Drosophila melanogaster

49 known processes

HP6 (Dmel_CG15636)

Heterochromatin protein 6

(Aliases: Umbrea,Dmel\CG15636,umbrea,CG15636)

HP6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome organization GO:0051276 360 0.460
homeostatic process GO:0042592 199 0.143
mitotic nuclear division GO:0007067 213 0.132
telomere organization GO:0032200 21 0.111
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.101
Fly
positive regulation of nucleic acid templated transcription GO:1903508 266 0.088
positive regulation of rna metabolic process GO:0051254 271 0.081
positive regulation of rna biosynthetic process GO:1902680 266 0.080
positive regulation of transcription dna templated GO:0045893 266 0.069
positive regulation of biosynthetic process GO:0009891 316 0.062
regulation of multicellular organismal development GO:2000026 414 0.059
determination of adult lifespan GO:0008340 137 0.057
positive regulation of cellular biosynthetic process GO:0031328 316 0.056
death GO:0016265 284 0.056
Fly
positive regulation of response to stimulus GO:0048584 323 0.052
transcription from rna polymerase ii promoter GO:0006366 368 0.051
endocytosis GO:0006897 310 0.051
positive regulation of macromolecule metabolic process GO:0010604 405 0.049
Fly
cellular response to dna damage stimulus GO:0006974 223 0.049
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.047
Fly
protein modification process GO:0036211 438 0.047
Fly
dna metabolic process GO:0006259 227 0.047
negative regulation of biosynthetic process GO:0009890 277 0.046
Fly
regulation of nervous system development GO:0051960 248 0.046
negative regulation of developmental process GO:0051093 201 0.045
morphogenesis of an epithelium GO:0002009 276 0.044
exocrine system development GO:0035272 162 0.044
catabolic process GO:0009056 409 0.043
sister chromatid segregation GO:0000819 92 0.041
negative regulation of signaling GO:0023057 219 0.041
cellular protein modification process GO:0006464 438 0.041
Fly
chromatin modification GO:0016568 147 0.040
Fly
positive regulation of signaling GO:0023056 243 0.040
sleep GO:0030431 49 0.038
salivary gland development GO:0007431 162 0.038
vesicle mediated transport GO:0016192 381 0.038
multicellular organismal aging GO:0010259 140 0.038
histone modification GO:0016570 106 0.037
Fly
neurological system process GO:0050877 358 0.037
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.037
positive regulation of signal transduction GO:0009967 223 0.037
chromatin organization GO:0006325 207 0.036
Fly
body morphogenesis GO:0010171 2 0.036
regulation of neurogenesis GO:0050767 158 0.036
negative regulation of gene expression GO:0010629 387 0.035
Fly
positive regulation of cell communication GO:0010647 250 0.034
proteolysis GO:0006508 192 0.034
telomere maintenance GO:0000723 21 0.034
protein catabolic process GO:0030163 101 0.034
regulation of programmed cell death GO:0043067 152 0.033
Fly
negative regulation of cellular metabolic process GO:0031324 382 0.033
Fly
regulation of organelle organization GO:0033043 196 0.033
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.032
dendrite development GO:0016358 204 0.032
regulation of cell death GO:0010941 173 0.031
Fly
regulation of neuron differentiation GO:0045664 103 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.030
organelle fission GO:0048285 340 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.030
Fly
positive regulation of developmental process GO:0051094 143 0.030
protein localization GO:0008104 284 0.030
anatomical structure homeostasis GO:0060249 97 0.030
regulation of anatomical structure morphogenesis GO:0022603 242 0.030
regulation of cellular protein metabolic process GO:0032268 243 0.029
Fly
regulation of cell differentiation GO:0045595 302 0.029
regulation of growth GO:0040008 233 0.029
negative regulation of response to stimulus GO:0048585 258 0.029
regulation of developmental growth GO:0048638 174 0.028
cognition GO:0050890 141 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.028
Fly
cell death GO:0008219 279 0.027
Fly
organic substance catabolic process GO:1901575 308 0.027
covalent chromatin modification GO:0016569 106 0.027
Fly
developmental growth GO:0048589 280 0.027
salivary gland morphogenesis GO:0007435 145 0.026
gland development GO:0048732 191 0.026
nuclear division GO:0000280 332 0.026
cell cell signaling involved in cell fate commitment GO:0045168 210 0.026
forebrain development GO:0030900 2 0.025
macromolecule catabolic process GO:0009057 161 0.024
regulation of cellular amine metabolic process GO:0033238 3 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.024
Fly
negative regulation of cell communication GO:0010648 223 0.024
regulation of cell development GO:0060284 215 0.024
dna conformation change GO:0071103 105 0.024
Fly
telomere capping GO:0016233 11 0.024
regionalization GO:0003002 416 0.024
developmental maturation GO:0021700 172 0.024
aging GO:0007568 143 0.023
regulation of intracellular signal transduction GO:1902531 236 0.023
regulation of protein metabolic process GO:0051246 256 0.023
Fly
phagocytosis GO:0006909 215 0.023
intracellular transport GO:0046907 228 0.023
cellular response to chemical stimulus GO:0070887 199 0.023
