Drosophila melanogaster

42 known processes

alpha-Cat (Dmel_CG17947)

alpha Catenin

(Aliases: alphaCat,alpha-ctn,Dalpha-catenin,Dalpha-cat,a-cat,alpha-CAT,CT39986,alphaCAT,alphacat,Dmcatp,DalphaC,Dalphacat,Dmel\CG17947,Dalpha-Cat,alpha-cat,CG17947,a-Cat)

alpha-Cat biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ovarian follicle cell development GO:0030707 248 0.999
germarium derived egg chamber formation GO:0007293 101 0.998
epithelial cell differentiation GO:0030855 322 0.996
germ line cyst formation GO:0048134 44 0.995
ovarian follicle cell migration GO:0007297 121 0.994
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.993
epithelial cell development GO:0002064 274 0.990
epithelial cell migration GO:0010631 148 0.988
female germ line cyst formation GO:0048135 42 0.979
germarium derived female germ line cyst formation GO:0030727 42 0.975
border follicle cell migration GO:0007298 113 0.963
localization of cell GO:0051674 257 0.959
columnar cuboidal epithelial cell development GO:0002066 249 0.938
cell migration GO:0016477 238 0.923
tissue migration GO:0090130 155 0.878
epithelium migration GO:0090132 148 0.876
programmed cell death GO:0012501 257 0.860
cell death GO:0008219 279 0.771
regulation of programmed cell death GO:0043067 152 0.767
cell motility GO:0048870 251 0.716
urogenital system development GO:0001655 72 0.697
cell proliferation GO:0008283 299 0.604
ameboidal type cell migration GO:0001667 151 0.575
immune system process GO:0002376 347 0.569
death GO:0016265 284 0.568
endocytosis GO:0006897 310 0.560
Fly
negative regulation of developmental process GO:0051093 201 0.512
larval development GO:0002164 104 0.511
regulation of multicellular organismal development GO:2000026 414 0.497
response to starvation GO:0042594 97 0.476
apoptotic process GO:0006915 159 0.467
sex differentiation GO:0007548 81 0.412
Rat
chromosome segregation GO:0007059 157 0.380
embryonic development via the syncytial blastoderm GO:0001700 148 0.380
embryo development ending in birth or egg hatching GO:0009792 152 0.376
cell projection assembly GO:0030031 94 0.372
meiotic cell cycle GO:0051321 171 0.372
actin filament based process GO:0030029 220 0.358
mrna metabolic process GO:0016071 124 0.348
organic substance catabolic process GO:1901575 308 0.346
regulation of cell shape GO:0008360 113 0.345
development of primary sexual characteristics GO:0045137 50 0.337
Rat
actin cytoskeleton organization GO:0030036 206 0.324
negative regulation of rna metabolic process GO:0051253 251 0.316
negative regulation of cellular metabolic process GO:0031324 382 0.314
multi organism behavior GO:0051705 175 0.305
reproductive behavior GO:0019098 122 0.288
axis specification GO:0009798 167 0.287
blastoderm segmentation GO:0007350 159 0.282
regulation of cellular component biogenesis GO:0044087 201 0.265
anterior posterior pattern specification GO:0009952 136 0.264
nucleobase containing compound catabolic process GO:0034655 165 0.241
meiotic chromosome segregation GO:0045132 59 0.239
negative regulation of gene expression GO:0010629 387 0.228
response to abiotic stimulus GO:0009628 341 0.215
single organism behavior GO:0044708 391 0.211
establishment of nucleus localization GO:0040023 26 0.208
regulation of notch signaling pathway GO:0008593 100 0.195
establishment or maintenance of cell polarity GO:0007163 167 0.185
eggshell formation GO:0030703 105 0.183
meiotic nuclear division GO:0007126 151 0.175
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.172
segmentation GO:0035282 207 0.166
nuclear division GO:0000280 332 0.159
regulation of actin filament based process GO:0032970 42 0.154
organic cyclic compound catabolic process GO:1901361 168 0.151
regulation of cell death GO:0010941 173 0.149
macromolecular complex assembly GO:0065003 256 0.143
Rat
nucleus localization GO:0051647 34 0.143
covalent chromatin modification GO:0016569 106 0.142
biological adhesion GO:0022610 138 0.142
Human Mouse
cellular catabolic process GO:0044248 372 0.140
actin filament based movement GO:0030048 26 0.138
compound eye development GO:0048749 307 0.133
multi multicellular organism process GO:0044706 123 0.132
organonitrogen compound metabolic process GO:1901564 318 0.129
oocyte axis specification GO:0007309 108 0.128
embryonic pattern specification GO:0009880 174 0.120
regionalization GO:0003002 416 0.117
asymmetric protein localization involved in cell fate determination GO:0045167 9 0.116
regulation of organelle organization GO:0033043 196 0.114
