior GO:0044708 391 0.021
intracellular signal transduction GO:0035556 300 0.020
wing disc morphogenesis GO:0007472 344 0.020
negative regulation of growth of symbiont involved in interaction with host GO:0044146 9 0.020
phagocytosis GO:0006909 215 0.020
spermatogenesis GO:0007283 200 0.020
response to oxygen containing compound GO:1901700 200 0.020
notch signaling pathway GO:0007219 120 0.020
metal ion transport GO:0030001 74 0.020
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.020
organophosphate metabolic process GO:0019637 195 0.019
regulation of translation GO:0006417 56 0.019
protein ubiquitination GO:0016567 70 0.019
immune response GO:0006955 246 0.019
regulation of cell cycle g1 s phase transition GO:1902806 23 0.019
determination of adult lifespan GO:0008340 137 0.019
cellular protein localization GO:0034613 160 0.019
interspecies interaction between organisms GO:0044419 16 0.019
embryonic development via the syncytial blastoderm GO:0001700 148 0.019
rna transport GO:0050658 46 0.019
positive regulation of molecular function GO:0044093 136 0.019
cellular response to lipopolysaccharide GO:0071222 3 0.019
protein glycosylation GO:0006486 32 0.018
response to radiation GO:0009314 155 0.018
cellular cation homeostasis GO:0030003 38 0.018
cellular ion homeostasis GO:0006873 39 0.018
eggshell chorion assembly GO:0007306 66 0.018
cellular nitrogen compound catabolic process GO:0044270 165 0.018
centrosome organization GO:0051297 163 0.018
response to alcohol GO:0097305 95 0.018
actin filament based process GO:0030029 220 0.018
nucleobase containing compound transport GO:0015931 56 0.018
regulation of intracellular transport GO:0032386 64 0.018
purine nucleoside metabolic process GO:0042278 127 0.017
vesicle mediated transport GO:0016192 381 0.017
intracellular protein transmembrane transport GO:0065002 4 0.017
striated muscle cell differentiation GO:0051146 90 0.017
mitochondrion organization GO:0007005 65 0.017
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.017
larval development GO:0002164 104 0.017
intracellular protein transport GO:0006886 104 0.017
negative regulation of transcription dna templated GO:0045892 237 0.017
gliogenesis GO:0042063 80 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.017
salivary gland histolysis GO:0035070 88 0.017
regulation of epithelial cell differentiation GO:0030856 4 0.017
regulation of catalytic activity GO:0050790 185 0.017
lateral inhibition GO:0046331 206 0.017
positive regulation of cell communication GO:0010647 250 0.016
regulation of cellular protein metabolic process GO:0032268 243 0.016
organic acid metabolic process GO:0006082 103 0.016
wing disc pattern formation GO:0035222 66 0.016
nucleoside triphosphate metabolic process GO:0009141 120 0.016
positive regulation of cell cycle GO:0045787 43 0.016
chemosensory behavior GO:0007635 106 0.016
g1 s transition of mitotic cell cycle GO:0000082 31 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
membrane budding GO:0006900 4 0.016
positive regulation of signal transduction GO:0009967 223 0.016
ion homeostasis GO:0050801 55 0.016
nuclear transport GO:0051169 72 0.016
protein complex disassembly GO:0043241 36 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
response to abiotic stimulus GO:0009628 341 0.015
negative regulation of epithelial cell proliferation GO:0050680 4 0.015
cell cycle g1 s phase transition GO:0044843 31 0.015
g2 dna damage checkpoint GO:0031572 69 0.015
compound eye photoreceptor development GO:0042051 78 0.015
oocyte axis specification GO:0007309 108 0.015
negative regulation of multicellular organismal process GO:0051241 142 0.015
establishment of protein localization GO:0045184 163 0.015
establishment of rna localization GO:0051236 47 0.015
stress activated protein kinase signaling cascade GO:0031098 55 0.015
nucleobase containing compound catabolic process GO:0034655 165 0.015
single organism membrane budding GO:1902591 2 0.015
hematopoietic or lymphoid organ development GO:0048534 57 0.015
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
wing disc dorsal ventral pattern formation GO:0048190 47 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
defense response to other organism GO:0098542 225 0.015
chromosome segregation GO:0007059 157 0.014
developmental growth GO:0048589 280 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
single organism cellular localization GO:1902580 180 0.014
regulation of phosphorylation GO:0042325 147 0.014
detection of abiotic stimulus GO:0009582 66 0.014
cell junction assembly GO:0034329 42 0.014
heterocycle catabolic process GO:0046700 166 0.014
regulation of cell shape GO:0008360 113 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.014
protein modification by small protein conjugation or removal GO:0070647 106 0.014
mitotic cell cycle embryonic GO:0045448 38 0.014
mrna polyadenylation GO:0006378 11 0.014
regulation of organelle organization GO:0033043 196 0.014
positive regulation of signaling GO:0023056 243 0.014
mesenchymal cell differentiation GO:0048762 1 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
protein dna complex assembly GO:0065004 63 0.014
developmental maturation GO:0021700 172 0.014
single organism catabolic process GO:0044712 228 0.014
dorsal ventral axis specification GO:0009950 66 0.014