regulation of cell cycle process GO:0010564 181 0.023
positive regulation of gene expression GO:0010628 290 0.023
g protein coupled receptor signaling pathway GO:0007186 136 0.023
chemical homeostasis GO:0048878 92 0.023
small gtpase mediated signal transduction GO:0007264 88 0.023
negative regulation of signal transduction GO:0009968 206 0.022
regulation of phosphate metabolic process GO:0019220 210 0.022
single organism behavior GO:0044708 391 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
regulation of cellular component biogenesis GO:0044087 201 0.022
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.022
spindle organization GO:0007051 253 0.022
somatic muscle development GO:0007525 66 0.021
cholesterol homeostasis GO:0042632 3 0.021
regulation of phosphorus metabolic process GO:0051174 210 0.021
oxoacid metabolic process GO:0043436 103 0.021
developmental programmed cell death GO:0010623 138 0.020
response to oxidative stress GO:0006979 86 0.020
regulation of apoptotic process GO:0042981 130 0.020
Fly
mitotic spindle organization GO:0007052 220 0.020
multi multicellular organism process GO:0044706 123 0.020
regulation of organ growth GO:0046620 42 0.020
phosphorylation GO:0016310 294 0.019
gland morphogenesis GO:0022612 145 0.019
ras protein signal transduction GO:0007265 88 0.019
enzyme linked receptor protein signaling pathway GO:0007167 179 0.019
protein phosphorylation GO:0006468 169 0.019
chromosome segregation GO:0007059 157 0.019
programmed cell death GO:0012501 257 0.018
Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.018
Fly
apoptotic process GO:0006915 159 0.018
Fly
negative regulation of growth GO:0045926 84 0.018
defense response to other organism GO:0098542 225 0.018
dendrite morphogenesis GO:0048813 199 0.018
compound eye development GO:0048749 307 0.018
microtubule organizing center organization GO:0031023 168 0.018
spermatogenesis GO:0007283 200 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
intracellular signal transduction GO:0035556 300 0.018
learning GO:0007612 75 0.018
mitotic sister chromatid segregation GO:0000070 87 0.018
negative regulation of nucleic acid templated transcription GO:1903507 240 0.018
Fly
negative regulation of developmental growth GO:0048640 64 0.018
growth GO:0040007 359 0.018
tissue morphogenesis GO:0048729 297 0.018
salivary gland cell autophagic cell death GO:0035071 83 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.018
regulation of cell cycle GO:0051726 291 0.018
kidney development GO:0001822 3 0.017
positive regulation of cellular component biogenesis GO:0044089 80 0.017
Fly
regulation of organ morphogenesis GO:2000027 78 0.017
centrosome cycle GO:0007098 137 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
negative regulation of cell differentiation GO:0045596 143 0.017
organ growth GO:0035265 56 0.017
regulation of ras protein signal transduction GO:0046578 93 0.017
cytoplasmic transport GO:0016482 130 0.017
hindbrain development GO:0030902 2 0.017
response to other organism GO:0051707 293 0.017
cellular catabolic process GO:0044248 372 0.017
response to abiotic stimulus GO:0009628 341 0.016
intracellular protein transport GO:0006886 104 0.016
neural retina development GO:0003407 4 0.016
regulation of response to stress GO:0080134 200 0.016
organic acid metabolic process GO:0006082 103 0.016
organelle assembly GO:0070925 198 0.016
organonitrogen compound metabolic process GO:1901564 318 0.016
cellular macromolecular complex assembly GO:0034622 153 0.016
regulation of transport GO:0051049 181 0.016
amine metabolic process GO:0009308 12 0.016
appendage development GO:0048736 401 0.016
response to bacterium GO:0009617 198 0.016
regulation of catalytic activity GO:0050790 185 0.016
stem cell differentiation GO:0048863 117 0.016
camera type eye development GO:0043010 4 0.016
regulation of epithelial cell differentiation GO:0030856 4 0.016
salivary gland histolysis GO:0035070 88 0.015
histolysis GO:0007559 102 0.015
synapse assembly GO:0007416 143 0.015
negative regulation of nervous system development GO:0051961 92 0.015
locomotory behavior GO:0007626 176 0.015
eye development GO:0001654 323 0.015
mapk cascade GO:0000165 107 0.015
telencephalon development GO:0021537 2 0.015
establishment of localization in cell GO:0051649 402 0.015
positive regulation of nervous system development GO:0051962 69 0.015
regulation of localization GO:0032879 275 0.015
negative regulation of cell cycle GO:0045786 116 0.015
wing disc morphogenesis GO:0007472 344 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
regulation of cell cycle phase transition GO:1901987 130 0.015
peptidyl amino acid modification GO:0018193 105 0.015
Fly
single organism intracellular transport GO:1902582 207 0.015
cation transmembrane transport GO:0098655 88 0.014
establishment of protein localization GO:0045184 163 0.014
signal transduction by phosphorylation GO:0023014 107 0.014
defense response to bacterium GO:0042742 178 0.014
regulation of cellular localization GO:0060341 136 0.014
cellular protein localization GO:0034613 160 0.014
sensory perception GO:0007600 196 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.014
Fly
positive regulation of multicellular organismal process GO:0051240 143 0.014