regulation of cell morphogenesis GO:0022604 163 0.110
cellular macromolecule catabolic process GO:0044265 136 0.109
maintenance of location GO:0051235 73 0.107
cleavage furrow formation GO:0036089 2 0.106
developmental growth GO:0048589 280 0.104
regulation of anatomical structure morphogenesis GO:0022603 242 0.102
pigmentation GO:0043473 75 0.099
cellular macromolecular complex assembly GO:0034622 153 0.098
negative regulation of signaling GO:0023057 219 0.097
catabolic process GO:0009056 409 0.095
oocyte development GO:0048599 124 0.095
digestive tract development GO:0048565 149 0.093
multi organism reproductive behavior GO:0044705 121 0.092
ras protein signal transduction GO:0007265 88 0.088
growth GO:0040007 359 0.087
axon development GO:0061564 297 0.086
Rat
formation of a compartment boundary GO:0060288 4 0.086
nucleoside phosphate metabolic process GO:0006753 162 0.086
asymmetric protein localization GO:0008105 33 0.085
regulation of transport GO:0051049 181 0.085
negative regulation of cell communication GO:0010648 223 0.084
tripartite regional subdivision GO:0007351 103 0.082
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.082
axonogenesis GO:0007409 290 0.081
oocyte differentiation GO:0009994 145 0.079
chromosome organization GO:0051276 360 0.079
reproductive system development GO:0061458 74 0.077
Rat
heterocycle catabolic process GO:0046700 166 0.076
cellular nitrogen compound catabolic process GO:0044270 165 0.073
positive regulation of phosphorus metabolic process GO:0010562 139 0.073
cellular response to chemical stimulus GO:0070887 199 0.071
meiotic cell cycle process GO:1903046 132 0.070
notch signaling pathway GO:0007219 120 0.069
eye development GO:0001654 323 0.066
small molecule metabolic process GO:0044281 305 0.066
small gtpase mediated signal transduction GO:0007264 88 0.066
negative regulation of protein secretion GO:0050709 2 0.064
anterior posterior axis specification embryo GO:0008595 103 0.064
renal tubule development GO:0061326 64 0.064
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.064
multicellular organismal reproductive behavior GO:0033057 110 0.064
regulation of endocytosis GO:0030100 37 0.063
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.063
morphogenesis of embryonic epithelium GO:0016331 94 0.062
macromolecule catabolic process GO:0009057 161 0.061
purine ribonucleotide metabolic process GO:0009150 145 0.061
regulation of phosphorus metabolic process GO:0051174 210 0.060
guanosine containing compound catabolic process GO:1901069 74 0.060
positive regulation of rna metabolic process GO:0051254 271 0.060
organelle fission GO:0048285 340 0.059
morphogenesis of an epithelium GO:0002009 276 0.058
cell adhesion GO:0007155 136 0.058
Human Mouse
protein modification process GO:0036211 438 0.057
negative regulation of necrotic cell death GO:0060547 1 0.057
regulation of protein complex assembly GO:0043254 42 0.055
aromatic compound catabolic process GO:0019439 166 0.053
head development GO:0060322 135 0.053
negative regulation of cell development GO:0010721 62 0.053
regulation of catalytic activity GO:0050790 185 0.052
protein complex biogenesis GO:0070271 201 0.052
Rat
regulation of apoptotic process GO:0042981 130 0.050
purine nucleoside metabolic process GO:0042278 127 0.050
positive regulation of ribosome biogenesis GO:0090070 3 0.050
maintenance of protein location in cell GO:0032507 26 0.049
regulation of protein polymerization GO:0032271 28 0.049
regulation of cell cycle process GO:0010564 181 0.048
meiotic nuclear envelope disassembly GO:0051078 2 0.048
negative regulation of cell differentiation GO:0045596 143 0.047
positive regulation of cellular component organization GO:0051130 156 0.047
positive regulation of signaling GO:0023056 243 0.046
positive regulation of phosphate metabolic process GO:0045937 139 0.046
rna splicing GO:0008380 83 0.046
regulation of cellular catabolic process GO:0031329 157 0.045
body morphogenesis GO:0010171 2 0.045
immune effector process GO:0002252 98 0.044
regulation of cellular component size GO:0032535 98 0.044
glycosyl compound metabolic process GO:1901657 127 0.044
developmental programmed cell death GO:0010623 138 0.044
regulation of cell development GO:0060284 215 0.043
actin filament polymerization GO:0030041 27 0.043
kidney development GO:0001822 3 0.042
brain development GO:0007420 120 0.042
anterior posterior axis specification GO:0009948 109 0.042
regulation of actin filament length GO:0030832 27 0.041