molting cycle GO:0042303 56 0.014
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.013
regulation of proteasomal protein catabolic process GO:0061136 39 0.013
regulation of growth GO:0040008 233 0.013
dendrite development GO:0016358 204 0.013
negative regulation of gene expression epigenetic GO:0045814 77 0.013
positive regulation of cell migration GO:0030335 2 0.013
maintenance of location GO:0051235 73 0.013
protein complex biogenesis GO:0070271 201 0.013
mitotic sister chromatid segregation GO:0000070 87 0.013
mesenchymal cell development GO:0014031 1 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.013
endosome transport via multivesicular body sorting pathway GO:0032509 12 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
regulation of protein metabolic process GO:0051246 256 0.013
translational initiation GO:0006413 11 0.013
camera type eye development GO:0043010 4 0.013
salivary gland cell autophagic cell death GO:0035071 83 0.012
negative regulation of immune system process GO:0002683 50 0.012
regulation of cell proliferation GO:0042127 163 0.012
mitotic spindle organization GO:0007052 220 0.012
central nervous system development GO:0007417 201 0.012
negative regulation of signal transduction GO:0009968 206 0.012
death GO:0016265 284 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
immune response activating signal transduction GO:0002757 2 0.012
cell adhesion GO:0007155 136 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.012
rna 3 end processing GO:0031123 45 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
chaeta development GO:0022416 97 0.012
regulation of mrna 3 end processing GO:0031440 7 0.012
protein complex assembly GO:0006461 200 0.012
translational termination GO:0006415 2 0.012
glial cell differentiation GO:0010001 35 0.012
microtubule organizing center organization GO:0031023 168 0.012
small molecule metabolic process GO:0044281 305 0.012
regulation of proteolysis GO:0030162 87 0.012
chromatin silencing GO:0006342 76 0.012
mrna 3 end processing GO:0031124 28 0.012
protein localization to organelle GO:0033365 82 0.012
germarium derived egg chamber formation GO:0007293 101 0.012
regulation of protein transport GO:0051223 57 0.012
meiotic cell cycle GO:0051321 171 0.012
dorsal appendage formation GO:0046843 47 0.012
aromatic compound catabolic process GO:0019439 166 0.011
protein import GO:0017038 55 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
mesoderm development GO:0007498 78 0.011
regulation of nucleocytoplasmic transport GO:0046822 35 0.011
regulation of vesicle mediated transport GO:0060627 59 0.011
embryonic pattern specification GO:0009880 174 0.011
aggressive behavior GO:0002118 63 0.011
posttranscriptional gene silencing GO:0016441 46 0.011
pole plasm assembly GO:0007315 61 0.011
neurological system process GO:0050877 358 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
posttranscriptional gene silencing by rna GO:0035194 45 0.011
humoral immune response GO:0006959 117 0.011
postreplication repair GO:0006301 2 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
gland morphogenesis GO:0022612 145 0.011
regulation of endocytosis GO:0030100 37 0.011
muscle cell development GO:0055001 50 0.011
positive regulation of proteolysis GO:0045862 52 0.011
chromatin modification GO:0016568 147 0.011
nucleotide metabolic process GO:0009117 161 0.011
cell growth GO:0016049 108 0.011
cellular homeostasis GO:0019725 80 0.011
cell maturation GO:0048469 144 0.011
protein targeting GO:0006605 64 0.011
behavioral response to ethanol GO:0048149 49 0.011
pigmentation GO:0043473 75 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
germarium derived oocyte differentiation GO:0030706 29 0.011
antimicrobial humoral response GO:0019730 99 0.011
immune system development GO:0002520 57 0.011
dna templated transcription elongation GO:0006354 18 0.011
protein k48 linked ubiquitination GO:0070936 3 0.011
embryonic morphogenesis GO:0048598 206 0.011
cytoplasm organization GO:0007028 64 0.011
detection of external stimulus GO:0009581 66 0.011
signal release GO:0023061 49 0.011
oocyte differentiation GO:0009994 145 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
spinal cord development GO:0021510 1 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.010
covalent chromatin modification GO:0016569 106 0.010
developmental programmed cell death GO:0010623 138 0.010
compound eye photoreceptor cell differentiation GO:0001751 140 0.010
developmental pigmentation GO:0048066 68 0.010
histone ubiquitination GO:0016574 4 0.010
positive regulation of intracellular transport GO:0032388 42 0.010
regulation of pole plasm oskar mrna localization GO:0007317 27 0.010
purine ribonucleoside catabolic process GO:0046130 112 0.010
eye pigmentation GO:0048069 43 0.010
negative regulation of neural precursor cell proliferation GO:2000178 27 0.010
actin cytoskeleton organization GO:0030036 206 0.010
hematopoietic progenitor cell differentiation GO:0002244 1 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
ion transport GO:0006811 145 0.010
pigment metabolic process GO:0042440 84 0.010

eIF-1A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
nervous system disease DOID:863 0 0.019
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015