centrosome duplication GO:0051298 121 0.014
cellular amino acid metabolic process GO:0006520 61 0.014
axon development GO:0061564 297 0.014
notch signaling pathway GO:0007219 120 0.014
regulation of small gtpase mediated signal transduction GO:0051056 93 0.014
chromatin remodeling GO:0006338 72 0.014
Fly
rna processing GO:0006396 147 0.014
protein modification by small protein conjugation or removal GO:0070647 106 0.014
nuclear transport GO:0051169 72 0.014
compound eye morphogenesis GO:0001745 249 0.014
regulation of multi organism process GO:0043900 131 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
wnt signaling pathway GO:0016055 98 0.013
synapse organization GO:0050808 196 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
regulation of phosphorylation GO:0042325 147 0.013
cellular macromolecule localization GO:0070727 220 0.013
post embryonic appendage morphogenesis GO:0035120 385 0.013
aromatic compound catabolic process GO:0019439 166 0.013
regulation of protein localization GO:0032880 76 0.013
insemination GO:0007320 22 0.013
mating GO:0007618 120 0.013
retina development in camera type eye GO:0060041 4 0.013
cellular modified amino acid metabolic process GO:0006575 45 0.013
small molecule metabolic process GO:0044281 305 0.013
posttranscriptional gene silencing by rna GO:0035194 45 0.013
response to oxygen containing compound GO:1901700 200 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
regulation of intracellular transport GO:0032386 64 0.013
rrna processing GO:0006364 3 0.013
germline stem cell asymmetric division GO:0098728 15 0.013
organic substance transport GO:0071702 257 0.013
axis specification GO:0009798 167 0.013
multicellular organism growth GO:0035264 46 0.013
regulation of dendrite development GO:0050773 37 0.013
chemotaxis GO:0006935 249 0.012
nucleocytoplasmic transport GO:0006913 72 0.012
cellular amine metabolic process GO:0044106 12 0.012
axonogenesis GO:0007409 290 0.012
regulation of reproductive process GO:2000241 54 0.012
larval behavior GO:0030537 42 0.012
regulation of embryonic development GO:0045995 68 0.012
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.012
stress activated mapk cascade GO:0051403 52 0.012
embryonic morphogenesis GO:0048598 206 0.012
single organismal cell cell adhesion GO:0016337 45 0.012
response to biotic stimulus GO:0009607 294 0.012
regulation of defense response GO:0031347 102 0.012
taxis GO:0042330 304 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
tube morphogenesis GO:0035239 191 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
sterol homeostasis GO:0055092 4 0.012
regulation of response to external stimulus GO:0032101 115 0.011
cellular response to organic substance GO:0071310 132 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.011
single organism cellular localization GO:1902580 180 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
Fly
negative regulation of transcription dna templated GO:0045892 237 0.011
Fly
protein processing GO:0016485 68 0.011
cell cycle checkpoint GO:0000075 95 0.011
regulation of behavior GO:0050795 75 0.011
appendage morphogenesis GO:0035107 397 0.011
cell fate determination GO:0001709 91 0.011
regulation of mapk cascade GO:0043408 92 0.011
tube development GO:0035295 244 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
regulation of molecular function GO:0065009 217 0.011
cation transport GO:0006812 110 0.011
muscle structure development GO:0061061 224 0.011
regulation of heart contraction GO:0008016 21 0.011
lipid metabolic process GO:0006629 121 0.011
eye morphogenesis GO:0048592 260 0.011
translation GO:0006412 69 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
positive regulation of molecular function GO:0044093 136 0.011
dna alkylation GO:0006305 4 0.011
Fly
negative regulation of cell development GO:0010721 62 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
Fly
monocarboxylic acid transport GO:0015718 3 0.011
sensory organ morphogenesis GO:0090596 260 0.011
eye photoreceptor cell differentiation GO:0001754 145 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.010
anterior posterior pattern specification GO:0009952 136 0.010
endomembrane system organization GO:0010256 119 0.010
male gamete generation GO:0048232 201 0.010
microtubule based movement GO:0007018 51 0.010
cellular ketone metabolic process GO:0042180 24 0.010
regulation of immune system process GO:0002682 176 0.010
autophagic cell death GO:0048102 83 0.010
cell division GO:0051301 248 0.010
regulation of neuron projection development GO:0010975 69 0.010
positive regulation of hydrolase activity GO:0051345 78 0.010
positive regulation of cell motility GO:2000147 3 0.010
spindle assembly involved in mitosis GO:0090307 50 0.010
adult locomotory behavior GO:0008344 76 0.010
positive regulation of protein metabolic process GO:0051247 128 0.010
Fly
mesenchymal cell development GO:0014031 1 0.010
epithelial tube morphogenesis GO:0060562 88 0.010
response to organic substance GO:0010033 284 0.010
regulation of mitotic cell cycle GO:0007346 190 0.010
protein dna complex subunit organization GO:0071824 86 0.010
jnk cascade GO:0007254 50 0.010

HP6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.014