regulation of hemocyte proliferation GO:0035206 37 0.041
organelle localization GO:0051640 148 0.041
regulation of catabolic process GO:0009894 170 0.040
positive regulation of transcription dna templated GO:0045893 266 0.040
camera type eye development GO:0043010 4 0.040
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.040
immune response GO:0006955 246 0.040
phagocytosis GO:0006909 215 0.039
Fly
negative regulation of nervous system development GO:0051961 92 0.039
negative regulation of signal transduction GO:0009968 206 0.039
intracellular signal transduction GO:0035556 300 0.039
regulation of cell projection organization GO:0031344 92 0.038
cytoskeleton dependent cytokinesis GO:0061640 81 0.038
regulation of ras gtpase activity GO:0032318 38 0.038
positive regulation of cellular biosynthetic process GO:0031328 316 0.038
organophosphate metabolic process GO:0019637 195 0.038
negative regulation of cellular biosynthetic process GO:0031327 277 0.037
vesicle mediated transport GO:0016192 381 0.037
Fly
negative regulation of response to stimulus GO:0048585 258 0.036
mrna processing GO:0006397 104 0.036
positive regulation of catabolic process GO:0009896 105 0.036
reproductive structure development GO:0048608 74 0.036
Rat
positive regulation of cellular catabolic process GO:0031331 95 0.035
spindle organization GO:0007051 253 0.035
actin filament organization GO:0007015 126 0.035
positive regulation of cell communication GO:0010647 250 0.034
amine metabolic process GO:0009308 12 0.033
protein localization GO:0008104 284 0.033
cellular ketone metabolic process GO:0042180 24 0.033
regulation of protein modification process GO:0031399 112 0.033
regulation of striated muscle contraction GO:0006942 2 0.032
regulation of hydrolase activity GO:0051336 97 0.032
regulation of nucleotide catabolic process GO:0030811 48 0.032
negative regulation of cellular component organization GO:0051129 108 0.032
negative regulation of nurse cell apoptotic process GO:0045849 2 0.032
renal system development GO:0072001 72 0.031
regulation of vesicle mediated transport GO:0060627 59 0.031
positive regulation of response to stimulus GO:0048584 323 0.031
single organism catabolic process GO:0044712 228 0.031
purine ribonucleoside metabolic process GO:0046128 127 0.031
peptidyl amino acid modification GO:0018193 105 0.031
locomotory behavior GO:0007626 176 0.030
positive regulation of signal transduction GO:0009967 223 0.030
sensory organ morphogenesis GO:0090596 260 0.030
endosomal vesicle fusion GO:0034058 4 0.030
establishment of localization in cell GO:0051649 402 0.030
purine containing compound metabolic process GO:0072521 155 0.030
intracellular transport GO:0046907 228 0.029
cellular component disassembly GO:0022411 46 0.029
nitric oxide metabolic process GO:0046209 1 0.029
cell cycle arrest GO:0007050 4 0.029
neurological system process GO:0050877 358 0.029
cell division GO:0051301 248 0.029
peptidyl lysine acetylation GO:0018394 39 0.029
regulation of growth GO:0040008 233 0.029
rac protein signal transduction GO:0016601 3 0.029
carboxylic acid metabolic process GO:0019752 92 0.028
negative regulation of transcription dna templated GO:0045892 237 0.028
chorion containing eggshell formation GO:0007304 105 0.028
carbohydrate derivative metabolic process GO:1901135 217 0.028
regulation of actin filament polymerization GO:0030833 25 0.027
dna integration GO:0015074 1 0.027
central nervous system development GO:0007417 201 0.027
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.026
mitotic dna integrity checkpoint GO:0044774 75 0.026
single organism intracellular transport GO:1902582 207 0.025
humoral immune response GO:0006959 117 0.025
renal tubule morphogenesis GO:0061333 44 0.025
cell fate specification GO:0001708 71 0.024
establishment of protein localization GO:0045184 163 0.024
regulation of purine nucleotide catabolic process GO:0033121 48 0.023
negative regulation of rna biosynthetic process GO:1902679 240 0.023
positive regulation of hydrolase activity GO:0051345 78 0.023
regulation of cell differentiation GO:0045595 302 0.023
female meiotic division GO:0007143 70 0.023
positive regulation of molecular function GO:0044093 136 0.022
hindbrain development GO:0030902 2 0.022
regulation of molecular function GO:0065009 217 0.022
regulation of protein phosphorylation GO:0001932 64 0.022
regulation of anatomical structure size GO:0090066 163 0.022
negative regulation of biosynthetic process GO:0009890 277 0.022
oocyte morphogenesis GO:0048601 3 0.022
stem cell differentiation GO:0048863 117 0.022
determination of adult lifespan GO:0008340 137 0.022
malpighian tubule development GO:0072002 64 0.022
mitochondrial membrane organization GO:0007006 3 0.022
developmental maturation GO:0021700 172 0.021
organophosphate catabolic process GO:0046434 112 0.021
pigment metabolic process GO:0042440 84 0.021
regulation of nucleotide metabolic process GO:0006140 62 0.021
hematopoietic or lymphoid organ development GO:0048534 57 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
cellular protein localization GO:0034613 160 0.021
positive regulation of neuron projection regeneration GO:0070572 3 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
eye morphogenesis GO:0048592 260 0.020
cellular protein complex assembly GO:0043623 71 0.020
negative regulation of protein binding GO:0032091 1 0.020
ribonucleoside metabolic process GO:0009119 127 0.020
regulation of protein kinase activity GO:0045859 51 0.020
enzyme linked receptor protein signaling pathway GO:0007167 179 0.020
protein polymerization GO:0051258 42 0.019
nucleotide metabolic process GO:0009117 161 0.019
ribonucleoside triphosphate catabolic process GO:0009203 108 0.019
morphogenesis of follicular epithelium GO:0016333 36 0.019
aging GO:0007568 143 0.019
Rat
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.019
gonad development GO:0008406 50 0.019
Rat
regulation of actin polymerization or depolymerization GO:0008064 27 0.019
regulation of nucleoside metabolic process GO:0009118 50 0.019
gtp metabolic process GO:0046039 72 0.019
single organism cellular localization GO:1902580 180 0.018
regulation of phosphate metabolic process GO:0019220 210 0.018
negative regulation of cellular protein metabolic process GO:0032269 85 0.018
genitalia development GO:0048806 26 0.018
eye photoreceptor cell development GO:0042462 81 0.018
purine containing compound catabolic process GO:0072523 112 0.018
positive regulation of cell cycle process GO:0090068 28 0.018
nuclear migration GO:0007097 20 0.018
neuron projection guidance GO:0097485 241 0.018
cytokinesis GO:0000910 90 0.018
lipid storage GO:0019915 38 0.018
oocyte nucleus localization involved in oocyte dorsal ventral axis specification GO:0051663 12 0.018
regulation of ras protein signal transduction GO:0046578 93 0.018
response to oxygen containing compound GO:1901700 200 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 0 0.018
negative regulation of terminal cell fate specification open tracheal system GO:0035155 2 0.018
rna processing GO:0006396 147 0.018
regulation of phosphatase activity GO:0010921 3 0.017
positive regulation of transport GO:0051050 92 0.017
gland development GO:0048732 191 0.017
mapk import into nucleus GO:0000189 1 0.017
rna localization GO:0006403 115 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.017
positive regulation of catalytic activity GO:0043085 118 0.016
gland morphogenesis GO:0022612 145 0.016
nucleoside catabolic process GO:0009164 112 0.016
nucleoside triphosphate metabolic process GO:0009141 120 0.016
regulation of multi organism process GO:0043900 131 0.016
imaginal disc derived wing morphogenesis GO:0007476 337 0.016
positive regulation of cellular component biogenesis GO:0044089 80 0.016
positive regulation of gtpase activity GO:0043547 43 0.016
regulation of embryonic development GO:0045995 68 0.016
purine nucleoside catabolic process GO:0006152 112 0.015
positive regulation of nucleotide catabolic process GO:0030813 46 0.015
response to nutrient levels GO:0031667 114 0.015
mitotic spindle organization GO:0007052 220 0.015
nucleotide catabolic process GO:0009166 109 0.015
positive regulation of developmental process GO:0051094 143 0.015
cortical actin cytoskeleton organization GO:0030866 24 0.015
epithelial cell morphogenesis involved in gastrulation GO:0003381 7 0.015
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded GO:0008071 1 0.015
positive regulation of cell maturation GO:1903431 2 0.015
regulation of protein localization GO:0032880 76 0.015
ribonucleoside catabolic process GO:0042454 112 0.015
positive regulation of programmed cell death GO:0043068 62 0.015
protein transport GO:0015031 155 0.015
transcription from rna polymerase ii promoter GO:0006366 368 0.015
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.015
tissue morphogenesis GO:0048729 297 0.015
regulation of cell projection assembly GO:0060491 30 0.015
nucleoside metabolic process GO:0009116 127 0.014
dendrite regeneration GO:0031104 2 0.014
regulation of signal transduction by p53 class mediator GO:1901796 1 0.014
regulation of transferase activity GO:0051338 58 0.014
compound eye morphogenesis GO:0001745 249 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.014
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.014
regulation of actin cytoskeleton organization GO:0032956 42 0.014
oocyte construction GO:0007308 112 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
regulation of gene expression epigenetic GO:0040029 128 0.014
retina development in camera type eye GO:0060041 4 0.014
signal transduction in response to dna damage GO:0042770 3 0.014
negative regulation of cell cycle GO:0045786 116 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
wound healing GO:0042060 75 0.013
negative regulation of cell death GO:0060548 81 0.013
immune system development GO:0002520 57 0.013
regulation of nervous system development GO:0051960 248 0.013
protein phosphorylation GO:0006468 169 0.013
response to extracellular stimulus GO:0009991 116 0.013
regulation of cell cycle GO:0051726 291 0.013
wnt signaling pathway GO:0016055 98 0.013
positive regulation of nucleotide metabolic process GO:0045981 55 0.012
regulation of synaptic transmission GO:0050804 69 0.012
regulation of immune system process GO:0002682 176 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
activation of ral gtpase activity GO:0032859 1 0.012
oocyte fate commitment GO:0048600 2 0.012
regulation of protein metabolic process GO:0051246 256 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.012
regulation of small gtpase mediated signal transduction GO:0051056 93 0.012
isoprenoid biosynthetic process GO:0008299 3 0.012
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
regulation of localization GO:0032879 275 0.012
regulation of neurogenesis GO:0050767 158 0.012
ribose phosphate metabolic process GO:0019693 145 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
negative regulation of transcription from rna polymerase iii promoter GO:0016480 2 0.012
cellular macromolecule localization GO:0070727 220 0.012
meiotic spindle checkpoint GO:0044779 1 0.012
positive regulation of defense response GO:0031349 59 0.012
lipid localization GO:0010876 54 0.012
synapse organization GO:0050808 196 0.012
salivary gland histolysis GO:0035070 88 0.012
protein localization to organelle GO:0033365 82 0.011
epithelial tube morphogenesis GO:0060562 88 0.011
unidimensional cell growth GO:0009826 15 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
cuticle development GO:0042335 86 0.011
cellular amine metabolic process GO:0044106 12 0.011
regulation of organ morphogenesis GO:2000027 78 0.011
regulation of purine nucleotide metabolic process GO:1900542 62 0.011
negative regulation of phosphatase activity GO:0010923 3 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
sirna loading onto risc involved in rna interference GO:0035087 4 0.011
oxoacid metabolic process GO:0043436 103 0.011
establishment of protein localization to organelle GO:0072594 62 0.011
juvenile hormone mediated signaling pathway GO:0035626 3 0.011
purine nucleoside monophosphate catabolic process GO:0009128 38 0.011
embryonic axis specification GO:0000578 107 0.011
mitotic cell cycle phase transition GO:0044772 138 0.010
regulation of cellular ketone metabolic process GO:0010565 3 0.010
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.010
mapk cascade GO:0000165 107 0.010
membrane organization GO:0061024 112 0.010
organelle assembly GO:0070925 198 0.010
cell maturation GO:0048469 144 0.010
dna endoreduplication GO:0042023 22 0.010
eye antennal disc development GO:0035214 60 0.010
regulation of embryonic cell shape GO:0016476 30 0.010
anterior posterior axis specification follicular epithelium GO:0030714 2 0.010
regulation of erbb signaling pathway GO:1901184 42 0.010
axon guidance GO:0007411 233 0.010

alpha-Cat disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
syndrome DOID:225 0 0.025
disease of anatomical entity DOID:7 0 0.022
Human
nervous system disease DOID:863 0 0.019
chromosomal disease DOID:0080014 0 0.016
gonadal dysgenesis DOID:14447 0 0.016
artery disease DOID:0050828 0 0.016
aortic aneurysm DOID:3627 0 0.016
vascular disease DOID:178 0 0.016
cardiovascular system disease DOID:1287 0 0.016
Human
aortic disease DOID:520 0 0.016
endocrine gland cancer DOID:170 0 0.010
thyroid cancer DOID:1781 0 0.010
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010